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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Metabolic Reprogramming in Health and Aging-Related Diseases

edited by

Hung-Yao Ho

submission deadline 31 May 2025 | Viewed by 155 | Submission Open

Keywords: aging; degenerative diseases; lifestyle intervention; metabolic reprogramming; metabolic syndromes; metabolome; metabolomics; neurodegenerative diseases; omics

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Molecular Research on Autophagy, 2nd Edition

edited by

Maria Ines Vaccaro

submission deadline 31 May 2025 | Viewed by 154 | Submission Open

Keywords: ATG molecules; transcriptional and post translational modification; selective pathways; secretory pathways; complexes diseases; degenerative processes; inflammatory diseases; tumorigenesis; metabolism; proteostasis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Development of Dopaminergic Neurons, 4th Edition

edited by

Yasemin M. Akay

submission deadline 31 May 2025 | Viewed by 145 | Submission Open

Keywords: neuron; dopamine; mDA; signalling pathways; human stem cell

(This special issue belongs to the Section Molecular Neurobiology)

Molecular and Cellular Targets on Anticancer Research and Perspectives

edited by

Apostolos E. Papalois

submission deadline 31 May 2025 | Viewed by 141 | Submission Open

Keywords: anticancer; molecular targets; targeted cancer therapies; malignancy

(This special issue belongs to the Section Molecular Oncology)

Neutrophil Extracellular Traps (NETs) in Immunity and Diseases, 3rd Edition

edited by

Jasmin Knopf

submission deadline 31 May 2025 | Viewed by 136 | Submission Open

Keywords: neutrophils; neutrophil functions; neutrophil extracellular traps (NETs); NET biology; NETs in autoimmune diseases; NETs in immune response; NETs in the development and progression of cancer diseases; NETs in immunothrombosis; degradation of NETs

(This special issue belongs to the Section Molecular Immunology)

Immunopathogenesis and Novel Therapeutic Strategies for Systemic Lupus Erythematosus: Third Edition

edited by

Marzena Olesińska

and Hanna Przepiera-Bȩdzak

submission deadline 31 May 2025 | Viewed by 136 | Submission Open

Keywords: systemic lupus erythematosus; SLE pathogenesis; the epigenetic regulation of lupus; the genetic background of SLE; interferon; cytokine networks; innate immunity; adaptive immunity

(This special issue belongs to the Section Molecular Immunology)

Immune-Liver Axis—from Disease Pathogenesis to Therapeutic Target

edited by

Beata Kasztelan-Szczerbińska

submission deadline 31 May 2025 | Viewed by 135 | Submission Open

Keywords: immune response; inflammation; liver disease; liver injury; liver cirrhosis; immune-related liver disease; alcohol-related liver disease; metabolic dysfunction-associated steatotic liver disease (MASLD); Wilson’ s disease; hemochromatosis; liver cancer

(This special issue belongs to the Section Molecular Immunology)

Recent Advances in the Biological Function of Tyrosinase

edited by

Kazumasa Wakamatsu

submission deadline 31 May 2025 | Viewed by 134 | Submission Open

Keywords: tyrosinase-related proteins; tyrosinase; melanogenesis; copper; zinc; metal enzymes; tyrosinase inhibitor; pigmentation disorders

(This special issue belongs to the Section Molecular Biology)

Advances in Leptin Biology

edited by

Víctor Sánchez-Margalet

submission deadline 31 May 2025 | Viewed by 133 | Submission Open

Keywords: leptin; leptin expression; leptin receptor; leptin action

(This special issue belongs to the Section Molecular Biology)

Unveiling the Complexity of TRPC Channels: From Molecular Mechanisms to Clinical Applications

edited by Oleksandra Tiapko

submission deadline 31 May 2025 | Viewed by 131 | Submission Open

Keywords: TRPC channels; TRPC– lipid interactions; TRPC– protein interactions; cellular homeostasis; TRPC-dependent disorders; (photo)pharmacology; TRPC in native tissue

(This special issue belongs to the Section Molecular Biology)

Epigenetic and RNA-Based Regulation in Cancer: Mechanism, Therapeutic Targets, and Translational Perspectives

edited by

Moon Nyeo Park

submission deadline 31 May 2025 | Viewed by 128 | Submission Open

Keywords: molecular underpinnings of DNA; histone; RNA-based epigenetic regulation; small molecules and epigenetic inhibitors; epigenetic signatures; oncology

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Signaling and Cellular Mechanisms in Asthma

edited by

Kapil Sirohi

submission deadline 31 May 2025 | Viewed by 127 | Submission Open

Keywords: asthma; endotypes; pausi-immune asthma; nonatopic asthma; steroid insensitivity; neutrophilic asthma; innate lymphoid cells; Th2 cells

(This special issue belongs to the Section Molecular Immunology)

Molecular Immunology of Infectious Diseases

edited by

Salvatore Giovanni De Simone

submission deadline 31 May 2025 | Viewed by 125 | Submission Open

Keywords: molecular immunology; infectious diseases; innate immunity; adaptive immunity; immunomodulation-based therapies

(This special issue belongs to the Section Molecular Immunology)

The Role of Embryonic Stem Cells in Human Disease and Health

edited by Fahad Kidwai

submission deadline 31 May 2025 | Viewed by 124 | Submission Open

Keywords: emrbryonic stem cells; human disease and health; regenerative therapy

(This special issue belongs to the Section Molecular Biology)

The Role of Extracellular Vesicles in Drug Delivery

edited by

Sara Biagiotti

and

Michele Guescini

submission deadline 31 May 2025 | Viewed by 123 | Submission Open

Keywords: red blood cells; red blood cell-extracellular vesicles; drug delivery systems; RNA therapies; EV engineering

(This special issue belongs to the Section Molecular Biology)

Cyclic Nucleotide-Signaling in Cells and Tissues: Molecular, Functional, and Pharmacological Aspects

edited by

Jens Schlossmann

submission deadline 31 May 2025 | Viewed by 122 | Submission Open

Keywords: cyclic nucleotide; cNMP; cAMP; cGMP; cCMP; cUMP; cGAMP; signaling proteins; signal transduction pathways; scaffolds; nitric oxide; natriuretic peptides; adenylyl cyclases; guanylyl cyclases; kinases; phosphodiesterases; channels; (patho)physiology; pharmacology

(This special issue belongs to the Section Biochemistry)

Advances in Molecular Research on Plant-Fungi Interactions

edited by Francisca Sempere-Ferre

submission deadline 31 May 2025 | Viewed by 122 | Submission Open

Keywords: plant– fungi interactions; mycorrhizal symbiosis; fungal pathogens; effector molecules; plant defense mechanisms; signal transduction; secondary metabolites; microbiome interactions; molecular plant biology; host– pathogen dynamics

(This special issue belongs to the Section Molecular Plant Sciences)

Latest Molecular Research on Polymer Coatings

edited by

Joanna Karasiewicz

submission deadline 31 May 2025 | Viewed by 120 | Submission Open

Keywords: synthesis of specialty compounds; specialty compounds in industrial treatment; amphiphilic compounds; wettability (including solids and biomaterials); antimicrobial activity; surface activity; superwetting; high hydrophobic/hydrophilic/olrophobic/olephilic properties; special applications: self-cleaning; anti-icing; self-healing; biocidal; etc.

(This special issue belongs to the Section Materials Science)

Nanodiagnosis and Treatment System for Human Health

edited by

Nan Gao

submission deadline 31 May 2025 | 1 articles | Viewed by 117 | Submission Open

Keywords: nanodiagnosis; nanodrugs; nano-antibody; nanosensor; nanoprobe technology

(This special issue belongs to the Section Molecular Nanoscience)

Advanced Cell Based Biomaterials for Musculoskeletal Tissue Engineering

edited by Isabel Calejo

submission deadline 31 May 2025 | Viewed by 116 | Submission Open

Keywords: cell-based materials; bioprinting; microfluidics; hydrogels; vascularization; innervation; hierarchical; fiber technologies; microtissues

(This special issue belongs to the Section Materials Science)

Latest Progress of Photocatalysts

edited by María J. Cabrera‐Afonso

submission deadline 31 May 2025 | Viewed by 115 | Submission Open

Keywords: metallaphotoredox; visible-light; photoredox; radicals; cross-coupling; bifunctional catalyst

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Photosynthesis and Stress Signaling

edited by

Liangsheng Wang

submission deadline 31 May 2025 | Viewed by 113 | Submission Open

Keywords: photosynthesis; chloroplasts; stress; signaling

(This special issue belongs to the Section Molecular Plant Sciences)

Emerging Trends in Adductomics: From Adduct Detection to Environmental Implications

edited by

Mu-Rong Chao

Marcus S. Cooke

and

Chiung Wen Hu

submission deadline 31 May 2025 | Viewed by 111 | Submission Open

Keywords: adductomics; covalent adducts; crosslinks; biomarkers; electrophilic species; exposome; environmental toxicants; high-resolution tandem mass spectrometry; post-data analysis

(This special issue belongs to the Section Molecular Toxicology)

Psoriasis and Associated Complications: Pathogenic Mechanisms, Gene Biomarkers and Treatments

edited by

Anna Michalak-Stoma

submission deadline 31 May 2025 | Viewed by 109 | Submission Open

Keywords: psoriasis; autoimmune disease; autoinflammatory disease; psoriatic arthritis; diabetes; hypertension; lipid disorders; obesity; cardiovascular diseases (CVDs); immunological biomarkers; genetic biomarkers; epigenetic biomarkers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Plant Phylogenomics and Genetic Diversity (3rd Edition)

edited by

Wenpan Dong

submission deadline 31 May 2025 | Viewed by 109 | Submission Open

Keywords: plant phylogenomics; genome gene; evolution species; diversity speciation; ecogenomics

(This special issue belongs to the Section Molecular Plant Sciences)

Innovative Advances and Applications in Medical and Molecular Virology

edited by

Vincent T. K. Chow

and

Julian Tang

submission deadline 31 May 2025 | Viewed by 105 | Submission Open

Keywords: medical virology; molecular virology; molecular diagnostics; genomics; metagenomics; interactomics; integrative omics

(This special issue belongs to the Section Molecular Microbiology)

Pulmonary Immune Research: Mechanisms, Disorders, and Solutions

edited by

Tsukasa Okiyoneda

and

Tsuyoshi Shuto

submission deadline 31 May 2025 | Viewed by 104 | Submission Open

Keywords: genetic lung disorders; chronic obstructive pulmonary disease (COPD); pulmonary fibrosis; asthma; inflammation; molecular mechanism; pathogen/pollutant; immune dysfunction; ciliary transport; therapeutic strategies

(This special issue belongs to the Section Molecular Immunology)

Strategies and Molecular Mechanisms to Enhance Outcomes in Orthobiologics

edited by Leonardo Oliveira

submission deadline 31 May 2025 | Viewed by 99 | Submission Open

Keywords: platelet-rich plasma; adipose-derived stem cells; microfragmented fat; nutrition; exercise; biomarkers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Cracking the Molecular Code of Breast Cancer

edited by Bartlomiej Taciak

submission deadline 31 May 2025 | Viewed by 96 | Submission Open

Keywords: breast cancer; TNBC; immunotherapy; microRNAs; NGS; therapeutics; biomarkers; epigenetics

(This special issue belongs to the Section Molecular Oncology)

Autophagy and Viral Infections: The Era of New Therapeutical Strategies

edited by

Marisa Granato

submission deadline 31 May 2025 | Viewed by 95 | Submission Open

Keywords: autophagy; macroautophagy system; virus; viral infection; influenzae virus

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Autophagic Related Proteins in Cancer

edited by Pietri Puustinen

submission deadline 31 May 2025 | Viewed by 93 | Submission Open

Keywords: cancer; autophagy; tumor suppressor; tumorigenesis; pro-survival mechanism; therapeutic strategies; cancer metabolism; signaling pathways; mTORC1; AMPK; CIP2A; PP2A; DNA damage response (DDR); DNA-PK; ATM/ATR; cellular growth

(This special issue belongs to the Section Molecular Oncology)

High-Performance Composites: Molecular Design and Applications in Extreme Environments

edited by Fan Yang

submission deadline 31 May 2025 | Viewed by 91 | Submission Open

Keywords: thermal protection materials; mechanical and physical properties; extreme environments; molecular dynamics analysis; composite molecular design; preparation; simulation; and characterization

(This special issue belongs to the Section Materials Science)

Antibacterial Activity of Novel Antimicrobial Agents

edited by Paweł Kowalczyk

submission deadline 31 May 2025 | Viewed by 82 | Submission Open

Keywords: novel antimicrobial agents; antibiotic resistance; chemical entities; phage therapy; bacterial pathogens; antimicrobial peptides; resistance mechanisms

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Advances in Tumor Hypoxia

edited by Klaudia K. Brodaczewska

submission deadline 31 May 2025 | Viewed by 75 | Submission Open

Keywords: tumor microenvironment; hypoxia; low oxygen; cancer therapy; cancer drug resistance; tumor immunosuppression; hypoxia biomarkers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms and Innovative Materials for Environmental and Climate Resilience

edited by

Sung Won Hwang

submission deadline 31 May 2025 | Viewed by 74 | Submission Open

Keywords: machine Learning; climatic condition; microplastic detection

(This special issue belongs to the Section Materials Science)

Biofunctionalization of Metals for Medical Application: Molecular Aspects

edited by

Luca Scotti

submission deadline 31 May 2025 | Viewed by 68 | Submission Open

Keywords: biofunctionalization; medical applications; nanomaterials; nanofunctionalized materials; molecular mechanisms; bacterial membranes; membrane polarity; bacterial resistance

(This special issue belongs to the Section Molecular Nanoscience)

Growth Factor Signaling in Cancer Progression

edited by

Hyeong-Reh Choi Kim

and Abdo J. Najy

submission deadline 1 Jun 2025 | Viewed by 172 | Submission Open

Keywords: growth factor signaling; proteolysis; cancer progression; tumor dormancy; metastasis; tumor microenvironment; therapeutic strategies

(This special issue belongs to the Section Molecular Biology)

Targeting Glioblastoma Metabolism

edited by

José M. Matés

and

José Ángel Campos Sandoval

submission deadline 10 Jun 2025 | 2 articles | Viewed by 3810 | Submission Open

Keywords: glioblastoma; metabolic heterogeneity; metabolic reprogramming; cancer stem cells; therapeutic resistance; metabolic vulnerabilities; IDH1/2 mutations; tumor microenvironment; epigenetic regulation

(This special issue belongs to the Section Molecular Oncology)

The Role of Platelets in Development and Disease: Thrombosis across the Lifespan

edited by

Jawaad Sheriff

submission deadline 10 Jun 2025 | 1 articles | Viewed by 3745 | Submission Open

Keywords: mechanobiology; biomechanics; signaling pathways; computational modeling; thrombosis; antithrombotic therapy; aging; systems biology; cardiovascular disease; diabetes; inflammation; cancer; platelet activation; platelet adhesion; platelet aggregation

(This special issue belongs to the Section Molecular Biology)

Essential Molecules in Life: Regulation, Defense, and Longevity, 2nd Edition

edited by

Eva E. Rufino Palomares

Amalia Pérez-Jiménez

and

José Antonio Lupiáñez

submission deadline 10 Jun 2025 | 1 articles | Viewed by 954 | Submission Open

Keywords: glucose metabolism and its regulation; enzimology and kinetics; metabolism and evolution; cell growth; protein synthesis and degradation; cell proliferation and apoptosis; cancer; metastasis and angiogenesis; oxidative stress; genomic; proteomic and metab

(This special issue belongs to the Section Molecular Immunology)

Molecular Mechanisms and Therapeutic Targets in Cardiometabolic Disorders

edited by Massimiliano M. Corsi Romanelli and

Pietro Formisano

submission deadline 10 Jun 2025 | Viewed by 479 | Submission Open

Keywords: atherosclerosis; angiotensin; endothelial cell; inflammation; biomarkers; gLP-1; sT-2

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Exosomes and Non-Coding RNA Research in Health and Disease

edited by

Stergios Boussios

submission deadline 11 Jun 2025 | 16 articles | Viewed by 50938 | Submission Open

Keywords: exosomes; non-coding RNA; health; disease; intercellular communication; cancer; neurodegenerative disorders; cardiovascular diseases; immune regulation; therapeutic strategies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Research in Aggressive Behavior

edited by

Flavia Venetucci Gouveia

submission deadline 13 Jun 2025 | 1 articles | Viewed by 1693 | Submission Open

Keywords: aggressive behaviour; molecular mechanisms; agitation; mental disorders

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Insights into Exosomes in Inflammatory Neurological and/or Peripheral Diseases

edited by

Eirini (Irene) Tsilioni

submission deadline 15 Jun 2025 | Viewed by 306 | Submission Open

Keywords: extracellular vesicles; neuroinflammation; peripheral inflammation; microglia; mast cells; immune response; biomarkers; blood– brain barrier; therapeutic applications; microRNAs; molecular mechanisms

(This special issue belongs to the Section Molecular Immunology)

Novel Antivirals against Respiratory Viruses

edited by

Fabiana Superti

Magda Marchetti

and

Lucia Nencioni

submission deadline 20 Jun 2025 | 10 articles | Viewed by 25975 | Submission Open

Keywords: respiratory virus; antivirals and mechanism of action; antiviral drugs; antiviral drug resistance; antiviral targets; in vitro models; antiviral combination therapy

(This special issue belongs to the Section Molecular Microbiology)

Role of Immune Cells in Non-infectious Inflammatory Diseases and Cancers

edited by

Evgeny E. Bezsonov

submission deadline 20 Jun 2025 | 10 articles | Viewed by 23338 | Submission Open

Keywords: cytokines; immunity cells; atherosclerosis; inflammation; immunity

(This special issue belongs to the Section Molecular Immunology)

Melanoma: From Molecular Pathology to Therapeutic Approaches

edited by

Michael Eccles

submission deadline 20 Jun 2025 | 8 articles | Viewed by 22688 | Submission Open

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Exploring the Molecular, Cellular, and Physiological Basis of Hearing Disorders

edited by Jing Zheng

submission deadline 20 Jun 2025 | 9 articles | Viewed by 21182 | Submission Open

Keywords: outer hair cells; biomarker; cochlear stress; hearing loss

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Kynurenic Acid: Emerging Research Advances and Therapeutic Implications

edited by

Piotr Paluszkiewicz

and Monika Turska-Kozłowska

submission deadline 20 Jun 2025 | 7 articles | Viewed by 20772 | Submission Open

Keywords: kynurenic acid; kynurenine pathway; kynurenine; therapeutic use; supply and distribution

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

The Advances in Antimicrobial Biomaterials

edited by

Hah Young Yoo

and

Jin Cheol Yoo

submission deadline 20 Jun 2025 | 7 articles | Viewed by 20622 | Submission Open

Keywords: biomaterials; biopolymers production; antimicrobial agents; antimicrobial activity; natural antibiotics; antioxidants; bioelastomers; food packaging

(This special issue belongs to the Section Materials Science)

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