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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Neuroendocrine Tumors (NETs): New Molecular Insights
edited by Juan Pablo Petiti
submission deadline 31 Oct 2026 | Viewed by 407 | Submission Open
Keywords: neuroendocrine neoplasms; cell signaling; biomarkers; molecular targets; tumor progression; invasion
(This special issue belongs to the Section Molecular Oncology)
Mesenchymal Stromal/Stem Cells (MSCs) in Regenerative Medicine
edited by
submission deadline 31 Oct 2026 | Viewed by 405 | Submission Open
Keywords: mesenchymal stromal cells; mesenchymal stem cells; regenerative medicine; cell therapy; immunomodulation; molecular mechanisms; extracellular vesicles; translational research; clinical applications; tissue regeneration
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular-Scale Design, Synthesis, and Applications of (Photo)Electrochemical Materials for Sustainable Energy and Environmental Solutions
edited by and
submission deadline 31 Oct 2026 | Viewed by 401 | Submission Open
Keywords: molecular-scale material engineering; photoelectrocatalysis/electrocatalysis; sustainable energy conversion; atomic-precision synthesis; environmental remediation technologies
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Molecular Plant Abiotic Stress: Recent Advances and Challenges
edited by
submission deadline 31 Oct 2026 | Viewed by 401 | Submission Open
Keywords: abiotic stress; plant stress tolerance; molecular mechanisms; gene expression; transcription factors; stress signaling pathways; functional genomics; plant hormones; omics technologies; gene family
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Progress of Cardiovascular and Metabolic Disease
edited by
submission deadline 31 Oct 2026 | Viewed by 383 | Submission Open
Keywords: cardiometabolic continuum; endothelial dysfunction; heart failure; metabolic complications
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Eco-Conscious Therapeutics: Molecular Foundations and Future Directions in Green Medicine
edited by and
submission deadline 31 Oct 2026 | Viewed by 375 | Submission Open
Keywords: green medicine; molecular therapeutics; sustainable healthcare; biomarker profiling; predictive toxicology; eco-friendly drug design; environmental impact; biodegradable materials
(This special issue belongs to the Section Molecular Toxicology)
Integrating Molecular Genetic and Geospatial Approaches for Advanced Monitoring of Plant Biodiversity submission deadline 31 Oct 2026 | Viewed by 375 | Submission Open
Keywords: plant biodiversity; biodiversity monitoring; genetic diversity; gene flow; population structure; landscape genetics; adaptive variation; spatiotemporal modelling; genetic erosion; conservation biology; geospatial analysis; remote sensing
(This special issue belongs to the Section Molecular Plant Sciences)
The Expanding Genetic Landscape of Parkinson's Disease submission deadline 31 Oct 2026 | Viewed by 372 | Submission Open
Keywords: Parkinson’s disease; monogenic; polygenic risk score; alpha-synuclein
(This special issue belongs to the Section Molecular Neurobiology)
Advances in Multicomponent Reactions (MCR) in Organic Synthesis
edited by , Camelia Elena Stecoza and Carmen Limban
submission deadline 31 Oct 2026 | Viewed by 370 | Submission Open
Keywords: multicomponent reactions; one-pot synthesis; green chemistry; drug discovery; bignelli reaction; mannich reaction; hantzsch reaction; sustainable synthesis; nanoparticle catalysts; supramolecular chemistry; mechanochemistry
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Research on Beneficial Mechanisms of Plant Growth Promoting Bacteria
edited by
submission deadline 31 Oct 2026 | Viewed by 363 | Submission Open
Keywords: biological control; plant resistance; induce systemic resistance (ISR); antifungal compounds; secondary compounds; siderophores; next-generation sequencing; soil biodiversity; microbiome; PGPF; trichoderma; mushroom; DSE; mycorrhiza
(This special issue belongs to the Section Molecular Plant Sciences)
Quorum Quenching in Medicine–Molecular Interactions
edited by
submission deadline 31 Oct 2026 | Viewed by 331 | Submission Open
Keywords: quorum sensing; quorum quenching; biofilm; virulence; host; pathogenicity
(This special issue belongs to the Section Molecular Microbiology)
Advances in Reprogramming of Mitochondrial Signalling and Metabolism in Cancers
edited by
submission deadline 31 Oct 2026 | Viewed by 329 | Submission Open
Keywords: mitochondria; metabolic reprogramming; cancer metabolism; redox signaling
(This special issue belongs to the Section Molecular Oncology)
Cold Atmospheric Plasma Effect on Cancer Cells submission deadline 31 Oct 2026 | Viewed by 322 | Submission Open
Keywords: cold atmospheric plasma; plasma medicine; cancer cells; reactive oxygen species; molecular mechanisms; apoptosis; redox biology; immunogenic cell death; plasma oncology
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Plant Bioactives: Sustainable Extraction, Characterization, and Antimicrobial Potential submission deadline 31 Oct 2026 | Viewed by 307 | Submission Open
Keywords: plant extracts; bioactive compounds; phytochemistry; natural compounds; green based extraction; therapeutic potential
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Metal Complexes: From Synthesis to Pharmacological Studies and Application
edited by Joksimović Nenad and
submission deadline 31 Oct 2026 | Viewed by 306 | Submission Open
Keywords: metal complexes; medicinal inorganic chemistry; bioactive ligands; pharmacological activity; molecular docking; biomolecular interactions; anticancer agents; antimicrobial activity; coordination chemistry; structure–activity relationship
(This special issue belongs to the Section Molecular Pharmacology)
Organ Axis: Insights from Molecular Metabolism
edited by
submission deadline 31 Oct 2026 | Viewed by 305 | Submission Open
Keywords: organ axis; molecular metabolism; interorgan crosstalk; metabolic regulation; metabolic diseases; biomarkers; molecular pathways; metabolites
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Exploring Plant Growth and Development: From Molecular Mechanisms to Environmental Adaptations
edited by Lénia Rodrigues, and
submission deadline 31 Oct 2026 | Viewed by 302 | Submission Open
Keywords: plant growth and development; molecular pathways; phytohormones; genome editing; high-throughput; omics; crop resilience; plant stress responses and adaptations
(This special issue belongs to the Section Molecular Plant Sciences)
Heart Failure: From Pathophysiology to Therapeutic Targets
edited by
submission deadline 31 Oct 2026 | Viewed by 297 | Submission Open
Keywords: heart failure; pathophysiology; pharmacological targets; congestion; edema; molecular mechanisms
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanisms of Dysfunctional Neural Circuits in Brain Disorders
edited by
submission deadline 31 Oct 2026 | Viewed by 290 | Submission Open
Keywords: dynamic wiring; brain network; brain connectivity; neuropathology; neuromodulation; neuroplasticity; circuit mapping
(This special issue belongs to the Section Molecular Neurobiology)
Latest Research Progress in Sport Genomics
edited by
submission deadline 31 Oct 2026 | Viewed by 286 | Submission Open
Keywords: sport genetics; genomics; athlete; performance; microbiota; epigenetics; injury; psychogenomics
(This special issue belongs to the Section Molecular Genetics and Genomics)
Microplastics and Nanoplastics: Cellular Toxicity and Health Implications
edited by Gaetana Gambino
submission deadline 31 Oct 2026 | Viewed by 286 | Submission Open
Keywords: microplastics (MPs); nanoplastics (NPs); cellular toxicity; human health; oxidative stress; inflammation; genotoxicity; mitochondrial; dysfunction; bioaccumulation; mechanistic toxicology
(This special issue belongs to the Section Molecular Toxicology)
Heart Diseases: Molecular Research and Novel Therapies
edited by Monika M. Gladka
submission deadline 31 Oct 2026 | Viewed by 283 | Submission Open
Keywords: cardiovascular diseases; molecular mechanisms; cardiac remodeling; heart failure; gene regulation; epigenetics; non-coding RNA; inflammation; regenerative medicine; novel therapies
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanisms and Therapeutic Approaches in Glaucoma and Retinal Neurodegeneration
edited by Yukihiro Shiga
submission deadline 31 Oct 2026 | Viewed by 283 | Submission Open
Keywords: glaucoma; retinal neurodegeneration; retinal ganglion cells; mitochondrial dysfunction; neuroinflammation; neuro-glial interactions; multi-omics; biomarkers; disease-modifying therapies; translational research
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Immune Crosstalk Between Host and Pathogens submission deadline 31 Oct 2026 | Viewed by 282 | Submission Open
Keywords: host-pathogen interactions; virus; bacteria; parasites; innate immunity; adaptive immunity, signal transduction; immune evasion; cytokines; inflammation
(This special issue belongs to the Section Molecular Immunology)
Molecular Mechanisms of Resistance to Targeted Cancer Therapies submission deadline 31 Oct 2026 | Viewed by 280 | Submission Open
Keywords: cancer therapy; drug resistance; molecular mechanism; artificial intelligence; singel-cell bioinformatics; spatial analysis
(This special issue belongs to the Section Molecular Oncology)
T-Cell Function and Molecular Regulation
edited by and
submission deadline 31 Oct 2026 | Viewed by 279 | Submission Open
Keywords: T-cell activation and differentiation; immune checkpoints; signaling pathways; epigenetic modifications; immune tolerance; T-cell exhaustion; adoptive immunotherapy; cytokine signaling
(This special issue belongs to the Section Molecular Immunology)
Molecular Insights into Cancer Biomarkers and Targeted Therapies in Solid Tumors
edited by Michele Ghidini
submission deadline 31 Oct 2026 | Viewed by 277 | Submission Open
Keywords: cancer biomarkers; target therapies; solid tumors; mutations; molecular biology; immunotherapy; TKI inhibitors; monoclonal antibodies; NGS; molecular panel
(This special issue belongs to the Section Molecular Oncology)
Effects and Applications of Nanoparticles in Plant-Pathogen Interactions and Plant Physiology submission deadline 31 Oct 2026 | Viewed by 265 | Submission Open
Keywords: plant–pathogen interaction; nanotechnology; plant physiology; transcriptomics; DNA methylation; antimicrobial mechanism; metabolomics; microbial structure analysis
(This special issue belongs to the Section Molecular Plant Sciences)
Antiviral Immune Responses and Mechanisms
edited by Xueqing Ma
submission deadline 31 Oct 2026 | Viewed by 264 | Submission Open
Keywords: antiviral immunity; immune response; molecular mechanism; animal virus; innate immunity; adaptive immunity; immune escape; veterinary infectious diseases
(This special issue belongs to the Section Molecular Immunology)
Molecular Docking Studies and Enzyme Inhibitory Assessment of Synthesized Heterocyclic Compounds
edited by
submission deadline 31 Oct 2026 | Viewed by 263 | Submission Open
Keywords: heterocyclic compounds; molecular docking; enzyme inhibition; structure activity relationships (SAR); synthetic medicinal chemistry; computational chemistry; in silico drug design; ADMET prediction; molecular dynamics simulation
(This special issue belongs to the Section Biochemistry)
Nanoparticle-Mediated Molecular Regulation of Plant Tolerance submission deadline 31 Oct 2026 | Viewed by 261 | Submission Open
Keywords: nanomaterials; plant stress physiology; antioxidant defense system; abiotic stress; molecular signaling; reactive oxygen species (ROS); phytoremediation; gene expression regulation; nutrient uptake; sustainable agriculture
(This special issue belongs to the Section Molecular Nanoscience)
The Basic Mechanisms of Brain Inflammation
edited by
submission deadline 31 Oct 2026 | Viewed by 260 | Submission Open
Keywords: health sciences; neuroscience; pathophysiology; cognitive impairment; inflammation; mental health; oxidative stress
(This special issue belongs to the Section Molecular Immunology)
Integrative Genetic and Multi-Omics Approaches to Disease Biology
edited by
submission deadline 31 Oct 2026 | Viewed by 256 | Submission Open
Keywords: disease genes; human genomics; GWAS; multi-omics; regulatory genomics; mendelian randomisation; gene prioritisation; pleiotropy; precision medicine; translational genetics
(This special issue belongs to the Section Molecular Genetics and Genomics)
Exercise and Immunopathology
edited by Rodolfo de Paula Vieira and Luis Vicente Franco Oliveira
submission deadline 31 Oct 2026 | Viewed by 254 | Submission Open
Keywords: exercise immunology; exercise physiology; inflammation; immune response; cardiopulmonary diseases; exercise rehabilitation; immune modulation; chronic diseases; aging and exercise; sports physiology
(This special issue belongs to the Section Molecular Immunology)
Molecular Mechanisms of Anesthetic Effects
edited by Jose Luis Guerrero Orriach
submission deadline 31 Oct 2026 | Viewed by 251 | Submission Open
Keywords: general anesthetics; molecular pharmacology; ion channels; gaba receptors; neuroprotection; signal transduction; mitochondrial dysfunction; local anesthetics; anesthetic-induced neurotoxicity; proteomic
(This special issue belongs to the Section Molecular Biology)
Unveiling Bioactive Marine Compounds
edited by
submission deadline 31 Oct 2026 | Viewed by 251 | Submission Open
Keywords: marine natural products; bioactive compounds; molecular diversity; biosynthetic gene clusters; combinatorial biosynthesis; drug discovery
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Biomarkers and AI in Cardiac Electrophysiology
edited by Kenneth C. Bilchick
submission deadline 31 Oct 2026 | Viewed by 251 | Submission Open
Keywords: cardiac electrophysiology; molecular biomarkers; artificial intelligence; machine learning; atrial fibrillation; ventricular arrhythmia; sudden cardiac death; electrocardiography (ECG); cardiac imaging; precision medicine
(This special issue belongs to the Section Molecular Biology)
New Molecules for Advanced Biosensors for Health, Food Safety and Environment
edited by , Piotr Bojarski and Beata Wielgus-Kutrowska
submission deadline 31 Oct 2026 | Viewed by 247 | Submission Open
Keywords: proteins; electrochemistry; biosensors; molecular diagnostics; food safety; environmental monitoring
(This special issue belongs to the Section Biochemistry)
Immune Defense Mechanisms of the External, Middle, and Inner Ear
edited by
submission deadline 31 Oct 2026 | Viewed by 247 | Submission Open
Keywords: ear immunology; mucosal immunity; autoimmune inner ear disease (AIED); innate immune response; blood–labyrinth barrier; middle ear immune defense
(This special issue belongs to the Section Molecular Immunology)
Precision Medicine and Rare Cancers
edited by Juha Rantala
submission deadline 31 Oct 2026 | Viewed by 245 | Submission Open
Keywords: precision medicine; rare cancers; biomarkers; targeted therapies; tumor models; drug repurposing; ex vivo drug screening
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Insights of Metabolomics
edited by
submission deadline 31 Oct 2026 | Viewed by 245 | Submission Open
Keywords: pathway; metabolites; metabolomics; LC; GC; NMR; mechanism; statistical analysis
(This special issue belongs to the Section Biochemistry)
Plant–Fungal Disease Interactions: Pathogenesis, Epidemiology, and Management submission deadline 31 Oct 2026 | Viewed by 241 | Submission Open
Keywords: plant–fungal interactions; fungal pathogenesis; disease epidemiology; virulence mechanisms; soilborne pathogens; postharvest diseases; biological control; sustainable disease management; oomycetes; population genetics
(This special issue belongs to the Section Molecular Plant Sciences)
Spatial Multi-Omics: From Molecular Maps to Precision Medicine
edited by
submission deadline 31 Oct 2026 | Viewed by 234 | Submission Open
Keywords: multi-omics; spatial multi-omics; cell-type-specific molecular alterations; tissue microenvironments; molecular diagnostics; precision medicine
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Studies on Natural Products: Anti-Inflammatory, Immune Response, and Anti-Bacterial Activities
edited by Hicham Wahnou
submission deadline 31 Oct 2026 | Viewed by 231 | Submission Open
Keywords: natural products; anti-inflammatory; immune response; antibacterial; molecular mechanisms; phytochemicals; immunomodulation; probiotics; prebiotics; synbiotics
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Inherited Metabolic Disorders: Genetic Insights and Therapeutic Strategies
edited by and Kristiane Michelin-Tirelli
submission deadline 31 Oct 2026 | Viewed by 231 | Submission Open
Keywords: inherited metabolic disorders; animal models; biomarkers; clinical laboratory techniques; tandem mass spectrometry; high-throughput nucleotide sequencing; cell- and tissue-based therapy; genetic therapy; enzyme replacement therapy; precision medicine
(This special issue belongs to the Section Molecular Genetics and Genomics)
Acute Lymphoblastic Leukemia (ALL): From Molecular Drivers to Therapeutic Innovation
edited by Carmen Maldonado-Bernal
submission deadline 31 Oct 2026 | Viewed by 231 | Submission Open
Keywords: acute lymphoblastic leukemia; minimal residual disease; molecular drivers; genetic drivers treatment approaches; immunotherapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Targeted Lipidomics Approaches in Cardiometabolic Diseases: From Sample Preparation to Data Interpretation for Combined Multiomics Analysis submission deadline 31 Oct 2026 | Viewed by 230 | Submission Open
Keywords: biomarkers; cardiometabolic diseases; cell signaling; lipids; lipid metabolism; lipoproteins; methodology; multiomics; therapies
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Recent Research Progress in Metal Complexes
edited by
submission deadline 31 Oct 2026 | Viewed by 229 | Submission Open
Keywords: coordination chemistry; metal–ligand complexes; ligand design and synthesis; d-block and f-block metals; spectroscopic and analytical characterizations; computational chemistry and theoretical investigations; photochemical properties and optoelectronic applications; metal complexes as catalysis; bioinorganic and medicinal applications
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Nanotechnology in Precision Medicine for Pancreatic Cancer
edited by Virendar Kumar
submission deadline 31 Oct 2026 | Viewed by 228 | Submission Open
Keywords: nanotechnology; precision medicine; pancreatic cancer; pancreatic ductal adenocarcinoma (PDAC); tumor microenvironment; desmoplasia / stromal barrier; targeted drug delivery; stimuli-responsive nanocarriers; theranostics; nucleic acid therapeutics (siRNA / mRNA); cancer immunotherapy; translational nanomedicine/clinical translation
(This special issue belongs to the Section Molecular Nanoscience)
Biochemical Functions and Therapeutic Potential of Dietary Bioactive Peptides
edited by
submission deadline 31 Oct 2026 | Viewed by 227 | Submission Open
Keywords: bioactive peptides; molecular mechanisms; structure–activity relationship; peptidomics; functional foods; by-product valorization; antioxidant activity; bioavailability; cellular signaling; multidisciplinary approaches
(This special issue belongs to the Section Biochemistry)
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