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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Gut Microbiota in Human Disease and Health: 2nd Edition

edited by

Silvia Turroni

and

Federica D'Amico

submission deadline 20 Aug 2026 | Viewed by 480 | Submission Open

Keywords: gut microbiota; human disease; human health; omics; microbiota–host interactions; microbiota manipulation

(This special issue belongs to the Section Molecular Microbiology)

Latest Advances in Pituitary Endocrinology

edited by

Antonio M. Picó

and Cristina Lamas

submission deadline 20 Aug 2026 | Viewed by 477 | Submission Open

Keywords: pituitary tumors; hypopituitarism; growth and puberty disorders; acromegaly; Cushing’s disease and silent corticotroph tumors; silent pituitary tumors; hypophysitis; molecular endocrinology and transcription factors; hormone resistance; precision endocrinology

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

PD-L1 – PD1 Signaling Axis: From Mechanism to Therapeutics

edited by

Grazyna Kochan

and

David Escors

submission deadline 20 Aug 2026 | Viewed by 467 | Submission Open

Keywords: PD-L1/PD1 immune checkpoints; cancer; mechnistic insights and resistances; adaptive immune regulation; therapeutic strategies

(This special issue belongs to the Section Molecular Oncology)

Peripheral Neuropathy: Exploring Pathogenic Pathways and Therapeutic Approaches

edited by Yuehling Hsieh

submission deadline 20 Aug 2026 | Viewed by 464 | Submission Open

Keywords: peripheral neuropathy; biochemical mechanisms; biomarkers; nerve regeneration; therapeutic approaches; pain management; denervated muscle atrophy; translational medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Long COVID Biology and Epidemiology: Predisposition, Molecular Mechanisms and Diagnostics

edited by Eduardo José Melo dos Santos

submission deadline 20 Aug 2026 | Viewed by 458 | Submission Open

Keywords: long COVID; genetic predisposing; long COVID epidemiology; pathogenesis; immunology of long COVID; long COVID etiology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Genetics, Epigenetics and Genomics of Neurodegenerative Diseases

edited by

Simone Agostini

submission deadline 20 Aug 2026 | Viewed by 449 | Submission Open

Keywords: epigenetics; microRNA; genetics; genomics; methylation; histone modification; neurodegenerative diseases

(This special issue belongs to the Section Molecular Genetics and Genomics)

New Molecular Insights into Antimicrobial Peptides

edited by

Gloria Bua

submission deadline 20 Aug 2026 | Viewed by 440 | Submission Open

Keywords: antimicrobial peptides; mode of action; molecular mechanism of biological activity; molecular targets; molecular modeling; structure–activity relationship

(This special issue belongs to the Section Molecular Microbiology)

Ion Regulation in Human Pathophysiology

edited by

Lars Kaestner

submission deadline 20 Aug 2026 | Viewed by 438 | Submission Open

Keywords: ion channels; ion gradients; membrane potential; action potential; ion pumps; uniporter; co-transporter; patch-clamp; ion flux; concentration gradient; ion stores; physiological processes; pathophysiological processes

(This special issue belongs to the Section Molecular Biology)

Dermatological Perspectives on Connective Tissue Diseases

edited by

Yoshihide Asano

submission deadline 20 Aug 2026 | Viewed by 427 | Submission Open

Keywords: connective tissue diseases; systemic sclerosis; systemic lupus erythematosus; dermatomyo-sitis; rheumatoid arthritis; Sjögren’s syndrome; skin immunology; fibrosis; cytokines; targeted therapy

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms and Combinatorial Strategies in Anti-Obesity Therapeutics

edited by

James Ernest Blevins

submission deadline 20 Aug 2026 | Viewed by 426 | Submission Open

Keywords: obesity; high-fat diet; rodents; pharmacotherapy; body weight; food intake

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Epigenetic Regulation in Cell Development, Differentiation and Cell Fate

edited by Gang Ren

submission deadline 20 Aug 2026 | Viewed by 425 | Submission Open

Keywords: 3D genome; myogenesis; transgenerational inheritance; enhancer–promoter interaction; histone modification; epigenetic variation; complex traits

(This special issue belongs to the Section Molecular Genetics and Genomics)

The Regulation of Metabolism by Sugars During Plant Responses to Environmental Factors and Their Function During Development

edited by

Iwona Morkunas

submission deadline 20 Aug 2026 | Viewed by 409 | Submission Open

Keywords: plant metabolism; sugar signalling; enzymes of sucrose metabolism; environmental factors; plant defense responses; developmental regulation; phytohormones; secondary metabolites

(This special issue belongs to the Section Molecular Plant Sciences)

Cellulose and Its Applications, 2nd Edition

edited by

Suresh Valiyaveettil

and Ce Sun

submission deadline 20 Aug 2026 | Viewed by 398 | Submission Open

Keywords: cellulose; biomedical applications; nanocomposites; biodegradable polymers; water purification; nanocellulose

(This special issue belongs to the Section Macromolecules)

Plant–Rhizobium Interaction

edited by Rujin Chen

submission deadline 20 Aug 2026 | Viewed by 396 | Submission Open

Keywords: legume; rhizobia; symbiotic nitrogen fixation

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Mechanisms of Vascular Sclerosis

edited by

Michishige Terasaki

submission deadline 20 Aug 2026 | Viewed by 395 | Submission Open

Keywords: atherosclerosis; genes; dyslipidemia; diabetes; macrophages; molecular mechanisms

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

RNA-Mediated Post-Transcriptional Regulation in Bacteria Roles of Small RNAs, Small Proteins, and RNA Modifications

edited by Karl M Thompson

submission deadline 20 Aug 2026 | Viewed by 388 | Submission Open

Keywords: bacterial post-transcriptional regulation; small RNAs (sRNAs); small open reading frames (smORFs); RNA modifications; epitranscriptomics

(This special issue belongs to the Section Molecular Biology)

The Medicinal Value of Plant Extracts

edited by

Myrna Déciga-Campos

and

Rosa Ventura-Martínez

submission deadline 20 Aug 2026 | Viewed by 383 | Submission Open

Keywords: medicinal plant; essential oil; cancer; diabetes; pain; inflammation; neurodegenerative diseases; metabolites; bioactive compounds; toxicity; safety; mutagenicity; genotoxicity; biological evaluations; efficacy; molecular

(This special issue belongs to the Section Molecular Pharmacology)

Study of the Molecular Mechanisms Underlying the Involvement of Viruses in the Progression of Autoimmune Diseases

edited by

Marco Miceli

submission deadline 20 Aug 2026 | Viewed by 378 | Submission Open

Keywords: multiple sclerosis; central nervous system; autoimmune; genetic and environmental factors; herpesviruses; CMV; immunopathology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Mechanisms of Action of Environmental Neurotoxicants During Critical Periods of Brain Development

edited by

Yael Abreu-Villaça

submission deadline 20 Aug 2026 | Viewed by 376 | Submission Open

Keywords: environmental neurotoxicants; developmental neurotoxicity; critical windows; animal models; early exposure; long-term programming

(This special issue belongs to the Section Molecular Neurobiology)

Plant-Based Early Therapeutics for Parasitic Infections Combined with Functional Modern Diagnosis Methods

edited by

Lee Tian Chang

submission deadline 20 Aug 2026 | Viewed by 369 | Submission Open

Keywords: active phytocompounds; antiparasitic agents; artificial intelligence; early diagnosis early treatment; life cycle; medicinal plants; parasite and vector; phytogenic feed additives; vision recognition

(This special issue belongs to the Section Molecular Plant Sciences)

Engineered Mesenchymal Stromal/Stem Cells: Increasing Targeting Precision in Cancer Therapy

edited by

Urban Švajger

submission deadline 20 Aug 2026 | Viewed by 369 | Submission Open

Keywords: engineered mesenchymal stromal stem cells; targeted cancer therapy; tumor microenvironment; cell-based drug delivery

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Symbiosis and Molecular Mechanisms in Water Treatment

edited by

Binghan Xie

submission deadline 20 Aug 2026 | Viewed by 368 | Submission Open

Keywords: microbiomics; water treatment; bioenergy recovery; emerging contaminant degradation; antibiotic resistance genes (ARGs); microalgae biotechnology

(This special issue belongs to the Section Molecular Microbiology)

Multiple Myeloma: Cancer Therapy and the Tumour Microenvironment

edited by Ruba Al Abdulla

submission deadline 20 Aug 2026 | Viewed by 356 | Submission Open

Keywords: multiple myeloma; cancer resistance; therapeutic strategies; stroma cells; cancer microenvironment; cancer immunity

(This special issue belongs to the Section Molecular Oncology)

Intracellular Host-Bacteria Dynamics: Unraveling the Molecular Basis

edited by

Apichai Tuanyok

submission deadline 20 Aug 2026 | Viewed by 356 | Submission Open

Keywords: intracellular bacteria; granuloma; immune invasion; Mycobacterium tuberculosis; Burkholderia pseudomallei; Francisella; Brucella; Listeria; Coxiella

(This special issue belongs to the Section Molecular Microbiology)

Lipopolysaccharide as a Drug Target

edited by

Martina Schmidt

submission deadline 20 Aug 2026 | Viewed by 349 | Submission Open

Keywords: tissue barriers; neuroinflammation; macrophages; microglia; organoids; scaffolds; infections; cry-EM

(This special issue belongs to the Section Molecular Pharmacology)

Decoding Protein Structure and Protein Dynamics in Cancer

edited by

Umesh Kalathiya

and

Monikaben Padariya

submission deadline 20 Aug 2026 | Viewed by 348 | Submission Open

Keywords: protein structures; oncogenes; post-translational modifications (PTMs); cancer; proteomics; computational biology; structural biology; molecular modeling; bioinformatics

(This special issue belongs to the Section Molecular Biology)

Macrophage Dysfunction and Cytokine Storm in Pulmonary Disorders

edited by

Elżbieta Rutkowska

submission deadline 20 Aug 2026 | Viewed by 343 | Submission Open

Keywords: macrophage dysfunction; cytokine storm; lung diseases

(This special issue belongs to the Section Molecular Immunology)

Molecular Perspective of Alzheimer’s Disease

edited by

Philippe Poindron

submission deadline 20 Aug 2026 | Viewed by 342 | Submission Open

Keywords: Alzheimer’s disease; amyloid peptide (toxic conformation); mutations (gamma-secretase); GWAS; risk factors; new treatment (monoclonal antibodies)

(This special issue belongs to the Section Molecular Neurobiology)

Natural Antioxidants: Molecular Mechanisms, Formulations and Therapeutic Perspectives

edited by

Lavinia Anamaria Purza

submission deadline 20 Aug 2026 | Viewed by 338 | Submission Open

Keywords: natural antioxidants; oxidative stress; redox signaling; polyphenols; reactive oxygen species; bioactive compounds; nutraceuticals; phytochemicals

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Predictive, Prognostic Biomarkers and Therapeutic Targets of Breast Cancer: Second Edition

edited by Antonella Ciabattoni and Fabiana Gregucci

submission deadline 20 Aug 2026 | Viewed by 338 | Submission Open

Keywords: radiotherapy; breast cancer; stereotactic body radiotherapy; brain radiosurgery; target therapy; immunotherapy; tailored systemic therapy

(This special issue belongs to the Section Molecular Oncology)

Neural Signaling: The Perspective of Molecular Genetics

edited by

Chunlai Wu

submission deadline 20 Aug 2026 | Viewed by 321 | Submission Open

Keywords: molecular neurogenetics; neural signaling; gene editing; neural circuits; neural plasticity; neurodegenerative disorders; single-cell technologies

(This special issue belongs to the Section Molecular Genetics and Genomics)

Plant Metabolites under Environmental Stress: Mechanisms, Responses and Adaptation Strategies

edited by

Alfosea-Simón Marina

submission deadline 20 Aug 2026 | Viewed by 319 | Submission Open

Keywords: omics; biosynthesis; defense; stress; adaptation; metabolites

(This special issue belongs to the Section Molecular Plant Sciences)

Sarcomeric Proteins in Health and Disease: Progress and Prospects

edited by

Thomas C. Irving

submission deadline 20 Aug 2026 | Viewed by 316 | Submission Open

Keywords: sarcomeric proteins; muscle contraction; sarcomere

(This special issue belongs to the Section Molecular Biophysics)

Vitamin D in Reproductive Disorders: Determinants, Metabolism, and Downstream Biological Mechanisms

edited by

Eugenia Mata-Greenwood

submission deadline 20 Aug 2026 | Viewed by 303 | Submission Open

Keywords: vitamin D; perinatal corticosteroids; placental insufficiency; intrauterine growth restriction; cortisol metabolism

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Cancer Stem Cells as Key Immunotherapy Targets

edited by Cosmin Andrei Cismaru

submission deadline 20 Aug 2026 | Viewed by 289 | Submission Open

Keywords: cancer stem cells; immunotherapy; immune escape; tumor antigens; cancer recurrence

(This special issue belongs to the Section Molecular Immunology)

Focus on Chemoradiation Resistance: The Challenge of Cancer Therapy

edited by

Karl Reinhard Aigner

and Hendrikx Marc José Henri

submission deadline 20 Aug 2026 | Viewed by 239 | Submission Open

Keywords: genetic, epigenetic, and metabolic determinants of chemoradiation resistance; tumor microenvironmental influences and immune system interactions; DNA damage response pathways and novel radiosensitizers/chemosensitizers; predictive and prognostic biomarkers for treatment response; emerging therapeutic combinations and personalized medicine strategies; concentration-dependent therapy and chemotherapy optimization; intra-arterial infusion and isolated perfusion chemotherapy; quality of life

(This special issue belongs to the Section Molecular Oncology)

Molecular Mechanisms of Innate Immunity and Disease Resistance in Animals

edited by

Sutian Wang

submission deadline 22 Aug 2026 | Viewed by 434 | Submission Open

Keywords: innate immunity; pathogenic microorganism; animals; pathogenesis; mechanism of disease-resistance; disease-resistant/therapeutic target

(This special issue belongs to the Section Molecular Immunology)

Recent Advances of Novel Pharmaceutical Designs for Anticancer Therapies, 4th Edition

edited by

Bernhard Biersack

submission deadline 25 Aug 2026 | 3 articles | Viewed by 2904 | Submission Open

Keywords: cancer; anticancer drugs; drug design; targeted therapy; immunotherapy; molecular target; molecular mechanism; drug resistance

(This special issue belongs to the Section Molecular Pharmacology)

Natural Compounds in Cancer Treatment and Prevention: Mechanisms, Evidence, and Clinical Perspectives

edited by

Vitor Engracia Valenti

submission deadline 25 Aug 2026 | 2 articles | Viewed by 2550 | Submission Open

Keywords: natural compounds; cancer treatment; cancer prevention; bioactive phytochemicals

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Current Research on Lipidomics

edited by

Agata Kot-Wasik

submission deadline 25 Aug 2026 | 1 articles | Viewed by 2323 | Submission Open

Keywords: lipids ; hyphenated chromatography–mass spectrometry ; biological samples ; sample preparation

(This special issue belongs to the Section Molecular Biology)

Muscle Atrophy Molecular Signaling Regulation

edited by

Tatiana Kostrominova

submission deadline 25 Aug 2026 | 1 articles | Viewed by 853 | Submission Open

Keywords: skeletal muscle atrophy; loss of mass and contractile force; molecular signaling pathways

(This special issue belongs to the Section Molecular Biology)

Circadian Clocks and Immunity: Unraveling the Rhythm of Immune Function

edited by Vincent Yuan and

Telma Quintela

submission deadline 25 Aug 2026 | Viewed by 350 | Submission Open

Keywords: circadian rhythm; biological clocks; immune regulation; innate immunity; adaptive immunity; inflammation; chronotherapy; immune-metabolic regulation; tissue-resident immune cells; autoimmune disease

(This special issue belongs to the Section Molecular Immunology)

The Cellular and Molecular Mechanisms of Sensory Map Development

edited by

Anindya Ganguly

submission deadline 25 Aug 2026 | Viewed by 255 | Submission Open

Keywords: sensory map development; axon guidance and synaptogenesis; molecular signaling pathways; neural circuit assembly

(This special issue belongs to the Section Molecular Neurobiology)

Endometriosis: Focusing on Molecular and Cellular Research, 2nd Edition

edited by

Alfonso Baldi

submission deadline 30 Aug 2026 | 2 articles | Viewed by 2749 | Submission Open

Keywords: endometriosis; reproductive system; endometrial cell; novel treatment

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Human Endogenous Retrovirus Expression and Its Implications for Human Health and Disease

edited by

Luiz Henrique Da Silva Nali

submission deadline 30 Aug 2026 | 2 articles | Viewed by 1654 | Submission Open

Keywords: human endogenous retrovirus; HERVs genes expression; HERV families; autoimmune diseases; degenerative diseases; physiological function; gene expression modulation; inflammation; immune response; molecular biology

(This special issue belongs to the Section Molecular Microbiology)

Discovery and Development of Functional Ingredients for Anti-Aging, Cognitive Enhancement and Skin Health

edited by

Sung-Joon Lee

and Jinbyung Park

submission deadline 30 Aug 2026 | 3 articles | Viewed by 1591 | Submission Open

Keywords: bioactive compounds; anti-aging; cognitive performance; skin health

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Autophagy: A Double-Edged Sword in Disease Pathogenesis and Cancer Progression

edited by

Antonio Ieni

submission deadline 30 Aug 2026 | 1 articles | Viewed by 1243 | Submission Open

Keywords: autophagy; cancer therapy resistance; tumor microenvironment; immunometabolism

(This special issue belongs to the Section Molecular Biology)

Cytotoxicity, Antioxidant, and Anticancer Activity of Natural Products, 3rd Edition

edited by

Balik Dzhambazov

submission deadline 30 Aug 2026 | 2 articles | Viewed by 1211 | Submission Open

Keywords: natural products; anticancer activity; apoptosis; immunomodulation; free radicals; proliferation; phytomolecules; nanoparticles; drug delivery

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Targeting Oxidative Stress: New Insights into Disease Pathogenesis, Emerging Preventive Strategies and Novel Therapeutic Approaches

edited by Fabio Vivarelli and

Donatella Canistro

submission deadline 30 Aug 2026 | 2 articles | Viewed by 1131 | Submission Open

Keywords: metabolism; inflammation; oxidative stress; diabetes; natural oxidative stress modulators; novel preventive/therapeutic strategies; ageing; cardiovascular diseases; regenerative medicine; neurodegeneration; environmental exposure; cancer

(This special issue belongs to the Section Molecular Biology)

Advanced Molecular Dynamics and Multiscale Modelling for Materials and Structures

edited by

Sandeep Kumar Singh

submission deadline 30 Aug 2026 | 1 articles | Viewed by 845 | Submission Open

Keywords: molecular dynamics simulations; atomistic modeling; multiscale modeling; high-entropy alloys; grain boundaries and defects; machine-learning interatomic potentials; computational materials science

(This special issue belongs to the Section Materials Science)

Displaying special issue 201-250 on page 5 of 62.

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