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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Neuropathology of Alzheimer’s Disease: Tau, Amyloid-β, and Novel Protein Associations

edited by

José Luna-Muñoz

and Alejandra Morlett-Paredes

submission deadline 31 Aug 2026 | Viewed by 720 | Submission Open

Keywords: tauopathies and protein aggregation; amyloid beta and neurotoxicity; emerging proteins in neurodegeneration; molecular and morphological biomarkers; innovative therapies and experimental targets; artificial intelligence and neuropathological analysis

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Targets in Reproductive Diseases

edited by

Changwon Yang

submission deadline 31 Aug 2026 | 1 articles | Viewed by 701 | Submission Open

Keywords: reproductive diseases; endometriosis; polycystic ovary syndrome; infertility-related disorders; pregnancy complications; reproductive system cancers; reproductive medicine; precise diagnosis; targeted therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Effects of Diet and Nutrients on Prediabetes/Diabetes

edited by Flavio Francini and Luis Flores

submission deadline 31 Aug 2026 | Viewed by 691 | Submission Open

Keywords: diabetes; prediabetes; insulin resistance; hyperglycemia; diet; dietary patterns; nutrients; molecular biology; pharmacology

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Metabolomics Research of Environmental Stress in Plants

edited by

Manish Kumar Patel

and Sonika Pandey

submission deadline 31 Aug 2026 | Viewed by 691 | Submission Open

Keywords: agricultural applications of primary and secondary metabolite;; crop improvement; integration of metabolomics with genomics and transcriptomics; medicinal plants; natural products in agriculture; plant metabolomics; plant biochemistry; primary metabolites; secondary metabolites; tools and techniques of plant metabolites in agriculture research

(This special issue belongs to the Section Molecular Plant Sciences)

Gut Microbiota and Host Immune Interactions in Inflammatory Diseases

edited by

Tomomi Kuwahara

submission deadline 31 Aug 2026 | 1 articles | Viewed by 679 | Submission Open

Keywords: gut microbiota; host–microbe interactions; innate and adaptive immunity; microbial metabolites; short-chain fatty acids; intestinal dysbiosis; inflammatory bowel disease (IBD); metabolic syndrome; autoimmune diseases; gut–organ axis; microbiome-targeted therapies

(This special issue belongs to the Section Molecular Microbiology)

New Insights in Microalgae and Cyanobacteria-Derived Bioactive Compounds

edited by

Tarik Aanniz

submission deadline 31 Aug 2026 | 1 articles | Viewed by 675 | Submission Open

Keywords: microalgal bioactive compounds; cyanobacterial bioactive compounds; mechanisms of action; structure–activity relationship; antimicrobial activity; anti-inflammatory agents; anticancer compounds; neuroprotective agents; nutraceuticals; therapeutic applications; biotechnological production

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Antibacterial Drug Discovery and Molecular Mechanisms of Antimicrobial Resistance

edited by

Eduardo Martins De Sousa

submission deadline 31 Aug 2026 | 1 articles | Viewed by 664 | Submission Open

Keywords: antibacterial drug discovery; molecular mechanisms of resistance; molecular microbiology; antibiotic targets; structure–function relationships; bacterial efflux pumps; drug-inactivating enzymes; bacterial biofilms

(This special issue belongs to the Section Molecular Microbiology)

Lipid Metabolism in Aging and Diseases: From Mechanisms to Therapy

edited by

Dominique Delmas

submission deadline 31 Aug 2026 | 1 articles | Viewed by 612 | Submission Open

Keywords: lipid metabolism; degenerative diseases; cardiovascular pathologies; neurodegeneration; inflammation; autoimmunity; cancer; lipid droplets; bioactive molecules; drug repositioning; oxidative stress; mitochondrial dysfunction; inflammatory processes

(This special issue belongs to the Section Biochemistry)

Novel Aspects in Diet-Induced Obesity and Diabetes

edited by

Salil Varshney

and Abhishek Gupta

submission deadline 31 Aug 2026 | Viewed by 566 | Submission Open

Keywords: obesity; adipocyte biology; insulin resistance; inflammation; adipokines

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Plant Extracts and Bioactive Molecules with Potential Benefits for Human Health—2nd Edition

edited by

Violeta Popovici

and

Cerasela Elena Gîrd

submission deadline 31 Aug 2026 | Viewed by 561 | Submission Open

Keywords: medicinal plants; plant extracts; bioactive phytocompound identification and quantification; pharmacological activity; health benefits; phytotherapy; plant-based diet; functional foods

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Periodontitis: From Cellular Mechanism to Therapy

edited by Mahmoud Elashiry

submission deadline 31 Aug 2026 | Viewed by 554 | Submission Open

Keywords: periodontitis; inflammatory bone disease; host–microbe interactions; innate and adaptive immunity; osteoimmunology; cellular signaling; immune dysregulation; tissue destruction; translational therapy; precision medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Exploring the New Cancer Biomarkers: Progress and Prospects

edited by

Marcelo José Barbosa Silva

submission deadline 31 Aug 2026 | Viewed by 544 | Submission Open

Keywords: prevention; diagnostic; prognostic; response; liquid biopsy; image biomarkers; clinicopathological biomarkers

(This special issue belongs to the Section Molecular Oncology)

Novel Strategies in the Development of New Therapies, Drug Substances and Drug Carriers, 4rd Edition

edited by

Andrzej Kutner

Geoffrey Brown

and Enikö Kallay

submission deadline 31 Aug 2026 | Viewed by 510 | Submission Open

Keywords: drug design and discovery antimicrobial drugs; antiviral drugs; antibiotics; cancer prevention and treatment molecular modeling; molecular mechanisms; crystallography preclinical studies; pharmacokinetics; pharmacodynamics; pharmacognosy drug-protein interactions nuclear receptors; receptor agonists and antagonists; stem cells; activity profiling; vaccines; markers; and diagnostics drug carriers; dosage form; anti-crystal engineering; nanoparticles; dissolution testing

(This special issue belongs to the Section Molecular Pharmacology)

Depression: From Molecular Basis to Therapy—3rd Edition

edited by

Terezia Kiskova-Simkova

submission deadline 31 Aug 2026 | Viewed by 469 | Submission Open

Keywords: depression; neurobiology; molecular basis; neurotransmitters; genetic factors; psychopharmacology; psychotherapy; genetic markers

(This special issue belongs to the Section Molecular Neurobiology)

Cell Penetrating Peptides: Novel Therapeutic Tools for Drug Delivery

edited by

Betty Revon Liu

submission deadline 31 Aug 2026 | Viewed by 454 | Submission Open

Keywords: cell-penetrating peptides; peptide design; drug delivery; controlled and release; clinical applica-tions; penetration mechanisms

(This special issue belongs to the Section Molecular Pharmacology)

Molecular and Translational Research on Late-Life Cognitive and Neuropsychiatric Disorders

edited by

Ioannis Liampas

submission deadline 31 Aug 2026 | Viewed by 442 | Submission Open

Keywords: dementia; Alzheimer’s disease; mild cognitive impairment; mild behavioral impairment; movement disorders; Parkinson’s disease; biomarkers; neurogenetics; molecular research

(This special issue belongs to the Section Molecular Neurobiology)

Innovations in Avian Reproduction: From Basic Science to Application

edited by

Ali Aygun

submission deadline 31 Aug 2026 | Viewed by 417 | Submission Open

Keywords: avian reproduction; reproductive physiology and technologies; incubation management; embryonic development; genetic approaches in reproduction; candidates genes of reproduction; nutrition and reproduction; genetic regulation of reproduction traits; GWAS in reproduction; avian sperm cryopreservation

(This special issue belongs to the Section Molecular Biology)

From Tryptophan to Circadian and Neurochemical Regulators: The Serotonin-Melatonin Pathway

edited by

Anna Cieslinska

submission deadline 31 Aug 2026 | Viewed by 414 | Submission Open

Keywords: tryptophan metabolism; serotonin; melatonin; indoleamines; circadian rhythm; neurotransmission; metabolites; gut–brain axis; chronobiology; metabolomics

(This special issue belongs to the Section Molecular Biology)

Recent Molecular Insights into Alzheimer's Disease

edited by

Giulia Sita

submission deadline 31 Aug 2026 | Viewed by 409 | Submission Open

Keywords: neurodegeneration; neuroprotection; pharmacology; toxicology; Alzheimer’s disease; neuroinflammation; aging

(This special issue belongs to the Section Molecular Neurobiology)

Functional Precision Medicine in Cancer: Organoid Models and Integrated Omics Profiling

edited by Gavin Robert Oliver and Carlton C Barnett

submission deadline 31 Aug 2026 | Viewed by 390 | Submission Open

Keywords: organoids; rare cancer; new approach methodologies; oncology; precision medicine; functional precision medicine; multiomics; genomics; transcriptomics; epigenomics

(This special issue belongs to the Section Molecular Oncology)

Microbiota and Gut–Brain–Eye Neuromodulators in Neurodegenerative Disorders: Biomolecular Targets and Therapeutic Challenges

edited by

Alessandra Micera

and

Filippo Biamonte

submission deadline 31 Aug 2026 | Viewed by 390 | Submission Open

Keywords: gut microbiota; brain; eye diseases; neuroinflammation; neurodegeneration; chronic inflammation; chronic pain; probiotics; gastrointestinal disorders; metabolic diseases; machine learning; artificial intelligence

(This special issue belongs to the Section Molecular Neurobiology)

Traumatic Brain Injury and Alzheimer's Disease: From Pathogenesis to Therapy

edited by

Dimitrios Kanakis

submission deadline 31 Aug 2026 | Viewed by 389 | Submission Open

Keywords: traumatic brain injury (TBI); chronic traumatic encephalopathy (CTE); head impacts; Alzheimer's disease (AD); neurodegeneration

(This special issue belongs to the Section Molecular Neurobiology)

Application of Metabolomics in Health and Human Diseases: Diagnostic, Therapeutic, Nutritional and Nutraceutical Perspectives

edited by

Barbara Tomasello

and Francesco Bellia

submission deadline 31 Aug 2026 | Viewed by 387 | Submission Open

Keywords: metabolomics; metabolomic profile biomarkers; preclinical studies; clinical studies; drug and nutraeuticals biological activities; precision medicine; personalized medicine

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

The Role of Endocrine Disruptors in Cancer

edited by Andrea Randi

submission deadline 31 Aug 2026 | Viewed by 387 | Submission Open

Keywords: endocrine disruptors; cancer; chronic exposure; cell proliferation; cancer progression; signaling pathway

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Transcription Factors and Chromatin Modifiers in Gene Regulation

edited by Takashi Ito

submission deadline 31 Aug 2026 | Viewed by 380 | Submission Open

Keywords: transcription; chromatin; epigenetics; enhancers; promoters; histone modification; gene expression; regulatory complexes; nuclear organization; cell fate regulation

(This special issue belongs to the Section Molecular Genetics and Genomics)

Current Challenges and Emerging Opportunities in Breast Cancer Immunotherapy

edited by María Florencia Mercogliano

submission deadline 31 Aug 2026 | Viewed by 378 | Submission Open

Keywords: breast cancer; tumor microenvironment; immunotherapy; immune evasion; therapy resistance; immune modulation; immune checkpoint inhibitors; antibody–drug conjugates; biomarkers, cell-based therapies

(This special issue belongs to the Section Molecular Immunology)

Nutrition from Cereal Foods: Molecular Perspectives

edited by

Yakindra Timilsena

submission deadline 31 Aug 2026 | Viewed by 366 | Submission Open

Keywords: cereal nutrition; molecular bioavailability; plant proteins; foodomics; grain processing; bioactive compounds; gut microbiome; nutraceuticals; food matrices; sustainable foods

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Natural-Derived Bioactive Compounds in Disease Treatment, 2nd Edition

edited by

Marilena Gilca

and

Adelina Vlad

submission deadline 31 Aug 2026 | Viewed by 351 | Submission Open

Keywords: medicinal plants; phytochemicals; vitamins; nutraceuticals; anti-oxidants; gene expression; protein expression; cellular signaling; nanoformulations

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Mechanisms and Pathways of Actions for Nutritional Effects on Brain Health

edited by

Fahimeh Martami

submission deadline 31 Aug 2026 | Viewed by 344 | Submission Open

Keywords: brain health; neuroplasticity; neurotransmission; neuroinflammation; oxidative stress; brain metabolism

(This special issue belongs to the Section Molecular Neurobiology)

Immune Responses as the Central Determinant of Gene Therapy Outcomes

edited by

Manoj Pandey

submission deadline 31 Aug 2026 | Viewed by 334 | Submission Open

Keywords: innate and adaptive immune sensing; TLR signaling; complement activation; antigen presentation; T‑cell cytotoxicity; humoral immunity (IgG, IgM, IgA); pediatric immunology; rare disease; lysosomal storage disease; neuroinflammation; immunomodulatory therapies; complement inhibitors

(This special issue belongs to the Section Molecular Immunology)

Heterocyclic Compounds: Synthesis, Design, and Biological Activity—2nd Edition

edited by

Josef Jampilek

submission deadline 31 Aug 2026 | Viewed by 330 | Submission Open

Keywords: heterocycles; bioactive molecules and materials; pharmacophore; design; targeting; computer studies; synthesis and analysis; natural compounds; carbohydrates; physicochemical properties; biological screening

(This special issue belongs to the Section Biochemistry)

Molecular Insights in Placental Function and Pregnancy Complications

edited by Jezid Miranda

submission deadline 31 Aug 2026 | Viewed by 328 | Submission Open

Keywords: placental biology; pregnancy complications; preeclampsia; fetal growth restriction; angiogenic markers; maternal–fetal immunity; fetal growth; trophoblast; implementation; precision obstetrics; maternal mortality

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Advancements in Cancer Immunotherapy

edited by

Pritam Sadhukhan

submission deadline 31 Aug 2026 | Viewed by 326 | Submission Open

Keywords: immune checkpoint inhibitor; PD-1 inhibitor; PDL-1 inhibitor; CTLA-4 inhibitor; B7H3 inhibitors; CAR-T cell therapy; nanotechnology in immunotherapy; tumor microenvironment remodeling

(This special issue belongs to the Section Molecular Oncology)

Chimeric Antigen Receptors Against Cancers and Autoimmune Diseases: 2nd Edition

edited by

Niels Schaft

submission deadline 31 Aug 2026 | 1 articles | Viewed by 326 | Submission Open

Keywords: chimeric antigen receptor (CAR); cancer; autoimmune disease; solid tumor; effector cell; CAR format; CAR transfer; tumor microenvironment; targeted antigen

(This special issue belongs to the Section Molecular Immunology)

Advances in Calcium Signaling: Physiological Roles and Implications for Disease

edited by

Adán Dagnino-Acosta

and

Luis Castro-Sánchez

submission deadline 31 Aug 2026 | Viewed by 320 | Submission Open

Keywords: calcium signaling; intracellular calcium; calcium homeostasis; calcium channels; muscle physiology; signal transduction; calcium-related diseases; mitochondrial calcium; genetic control of calcium signaling

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms in Cardiovascular and Metabolic Diseases: Effective and Potential Treatments

edited by

Alex Cleber Improta-Caria

submission deadline 31 Aug 2026 | Viewed by 314 | Submission Open

Keywords: molecular mechanisms; cardiovascular diseases; metabolic diseases; microRNAs; circRNAs; long non-coding RNAs; epigenetics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Research on Host–Oral Bacteria Interactions in Periodontal Pathogenesis

edited by

Ana María Fernández Presas

submission deadline 31 Aug 2026 | Viewed by 310 | Submission Open

Keywords: periodontitis; Porphyromonas gingivalis; biofilms; cytokines; dysbiosis; quorum sensing; gingipains; alveolar bone therapeutics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Neuropharmacology: From Molecular Design to Preclinical Models

edited by

Jana Tchekalarova

and Miroslav A. Rangelov

submission deadline 31 Aug 2026 | Viewed by 306 | Submission Open

Keywords: neuropharmacology; drug discovery; molecular modeling; preclinical models

(This special issue belongs to the Section Molecular Neurobiology)

Kidney Transplantation: Current Framework and New Perspectives

edited by Alberto Rosati

submission deadline 31 Aug 2026 | 1 articles | Viewed by 306 | Submission Open

Keywords: renal transplantation; organ donation; living donation; transplant survival; organ preservation; healthcare costs; acute and chronic rejection; immune tolerance; xenotransplantation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

DNA Damage and Repair Mechanisms in Cancer Development

edited by

Mengfan Tang

submission deadline 31 Aug 2026 | Viewed by 298 | Submission Open

Keywords: DNA damage response and repair; DNA replication; genome instability; drug resistance; targeted therapy; cellular senescence; innate immunity; nucleic acid homeostasis

(This special issue belongs to the Section Molecular Oncology)

Molecular Advances in Schwannomas: So-Called Benign Nervous System Tumors

edited by Sheila Mansouri

submission deadline 31 Aug 2026 | Viewed by 293 | Submission Open

Keywords: schwannoma; omics technology; liquid biopsy; tumour imaging; artificial intelligence; cell biology; tumour microenvironment; model organisms; organoids

(This special issue belongs to the Section Molecular Oncology)

Molecular Mechanisms and Advanced Diagnostic Technologies in Hair Disorders

edited by Maria Fernanda Reis Gavazzoni-Dias

submission deadline 31 Aug 2026 | Viewed by 288 | Submission Open

Keywords: inflammatory hair disorders; scarring and non-scarring alopecias; trichoscopy and scalp pathology; immunologic mechanisms in hair loss

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Contemporary Advancement in Personalized Medicine in Urological Cancers

edited by

Elenko Popov

submission deadline 31 Aug 2026 | Viewed by 287 | Submission Open

Keywords: urological cancers; prostate cancer; bladder cancer; renal/kidney cancer; personalized medicine

(This special issue belongs to the Section Molecular Oncology)

Mycobacterial Infections: Redox Modulation, Cytokine Reprogramming, and Host-Directed Therapy

edited by

Vishwanath Venketaraman

submission deadline 31 Aug 2026 | Viewed by 277 | Submission Open

Keywords: TB; NTM; redox imbalance; cytokine reprogramming; host-directed thera

(This special issue belongs to the Section Molecular Microbiology)

Advances in Structural, Dynamic, and Functional Biophysics of Membrane Proteins

edited by

F. Luis González Flecha

submission deadline 31 Aug 2026 | Viewed by 271 | Submission Open

Keywords: cryo-EM; x-ray crystallography and scattering; NMR spectroscopy; neutron scattering and reflectometry; single-molecule biophysics; molecular dynamics simulations; membrane protein dynamics; free energy analysis; mechanistic models of transport and signaling; membrane mimetics (nanodiscs, SMALPs, etc)

(This special issue belongs to the Section Molecular Biophysics)

Molecular Research in Bamboo, Tree, Grass, and Other Forest Products—2nd Edition

edited by

Huayu Sun

submission deadline 31 Aug 2026 | Viewed by 270 | Submission Open

Keywords: bamboo; tree; grass; molecular biology; gene function

(This special issue belongs to the Section Molecular Plant Sciences)

Bacteriophages in the One Health Perspective: From Infection Therapy to Precision Medicine Through Diagnostics

edited by

Alicja Wegrzyn

submission deadline 31 Aug 2026 | Viewed by 270 | Submission Open

Keywords: bacteriophages; one health concept; bacteriophage therapy

(This special issue belongs to the Section Molecular Microbiology)

Molecular Mechanisms of Protein Inhibition and Metabolism

edited by Song Wang

submission deadline 31 Aug 2026 | Viewed by 270 | Submission Open

Keywords: protein inhibition; metabolism; computational chemistry; molecular modeling; therapeutic targets

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Tissue Regeneration Mechanisms and Applications in Degenerative and Inflammatory Diseases

edited by

Daiva Bironaite

submission deadline 31 Aug 2026 | Viewed by 269 | Submission Open

Keywords: regenerative medicine; stem cells; inflammation; degenerative disease models; extracellular matrix remodeling and intracellular signaling; tissue engineering; biomaterials and bioactive scaffolds; organoids; translational and cell-based therapies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Current Advances and Challenges in Nanomedicine Delivery Systems

edited by

Shiyan Dong

submission deadline 31 Aug 2026 | Viewed by 253 | Submission Open

Keywords: nanomedicine; drug delivery; gene delivery; mRNA delivery; lipid nanoparticles (LNPs); liposomes; extracellular vesicles; biomimetic nanocarriers; targeted delivery; translational nanomedicine

(This special issue belongs to the Section Molecular Nanoscience)

Displaying special issue 301-350 on page 7 of 63.

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