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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Applications of Seaweed Bioactive Compounds in Agriculture and Biotechnology

edited by

Samira Etahiri

and

Omar Assobhei

submission deadline 28 Dec 2026 | Viewed by 200 | Submission Open

Keywords: seaweed bioactive compounds; marine algae; sustainable agriculture; biostimulants; biopesticides; plant growth promotion; crop stress tolerance; antimicrobial activity; natural products; biomaterials

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Mechanisms of Exercise Training on Vascular Disease

edited by Maxime Pellegrin

submission deadline 28 Dec 2026 | Viewed by 122 | Submission Open

Keywords: vascular disease; vascular health; exercise training; training modalities; molecular and cellular mechanisms; sex-dependent responses

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Plant Tolerance to Stress

edited by

Xingguo Li

submission deadline 30 Dec 2026 | 8 articles | Viewed by 8735 | Submission Open

Keywords: plant; genetic breeding; biotic stress; abiotic stress; gene regulation

(This special issue belongs to the Section Molecular Plant Sciences)

Gene Editing for Cereal Crops

edited by

Ke Wang

submission deadline 30 Dec 2026 | 2 articles | Viewed by 5778 | Submission Open

Keywords: gene-editing techniques; novel germplasm; quality; nutrition; agronomic traits

(This special issue belongs to the Section Molecular Plant Sciences)

Mitochondrial Function and Therapies

edited by

Iain P. Hargreaves

submission deadline 30 Dec 2026 | 4 articles | Viewed by 5078 | Submission Open

Keywords: mitochondrial dysfunction; oxidative stress; antioxidants; biogenesis; transcription factors

(This special issue belongs to the Section Biochemistry)

Advances in T Cell-Based Cancer Immunotherapy

edited by

Ying Luo

submission deadline 30 Dec 2026 | 2 articles | Viewed by 3956 | Submission Open

Keywords: T cell immunotherapy; CAR-T cell; immune checkpoint blockade; T cell exhaustion; tumor microenvironment

(This special issue belongs to the Section Molecular Immunology)

Research Progress on Disease Models Based on Induced Pluripotent Stem Cells

edited by

Delger Bayarsaikhan

submission deadline 30 Dec 2026 | 2 articles | Viewed by 1931 | Submission Open

Keywords: induced pluripotent stem cells; iPSC-derived cells; disease modeling; precision and regenerative medicine; genome editing; CRISP/Cas; organoid; cell sheet; personalized therapeutics; drug discovery

(This special issue belongs to the Section Molecular Biology)

Advanced Research in Antioxidant Activity: Second Edition

edited by

Fotios Tekos

and Demetrios Kouretas

submission deadline 30 Dec 2026 | 2 articles | Viewed by 1152 | Submission Open

Keywords: xenobiotics; oxidative stress; free radicals; reactive oxygen species; reactive nitrogen species; antioxidants; glutathione; toxicology; redox metabolism; redox imbalance

(This special issue belongs to the Section Biochemistry)

Stem Cell Innovations and Reproductive Biotechnologies

edited by

Marcin Samiec

submission deadline 30 Dec 2026 | Viewed by 937 | Submission Open

Keywords: mammals; birds; stem cell research; pluri-/multipotency; differentiation/dedifferentiation; assisted reproductive technologies (ARTs); transgenic research; biomedicine

(This special issue belongs to the Section Molecular Biology)

Plant Responses to Biotic and Abiotic Stresses—Second Edition

edited by

Shu Yuan

submission deadline 30 Dec 2026 | 1 articles | Viewed by 591 | Submission Open

Keywords: plant enzymes and metabolites; abiotic stress; acclimation and tolerance; phytohormones; secondary metabolism; gene regulation network; developmental and environmental adaptation; microbial interactions; biotic stress; pathogen resistance

(This special issue belongs to the Section Molecular Plant Sciences)

Advances in Malnutrition and Infectious Diseases: Molecular Perspectives and Host-Pathogen Interactions

edited by

Sajid Ur Rahman

submission deadline 30 Dec 2026 | Viewed by 455 | Submission Open

Keywords: malnutrition; host-pathogen interactions; immunometabolism; micronutrient deficiency; innate and adaptive immunity; microbiome dysbiosis; infection-induced inflammation

(This special issue belongs to the Section Molecular Microbiology)

Molecular Animal Nutrition

edited by

Umair Ahsan

submission deadline 30 Dec 2026 | 1 articles | Viewed by 440 | Submission Open

Keywords: animal nutrition; feed additives; molecular mechanisms; nutrition and health; sustainability

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Hybrid Materials: Antimicrobial Performance and Molecular Mechanisms

edited by

Albena Bachvarova-Nedelcheva

and Kalina Ivanova

submission deadline 30 Dec 2026 | Viewed by 371 | Submission Open

Keywords: hybrid materials; molecular mechanisms; antimicrobial activity; nanomaterials; chemistry of ma-terials

(This special issue belongs to the Section Materials Science)

Molecular Interactions for Advanced Food Safety Biosensing

edited by

Long Wu

and Yang Zhou

submission deadline 30 Dec 2026 | Viewed by 321 | Submission Open

Keywords: food safety; molecular interaction; biosensors; signal transduction; precise recognition

(This special issue belongs to the Section Biochemistry)

New Concepts on the Mechanisms of Inflammation, Autoimmunity and Tumorigenesis

edited by

Marina Arleevskaya

and Yves Renaudineau

submission deadline 30 Dec 2026 | Viewed by 272 | Submission Open

Keywords: autoimmunity; immunology; inflammation; tumorigenesis; lipid metabolism; rheumatology

(This special issue belongs to the Section Molecular Immunology)

Molecular Synthesis, Properties, and Biomedical Applications of Bioceramics

edited by

Amine Bendahhou

and

Mohamed Azzouzi

submission deadline 30 Dec 2026 | Viewed by 267 | Submission Open

Keywords: bioceramics; ceramic materials; dielectric materials; photocatalysis; perovskite ceramics; materials chemistry; solid-state materials; functional materials; environmental materials; energy materials

(This special issue belongs to the Section Materials Science)

Natural Bioactive Compounds as Modulators of Oxidative Stress and Inflammation

edited by

Ignazio Barbagallo

submission deadline 30 Dec 2026 | Viewed by 260 | Submission Open

Keywords: natural compounds; redox homeostasis; inflammatory signaling; nutraceuticals; antioxidant response; sports nutrition

(This special issue belongs to the Section Biochemistry)

Advances in the Pathology and Pathogenetic Mechanisms of Diabetic Neuropathy

edited by

Aditya K. Singh

submission deadline 30 Dec 2026 | Viewed by 252 | Submission Open

Keywords: diabetic; neuroinflammation; neurovascular pathology; neuropathy; nerve injury

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

AI-Driven Molecular Modeling and Simulation in Biomedical Research and Biophysics

edited by

Whelton Miller

submission deadline 30 Dec 2026 | Viewed by 193 | Submission Open

Keywords: artificial intelligence (AI); machine learning (ML); biophysics; computational biology; molecular docking; molecular dynamics (MD); quantum mechanics; structure–activity relationships; computer-aided drug design (CADD); homology modeling

(This special issue belongs to the Section Molecular Informatics)

Natural Products and Derivatives: Isolation, Characterization, and Biological Activities

edited by

Cristian Paz

submission deadline 30 Dec 2026 | Viewed by 191 | Submission Open

Keywords: natural products; bioactive compounds; structure elucidation; biotransformation; semisynthesis; chemical modification; medicinal chemistry; molecular docking; molecular dynamics; artificial intelligence; drug discovery; enzyme inhibitors; protein modulators; antimicrobial agents; anticancer agents; neuroprotective compounds; pharmacological evaluation

(This special issue belongs to the Section Bioactives and Nutraceuticals)

New Molecular Research on Antimicrobial Resistance

edited by

Anastasia Spiliopoulou

submission deadline 30 Dec 2026 | Viewed by 189 | Submission Open

Keywords: antimicrobial resistance; carbapenem-resistant enterobacterales; carbapenemases; multidrug-resistant organisms (MDROs); antifungal resistance; vancomycin-resistant Enterococcus (VRE); methicillin-resistant Staphylococcus aureus (MRSA); colonization by multidrug-resistant pathogens; healthcare-associated infections

(This special issue belongs to the Section Molecular Microbiology)

Molecular Genetic Regulation, Omics Innovation and Precision Breeding in Crops

edited by

Shaozhen He

and Xu Li

submission deadline 30 Dec 2026 | Viewed by 142 | Submission Open

Keywords: crop molecular breeding; omics analysis; biotic and abiotic stress tolerance; gene function; transcriptional regulation; protein–protein interactions; germplasm innovation; genetic regulatory mechanisms

(This special issue belongs to the Section Molecular Plant Sciences)

The Biology of Human Melanocytes and Pigmentation

edited by Tai Kyung Noh

submission deadline 30 Dec 2026 | Viewed by 134 | Submission Open

Keywords: melanogenesis; pigmentary disorders; hyperpigmentation; molecular signaling pathways; dermatological therapeutics; skin microenvironment; laser–tissue interaction; skin-brightening agents; melasma; photobiology

(This special issue belongs to the Section Molecular Biology)

Advances in Cell Metabolism in Endocrine Diseases, 2nd Edition

edited by

Antonella Muscella

submission deadline 30 Dec 2026 | Viewed by 130 | Submission Open

Keywords: cellular metabolism; homeostasis; endocrine disorders; hormonal signals; dynamic system

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Next-Gen Cell Immunotherapies: From CAR-T to Synthetic Platforms

edited by Claudio Mussolino

submission deadline 30 Dec 2026 | Viewed by 124 | Submission Open

Keywords: cell-based immunotherapy; CAR-T cells; genome engineering; epigenetic engineering; synthetic biology; CRISPR; immune cell engineering; CAR-NK cells; T cell exhaustion; multiplex editing

(This special issue belongs to the Section Molecular Immunology)

Food and Plants Nanotechnology: Challenges and Future Prospects

edited by Luís R. Silva

submission deadline 30 Dec 2026 | Viewed by 96 | Submission Open

Keywords: nanotechnology; food safety; smart nanocarriers; nanosensors; antimicrobial nanomaterials; nano-enabled delivery systems

(This special issue belongs to the Section Molecular Nanoscience)

Galectins (Gals), 2nd Edition

edited by

Luciano Pirone

submission deadline 31 Dec 2026 | 12 articles | Viewed by 28198 | Submission Open

Keywords: galectin; inhibitors; cancer; inflammation; glycans; drug design; modeling; biomarkers

(This special issue belongs to the Section Molecular Biology)

25th Anniversary of IJMS: Updates and Advances in Molecular Nanoscience

edited by Qi Zhang,

Marilena Carbone

and

André F. Moreira

submission deadline 31 Dec 2026 | 15 articles | Viewed by 21087 | Submission Open

Keywords: nanotechnology; nanomaterials; nanomedicine; nanostructures; 2D materials; smart nanomaterials; nanocatalysts; nanozymes

(This special issue belongs to the Section Molecular Nanoscience)

Hormonal Regulatory Networks in Aging, Cancers, Alzheimer’s Disease, and Therapeutics

edited by

Pulak R. Manna

submission deadline 31 Dec 2026 | 4 articles | Viewed by 20255 | Submission Open

Keywords: hormonal imbalance and aging; endocrinology; physiology and pathophysiology; steroidogenesis; sex hormones and neurosteroids; age-related complications and diseases; tumorigenesis; hormone-dependent cancers; neurodegenrative diseases; Alzheimer’s disease; therapeutics; healthy aging

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Environmental Sensitivity Illnesses: Advances in Mechanisms and Molecular Signatures

edited by

Daniela Caccamo

submission deadline 31 Dec 2026 | 3 articles | Viewed by 17139 | Submission Open

Keywords: electromagnetic hypersensitivity; multiple chemical sensitivity; fibromyalgia; chronic fatigue syndrome; chronic pain disorder; toxicant-induced loss of tolerance; total allergy syndrome; circulating biomarkers; genetic susceptibility factors; immune system alterations

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Microglia in Neurological Disorders: Potential Therapeutic Targets and Underlying Mechanisms

edited by

Masashi Tanaka

submission deadline 31 Dec 2026 | 4 articles | Viewed by 15996 | Submission Open

Keywords: cerebral amyloid angiopathy; Alzheimer's disease; amyloid-β fibril formation

(This special issue belongs to the Section Molecular Neurobiology)

Natural Products for Neuroprotection and Neurodegeneration

edited by

Patrycja Kupnicka

submission deadline 31 Dec 2026 | 8 articles | Viewed by 12679 | Submission Open

Keywords: natural products; bioactive compounds; neuroprotection; neurodegeneration

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Research and Advances in Ocular Disease

edited by Da-Wen Lu

submission deadline 31 Dec 2026 | 5 articles | Viewed by 10579 | Submission Open

Keywords: ophthalmology; AI; ocular; eye diseases; retina; cornea; glaucoma; neuro-ophthalmology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Current Trends in Redox Physiology Research

edited by Fotios Tekos

submission deadline 31 Dec 2026 | 5 articles | Viewed by 9728 | Submission Open

Keywords: redox biology; oxidative stress; antioxidant mechanisms; redox signaling; cellular homeostasis; inflammation and redox; nutritional redox modulation; environmental toxicology and redox; mitochondrial dysfunction; oxidative stress biomarkers

(This special issue belongs to the Section Biochemistry)

Highlights in Pathophysiology and Treatment of Osteoarthritis

edited by

Antonella Fioravanti

and

Serena Guiducci

submission deadline 31 Dec 2026 | 4 articles | Viewed by 9354 | Submission Open

Keywords: osteoarthritis; pathophysiology (cytokines, adipokines, chemokines, epigenetics, microbiome); cartilage; synovial membrane; subchondral bone; treatment; disease-modifying osteoarthritis drugs; non-pharmacological treatment

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Basis and Treatment of Skin Diseases and Their Associated Complications (2nd Edition)

edited by

Maria Maisto

and

Vincenzo Piccolo

submission deadline 31 Dec 2026 | 5 articles | Viewed by 8849 | Submission Open

Keywords: diagnosis; biomarkers; imaging; histopathology; cutaneous comorbidities complication; therapy; management; clinical Trials

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Viral Biology: Infection and Pathology, Diagnosis and Treatment

edited by

Gergana Zahmanova

submission deadline 31 Dec 2026 | 8 articles | Viewed by 8667 | Submission Open

Keywords: viral infection; viral pathogenesis; diagnostics; antiviral therapy; host–virus interactions; emerging viruses; zoonotic viruses; one health; vaccine development; CRISPR antivirals

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Insights into Tryptophan Metabolism

edited by

Katsunori Nonogaki

submission deadline 31 Dec 2026 | 2 articles | Viewed by 7083 | Submission Open

Keywords: tryptophan; serotonin; kynurenine; indole; metabolism; IPA; Tph; IDO1; health; disease

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Osteoporosis: From Molecular Research to Novel Therapies

edited by

Agostino Gaudio

and Anastasia Xourafa

submission deadline 31 Dec 2026 | 3 articles | Viewed by 6713 | Submission Open

Keywords: osteoporosis; bone metabolism; OPG/RANK/RANKL system; Wnt/beta catenin signalling; secondary osteoporosis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Natural and Synthetic Modified Nucleic Acids: Their Properties, Functions and Applications

edited by

Malgorzata Sierant

submission deadline 31 Dec 2026 | 3 articles | Viewed by 6636 | Submission Open

Keywords: DNA; RNA; nucleic acid analogues; modified nucleosides; modified nucleosides identification techniques; nucleoside modifying enzymes; gene therapy; therapeutic nucleic acids; biomedical applications; drug delivery

(This special issue belongs to the Section Molecular Biology)

Liquid Biopsies in Oncology—3rd Edition

edited by

Sandra V. Fernandez

and

Carmela Paolillo

submission deadline 31 Dec 2026 | 3 articles | Viewed by 6623 | Submission Open

Keywords: precision oncology; personalized therapy; cancer biomarkers; liquid biopsy; biological fluids; circulating molecules; circulating tumor cells; CTCs; ctDNA; ctRNA; cell-free DNA; cfDNA; NGS; circulating miRNAs; exosomes; extracellular vesicles

(This special issue belongs to the Section Molecular Oncology)

Plant Adaptation to Abiotic Stresses: Evolutionary, Multi-Omics, and Molecular Perspectives

edited by

Guang Chen

and

Qiufang Shen

submission deadline 31 Dec 2026 | 6 articles | Viewed by 6484 | Submission Open

Keywords: plant; evolutionary adaptation; molecular evolution; abiotic stresses; stress tolerance; functional genomics; molecular regulatory network; genomics; transcriptomics; metabolomics; proteomics; epigenomics

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Mechanisms and Translational Insights in Neurological Disorders

edited by Tiago Santos

submission deadline 31 Dec 2026 | 5 articles | Viewed by 6324 | Submission Open

Keywords: neurological disorders; molecular mechanisms; translational neuroscience; drug targets; biomarkers; neurodegenerative disorders; neuroinflammatory conditions; demyelinating conditions; cerebrovascular conditions; neurodevelopmental disorders; mood disorders; anxiety disorders; spinal cord injury; traumatic brain injury; precision neurology; therapeutic development

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Insights into Sex Determination and Differentiation

edited by

Martin A. Estermann

submission deadline 31 Dec 2026 | 3 articles | Viewed by 5909 | Submission Open

Keywords: sex determination; sex differentiation; ovary; testis; epigenetics; gene regulatory networks; DSDs; transcriptomics; evolution

(This special issue belongs to the Section Molecular Biology)

Red Blood Cells: Dynamic Regulators, Disease Indicators and Therapeutic Targets

edited by Leonid Livshits

submission deadline 31 Dec 2026 | 2 articles | Viewed by 5542 | Submission Open

Keywords: red blood cell (RBC); RBC biochemical; hemodynamic; biophysical properties

(This special issue belongs to the Section Molecular Biology)

Current Insights into the Role of Exosomes in Intercellular Communication, 2nd Edition

edited by

Orit Uziel

submission deadline 31 Dec 2026 | 5 articles | Viewed by 5326 | Submission Open

Keywords: exosomes; extracellular vesicles; intracellular communication; intercellular communication

(This special issue belongs to the Section Molecular Biology)

Machine Learning Applications in Bioinformatics and Biomedicine: 4th Edition

edited by Hao Lv

submission deadline 31 Dec 2026 | 8 articles | Viewed by 5275 | Submission Open

Keywords: genome; transcriptome; proteome; metabolome; drug target; machine learning; prediction of drug side effects; epigenetic marker discovery for diseases; molecular network marker; early screening of diseases

(This special issue belongs to the Section Molecular Informatics)

The Interactions Between Nutrients and Adipose Tissue

edited by

Junseok Son

submission deadline 31 Dec 2026 | 5 articles | Viewed by 5165 | Submission Open

Keywords: adipose tissue; nutrients; metabolic health; insulin resistance; inflammation; energy homeostasis; adipokines; obesity; lipolysis; thermogenesis

(This special issue belongs to the Section Bioactives and Nutraceuticals)

The Role of Natural Products in Drug Discovery: 2nd Edition

edited by