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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular and Systems Mechanisms of Neural Circuit Function and Plasticity

edited by

Hyunjung Oh

submission deadline 31 Jan 2027 | 1 articles | Viewed by 781 | Submission Open

Keywords: neural circuits; neuroplasticity; synaptic organization; brain aging; mood disorders; neurodegenerative disorders; cognitive function

(This special issue belongs to the Section Molecular Neurobiology)

Exploring the Crossroads of Autoimmunity, Inflammatory Diseases, and Cancer

edited by

Xuming Mao

submission deadline 31 Jan 2027 | 1 articles | Viewed by 770 | Submission Open

Keywords: autoimmune disorders; tumor microenvironment; chronic inflammation; immune checkpoint inhibitors; machine learning; epidemiology

(This special issue belongs to the Section Molecular Immunology)

Molecular Insights into Stroke: Biomarkers and Mechanisms

edited by Jae Sang Oh

submission deadline 31 Jan 2027 | 1 articles | Viewed by 753 | Submission Open

Keywords: stroke; glymphatic system; biomarkers; human-derived specimens; molecular mechanisms

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Molecular Basis of Vascular Pathology: 2nd Edition

edited by

Jolanta Neubauer-Geryk

submission deadline 31 Jan 2027 | 1 articles | Viewed by 726 | Submission Open

Keywords: vascular pathologies; blood vessels; dysfunction; vascular damage; blood flow; biomarkers; biomolecules; cytokines

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Identification of Molecular Biomarkers Through Digital Pathology

edited by

Rafael Parra-Medina

submission deadline 31 Jan 2027 | 1 articles | Viewed by 719 | Submission Open

Keywords: digital pathology; molecular biomarkers; computational pathology; artificial intelligence; deep learning; spatial biology; multi-omics integration; tumor microenvironment; precision medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms and Therapeutic Innovations in Urological Cancers

edited by Michele Marchioni,

Luigi Schips

and Angelo Cafarelli

submission deadline 31 Jan 2027 | 1 articles | Viewed by 706 | Submission Open

Keywords: urological cancers; molecular pathways; precision oncology; biomarkers; targeted therapies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Diverse Molecular Mechanisms of Berberine Action—Identifying Potential Targets and Therapeutic Potential

edited by

Dariusz Szukiewicz

submission deadline 31 Jan 2027 | 1 articles | Viewed by 700 | Submission Open

Keywords: berberine; isoquinoline alkaloid; AMPK activator; natural compound; metabolic syndrome; wieight loss; antioxidant effects; anti-inflammatory effects; antitumor activity; neuroprotection

(This special issue belongs to the Section Bioactives and Nutraceuticals)

New Mechanisms and Therapeutics in Neurological Diseases—5th Edition

edited by

Barbara Mroczko

submission deadline 31 Jan 2027 | 1 articles | Viewed by 678 | Submission Open

Keywords: neurodegeneration; neuroinflammation; neurodegenerative diseases; neurodevelopmental disorders; tumor markers; specific proteins

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Insights into Agricultural Hydrology: Plant-Soil-Water Interactions

edited by

Muhammad Bilal Khan

submission deadline 31 Jan 2027 | Viewed by 660 | Submission Open

Keywords: soil–plant–water system; agricultural hydrology; water-use efficiency; root water uptake; rhizosphere interactions; biogeochemical cycling; ecosystem functioning; climate change impacts; wastewater treatment

(This special issue belongs to the Section Molecular Plant Sciences)

Advances in Computational Drug Design and Molecular Modeling

edited by Ana C Stucki-Mafud

submission deadline 31 Jan 2027 | Viewed by 627 | Submission Open

Keywords: preclinical phase of drug development; computer-aided drug design; artificial intelligence; machine learning; deep learning; structure-based drug design; ligand-based drug design; virtual screening; pharmacophore modeling; molecular modeling

(This special issue belongs to the Section Molecular Informatics)

Aptamers in Cancer Therapy: Mechanisms, Applications, and Translational Perspectives

edited by

Gabor István Csonka

submission deadline 31 Jan 2027 | Viewed by 616 | Submission Open

Keywords: aptamers; targeted drug delivery; cancer immunotherapy; molecular imaging; biomarkers; precision oncology; SELEX; theranostics; translational oncology; mechanistic insights

(This special issue belongs to the Section Molecular Oncology)

Immunoregulatory Mechanisms of Gut Microbiota

edited by

José Fachi

submission deadline 31 Jan 2027 | 1 articles | Viewed by 604 | Submission Open

Keywords: gut microbiota; mucosal immunity; host–microbe interactions; immune homeostasis; dysbiosis; microbial metabolites; short-chain fatty acids; barrier function; colitis

(This special issue belongs to the Section Molecular Microbiology)

Valorization of Lignocellulosic Biomass: 2nd Edition

edited by

Haishun Du

submission deadline 31 Jan 2027 | Viewed by 600 | Submission Open

Keywords: lignocellulosic biomass; biorefinery; biomass conversion; bioenergy; biofuels; bioproducts; platform chemicals; cellulose nanomaterials; lignin nanoparticles; functional materials

(This special issue belongs to the Section Materials Science)

Cancer Drugs That Target Epigenetic Processes

edited by Eileen Brantley

submission deadline 31 Jan 2027 | 1 articles | Viewed by 596 | Submission Open

Keywords: histone modifications; non-coding RNA; DNA methylation; cancer agents

(This special issue belongs to the Section Molecular Oncology)

Emerging Roles of Extracellular Vesicles in Neurological Diseases

edited by Anudeep Yekula

submission deadline 31 Jan 2027 | Viewed by 594 | Submission Open

Keywords: extracellular vesicles; exosomes; neurological diseases; liquid biopsy; neurodegeneration; neuro-oncology; biomarkers

(This special issue belongs to the Section Molecular Neurobiology)

Progress of Novel Biomarkers and Molecular Targets in Cancer

edited by

Pietro Tralongo

submission deadline 31 Jan 2027 | 1 articles | Viewed by 581 | Submission Open

Keywords: cancer biomarkers; molecular targets; precision oncology; molecular pathology; translational oncology; next-generation sequencing; liquid biopsy; tumor microenvironment; predictive biomarkers; targeted therapy

(This special issue belongs to the Section Molecular Oncology)

Nanoparticles in Nanobiotechnology and Nanomedicine: 3rd Edition

edited by

Costica Caizer

submission deadline 31 Jan 2027 | Viewed by 580 | Submission Open

Keywords: nanoparticles; properties of nanoparticles; methods of obtaining nanoparticles; characterization techniques; theoretical models; computational simulation; applications in nanomedicine; applications in nanobiotechnology

(This special issue belongs to the Section Molecular Nanoscience)

Bioactive Peptides: Microbial Fermentation-Driven Synthesis and Multifunctional Applications in Health and Industry

edited by

Yongjun Wei

submission deadline 31 Jan 2027 | Viewed by 571 | Submission Open

Keywords: bioactive peptides; foods; probiotics; fermentation; pharmaceutical; herbs

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Current Research on the Molecular and Cellular Mechanisms of Cancer

edited by Seungbaek Lee

submission deadline 31 Jan 2027 | 1 articles | Viewed by 566 | Submission Open

Keywords: cancer biology; molecular oncology; tumor microenvironment; therapeutic resistance; precision oncology

(This special issue belongs to the Section Molecular Biology)

Advanced Antimicrobial Materials: Molecular Design, Mechanism of Action and Applications

edited by

Katsuaki Dan

submission deadline 31 Jan 2027 | 1 articles | Viewed by 561 | Submission Open

Keywords: bacteria; viruses; antimicrobial materials; molecular design; action mechanism; social implementation; antimicrobial resistance; synergistic effects; infectious diseases; anti-inflammatory diseases

(This special issue belongs to the Section Materials Science)

Plant Genomics and Genome Editing, 3rd Edition

edited by

Hikmet Budak

submission deadline 31 Jan 2027 | Viewed by 557 | Submission Open

Keywords: next-generation sequencing; structural and functional genomics; SNPs; miRNA; LncRNA; CRISPR/Cas9; TALEN; genome editing

(This special issue belongs to the Section Molecular Plant Sciences)

Translational Pharmacology of GLP-1 Receptor Agonists Beyond Metabolic Diseases

edited by

Carlos-Alberto Calderon-Ospina

submission deadline 31 Jan 2027 | 1 articles | Viewed by 556 | Submission Open

Keywords: GLP-1 receptor agonists; translational pharmacology; neuroprotection; pleiotropic effects; inflammation; neuropsychiatric disorders; addiction; obstructive sleep apnea; energy balance; pharmacokinetics; cardiovascular protection

(This special issue belongs to the Section Molecular Pharmacology)

Genetic and Molecular Mechanisms in Neurological Diseases

edited by Serena Barral

submission deadline 31 Jan 2027 | Viewed by 544 | Submission Open

Keywords: neurological diseases; genetic mechanisms; molecular pathways; human neuronal models; brain organoids; iPSC-derived neural cells; neurodevelopment and neurodegeneration; disease modeling; human in vitro systems; genotype-phenotype relationships

(This special issue belongs to the Section Molecular Neurobiology)

Physiological and Molecular Responses of Plants to Drought Stress

edited by

Muhammad Waseem

submission deadline 31 Jan 2027 | Viewed by 524 | Submission Open

Keywords: drought stress; photosynthesis; stomatal regulation; signal transduction; phytohormones; anti-oxidants

(This special issue belongs to the Section Molecular Plant Sciences)

Novel Therapeutic Strategies for Cystic Fibrosis

edited by Hartmut Grasemann and

Dominik Funken

submission deadline 31 Jan 2027 | 1 articles | Viewed by 523 | Submission Open

Keywords: cystic fibrosis; CFTR modulators; gene therapy; airway inflammation; antimicrobial therapy; biomarkers; mucus; extrapulmonary disease; clinical trials; precision medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Maternal–Fetal Immunity and Antibody Transfer: Molecular Mechanisms and Clinical Implications

edited by

Vasileios Giapros

and Aikaterini Nikolaou

submission deadline 31 Jan 2027 | 1 articles | Viewed by 511 | Submission Open

Keywords: maternal immunization; transplacental antibody transfer; neonatal immunity; FcRn; antibody glycosylation; placental immunology; Fc-mediated effector functions; maternal–fetal immunity; passive immunity

(This special issue belongs to the Section Molecular Immunology)

Strategies and Visions for Nano- and Molecular-Design Materials in Future Photovoltaic Applications

edited by

Ivana Validžić

submission deadline 31 Jan 2027 | 1 articles | Viewed by 511 | Submission Open

Keywords: novel photovoltaic materials; semiconductors; perovskites; organic materials; dye-sensitized materials; bio-based materials; advanced materials; innovative energy materials

(This special issue belongs to the Section Materials Science)

Research Advances in Reproductive Biology

edited by Karl Kerns

submission deadline 31 Jan 2027 | 1 articles | Viewed by 504 | Submission Open

Keywords: reproductive biology; fertility; infertility; gametogenesis; fertilization; embryo development; reproductive endocrinology; reproductive health; epigenetics; single-cell omics

(This special issue belongs to the Section Molecular Biology)

Advances in Male Infertility and Fertility

edited by

Mariaimmacolata Preianò

submission deadline 31 Jan 2027 | Viewed by 503 | Submission Open

Keywords: male infertility; infertility treatment; omics approaches; proteomics; metabolomics; lipidomics; mass spectrometry; signaling pathways; biomarker discovery; reproductive medicine; precision medicine; diagnostic tools

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Progress in Nanomedicine for Cancer Therapy

edited by Peisheng Xu

submission deadline 31 Jan 2027 | Viewed by 501 | Submission Open

Keywords: nanomedicine; cancer-targeted therapy; theragnostic; nanodevice

(This special issue belongs to the Section Molecular Nanoscience)

Kidney Diseases: Molecular Mechanisms and Therapies

edited by

George J. Dugbartey

submission deadline 31 Jan 2027 | 1 articles | Viewed by 497 | Submission Open

Keywords: kidney diseases; pathophysiology; molecular mechanisms; therapeutic targets; acute kidney injury; chronic kidney disease; polycystic kidney disease; end-stage renal disease; IgA nephropathy; diabetic nephropathy; hypertensive nephropathy; renal cancer; kidney infarction; kidney infection; kidney failure; kidney stones; renal tubular acidosis; renal artery stenosis; acute tubular necrosis; glomerulopathy; interstitial nephritis; nephrotic syndrome; simple kidney cyst

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Eukaryotic Cells Under Stress: Biochemical and Physiological Mechanisms of Resistance and Resilience

edited by

Bruno Hay Mele

and

Carmen Arena

submission deadline 31 Jan 2027 | Viewed by 491 | Submission Open

Keywords: cellular stress response; oxidative stress; bioactive compounds; ROS; DNA damage/repair; environmental stressors; molecular chaperones; antioxidant in human diseases

(This special issue belongs to the Section Molecular Biology)

3D Printing in Pharmaceutical Drug Delivery

edited by

Sagar Narala

and

Dinesh Nyavanandi

submission deadline 31 Jan 2027 | Viewed by 479 | Submission Open

Keywords: personalized medication; 3-dimensional printing; solubility and bioavailability enhancement; polymers for 3D printing; bio-inks; 3D-printed implants; additive manufacturing

(This special issue belongs to the Section Molecular Pharmacology)

Stress Signaling and Horticultural Crops Quality Control

edited by

Weibiao Liao

and

Yanjie Xie

submission deadline 31 Jan 2027 | Viewed by 478 | Submission Open

Keywords: stress tolerance; molecular mechanisms; quality traits; redox regulation; postharvest physiology; signal transduction

(This special issue belongs to the Section Molecular Plant Sciences)

Environmental Contaminants and Health: Biological Effects, Molecular Mechanisms, and Protective Strategies

edited by

Massimo Venditti

and

Gabriella Chieffi Baccari

submission deadline 31 Jan 2027 | 1 articles | Viewed by 477 | Submission Open

Keywords: environmental contaminants; environmental exposure; health effects; cellular responses; oxidative stress; inflammation; epigenetics; non-coding RNAs; biomarkers; protective strategies

(This special issue belongs to the Section Molecular Toxicology)

Molecular Mechanisms of Chronic Obstructive Pulmonary Disease (COPD): From Pathogenesis to Therapeutic Response

edited by

Bassam Redwan

submission deadline 31 Jan 2027 | 1 articles | Viewed by 467 | Submission Open

Keywords: COPD; emphysema; pulmonary endothelium; inhaled corticosteroids; β2-agonists; oxidative stress; efferocytosis; airway inflammation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms and Diagnostics in Hereditary Hemolytic Anemias

edited by Joan-Lluís Vives-Corrons

submission deadline 31 Jan 2027 | Viewed by 460 | Submission Open

Keywords: anemia; red blood cell erythropoiesis; membranopathies ; erythro enzymopathies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Transcriptional Reprogramming and Metabolic Plasticity in the Tumor Microenvironment: Implications for Immune Evasion and Therapeutic Resistance

edited by

Inhak Choi

submission deadline 31 Jan 2027 | 1 articles | Viewed by 457 | Submission Open

Keywords: transcriptional reprogramming; epigenetic regulation; metabolic plasticity; immunometabolism; tumor microenvironment; cellular heterogeneity; immune evasion; T cell exhaustion; therapeutic resistance; single-cell omics; spatial transcriptomics; precision immunotherapy; biomarker discovery

(This special issue belongs to the Section Molecular Oncology)

Molecular Insights into T Cell Exhaustion and Tumor Immune Evasion

edited by

Apostolos Zaravinos

submission deadline 31 Jan 2027 | Viewed by 454 | Submission Open

Keywords: T cell exhaustion; immune evasion; tumor microenvironment; immune checkpoints; immunometabolism; epigenetics; cancer immunology; molecular immunotherapy; single-cell analysis; transcriptional regulation

(This special issue belongs to the Section Molecular Immunology)

Osteoimmunology and Drug Discovery: Molecular Mechanisms, Bone Resorption Pathways and Therapeutic Opportunities

edited by

Vishwa Deepak

submission deadline 31 Jan 2027 | 1 articles | Viewed by 451 | Submission Open

Keywords: osteoimmunology; osteoclasts; bone resorption; drug discovery; inflammation; RANKL; NF-κB; NFATc1; natural products; bone therapeutics

(This special issue belongs to the Section Molecular Immunology)

Molecular Understanding of Horticultural Crops Response to Environmental Stresses

edited by

Rahat Sharif

submission deadline 31 Jan 2027 | 1 articles | Viewed by 449 | Submission Open

Keywords: genome editing; functional genomics; abiotic and biotic stress responses; gene regulatory networks; horticultural crops

(This special issue belongs to the Section Molecular Plant Sciences)

Cryo-EM and Cryo-Tomography in Macromolecular Structure Analysis

edited by

R. Holland Cheng

submission deadline 31 Jan 2027 | Viewed by 448 | Submission Open

Keywords: macromolecular structure; precision nanomedicine; cryo-electron microscopy (cryo-EM); cryo-electron tomography (cryo-ET); viral capsids; AI/ML in structural analysis; time-resolved imaging; nanoparticle delivery; in-cell tomography; structural dynamics; molecular mechanisms; protein complexes; membrane proteins; macromolecular assemblies; conformational changes; integrative structural biology; cellular structural biology; drug delivery systems; therapeutic design

(This special issue belongs to the Section Macromolecules)

Relevant Molecules in the Process of Oxidative Stress

edited by

Anna De Maio

Carmen Di Giovanni

and

Anna Rita Bianchi

submission deadline 31 Jan 2027 | Viewed by 444 | Submission Open

Keywords: oxidative stress; reactive oxygen species; reactive nitrogen species; antioxidant enzymes; non-enzymatic antioxidants; poly(ADPribosyl)ation; transcription factors

(This special issue belongs to the Section Biochemistry)

Progress in Molecular Breeding and Genetic Engineering for Fruit Crop Improvement

edited by

Amelia Salimonti

submission deadline 31 Jan 2027 | Viewed by 442 | Submission Open

Keywords: genetics; GWAS; genome; abiotic and biotic stress; transcriptomic analysis; fruit crop germplasm; breeding

(This special issue belongs to the Section Molecular Plant Sciences)

Biomedical Applications of Mesenchymal Stem Cells, 2nd Edition

edited by

Giuliana Mannino

and

Debora Lo Furno

submission deadline 31 Jan 2027 | Viewed by 439 | Submission Open

Keywords: mesenchymal stem cells; cell differentiation; cell therapy; regenerative medicine; tissue homeostasis; disease; cartilage

(This special issue belongs to the Section Molecular Biology)

Targeting the Renin–Angiotensin System: A Molecular Strategy for Disease Intervention

edited by

Alexis A. Gonzalez

submission deadline 31 Jan 2027 | 1 articles | Viewed by 437 | Submission Open

Keywords: tissue-specific RAS; cardiovascular disease; biomarkers; signal transduction; precision medicine; immune regulation; tubular transport; kidney disease; RAS inhibitors; translational research

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Biomaterials: From Design, Synthesis and Characterization to Application—2nd Edition

edited by

Tao Sun

and

Xujin Bao

submission deadline 31 Jan 2027 | Viewed by 436 | Submission Open

Keywords: biomaterials; synthesis; characterization; therapeutics; diagnosis

(This special issue belongs to the Section Materials Science)

Lysosomal Storage Disorders: Molecular Pathogenesis and Next-Generation Therapeutics

edited by

Olga Amaral

and

Ari Zimran

submission deadline 31 Jan 2027 | Viewed by 427 | Submission Open

Keywords: lysosomal storage disorders; cellular mechanisms; multi-omics biomarkers; gene therapy; precision medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Microbial Bioconversion of Agri-Food Waste for the Production of Pharmacologically Active Compound

edited by Alicia Paz

submission deadline 31 Jan 2027 | Viewed by 412 | Submission Open

Keywords: microbial bioconversion; agri-food waste valorization; bioactive compounds; bioprocess optimization; pharmaceuticals; functional foods; cosmetic bioactives

(This special issue belongs to the Section Molecular Microbiology)

Cellular Immunotherapy in Cancer: Current Trends and Future Directions

edited by

Vahid Vahedian

submission deadline 31 Jan 2027 | Viewed by 412 | Submission Open

Keywords: cellular immunotherapy; CAR-T cells; CAR-NK cells; CAR-macrophages; tumor-infiltrating lymphocytes (TILs); immune receptor signaling; tumor microenvironment; CRISPR/Cas9 genome editing; precision cancer immunotherapy; translational immuno-oncology

(This special issue belongs to the Section Molecular Immunology)

Displaying special issue 2451-2500 on page 50 of 64.

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