MOFs and MCOFs: Design, Synthesis and Application

A special issue of Inorganics (ISSN 2304-6740). This special issue belongs to the section "Organometallic Chemistry".

Deadline for manuscript submissions: 30 June 2026 | Viewed by 1536

Special Issue Editor


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Guest Editor
School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou 511436, China.
Interests: metal-organic framework; covalent-organic framework; MOFs; COFs)

Special Issue Information

Dear Colleagues,

We are delighted to announce and invite you to contribute to this Special Issue of Inorganics, titled "MOFs and MCOFs: Design, Synthesis and Application".

Metal–Organic Frameworks (MOFs) and Metal–Covalent Organic Frameworks (MCOFs), represent two of the most exciting classes of porous crystalline materials developed in recent years. Their exceptional characteristics—including ultrahigh surface areas, structural and functional tunability, and well-defined porosity—have positioned them as prime candidates for a myriad of advanced applications. The ability to precisely engineer their building blocks at the molecular level allows the tailoring of their properties to meet specific functional demands, pushing the boundaries of materials science and technology.

Significant strides have been made in the design and synthesis of MOFs and MCOFs, ranging from novel synthetic strategies and post-synthetic modification techniques to the development of scalable production methods. These advancements are crucial for translating laboratory discoveries into practical technologies. To unlock the full potential of these frameworks, a synergistic combination of experimental and theoretical approaches should be employed, which can lead to uncovering deeper insights into their formation mechanisms, structure–property relationships, and performance optimization.

This Special Issue aims to compile a collection of original research articles and comprehensive reviews that reflect the latest progress in the field. We welcome contributions that span the entire spectrum of MOF and MCOF research, with a focus on their design, synthesis, and functional applications. Potential topics include, but are not limited to the following:

Design and Synthesis: Novel ligand design, synthetic methodologies, green synthesis, post-synthetic modification, and theoretical modeling of structures and properties.

Biological Applications:

  • Antimicrobial material
  • Antiviral material
  • Nanomedicine: Drug delivery systems for anti-tumor and antibacterial therapy.
  • Biomaterials, Nanozymes, and applications in Nanomedicine and Bionanotechnology.

Sensing: Chemical sensors, biosensors, and optical sensors for the detection of various analytes.

Gas Adsorption and Separation: Capture of CO2, storage of H2 or CH4, and separation of gas mixtures (e.g., O2/N2, C2H4/C2H6).

Catalysis: Heterogeneous organic catalysis, photocatalysis (for water splitting, CO2 reduction, pollutant degradation), and electrocatalysis (for ORR, OER, HER).

We look forward to receiving your valuable contributions and sharing a impactful collection of research that will advance the frontiers of MOF and MCOF science.

Prof. Dr. Xujia Hong
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Inorganics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • metal–organic frameworks
  • MOFs
  • metal–covalent organic frameworks
  • MCOFs
  • design
  • synthesis
  • sensing
  • gas adsorption and separation
  • catalysis

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Published Papers (1 paper)

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Review

36 pages, 5629 KB  
Review
Review of the Applications of Metal–Organic Frameworks (MOFs) in Multi-Field Detection
by Boyu Zhang, Ming Zhang, Siqi Huang, Weie Wang, Yuguang Lv, Fenghua Liu, Xi Cao and Kuilin Lv
Inorganics 2026, 14(4), 93; https://doi.org/10.3390/inorganics14040093 - 27 Mar 2026
Viewed by 1227
Abstract
As a novel organic–inorganic hybrid porous crystalline material, metal–organic frameworks (MOFs) are ideal sensitive materials for detecting gases, antibiotics, and ions, owing to their ultra-high specific surface area, tunable pore structures, abundant active sites, and tailorable architectures. This review systematically summarizes the core [...] Read more.
As a novel organic–inorganic hybrid porous crystalline material, metal–organic frameworks (MOFs) are ideal sensitive materials for detecting gases, antibiotics, and ions, owing to their ultra-high specific surface area, tunable pore structures, abundant active sites, and tailorable architectures. This review systematically summarizes the core structural features, preparation methods, and modification strategies of MOFs, elaborates on the adsorption and signal conversion mechanisms in target detection, and highlights typical applications, performance advantages, and practical scenarios of MOF-based sensors, clarifying their structure–activity relationships and performance differences from traditional semiconductor sensors. It further analyzes key challenges, including insufficient stability, poor conductivity, large-scale preparation difficulties, and real-sample interference, as well as industrialization bottlenecks such as batch-to-batch reproducibility, instrument integration, and high costs. Additionally, it supplements cross-field synergistic innovations and industrialization progress, and prospects future directions: function-oriented precise design, multifunctional composite optimization, portable intelligent devices, green large-scale synthesis, and standardization promotion. This review provides a comprehensive reference for advancing MOF-based detection research and applications in environmental monitoring, industrial safety, food safety, and healthcare. Full article
(This article belongs to the Special Issue MOFs and MCOFs: Design, Synthesis and Application)
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