Inorganic Nanoparticles in Cancer Therapy

A special issue of Inorganics (ISSN 2304-6740). This special issue belongs to the section "Bioinorganic Chemistry".

Deadline for manuscript submissions: closed (10 December 2019) | Viewed by 7518

Special Issue Editors


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Guest Editor
Department of Engineering and Natural Sciences, University of Applied Sciences Merseburg, Eberhard-Leibnitz-Strasse 2, 06217 Merseburg, Germany
Interests: antitumor drugs; molecular oncology; drug targeting; medicinal chemistry
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Guest Editor
Associate research professor, Biosense Institute, University of Novi Sad, Serbia
Interests: nanomaterials; materials chemistry; targeted cancer therapy; drug delivery; biosensors
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The research field on inorganic nanomaterials has been yielding increasingly complex architectures and demonstrating a plethora of novel application possibilities. Thus, even in the case of the construction of nanomaterials for cancer treatment, which initially was mostly considered as the area fitted for organic types of materials (e.g. polymers or liposomes), there have been huge breakthroughs in demonstrating the applicability of inorganic nanoparticles for cancer treatment and diagnostics. Such nanomaterials may encompass functionalized gold, silver, silica, organosilica, silicon, magnetite and other metal oxides, diamond, hydroxyapatite, and further types of inorganic nanoparticles that may benefit as the sole drug carrier, or in the form of more complex nanoarchitectures composed of different types of nanoparticles, for more efficient cancer treatment and diagnostics. This Special Issue aims to highlight the compositional, morphological, and functional diversity of the inorganic nanoparticles for applications in the construction of novel, smart nanoassemblies for targeting, selective treatment, and diagnosis of cancer.

Prof. Dr. Goran Kaluderovic
Dr. Nikola Knežević
Guest Editors

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Keywords

  • inorganic nanoparticles
  • cancer treatment
  • cancer diagnostics
  • drug delivery systems
  • cancer targeting

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Published Papers (2 papers)

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Research

13 pages, 2864 KiB  
Article
Photocracking Silica: Tuning the Plasmonic Photothermal Degradation of Mesoporous Silica Encapsulating Gold Nanoparticles for Cargo Release
by Jonas G. Croissant and Tania M. Guardado-Alvarez
Inorganics 2019, 7(6), 72; https://doi.org/10.3390/inorganics7060072 - 06 Jun 2019
Cited by 11 | Viewed by 3813
Abstract
The degradation of bionanomaterials is essential for medical applications of nanoformulations, but most inorganic-based delivery agents do not biodegrade at controllable rates. In this contribution, we describe the controllable plasmonic photocracking of gold@silica nanoparticles by tuning the power and wavelength of the laser [...] Read more.
The degradation of bionanomaterials is essential for medical applications of nanoformulations, but most inorganic-based delivery agents do not biodegrade at controllable rates. In this contribution, we describe the controllable plasmonic photocracking of gold@silica nanoparticles by tuning the power and wavelength of the laser irradiation, or by tuning the size of the encapsulated gold cores. Particles were literally broken to pieces or dissolved from the inside out upon laser excitation of the plasmonic cores. The photothermal cracking of silica, probably analogous to thermal fracturing in glass, was then harnessed to release cargo molecules from gold@silica@polycaprolactone nanovectors. This unique and controllable plasmonic photodegradation has implications for nanomedicine, photopatterning, and sensing applications. Full article
(This article belongs to the Special Issue Inorganic Nanoparticles in Cancer Therapy)
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9 pages, 2388 KiB  
Article
Functionalized Periodic Mesoporous Organosilica Nanoparticles for Loading and Delivery of Suramin
by Nikola Ž. Knežević, Sanja Djordjević, Vesna Kojić and Djordje Janaćković
Inorganics 2019, 7(2), 16; https://doi.org/10.3390/inorganics7020016 - 05 Feb 2019
Cited by 6 | Viewed by 3259
Abstract
Suramin (SUR) is a known drug for treating parasitic infections though research studies and some clinical trials have shown its applicability for a plethora of other diseases. Herein we report on a novel SUR nanocarrier for the drug delivery to cells. We synthesized [...] Read more.
Suramin (SUR) is a known drug for treating parasitic infections though research studies and some clinical trials have shown its applicability for a plethora of other diseases. Herein we report on a novel SUR nanocarrier for the drug delivery to cells. We synthesized periodic mesoporous organosilica nanoparticles with spherical morphology, having mean diameter of 240 nm and high surface area (778 m2/g). The material’s surface is modified with an amine-containing organic moiety N-[3-(Trimethoxysilyl)propyl]ethylenediamine (DA), followed by surface attachment with the drug. The rate of SUR release in physiological condition was low, though in vitro experiments on MRC-5 cell line demonstrate effective delivery of the drug to the cells and low toxicity of the materials without the adsorbed drug. These results are promising for opening new treatment strategies with SUR-bearing nanocarriers, with high efficiency and low adverse effects on healthy tissues. Full article
(This article belongs to the Special Issue Inorganic Nanoparticles in Cancer Therapy)
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