Pathophysiology and Treatment of Hypertension: Current Challenges and Future Perspectives

Dear Colleagues,

Hypertension is a leading cardiovascular disorder and a major risk factor for the development and progression of cardiovascular disease, including coronary artery disease, heart failure, stroke, and vascular and heart remodeling. Although significant progress has been made in understanding its underlying mechanisms and developing effective therapies, the prevalence of uncontrolled hypertension remains high, highlighting persistent gaps in knowledge and clinical practice. This Special Issue, “Pathophysiology and Treatment of Hypertension: Current Challenges and Future Perspectives”, aims to present current advances and emerging new concepts in hypertension research, spanning basic, translational, and clinical studies, as well as therapeutic strategies related to hypertension. This Special Issue invites original research articles and reviews that explore the molecular, cellular, and systemic pathophysiology underlying hypertension, including vascular dysfunction, neurohormonal regulation, inflammation, metabolic abnormalities, and genetic and epigenetic contributions.

In addition, this Special Issue seeks to highlight recent developments and ongoing challenges in the treatment and management of hypertension. Topics of interest include pharmacological and non-pharmacological interventions, combination therapies, personalized and precision medicine approaches, and strategies to improve blood pressure control and cardiovascular outcomes. By integrating mechanistic insights with clinical evidence, this Special Issue aims to advance understanding and inform future directions in hypertension research and care.

Dr. Hua Zhang
Dr. De-Pei Li
Guest Editors

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