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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advancing Forensic Genetics Through Massive Parallel Sequencing
edited by Daniel Kling
submission deadline 31 Jul 2025 | Viewed by 66 | Submission Open
Keywords: forensic genetics; molecular biology; genetics and aging; biochemistry; population genetics; fo-rensic statistics
(This special issue belongs to the Section Molecular Genetics and Genomics)
Extracellular Vesicles: Unraveling Molecular Pathways for Targeted Therapy
edited by
submission deadline 31 Jul 2025 | Viewed by 66 | Submission Open
Keywords: stem cells; cellular reprogramming; extracellular vesicles; exosomes; targeted therapy; regenerative medicine; rejuvenation; anti-inflammation therapy; pain syndrome
(This special issue belongs to the Section Molecular Biology)
Advancements in Cytopathology: Challenges and Changes
edited by Panagiota Mikou
submission deadline 31 Jul 2025 | Viewed by 64 | Submission Open
Keywords: cytopathology; cancer diagnosis; cytology; early cancer detection; exfoliative cytology
(This special issue belongs to the Section Molecular Biology)
Advancing Precision Medicine in Urological Cancers: Integrating Multi-Omics and Optimizing Therapeutic Approaches
edited by Magaly Martinez-Ferrer
submission deadline 31 Jul 2025 | Viewed by 64 | Submission Open
Keywords: prostate cancer; proteomics; metabolomics; precision medicine; biomarker
(This special issue belongs to the Section Molecular Oncology)
Extracellular Vesicles as Biomarkers in Personalized Medicine
edited by Thi Thuy Nguyen Dao
submission deadline 31 Jul 2025 | Viewed by 64 | Submission Open
Keywords: extracellular vesicles; biomarkers; cancer; cardiovascular diseases; neurodegenerative diseases; personalized medicineg
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Coagulation Factors and Natural Anticoagulants in Health and Disease
edited by
submission deadline 31 Jul 2025 | Viewed by 64 | Submission Open
Keywords: coagulation factor; natural anticoagulant; hemostasis; thrombosis; molecular studies; molecular interactions; structure; functional studies
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Genetics, Genomics and Breeding in Field Crops
edited by
submission deadline 31 Jul 2025 | Viewed by 63 | Submission Open
Keywords: field crop; genomics; molecular genetics; breeding technologies; germplasm utilization
(This special issue belongs to the Section Molecular Plant Sciences)
Progress in Spectroscopic Studies of Biomolecules
edited by
submission deadline 31 Jul 2025 | Viewed by 63 | Submission Open
Keywords: spectroscopic; nuclear magnetic resonance; X-ray; neutron scattering; biomolecular structure
(This special issue belongs to the Section Molecular Biophysics)
New Research on the Biological Activities of Natural Components and Their Application submission deadline 31 Jul 2025 | Viewed by 63 | Submission Open
Keywords: natural compounds; traditional and medicinal plants; biological activities
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Advanced of Layered Double Hydroxides (LDH) for Corrosion Protection
edited by
submission deadline 31 Jul 2025 | Viewed by 63 | Submission Open
Keywords: layered double hydroxide (LDHs); corrosion resistance; coatings; corrosion products
(This special issue belongs to the Section Materials Science)
Molecular Research in Epilepsy and Epileptogenesis—2nd Edition submission deadline 31 Jul 2025 | Viewed by 62 | Submission Open
Keywords: epilepsy; antiseizure; anti-epileptogenic drugs; biomarkers
(This special issue belongs to the Section Molecular Neurobiology)
Musculoskeletal Injuries and Conditions: From Pathophysiology to Novel Therapeutic Approaches
edited by
submission deadline 31 Jul 2025 | Viewed by 60 | Submission Open
Keywords: musculoskeletal disorder; pathophysiology; diagnosis; biomarkers; regenerative medicine
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances in Molecular Research on Axon Demyelination and Remyelination
edited by Rachelle Frazen
submission deadline 31 Jul 2025 | Viewed by 52 | Submission Open
Keywords: myelin; Schwann; OPC/oligodendrocytes; axon— glia crosstalk; peripheral neuropathies; multiple sclerosis; remyelination; myelin maintenance; molecular targets; signaling pathways
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances in the Molecular Diagnosis and Treatment of Neurodegenerative Diseases
edited by
submission deadline 31 Jul 2025 | Viewed by 51 | Submission Open
Keywords: neurodegenerative disorders; biomarkers; treatment; omics; systems biology
(This special issue belongs to the Section Molecular Neurobiology)
Impact of Vitamins on Cardiovascular Disease
edited by León Ferder
submission deadline 31 Jul 2025 | Viewed by 50 | Submission Open
Keywords: vitamins; cardiovascular disease; atherosclerosis; hypertension; heart failure; endothelial dysfunction; mitochondrial metabolism; oxidative stress; longevity
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Fluorogenic Molecular Probes for Biomedical Analysis
edited by Aleksey A. Vasilev
submission deadline 31 Jul 2025 | Viewed by 45 | Submission Open
Keywords: fluorogenic dyes; nucleic acid binders; nucleic acid labels; molecular probes; fluorogenic polymers and nanomaterials
(This special issue belongs to the Section Materials Science)
Galectins (Gals), 2nd Edition
edited by
submission deadline 10 Aug 2025 | 2 articles | Viewed by 846 | Submission Open
Keywords: galectin; inhibitors; cancer; inflammation; glycans; drug design; modeling; biomarkers
(This special issue belongs to the Section Molecular Biology)
Molecular Characterization and Applications of Nanomaterials in Nanomedicine and Cancer Therapy
edited by
submission deadline 15 Aug 2025 | 1 articles | Viewed by 710 | Submission Open
Keywords: nanomaterials (preparation methods; characterization techniques; properties); theoretical studies of nanomaterials and computational simulations; biocompatibility and biofunctionalization; applications in nanomedicine; applications in cancer therapy; drug delivery; nanoparticle imaging; magnetic resonance imaging (MRI); contrast agents; nanotheranostics
(This special issue belongs to the Section Molecular Nanoscience)
Anti-Cancer, Anti-Inflammatory, and Antioxidation Active Substances: 3rd Edition
edited by
submission deadline 15 Aug 2025 | 1 articles | Viewed by 637 | Submission Open
Keywords: anti-inflammatory; anti-cancer; antioxidants; antiproliferative; antiviral; antibacterial; antibodies; molecular mechanism; chemoresistance; molecular biology
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular and Cellular Therapies Barriers and Opportunities submission deadline 15 Aug 2025 | Viewed by 96 | Submission Open
Keywords: gene therapy; gene editing; RNA therapy; RNA editing; protein therapy; stem cells; cell therapy; genomics; proteomics; molecular pathology
(This special issue belongs to the Section Molecular Biology)
The Role of the Gut and Oral Microbiota in Neurodevelopment: Molecular Biological Insights
edited by Ioannis Alexandros Charitos
submission deadline 15 Aug 2025 | Viewed by 55 | Submission Open
Keywords: neuroscience; central nervous system; peripheral nervous system; human microbiota; metabolome; gut– oral-microbiota– brain axis; neurodevelopment disorders; cognitive modulation; neurodegenerative diseases; psychobiotics
(This special issue belongs to the Section Molecular Microbiology)
Novel Therapeutic Strategies for Gynecological Cancer
edited by
submission deadline 15 Aug 2025 | Viewed by 47 | Submission Open
Keywords: gynecological cancer; therapeutic strategies; genomic medicine; multimodality treatment; biomarker; molecular targeted therapy; immunotherapy
(This special issue belongs to the Section Molecular Oncology)
Molecular Pathologies and Treatment for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
edited by
submission deadline 20 Aug 2025 | 2 articles | Viewed by 26395 | Submission Open
Keywords: myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS); diagnosis; post-exertional malaise (PEM); comorbidity; biomarker; therapy; immunity; microbiome
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanisms and Targeted Therapies of Breast Cancer
edited by , Karolina Jabłońska and
submission deadline 20 Aug 2025 | 8 articles | Viewed by 24462 | Submission Open
Keywords: breast cancer; cancer progression; cancer metastasis; tumor microenvironment; molecular mechanisms; molecular markers; epigenetics; genomics; transcriptomics; EMT; targeted therapies; signaling pathways; exosomes; EMT; hormonal regulation; drugs; apoptosis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Retinal Degenerative Diseases: 2nd Edition submission deadline 20 Aug 2025 | 5 articles | Viewed by 20189 | Submission Open
Keywords: retina; photoreceptor degenerative diseases; inherited retinal degenerations; glaucoma; retinal pigment epithelial cells; retinal ganglion cells (RGCs); neuronal degeneration; glial activation
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Plant Metabolomics: Uncovering the Hidden World of Plant Secondary Metabolites
edited by
submission deadline 20 Aug 2025 | 12 articles | Viewed by 16799 | Submission Open
Keywords: metabolomics; secondary metabolites; plant biochemistry; mass spectrometry; NMR spectroscopy; plant signaling pathways; natural products; chemical ecology; metabolic profiling; phytochemicals; medicinal plants; herbal medicines
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Mechanisms of Bioactive Nutrients Promoting Human Health
edited by
submission deadline 20 Aug 2025 | 9 articles | Viewed by 15181 | Submission Open
Keywords: bioactive nutrients; antioxidants; anti-inflammatory; disease prevention; molecular mechanisms
(This special issue belongs to the Section Bioactives and Nutraceuticals)
The Role of Trace Elements in Nutrition and Health
edited by Jie Feng
submission deadline 20 Aug 2025 | 7 articles | Viewed by 14105 | Submission Open
Keywords: trace elements; nutrition; health; function; disease; metabolism; homeostasis
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Advances in Skin Cancer Pathology: From Pathogenesis to Precision Therapies submission deadline 20 Aug 2025 | 4 articles | Viewed by 13995 | Submission Open
Keywords: skin cancer; melanoma; non-melanoma; immunotherapy; cutaneous malignancies; targeted therapy; early detection
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Links between Sensory Nerves, Inflammation, and Pain 3.0 submission deadline 20 Aug 2025 | 5 articles | Viewed by 13445 | Submission Open
Keywords: sensory neuropeptides; inflammation; neurogenic inflammation; pain; arthritis; colitis; neuropathy; migraine; novel drug targets; TRP channels; neuroinflammation
(This special issue belongs to the Section Molecular Biology)
Cytokines in Inflammatory Signaling: 2nd Edition submission deadline 20 Aug 2025 | 7 articles | Viewed by 13036 | Submission Open
Keywords: cytokines; inflammation; autoimmune diseases; immune homeostasis; signaling pathway; immunotherapy
(This special issue belongs to the Section Molecular Immunology)
Advances in Neurodegenerative Diseases Research and Therapy—Third Edition
edited by
submission deadline 20 Aug 2025 | 7 articles | Viewed by 12665 | Submission Open
Keywords: neurodegenerative diseases; therapy; molecular mechanisms; neuron; astrocytes; microglia; inflammation; brain; drug delivery
(This special issue belongs to the Section Molecular Neurobiology)
Advanced Research of Skin Inflammation and Related Diseases submission deadline 20 Aug 2025 | 6 articles | Viewed by 12516 | Submission Open
Keywords: skin; inflammation; molecular target; inflammatory skin diseases; psoriasis; urticaria; atopic dermatitis; systemic sclerosis; skin fibrosis; immune system
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Novel Targeted Therapies and Drugs in Cancer submission deadline 20 Aug 2025 | 5 articles | Viewed by 12193 | Submission Open
Keywords: targeted therapies; genetic mutation; PARP inhibitors; immunotherapy; drug development; cancer molecular analysis; drug response; molecular-targeted therapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Exercise and Health: Cellular and Molecular Perspectives
edited by
submission deadline 20 Aug 2025 | 4 articles | Viewed by 12107 | Submission Open
Keywords: promoting health; anti-inflammatory action; anti-ageing action; mental health; mitochondrial adaptation; cellular function; regulation of gene expression; metabolic response to exercise
(This special issue belongs to the Section Molecular Biology)
Molecular Diagnostics and Genomics of Tumors
edited by
submission deadline 20 Aug 2025 | 9 articles | Viewed by 11979 | Submission Open
Keywords: tumor biology; cancer genomics; molecular diagnostics; biomarkers; precision medicine
(This special issue belongs to the Section Molecular Oncology)
Molecular Approach to Fern Development
edited by
submission deadline 20 Aug 2025 | 5 articles | Viewed by 11771 | Submission Open
Keywords: apomixis; apogamy; asexual reproduction; fern; proteomics; genomics; plant development; evo-devo; plant biotechnology
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Pathophysiology of Lung Diseases
edited by and Brenda M. Juan-Guardela
submission deadline 20 Aug 2025 | 5 articles | Viewed by 11479 | Submission Open
Keywords: biomarkers; asthma; COPD; pulmonary fibrosis; post-COVID-19 interstitial lung disease; pathogenesis; personalized medicine
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Photodynamic Therapy and Photodetection, 2nd Edition
edited by
submission deadline 20 Aug 2025 | 9 articles | Viewed by 11017 | Submission Open
Keywords: photodynamic therapy (PDT); photodetection (PD); photosensitiser; photochemical internalization (PCI); quantum dots; nanoparticles; nanotechnology; targeted therapy; immunotherapy; vaccines
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Epigenetic Genes, Biomarkers and Immunotherapy in Cancers submission deadline 20 Aug 2025 | 5 articles | Viewed by 10750 | Submission Open
Keywords: epigenetics; epigenetic modifications; immunotherapies; immune checkpoint; DNA methylation; histone modifications; epigenetic biomarkers; epidrugs; endogenous retroviruses
(This special issue belongs to the Section Molecular Oncology)
Molecular Research on Epigenetic Modifications
edited by , Mariella Cuomo and
submission deadline 20 Aug 2025 | 4 articles | Viewed by 10720 | Submission Open
Keywords: epigenetic modifications; chromatin remodeling; transcription factors; RNA modification; histones; methylation; diseases; epigenetic drugs development
(This special issue belongs to the Section Molecular Genetics and Genomics)
Biomedical Applications of Mesenchymal Stem Cells submission deadline 20 Aug 2025 | 6 articles | Viewed by 10451 | Submission Open
Keywords: mesenchymal stem cells; cell differentiation; cell therapy; regenerative medicine; tissue homeostasis; cartilage
(This special issue belongs to the Section Molecular Pharmacology)
Molecular and Cellular Advances in Endometriosis Research: 3rd Edition submission deadline 20 Aug 2025 | 3 articles | Viewed by 10412 | Submission Open
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Computational Molecular Biology of Metabolic Pathways and Signal Transduction Pathways
edited by Ralf Herwig
submission deadline 20 Aug 2025 | 6 articles | Viewed by 10211 | Submission Open
Keywords: computational genomics; computational structural and molecular biology; molecular dynamics simulations; artificial intelligence; AI-driven drug design and development; molecular modeling; computer-aided drug design; computational proteomics; computational and theoretical chemistry
(This special issue belongs to the Section Molecular Biology)
New Insights into CKD and Age-Related Bone and Mineral Disorders submission deadline 20 Aug 2025 | 4 articles | Viewed by 10200 | Submission Open
Keywords: chronic kidney disease; CKD; CKD-MBD; mineral and bone disorder
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Novel Therapeutic Targets in Cancers: 3rd Edition
edited by
submission deadline 20 Aug 2025 | 5 articles | Viewed by 9951 | Submission Open
Keywords: targeted therapy; precision oncology; immune modulation; cancer stem cell targeting; RNA-based therapy
(This special issue belongs to the Section Molecular Oncology)
Viral Infection and Virology Methods
edited by
submission deadline 20 Aug 2025 | 5 articles | Viewed by 9916 | Submission Open
Keywords: acute and chronic viral infection; molecular mechanism; new methodologies; emerging disease; innate and adaptive immunity
(This special issue belongs to the Section Molecular Microbiology)
Molecular Pharmacology in Diabetes, 2nd Edition submission deadline 20 Aug 2025 | 3 articles | Viewed by 9853 | Submission Open
Keywords: diabetes; vascular complications; cancer; neurodegenerative disorders; key molecular players; signaling pathways; molecular biomarkers; pharmacological agents; antioxidants; anti-inflammatory agents
(This special issue belongs to the Section Molecular Pharmacology)
Molecular Mechanisms and Regulation in Chronic Kidney Diseases
edited by
submission deadline 20 Aug 2025 | 4 articles | Viewed by 9677 | Submission Open
Keywords: chronic kidney disease; pathophysiology; genetic and epigenetic factors; metabolic and inflammatory pathways
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
The Role of Glycosaminoglycans in Human Diseases
edited by
submission deadline 20 Aug 2025 | 4 articles | Viewed by 9568 | Submission Open
Keywords: glycosaminoglycans; inflammation; infectious disease; cancer
(This special issue belongs to the Section Biochemistry)
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