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Inorganics
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Inorganic Nanoparticles in Cancer Therapy II
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Inorganic Nanoparticles in Cancer Therapy II

A special issue of Inorganics (ISSN 2304-6740). This special issue belongs to the section "Bioinorganic Chemistry".

Deadline for manuscript submissions: closed (28 February 2023) | Viewed by 2409

Special Issue Editor

Dr. Nikola Knežević

E-Mail Website
Guest Editor
BioSense Institute, University of Novi Sad, 21000 Novi Sad, Serbia
Interests: nanomaterials; materials chemistry; targeted cancer therapy and imaging; drug delivery; biosensors
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Different types of complex inorganic nanoarchitectures involving functionalized mesoporous silica, silicon, gold, silver, magnetite and other metal oxides, diamond, hydroxyapatite, and other types of inorganic nanoparticles are being demonstrated in the literature for efficient cancer treatment, imaging and construction of cancer-related biosensors. Even though organic types of nanomaterials (e.g., polymers or liposomes) are predominantly approved for clinical applications, inorganic nanoparticles are gaining substantial interest, with some also clinically approved, such as superparamagnetic nanoparticles (SPION) and some other types of nanoparticles that are currently in the clinical trials (e.g., silica-based Cornell dots).

This Special Issue aims to continue upon our first Special Issue “Inorganic Nanoparticles in Cancer Therapy” in highlighting the richness of the inorganic nanoparticles in terms of their composition and morphology for applications in the construction of nano architectures for targeted therapy and imaging of cancer, as well as for the construction of cancer-related biosensors.

Dr. Nikola Knežević
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Inorganics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • inorganic nanoparticles
  • cancer treatment
  • cancer diagnostics
  • cancer biosensors
  • drug delivery systems
  • cancer targeting
  • stimuli-responsive cancer therapy
  • cancer imaging

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Published Papers (1 paper)

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Research

9 pages, 3240 KiB  
Article
Mesoporous Silica Nanoparticles for pH-Responsive Delivery of Iridium Metallotherapeutics and Treatment of Glioblastoma Multiforme
by Nikola Ž. Knežević, Nebojša Ilić and Goran N. Kaluđerović
Inorganics 2022, 10(12), 250; https://doi.org/10.3390/inorganics10120250 - 08 Dec 2022
Viewed by 1884
Abstract
Using nanoparticles for controlled drug delivery to cancer, in response to its weakly acidic environment, represents a promising approach toward increasing the effectiveness and reducing the adverse effects of cancer therapy. Hence, the aim of this study is to construct novel mesoporous silica [...] Read more.
Using nanoparticles for controlled drug delivery to cancer, in response to its weakly acidic environment, represents a promising approach toward increasing the effectiveness and reducing the adverse effects of cancer therapy. Hence, the aim of this study is to construct novel mesoporous silica nanoparticle (MSN)-based acidification-responsive drug delivery systems for targeted cancer therapy. Herein, the surface of MSN is covalently functionalized with Ir(III)-based complex through a pH-cleavable hydrazone-based linker and characterized by nitrogen sorption, SEM, FTIR, EDS, TGA, DSC, DLS, and zeta potential measurements. Enhanced release of Ir(III)-complexes is evidenced by UV/VIS spectroscopy at the weakly acidic environments (pH 5 and pH 6) in comparison to the release at physiological conditions. The in vitro toxicity of the prepared materials is tested on healthy MRC-5 cells while their potential for the efficient treatment of glioblastoma multiforme is demonstrated on the U251 cell line. Full article
(This article belongs to the Special Issue Inorganic Nanoparticles in Cancer Therapy II)
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