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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Insights into Amyotrophic Lateral Sclerosis

edited by

Viviana Greco

submission deadline 30 Nov 2026 | Viewed by 580 | Submission Open

Keywords: amyotrophic lateral sclerosis; proteomics; protein aggregation; mitochondria; neurodegeneration; RNA metabolism; oxidative stress; neuroinflammation; systems biology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Metabolic Diseases: From Molecular Mechanisms to Innovative Therapeutics

edited by

Aleksandra Szopa

and Anna D. Serefko

submission deadline 30 Nov 2026 | Viewed by 578 | Submission Open

Keywords: metabolic dysregulation; neuropsychiatric disorders; molecular crosstalk; neuroinflammation; mitochondrial dysfunction; neuroendocrine signaling; gut–brain axis; innovative therapeutic strategies; natural compounds; drug repurposing

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Neuroinflammation: Emerging Insights and Advances in Drug Development

edited by

Guya Diletta Marconi

Francesca Diomede

Jacopo Pizzicannella

and Paolo Gugliemi

submission deadline 30 Nov 2026 | Viewed by 565 | Submission Open

Keywords: neuroinflammation; drugs; neurodegenerative; Parkinson’s disease; Alzheimer’s disease; multiple scleroris; stroke

(This special issue belongs to the Section Molecular Neurobiology)

Plant Reproductive Genetics and Genomics in Crop Breeding

edited by

Alejandro Garcia Ramirez

submission deadline 30 Nov 2026 | 1 articles | Viewed by 548 | Submission Open

Keywords: genetics; heredity; agronomy; maize breeding

(This special issue belongs to the Section Molecular Plant Sciences)

Kidney Disease: From Biomarkers, Molecular Mechanisms to Targeted Therapy

edited by

Rusu Crina Claudia

submission deadline 30 Nov 2026 | Viewed by 547 | Submission Open

Keywords: kidney disease; biomarkers; molecular mechanisms; precision nephrology; chronic kidney disease; acute kidney injury; renal fibrosis; omics technologies; targeted therapy; personalized medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

State-of-the-Art Molecular Pharmacology in Thailand

edited by

Sitthivut Charoensutthivarakul

submission deadline 30 Nov 2026 | 1 articles | Viewed by 544 | Submission Open

Keywords: molecular pharmacology; pharmacogenomics; bioactive natural products; drug discovery and design; molecular targets; precision medicine; signal transduction; cholangiocarcinoma therapeutics; neuropharmacology

(This special issue belongs to the Section Molecular Pharmacology)

Roles of Erythrocytes in Human Health and Disease: 4th Edition

edited by

Francesco Misiti

submission deadline 30 Nov 2026 | Viewed by 530 | Submission Open

Keywords: erythrocytes; red blood cells; red blood functions; vascular function; blood bank storage

(This special issue belongs to the Section Molecular Biology)

Skeletal Muscle Aging: Mechanisms, Biomarkers, and Interventions

edited by

Ida Cariati

submission deadline 30 Nov 2026 | Viewed by 527 | Submission Open

Keywords: skeletal muscle aging; sarcopenia; muscle metabolism; mitochondrial dysfunction; inflammation; exercise adaptation; muscle adaptation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Quantum Chemical Intelligence: New Horizons of Molecular Structure and Reactivity

edited by

Mihai V. Putz

submission deadline 30 Nov 2026 | Viewed by 525 | Submission Open

Keywords: chemical bond and bonding; quantum states and measurements; chemical reactivity; valence models; complex coordination; reaction coordinates and paths; bio-nano-materials

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Hormetic Responses of Plants to Environmental Stress

edited by

Michael Moustakas

submission deadline 30 Nov 2026 | Viewed by 522 | Submission Open

Keywords: hormesis; environmental stress; dose–response; molecular mechanisms

(This special issue belongs to the Section Molecular Plant Sciences)

Modern Synthetic Pathways for Anticancer Drug Discovery

edited by

Łukasz Struk

submission deadline 30 Nov 2026 | 1 articles | Viewed by 516 | Submission Open

Keywords: new anticancer agents; bioactive molecules; drug design; drug synthesis; cancer therapy; medicinal chemistry

(This special issue belongs to the Section Molecular Oncology)

Translational Insights in Solid Tumors: Bridging Molecular Mechanisms to Therapeutic Advances

edited by

Samarpan Majumder

submission deadline 30 Nov 2026 | 1 articles | Viewed by 503 | Submission Open

Keywords: solid tumors; translational research; molecular mechanisms; targeted therapy; immunotherapy; tumor microenvironment; biomarkers; drug resistance; precision oncology; clinical translation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Research Advances in Vegetable Breeding and Genetics

edited by

Jinglei Wang

submission deadline 30 Nov 2026 | 1 articles | Viewed by 498 | Submission Open

Keywords: vegetable; breeding; genetics; genomics; gene editing; marker-assisted selection; stress resistance; quality improvement; crop improvement; horticulture

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Mechanisms of Nutrient Uptake and Utilization in Plants

edited by

Stella Karydogianni

submission deadline 30 Nov 2026 | Viewed by 498 | Submission Open

Keywords: agriculture and crop improvement; molecular and cellular mechanisms; nitrogen; nutrient efficiency; protein

(This special issue belongs to the Section Molecular Plant Sciences)

Transcription Factors in Plant Gene Expression Regulation, 3rd Edition

edited by

Piotr Szymczyk

submission deadline 30 Nov 2026 | 1 articles | Viewed by 497 | Submission Open

Keywords: plant trans-factor ; cis-active sequence ; post-translational modification ; dimerization and oligomerization ; DNA modules

(This special issue belongs to the Section Molecular Plant Sciences)

Bridging the Omics of Protein Landscape of Aging and Disease: New Insights and Opportunities

edited by

Fátima Milhano Santos

submission deadline 30 Nov 2026 | Viewed by 496 | Submission Open

Keywords: age-related disease; aging; biomarkers; chronic diseases; neurodegenerative diseases; ocular diseases; proteomics; kidney diseases

(This special issue belongs to the Section Molecular Biology)

Cancer Biomarkers: From Early Detection to Prognosis

edited by

Luís Lima

submission deadline 30 Nov 2026 | 1 articles | Viewed by 492 | Submission Open

Keywords: cancer biomarkers; early detection; prognosis; liquid biopsy; personalized oncology; multi-omics; translational research; predictive modeling

(This special issue belongs to the Section Molecular Oncology)

Nutrition of Crustaceans: A Molecular Perspective

edited by

Cheng Chi

submission deadline 30 Nov 2026 | Viewed by 490 | Submission Open

Keywords: crustacean nutrition; molecular mechanisms; aquaculture; nutrient metabolism; reproduction

(This special issue belongs to the Section Molecular Biology)

Advances in Plant-Derived Nanomaterials: From Molecular Mechanisms to Biofortification

edited by

Ágnes Szepesi

submission deadline 30 Nov 2026 | Viewed by 489 | Submission Open

Keywords: nanotechnology; green synthesis; sustainable nanomaterials; nano–bio interactions; crop production; plant-based solutions; bio-corona

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Insights into Probiotics and Prebiotics in Gut Health and Disease

edited by

Hikmate Abriouel

submission deadline 30 Nov 2026 | Viewed by 483 | Submission Open

Keywords: probiotics; prebiotics; gut microbiota; intestinal health; dysbiosis; host–microbe interactions; omics; gut–brain axis

(This special issue belongs to the Section Molecular Microbiology)

Peptides in Healthcare and Beyond: Emerging Roles in Skincare, Nutrition, Medicine, and Animal Health

edited by

Jiazhong Li

and Lijing Fang

submission deadline 30 Nov 2026 | Viewed by 483 | Submission Open

Keywords: peptides; efficacy; healthcare; skincare; nutrition; medicine; animal health

(This special issue belongs to the Section Biochemistry)

Bioactive Peptides from Natural Sources: Pharmacological Effects, Recombinant Expression, Modification, Molecular Mechanisms, and Therapeutic Potential

edited by Linchun Shi

submission deadline 30 Nov 2026 | Viewed by 480 | Submission Open

Keywords: bioactive peptides; functional peptides; antimicrobial peptides; host-defense peptides; venom peptides; ribosomally synthesized and post-translationally modified peptides; peptide precursor gene families; comparative genomics; phylogeny; structure–activity relationship

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Mitochondrial DNA and Its Multiple Functions in Health and Disease

edited by

Izinara Rosse

and Vanessa F. Gonçalves

submission deadline 30 Nov 2026 | Viewed by 479 | Submission Open

Keywords: mitochondrial DNA; mtDNA; mitochondrial genome sequencing; mitochondrial dysfunction; precision medicine

(This special issue belongs to the Section Molecular Genetics and Genomics)

The Influence of Genetics on Lymphatic System Diseases

edited by

Tomomi Watanabe-Asaka

submission deadline 30 Nov 2026 | Viewed by 470 | Submission Open

Keywords: lymphatic system; gene expression; disease model; medical application; lymphatic development; lymphatic function

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Research on Skin Inflammation (2nd Edition)

edited by

Nabiha Yusuf

submission deadline 30 Nov 2026 | 1 articles | Viewed by 470 | Submission Open

Keywords: skin inflammation; molecular diagnosis; dermatitis; molecular pathogenesis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular, Cellular and Systems Research on Neuroanatomy, Brain Function and Its Impact on Human Behavior

edited by

Frank Schmitz

submission deadline 30 Nov 2026 | Viewed by 462 | Submission Open

Keywords: central nervous system; neuroanatomy; human behavior; nuclei; neuronal circuits; connectivity channels

(This special issue belongs to the Section Molecular Neurobiology)

Molecular and Cellular Pathways Involved in Age-Related Musculoskeletal Disorders

edited by

Abhishek Chandra

and Neha Dole

submission deadline 30 Nov 2026 | Viewed by 462 | Submission Open

Keywords: musculoskeletal disorders; cellular senescence; aging; genetic mutations; oxidative stress; mitochondrial dysfunction; bone homeostasis

(This special issue belongs to the Section Molecular Biology)

Effects of the Environmental Conditions on Bacterial Growth and Functions

edited by

Fernanda Abreu

submission deadline 30 Nov 2026 | Viewed by 461 | Submission Open

Keywords: bacterial growth; growth conditions; gene expression; bioproducts; biofilm; resistance; population dynamics

(This special issue belongs to the Section Molecular Microbiology)

Molecular Research on Central Nervous System Inflammatory Demyelinating Diseases

edited by Yong Guo

submission deadline 30 Nov 2026 | Viewed by 460 | Submission Open

Keywords: central nervous system; autoimmune; demyelination; inflammation; multiple sclerosis; pathology

(This special issue belongs to the Section Molecular Neurobiology)

T Cell Malignancies: Translating Basic Research into Better Therapy

edited by

Grzegorz Przybylski

submission deadline 30 Nov 2026 | Viewed by 459 | Submission Open

Keywords: T-Cell malignancies; specific target antigens; gene-targeted therapies

(This special issue belongs to the Section Molecular Oncology)

Molecular Engineering of Antimicrobial Agents: From Structure-Function Insights to Combinatorial Therapies

edited by Mingrui Liao

submission deadline 30 Nov 2026 | Viewed by 451 | Submission Open

Keywords: antimicrobial amphiphiles; antimicrobial resistance; structure–activity relationship; synergistic antimicrobial therapy; drug delivery systems

(This special issue belongs to the Section Molecular Biology)

Understanding and Combating Antimicrobial Resistance: Molecular Insights and Innovative Approaches

edited by

Giovanni Di Bonaventura

submission deadline 30 Nov 2026 | Viewed by 444 | Submission Open

Keywords: genetic mutations; horizontal gene transfer; efflux pump mechanisms; biofilm formation; novel antibiotic development; antimicrobial peptides; phage therapy; CRISPR-based tools; antimicrobial stewardship programs

(This special issue belongs to the Section Molecular Biology)

Molecular Advances of Layered Double Hydroxides (LDH) for Corrosion Protection

edited by

Henryk Kania

submission deadline 30 Nov 2026 | Viewed by 434 | Submission Open

Keywords: layered double hydroxide (LDHs); corrosion resistance; coatings; corrosion products

(This special issue belongs to the Section Materials Science)

Molecular Progress in Male Reproduction

edited by

Ahmet Ayaz

submission deadline 30 Nov 2026 | Viewed by 433 | Submission Open

Keywords: male infertility; spermatogenesis; epigenetics; sperm function; testicular molecular biology; bioinformatics; reproductive genomics

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Molecular Research in Leukemia

edited by

Juan Manuel Mejia-Arangure

submission deadline 30 Nov 2026 | Viewed by 426 | Submission Open

Keywords: leukemia; molecular biology; genetic testing; epigenomics; targeted therapy; precision medicine; diagnostic techniques; molecular pathways

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Research on Stress Signaling in Embryonic Development

edited by

Poongodi Geetha-Loganathan

and Norihisa Higashihori

submission deadline 30 Nov 2026 | Viewed by 426 | Submission Open

Keywords: stress signaling; embryonic development; morphogenesis; signal transduction; teratogenesis

(This special issue belongs to the Section Molecular Biology)

The Role of Transcription Factors in Cancer

edited by

Tomasz Wilanowski

submission deadline 30 Nov 2026 | Viewed by 424 | Submission Open

Keywords: transcription factor; oncogene; tumor suppressor; nuclear receptor; genetic regulation; post-translational regulation; biomarker; drug target

(This special issue belongs to the Section Molecular Oncology)

Molecular Pathogenesis and Targeted Therapies of Hematological Malignancies

edited by

Can Küçük

submission deadline 30 Nov 2026 | Viewed by 419 | Submission Open

Keywords: hematological malignancies; precision oncology; molecular mechanisms; therapeutic resistance; targeted therapy; cellular immunotherapies; multi-omics; artificial intelligence; translational medicine

(This special issue belongs to the Section Molecular Oncology)

Molecular Advances in Periodontitis

edited by Maja Miletić and

Natasa Nikolic-Jakoba

submission deadline 30 Nov 2026 | 1 articles | Viewed by 417 | Submission Open

Keywords: periodontitis; molecular mechanisms; inflammation; oral microbiome; multi-omics; biomarkers; cytokines; oxidative stress; immune regulation; tissue regeneration

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Application of Biomaterial in Skin Diseases

edited by

Danuta Nowicka

submission deadline 30 Nov 2026 | Viewed by 416 | Submission Open

Keywords: chronic dermatoses; autologus material; PRP; stem cells; growth factors

(This special issue belongs to the Section Materials Science)

Antimicrobial Agents and the Quest for Resistance Breakthroughs

edited by

Inês Bártolo

submission deadline 30 Nov 2026 | Viewed by 415 | Submission Open

Keywords: drug resistance; antimicrobial resistance (AMR); drug-resistant bacteria; drug-resistant viruses; drug-resistant fungi; drug-resistant parasite; drug resistance biomolecular studies; mechanism of resistance; novel antimicrobial agents; treatment of infectious diseases

(This special issue belongs to the Section Molecular Pharmacology)

Plant–Microbe Interactions Driving Abiotic Stress Adaptation

edited by Saeed Ur Rahman and Nan Hui

submission deadline 30 Nov 2026 | Viewed by 412 | Submission Open

Keywords: plant–microbe interactions; abiotic stress; rhizosphere microbiome; stress tolerance; horticultural crops; molecular mechanisms; plant growth-promoting microbes; omics approaches; sustainable agriculture; signaling pathways

(This special issue belongs to the Section Molecular Plant Sciences)

Vascular Calcification: Molecular Regulation, Inflammation and Translational Perspectives

edited by

Laia Cañes

submission deadline 30 Nov 2026 | Viewed by 410 | Submission Open

Keywords: vascular calcification; inflammation; calcium-phosphate alterations; osteogenic differentiation; vascular smooth muscle cells; cardiovascular disease

(This special issue belongs to the Section Molecular Biology)

The Role of Dopamine Neurotransmission in Schizophrenia

edited by

Mirian Akemi Furuie Hayashi

submission deadline 30 Nov 2026 | Viewed by 404 | Submission Open

Keywords: schizophrenia; dopamine; dopaminergic system; neurotransmission; psychosis; pathophysiology; molecular psychiatry

(This special issue belongs to the Section Molecular Neurobiology)

Advances in the Molecular Biology of Lipids and Mitochondria

edited by

Alejandra Espinosa

submission deadline 30 Nov 2026 | Viewed by 402 | Submission Open

Keywords: lipids; lipid transport mechanisms; lipid peroxidation; mitochondrial integrity; bioenergetics; mitochondrial phospholipid

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Recent Genetic Insights into Neurodevelopmental Disorders

edited by Maria Cristina Aspromonte and Emanuela Dazzo

submission deadline 30 Nov 2026 | Viewed by 400 | Submission Open

Keywords: neurodevelopmental disorders; autism spectrum disorder; intellectual disability; attention deficit hyperactivity disorder; epilepsy; motor disorders; chromosomal rearrangements; genetic variant; integrative omics approaches

(This special issue belongs to the Section Molecular Neurobiology)

Integrative Regenerative Medicine: Bridging Molecular Mechanisms and Therapeutic Applications

edited by

Jerran Santos

submission deadline 30 Nov 2026 | Viewed by 396 | Submission Open

Keywords: regenerative medicine; stem cells; molecular mechanisms; tissue engineering; organoids; biomaterials; biofabrication; clinical translation; cell therapy; integrative biology

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms in Mucosal Immunity

edited by