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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advances in Research on Neurotransmitters
edited by , and Jing-Ning Zhu
submission deadline 20 Jan 2026 | 6 articles | Viewed by 17261 | Submission Open
Keywords: neurotransmitter; GABA; glutamate; monoamines; dopamine; serotonin; norepinephrine; neuropeptides; nitric oxide; neurosteroids; stress; neurotrophins; epigenetics; gut– brain axis
(This special issue belongs to the Section Molecular Neurobiology)
Genomic Research of Rare Diseases
edited by Shira Rockowitz and Piotr Sliz
submission deadline 20 Jan 2026 | 7 articles | Viewed by 16932 | Submission Open
Keywords: rare disease ontology; variants of uncertain significance; candidate genes; whole genome sequencing; long read whole genome sequencing; machine learning; multi-omics
(This special issue belongs to the Section Molecular Genetics and Genomics)
Growth Hormone Deficiency: Molecular Pathologies and Therapeutic Strategies
edited by
submission deadline 20 Jan 2026 | 8 articles | Viewed by 16910 | Submission Open
Keywords: growth hormone (GH); growth hormone deficiency (GHD); growth hormone therapy; long-acting growth hormone (LAGH); insulin-like growth factor-1 (IGF-1); growth hormone secretagogues; signaling pathways of the GH-IGF-1 axis; transition phase
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Diagnosis and Monitoring of Kidney Disease: From Biology to Biomarkers submission deadline 20 Jan 2026 | 6 articles | Viewed by 16685 | Submission Open
Keywords: chronic kidney disease (CKD); end-stage renal disease; CKD biomarkers; CKD progression; metabolomics; molecular pathways; biomolecules; CKD anemia; cardiovascular disease risk; CKD-related disease
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Bioactive Compounds in the Prevention of Chronic Diseases submission deadline 20 Jan 2026 | 6 articles | Viewed by 16268 | Submission Open
Keywords: bioactives; chronic disease; inflammation; oxidative stress; obesity; diabetes; cancer
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Recent Advances in Pathophysiology and Immunology Related to SARS-CoV-2 Infection
edited by
submission deadline 20 Jan 2026 | 9 articles | Viewed by 15969 | Submission Open
Keywords: SARS-CoV-2; COVID-19; immunology; pathophysiology; immunopathology
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Novel Insight into Epigenomic Studies of Human Disease
edited by and Takashi Ito
submission deadline 20 Jan 2026 | 7 articles | Viewed by 15554 | Submission Open
Keywords: epigenetic regulation; DNA methylation; protein methylation; protein acetylation; histone modification; noncoding RNAs (ncRNAs); post-translational modifications (PTMs); chromatin; human disease
(This special issue belongs to the Section Molecular Genetics and Genomics)
Focus on Hippocampus Biology: From Neurophysiology to Dysfunctions (2nd Edition)
edited by
submission deadline 20 Jan 2026 | 4 articles | Viewed by 15015 | Submission Open
Keywords: hippocampus; dentate gyrus; cornu ammonis (CA); spatial memory; episodic memory; learning; spatial navigation; synaptic plasticity; neuroplasticity; neurogenesis; ischemia; neuroinflammation; chronic stress; aging; neurodegenerative diseases; Alzheimer’ s disease; epilepsy; depression; anxiety
(This special issue belongs to the Section Molecular Neurobiology)
New Insights into the Treatment of Metabolic Syndrome and Diabetes
edited by
submission deadline 20 Jan 2026 | 6 articles | Viewed by 14949 | Submission Open
Keywords: metabolic dysfunction; metabolic disorder; diabetes
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Cytotoxicity, Antioxidant and Anticancer Activity of Natural Products, 2nd Edition
edited by
submission deadline 20 Jan 2026 | 7 articles | Viewed by 14723 | Submission Open
Keywords: natural products; anticancer activity; apoptosis; immunomodulation; free radicals; proliferation; phytomolecules; nanoparticles; drug delivery
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Insights into Zoology
edited by
submission deadline 20 Jan 2026 | 10 articles | Viewed by 14235 | Submission Open
Keywords: zoology; genomics; transcriptomics; phylogeny; molecular evolution; mtDNA; eDNA; RNA; molecular zoolog
(This special issue belongs to the Section Molecular Biology)
Editorial Board Members’ Collection Series: Cardiovascular Diseases submission deadline 20 Jan 2026 | 5 articles | Viewed by 14161 | Submission Open
Keywords: cardiovascular disease; metabolism; cardiometabolic risk; coronary artery disease; CVD
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
The Structures and Biologic Activity of Marine Natural Products submission deadline 20 Jan 2026 | 4 articles | Viewed by 13187 | Submission Open
Keywords: marine natural products; secondary metabolites; structure elucidation; biologic activity; structure-activity relationships; taxonomic distribution; biosynthesis; functions
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Research Advances in the Bioinformatics of Genome Editing and Gene Function Analysis
edited by
submission deadline 20 Jan 2026 | 4 articles | Viewed by 13156 | Submission Open
Keywords: genome editing; functional genomics; genome analysis; transcriptome analysis; metagenome analysis; meta-analysis; bioinformatics; large language model (LLM); public databases
(This special issue belongs to the Section Molecular Informatics)
Molecular Progression of Genetics in Breeding of Farm Animals
edited by
submission deadline 20 Jan 2026 | 6 articles | Viewed by 12566 | Submission Open
Keywords: farm animal; livestock; genome sequencing
(This special issue belongs to the Section Molecular Genetics and Genomics)
Molecular Advances in Neurologic and Neurodegenerative Disorders submission deadline 20 Jan 2026 | 4 articles | Viewed by 12264 | Submission Open
Keywords: traumatic brain injury; chronic traumatic encephalopathy; Alzheimer’ s disease; motor neuron disease; amyotrophic lateral sclerosis; neurosignalling; neurodegeneration; brain– gut axis impairment; oxidative stress; chronic inflammation
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Aspects of Bacterial Infection submission deadline 20 Jan 2026 | 5 articles | Viewed by 11973 | Submission Open
Keywords: bacterial pathogenesis; antimicrobial resistance; molecular mechanism of host-pathogen interaction; biofilm; infectious diseases
(This special issue belongs to the Section Molecular Microbiology)
Renin-Angiotensin System in Health and Diseases
edited by
submission deadline 20 Jan 2026 | 3 articles | Viewed by 11817 | Submission Open
Keywords: coronavirus disease 2019 (COVID-19); SARS-CoV-2; RAAS; spike protein; angiotensin; ACE2; clinical study; basic experiments
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
New Advances in the Treatment and Diagnosis of Neuromuscular Diseases
edited by Silvia Consalvi
submission deadline 20 Jan 2026 | 2 articles | Viewed by 11747 | Submission Open
Keywords: neuromuscular diseases; gene therapies; stem cell therapy; treatment and diagnosis
(This special issue belongs to the Section Molecular Neurobiology)
Advances in Molecular Forensic Pathology and Toxicology: An Update
edited by
submission deadline 20 Jan 2026 | 5 articles | Viewed by 11745 | Submission Open
Keywords: biomarkers; immunohistochemistry; histopathology; forensic pathology; forensic toxicology; forensic biomarkers; toxicological biomarkers; neuropathology; mRNA; post-mortem interval; cerebral damage; in vitro; in vivo; and in silico models; hypoxic– ischemic brain injury; pregnancy biomarkers; vitality
(This special issue belongs to the Section Molecular Biology)
Developmental Biology: Computational and Experimental Approaches, 2nd Edition submission deadline 20 Jan 2026 | 5 articles | Viewed by 11348 | Submission Open
Keywords: animal; plant; fungus; biological organization hierarchy; evolutionary limitations
(This special issue belongs to the Section Molecular Biology)
Molecular Mechanism Underlying Plant Drought and Salinity Stress Tolerance submission deadline 20 Jan 2026 | 4 articles | Viewed by 11182 | Submission Open
Keywords: drought; salinity; oxidative stress; antioxidant mechanism; photosynthesis; aquaporins; gene expression analysis
(This special issue belongs to the Section Molecular Plant Sciences)
Inflammation in Chronic Disease: Molecular Mechanisms and Signaling Pathways
edited by
submission deadline 20 Jan 2026 | 4 articles | Viewed by 11107 | Submission Open
Keywords: inflammation; neuroinflammation; immune response; inflammation-associated disease; inflammation mediators (proteins; enzymes; ecc); cytokines; macrophages; mast cells; monocytes; dendritic cells; oxidative stress; signaling pathways
(This special issue belongs to the Section Molecular Immunology)
Natural Compounds in Human Health and Disease
edited by
submission deadline 20 Jan 2026 | 4 articles | Viewed by 11054 | Submission Open
Keywords: nutrition; human health; obesity; polyphenol; tea; pathology; animal model
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Studies of Natural Compounds and Plant Extracts—3rd Edition
edited by
submission deadline 20 Jan 2026 | 6 articles | Viewed by 10993 | Submission Open
Keywords: bioactive substances; plant chemistry; polysaccharides; flavonoids; alkaloids; saponins; terpenes; phenolic acids; volatile oils; antioxidant/anti-inflammatory/anti-cancer; blood pressure lowering; blood sugar lowering; antibacterial; antiviral; antiallergic
(This special issue belongs to the Section Biochemistry)
Molecular Perspective of Precision Medicine Revolutionizing Kidney Disease submission deadline 20 Jan 2026 | 1 articles | Viewed by 10754 | Submission Open
Keywords: personalized medicine; kidney diseases; genomics; biomarkers; therapeutics; proteomics; metabolomics; machine learning
(This special issue belongs to the Section Molecular Informatics)
Recent Trends in Experimental Models for Cancer Research submission deadline 20 Jan 2026 | 4 articles | Viewed by 10619 | Submission Open
Keywords: experimental models; cancer research; cell culture; animal models; organoids; computational models
(This special issue belongs to the Section Molecular Oncology)
Multiple Sclerosis: From Molecular Pathology to Novel Therapeutic Approaches submission deadline 20 Jan 2026 | 6 articles | Viewed by 10546 | Submission Open
Keywords: progression-independent relapses (PIRAs); smouldering-associated worsening (SAW); lack of new relapses and of new magnetic resonance imaging activity (NEIDA); slowly expanding lesions (SEL); no evidence of smouldering disease activity (NESDA); neurofilament (NfL); glial fibrillary acidic protein (GFAP); patient-reported outcome (PRO); paramagnetic rim lesions (PRLs); relapse-associated worsening (RAW)
(This special issue belongs to the Section Molecular Neurobiology)
Respiratory Virus Infection
edited by Nikolaos Siafakas
submission deadline 20 Jan 2026 | 6 articles | Viewed by 10370 | Submission Open
Keywords: respiratory virus; diagnosis; surveillance; epidemiology; therapy; vaccination; influenza virus; coronavirus; respiratory syncytial virus; rhinovirus/enterovirus
(This special issue belongs to the Section Molecular Microbiology)
Herpes Simplex Virus: Immunity, Pathogenicity, Immune Escape Mechanisms, and Antiviral Strategies submission deadline 20 Jan 2026 | 2 articles | Viewed by 10053 | Submission Open
Keywords: herpes simplex virus (HSV); latency; immune evasion; tegument proteins; epigenetic mechanisms; viral pathogenesis; antiviral strategies; molecular mechanisms; therapeutic interventions
(This special issue belongs to the Section Molecular Immunology)
Molecular Biomarkers in Cancers: Advances and Challenges, 2nd Edition submission deadline 20 Jan 2026 | 6 articles | Viewed by 9461 | Submission Open
Keywords: cancer; cancer staging; diagnostic tools; novel biomarkers; proteomics; molecular markers; metabolic profiling; prognostic value
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Protein and Protein Interactions
edited by Wu Xu
submission deadline 20 Jan 2026 | 4 articles | Viewed by 9040 | Submission Open
Keywords: protein and protein interactions; ligand and protein interactions; computational method; geometry-based; energy-based; conformational changes; binding site prediction; structural biology; computational biology and bioinformatics
(This special issue belongs to the Section Molecular Biology)
Molecular Research in Bone and Soft Tissue Tumors
edited by
submission deadline 20 Jan 2026 | 4 articles | Viewed by 9021 | Submission Open
Keywords: sarcoma; therapeutic target; metastasis; anticancer agent; immunotherapy
(This special issue belongs to the Section Molecular Oncology)
Diabetes and Its Complications: From Molecular Mechanisms to Novel Therapeutic Approaches—2nd Edition submission deadline 20 Jan 2026 | 1 articles | Viewed by 9008 | Submission Open
Keywords: diabetes; diabetes complications; environmental factors; endocrine disruptors; nutrition; sleep; therapy; molecular mechanisms
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Biochemical and Molecular Aspects of Bioremediation of Soils with Organic Pollutants by Microorganisms
edited by
submission deadline 20 Jan 2026 | 5 articles | Viewed by 8993 | Submission Open
Keywords: bioremediation; soil pollution; organic pollutants; microorganisms; microbial communities; gene expression; enzyme degradation; molecular tools; indigenous soil microorganisms; contaminated soils
(This special issue belongs to the Section Molecular Microbiology)
Abiotic Stresses in Plants: From Molecules to Environment—2nd Edition
edited by
submission deadline 20 Jan 2026 | 7 articles | Viewed by 8781 | Submission Open
Keywords: stress signaling; abiotic stress; oxidative stress; genotoxic stress
(This special issue belongs to the Section Molecular Plant Sciences)
Mesenchymal Stem Cell-Based Therapy: Cell Therapy vs. EV Therapy
edited by Masahito Nakazaki
submission deadline 20 Jan 2026 | 2 articles | Viewed by 8714 | Submission Open
Keywords: mesenchymal stromal/stem cells; small extracellular vesicles; large extracellular vesicles; clinical trials; spinal cord injury; cerebrovascular disease
(This special issue belongs to the Section Biochemistry)
Latest Research on Plant Genomics and Genome Editing, 2nd Edition
edited by
submission deadline 20 Jan 2026 | 6 articles | Viewed by 8631 | Submission Open
Keywords: next-generation sequencing; structural and functional genomics; SNPs; miRNA; LncRNA; CRISPR/Cas9; TALEN; genome editing
(This special issue belongs to the Section Molecular Plant Sciences)
Recent Advances in Electrochemical-Related Materials
edited by Celia García-Hernandez
submission deadline 20 Jan 2026 | 6 articles | Viewed by 8541 | Submission Open
Keywords: novel electrochemical devices; advanced micro- and nanomaterials for electrochemical applications; batteries; fuel and photoelectrochemical cells; electrochemical sensors and biosensors; new advances in supercapacitors; electrochemical electrolyzers; advanced electrochemical materials for environmental applications
(This special issue belongs to the Section Materials Science)
Investigating Host-Parasite Interactions for the Discovery of Novel Therapies and Vaccine Targets submission deadline 20 Jan 2026 | 6 articles | Viewed by 8485 | Submission Open
Keywords: parasites; host-pathogen interactions; helminths; worms; protozoans; leishmania; malaria; schistosomiasis; trypanosomiasis; ascariasis; anisakiasis; vectors; mosquitoes; ticks; neglected tropical diseases
(This special issue belongs to the Section Molecular Immunology)
Molecular Mechanisms and Therapies for Melanoma
edited by Anna Piotrowska
submission deadline 20 Jan 2026 | 3 articles | Viewed by 8381 | Submission Open
Keywords: melanoma; targeted therapy; BRAF/MEK inhibitors; immunotherapy; anti-PD-1 and anti-CTLA-4 immunotherapy; melanoma microenvironment; cancer-associated fibroblasts (CAFs)/melanoma-associated fibroblasts (MAFs); MAPK (mitogen-activated protein kinase) signaling pathway
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Endometriosis Pathophysiology, Diagnosis and Emerging Therapeutic Strategies submission deadline 20 Jan 2026 | 1 articles | Viewed by 8290 | Submission Open
Keywords: endometriosis; pathophysiology; infertility; biomarkers; pharmacological treatments
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
New Insights into the Immunopathology of Infectious Diseases
edited by Marta Camici
submission deadline 20 Jan 2026 | 4 articles | Viewed by 8263 | Submission Open
Keywords: infection immunology; immune dysregulation in infectious diseases; interactions between infective agents and immune responses; modeling of the immune system; new pathways of pathogenesis
(This special issue belongs to the Section Molecular Immunology)
Virus Infection and Infectious Diseases: Unraveling Mechanisms, Innovations and Therapeutic Strategies—Second Edition
edited by Jung-Hyun Lee
submission deadline 20 Jan 2026 | 5 articles | Viewed by 8051 | Submission Open
Keywords: mechanism of virus infection; host immune responses; innovations in diagnostics and surveillance; therapeutic strategies; epidemiology and global health; data science for infectious disease; zoonotic transmission; virus evolution
(This special issue belongs to the Section Molecular Immunology)
Recent Advances in Adult Stem Cell Research
edited by Dongsu Park
submission deadline 20 Jan 2026 | 4 articles | Viewed by 7885 | Submission Open
Keywords: tissue-resident stem cells; skeletal stem/progenitor cells; hematopoietic stem cells; tendon/ligament stem cells; musculoskeletal tissue regeneration; stem cell microenvironment; stem cell aging
(This special issue belongs to the Section Molecular Biology)
Advanced Electrode and Electrolyte Materials: Molecular Scale Design, Synthesis, Mechanisms and Applications
edited by
submission deadline 20 Jan 2026 | 3 articles | Viewed by 7843 | Submission Open
Keywords: cathode; anode; electrolyte; synthesis; electrochemistry; rechargeable batteries; lithium-ion batteries; all-solid-state lithium metal batteries
(This special issue belongs to the Section Materials Science)
Molecular and Cellular Mechanisms of Skin Diseases (Second Edition)
edited by
submission deadline 20 Jan 2026 | 4 articles | Viewed by 7799 | Submission Open
Keywords: hyperproliferative skin diseases; psoriasis; keratinocyte carcinoma; actinic keratosis; atopic dermatitis; skin inflammation; inflammation-associated skin diseases; epidermal differentiation; epidermal cell metabolism; 3D models; in vivo models
(This special issue belongs to the Section Molecular Biology)
Molecular Mechanism and Pathogenesis of Cardiac Disease
edited by Yu-Hsun Kao
submission deadline 20 Jan 2026 | 3 articles | Viewed by 7742 | Submission Open
Keywords: cardiac diseases; cardiac metabolidm; epigenetics; ER stress; mitochondrial dysfunction; molecular mechanisms; therapeutic targets  
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Biomaterials for Drug Delivery and Advanced Therapies
edited by
submission deadline 20 Jan 2026 | 3 articles | Viewed by 7697 | Submission Open
Keywords: polymers; biomaterials; drug delivery; scaffold; ATMPs; tissue regeneration
(This special issue belongs to the Section Materials Science)
Biomarkers in Cardiovascular Diseases: Diagnosis, Pathology and Treatment submission deadline 20 Jan 2026 | 3 articles | Viewed by 7326 | Submission Open
Keywords: heart failure; myocardial remodeling; ischemic heart disease; myocarditis; cardiomyopathies; prevention; diagnosis; therapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
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