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Molecular Research in Aggressive Behavior

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Guest Editor
Neurosciences and Mental Health, The Hospital for Sick Children, 170 Elizabeth St, Toronto, ON M5G 1E8, Canada
Interests: neuropsychiatric symptoms; neuromodulation; translational research; aggressive behaviour; fronto-limbic-striatal network

Special Issue Information

Dear Colleagues,

We invite submissions for inclusion in our Special Issue of the International Journal of Molecular Sciences on the topic of “Molecular Research in Aggressive Behavior”. This Special Issue will bring together cutting-edge research from molecular research fields to enhance our understanding of aggressive behaviour in the context of mental disorders.

Aggressive behaviour is a complex and multifaceted behavioural syndrome that can significantly impact individuals suffering from psychiatric disorders. It often exacerbates the severity of the condition, complicates treatment approaches, and diminishes quality of life for patients and their families. Understanding the molecular mechanisms underlying aggression and translating these findings into clinical practice is crucial for developing effective interventions and improving patient outcomes.

We encourage the submission of original research articles, reviews, and short communications that address various aspects of the molecular basis of aggression in mental disorders. Since IJMS is a journal of molecular science, purely clinical studies will not be suitable. However, clinical or pure model submissions with biomolecular experiments are welcome. Topics of interest include, but are not limited to, the following:

  • Aggressive behaviour and its neuropsychiatric manifestations;
  • Molecular mechanisms and pathways involved in aggression;
  • Novel therapeutic approaches targeting aggression in mental disorders.

Dr. Flavia Venetucci Gouveia
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • aggressive behaviour
  • molecular mechanisms
  • agitation
  • mental disorders

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Published Papers (1 paper)

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Review

34 pages, 1261 KiB  
Review
Molecular Pathways, Neural Circuits and Emerging Therapies for Self-Injurious Behaviour
by Kristina Zhang, George M. Ibrahim and Flavia Venetucci Gouveia
Int. J. Mol. Sci. 2025, 26(5), 1938; https://doi.org/10.3390/ijms26051938 - 24 Feb 2025
Viewed by 739
Abstract
Nonsuicidal self-injurious behaviour (SIB) is a debilitating manifestation of physical aggression commonly observed across neurodevelopmental, psychiatric, and genetic disorders. This behaviour arises from a multifactorial aetiology involving genetic predispositions, epigenetic modifications, neurotransmitter dysregulation, and environmental stressors. Dysregulation in dopaminergic, serotonergic, glutamatergic, and GABAergic [...] Read more.
Nonsuicidal self-injurious behaviour (SIB) is a debilitating manifestation of physical aggression commonly observed across neurodevelopmental, psychiatric, and genetic disorders. This behaviour arises from a multifactorial aetiology involving genetic predispositions, epigenetic modifications, neurotransmitter dysregulation, and environmental stressors. Dysregulation in dopaminergic, serotonergic, glutamatergic, and GABAergic systems has been implicated in the pathophysiology of SIB, alongside structural and functional abnormalities within fronto-limbic-striatal circuits. These disruptions impair key processes, such as emotional regulation, reward processing, and behavioural inhibition, contributing to the emergence and reinforcement of SIB. Advances in preclinical research using genetic, lesion-based, pharmacological, and environmental animal models have been instrumental in elucidating the molecular and neurocircuitry underpinnings of SIB. Emerging neuromodulation therapies targeting critical nodes within the fronto-limbic-striatal network, particularly deep brain stimulation, have shown promise in treating severe, refractory SIB and improving quality of life. This review integrates current evidence from clinical studies, molecular research, and preclinical models to provide a comprehensive overview of the pathophysiology of SIB and therapeutic approaches. By focusing on the molecular mechanisms and neural circuits underlying SIB, we highlight the translational potential of emerging pharmacological and neuromodulatory therapies. A deeper understanding of these pathways will pave the way for precision-based interventions, bridging the gap between molecular research and clinical applications in SIB and related conditions. Full article
(This article belongs to the Special Issue Molecular Research in Aggressive Behavior)
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