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Pulmonary Immune Research: Mechanisms, Disorders, and Solutions

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".

Deadline for manuscript submissions: closed (31 October 2025) | Viewed by 422

Special Issue Editors


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Guest Editor
Department of Biomedical Sciences, School of Biological and Environmental Sciences, Kwansei Gakuin University, Hyogo 669-1330, Japan
Interests: cystic fibrosis; cystic fibrosis transmembrane conductance regulator (CFTR); chloride channel
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Department of Molecular Medicine, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
Interests: chronic obstructive lung diseases; chronic kidney diseases; physical medicine; healthy lifespan; amyloidosis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The lungs serve as a primary point of contact with pathogens and foreign substances from the external environment. They have a highly developed immune system, including ciliary transport mechanisms. Dysfunction in lung immunity can result in the development of genetic diseases such as cystic fibrosis and lifestyle-related conditions such as COPD. Conversely, excessive immune responses contribute to diseases such as pulmonary fibrosis and asthma. Understanding the immune mechanisms in the lungs is essential in elucidating the pathogenesis of these diverse conditions and developing innovative therapeutic strategies.

This Special Issue, “Pulmonary Immunology Research: Mechanisms, Disorders, and Solutions”, will include reviews and original research articles exploring the molecular mechanisms underlying diverse immune responses in the lungs, alterations in immune functions associated with hereditary and lifestyle-related lung diseases, and innovative therapeutic strategies. By addressing advances at the basic, translational, and clinical levels, this Special Issue will provide expert insights and perspectives to advance our knowledge in this evolving field.

Prof. Dr. Tsukasa Okiyoneda
Dr. Tsuyoshi Shuto
Guest Editors

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Keywords

  • genetic lung disorders
  • chronic obstructive pulmonary disease (COPD)
  • pulmonary fibrosis
  • asthma
  • inflammation
  • molecular mechanism
  • pathogen/pollutant
  • immune dysfunction
  • ciliary transport
  • therapeutic strategies

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Published Papers (1 paper)

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Review

24 pages, 1483 KB  
Review
Exploring Oxygen Therapy as a Supporting Treatment for Asthma: Current Insights and Perspectives
by Michał Zwoliński, Adrian Hovagimyan, Jakub Ignatowicz, Marta Stelmasiak, Aneta Lewicka, Tomasz Szopiński, Łukasz Szymański, Justyna Bień-Kalinowska, Bałan J. Barbara and Sławomir Lewicki
Int. J. Mol. Sci. 2026, 27(1), 24; https://doi.org/10.3390/ijms27010024 - 19 Dec 2025
Viewed by 153
Abstract
Asthma is a chronic inflammatory disorder of the airways affecting over 260 million people worldwide and remains a major clinical and socioeconomic challenge. Despite substantial advances in pharmacological management (including inhaled corticosteroids, β2-agonists, leukotriene receptor antagonists, and biologic therapies), many patients [...] Read more.
Asthma is a chronic inflammatory disorder of the airways affecting over 260 million people worldwide and remains a major clinical and socioeconomic challenge. Despite substantial advances in pharmacological management (including inhaled corticosteroids, β2-agonists, leukotriene receptor antagonists, and biologic therapies), many patients continue to experience uncontrolled symptoms or corticosteroid resistance. This persistent unmet need has prompted interest in adjunctive and alternative treatment strategies. Oxygen therapy during asthma exacerbations and worsening pulmonary obstruction is a standard life-saving procedure. However, various forms of oxygen therapy are being considered for long-term treatment to reduce the number of exacerbations. Experimental and preliminary clinical data indicate that oxygen therapy may offer multiple benefits, including improved oxygenation, anti-inflammatory effects, reduced oxidative stress, modulation of nitric oxide signaling, enhanced immune responses, and promotion of angiogenesis. These mechanisms may collectively alleviate airway inflammation and improve pulmonary function. Nevertheless, clinical evidence on hyperbaric oxygen therapy (HBOT) in asthma remains limited. Existing small-scale studies suggest its safety but provide inconclusive results regarding its efficacy. Potential adverse effects such as barotrauma, oxygen toxicity, and transient anxiety necessitate careful patient selection and standardized treatment protocols. Further large-scale, randomized controlled trials are required to determine the therapeutic value of HBOT and to define its role as an adjunctive therapy in the comprehensive management of asthma. Full article
(This article belongs to the Special Issue Pulmonary Immune Research: Mechanisms, Disorders, and Solutions)
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