Molecular Insights into Exosomes in Inflammatory Neurological and/or Peripheral Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".
Deadline for manuscript submissions: 15 June 2025 | Viewed by 303
Special Issue Editor
Interests: mast cells; microglia; exosomes; neuroinflammation; neuroimmune/neuroinflammatory/neurodegenerative diseases; inflammatory triggers; cytokines; chemokines
Special Issue Information
Dear Colleagues,
Exosomes, small extracellular vesicles secreted by various cell types, are key mediators of intercellular communication, influencing both physiological and pathological processes. In inflammatory brain and peripheral diseases, exosomes play a crucial role in regulating immune responses, inflammation, and disease progression. However, further research is needed to better understand their molecular biology, role in inflammatory diseases, and therapeutic potential. This Special Issue will present cutting-edge molecular research that explores the involvement of exosomes in neuroinflammatory conditions (e.g., Alzheimer's, Parkinson's, and multiple sclerosis), as well as peripheral inflammatory disorders affecting organs such as the lungs and skin, as well as joints and nerves. It will explore the molecular mechanisms by which the exosomal cargo—proteins, lipids, microRNAs, and metabolites—regulates inflammation within the central nervous system and peripheral tissues. Additionally, it will address the potential use of exosomes as diagnostic biomarkers and therapeutic agents, leveraging their ability to cross biological barriers such as the blood–brain barrier. Exosome-based therapies also represent a promising strategy for modulating inflammation in chronic inflammatory diseases. We invite studies employing preclinical in vitro and in vivo models, as well as clinical research involving human subjects.
Dr. Eirini (Irene) Tsilioni
Guest Editor
Manuscript Submission Information
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Keywords
- extracellular vesicles
- neuroinflammation
- peripheral inflammation
- microglia
- mast cells
- immune response
- biomarkers
- blood–brain barrier
- therapeutic applications
- microRNAs
- molecular mechanisms
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