Special Issue "Inorganic Nanoparticles in Cancer Therapy"

A special issue of Inorganics (ISSN 2304-6740). This special issue belongs to the section "Bioinorganic Chemistry".

Deadline for manuscript submissions: 10 December 2019.

Special Issue Editors

Guest Editor
Prof. Dr. Goran Kaluderovic

Department of Engineering and Natural Sciences, University of Applied Sciences Merseburg, Eberhard-Leibnitz-Strasse 2, 06217 Merseburg, Germany
Website | E-Mail
Interests: inorganic nanoparticles; cancer treatment; cancer diagnostics; drug delivery systems; cancer targeting
Guest Editor
Dr. Nikola Knežević

Group of Nano and Microelectronics; BioSense Institute, University of Novi Sad, Dr Zorana Đinđića 1, Novi Sad 21000, Serbia
E-Mail
Interests: nanomaterials; inorganic materials chemistry; targeted cancer therapy; drug delivery systems; biosensors

Special Issue Information

Dear Colleagues,

The research field on inorganic nanomaterials has been yielding increasingly complex architectures and demonstrating a plethora of novel application possibilities. Thus, even in the case of the construction of nanomaterials for cancer treatment, which initially was mostly considered as the area fitted for organic types of materials (e.g. polymers or liposomes), there have been huge breakthroughs in demonstrating the applicability of inorganic nanoparticles for cancer treatment and diagnostics. Such nanomaterials may encompass functionalized gold, silver, silica, organosilica, silicon, magnetite and other metal oxides, diamond, hydroxyapatite, and further types of inorganic nanoparticles that may benefit as the sole drug carrier, or in the form of more complex nanoarchitectures composed of different types of nanoparticles, for more efficient cancer treatment and diagnostics. This Special Issue aims to highlight the compositional, morphological, and functional diversity of the inorganic nanoparticles for applications in the construction of novel, smart nanoassemblies for targeting, selective treatment, and diagnosis of cancer.

Prof. Dr. Goran Kaluderovic
Dr. Nikola Knežević
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Inorganics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • inorganic nanoparticles
  • cancer treatment
  • cancer diagnostics
  • drug delivery systems
  • cancer targeting

Published Papers (2 papers)

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Research

Open AccessArticle
Photocracking Silica: Tuning the Plasmonic Photothermal Degradation of Mesoporous Silica Encapsulating Gold Nanoparticles for Cargo Release
Received: 6 May 2019 / Revised: 31 May 2019 / Accepted: 31 May 2019 / Published: 6 June 2019
PDF Full-text (2864 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
The degradation of bionanomaterials is essential for medical applications of nanoformulations, but most inorganic-based delivery agents do not biodegrade at controllable rates. In this contribution, we describe the controllable plasmonic photocracking of [email protected] nanoparticles by tuning the power and wavelength of the laser [...] Read more.
The degradation of bionanomaterials is essential for medical applications of nanoformulations, but most inorganic-based delivery agents do not biodegrade at controllable rates. In this contribution, we describe the controllable plasmonic photocracking of [email protected] nanoparticles by tuning the power and wavelength of the laser irradiation, or by tuning the size of the encapsulated gold cores. Particles were literally broken to pieces or dissolved from the inside out upon laser excitation of the plasmonic cores. The photothermal cracking of silica, probably analogous to thermal fracturing in glass, was then harnessed to release cargo molecules from [email protected]@polycaprolactone nanovectors. This unique and controllable plasmonic photodegradation has implications for nanomedicine, photopatterning, and sensing applications. Full article
(This article belongs to the Special Issue Inorganic Nanoparticles in Cancer Therapy)
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Graphical abstract

Open AccessArticle
Functionalized Periodic Mesoporous Organosilica Nanoparticles for Loading and Delivery of Suramin
Received: 15 January 2019 / Revised: 31 January 2019 / Accepted: 1 February 2019 / Published: 5 February 2019
PDF Full-text (2388 KB) | HTML Full-text | XML Full-text
Abstract
Suramin (SUR) is a known drug for treating parasitic infections though research studies and some clinical trials have shown its applicability for a plethora of other diseases. Herein we report on a novel SUR nanocarrier for the drug delivery to cells. We synthesized [...] Read more.
Suramin (SUR) is a known drug for treating parasitic infections though research studies and some clinical trials have shown its applicability for a plethora of other diseases. Herein we report on a novel SUR nanocarrier for the drug delivery to cells. We synthesized periodic mesoporous organosilica nanoparticles with spherical morphology, having mean diameter of 240 nm and high surface area (778 m2/g). The material’s surface is modified with an amine-containing organic moiety N-[3-(Trimethoxysilyl)propyl]ethylenediamine (DA), followed by surface attachment with the drug. The rate of SUR release in physiological condition was low, though in vitro experiments on MRC-5 cell line demonstrate effective delivery of the drug to the cells and low toxicity of the materials without the adsorbed drug. These results are promising for opening new treatment strategies with SUR-bearing nanocarriers, with high efficiency and low adverse effects on healthy tissues. Full article
(This article belongs to the Special Issue Inorganic Nanoparticles in Cancer Therapy)
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Graphical abstract

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