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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advances in the Molecular Biology of Lipids and Mitochondria

edited by

Alejandra Espinosa

submission deadline 30 Nov 2026 | Viewed by 399 | Submission Open

Keywords: lipids; lipid transport mechanisms; lipid peroxidation; mitochondrial integrity; bioenergetics; mitochondrial phospholipid

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Integrative Regenerative Medicine: Bridging Molecular Mechanisms and Therapeutic Applications

edited by

Jerran Santos

submission deadline 30 Nov 2026 | Viewed by 396 | Submission Open

Keywords: regenerative medicine; stem cells; molecular mechanisms; tissue engineering; organoids; biomaterials; biofabrication; clinical translation; cell therapy; integrative biology

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms in Mucosal Immunity

edited by

Mónica Vermeulen

submission deadline 30 Nov 2026 | Viewed by 391 | Submission Open

Keywords: mucosal immunity; metabolism; innate memory; trainers and inflammatory stimuli

(This special issue belongs to the Section Molecular Immunology)

Advances in Osteogenesis: 2nd Edition

edited by

Andrea Del Fattore

submission deadline 30 Nov 2026 | Viewed by 388 | Submission Open

Keywords: osteogenesis; osteoblast; bone formation; disease; bone

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Molecular Advances in Periodontitis

edited by Maja Miletić and

Natasa Nikolic-Jakoba

submission deadline 30 Nov 2026 | 1 articles | Viewed by 382 | Submission Open

Keywords: periodontitis; molecular mechanisms; inflammation; oral microbiome; multi-omics; biomarkers; cytokines; oxidative stress; immune regulation; tissue regeneration

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Magnetic Nanoparticles: From Synthesis and Modification to Biomedical Applications

edited by

Ahmet Kertmen

submission deadline 30 Nov 2026 | Viewed by 381 | Submission Open

Keywords: magnetite nanoparticles; colloidal interactions; X-ray characterizations; biomedical applications; method development; imaging

(This special issue belongs to the Section Molecular Nanoscience)

Apoptosis in Health and Disease: Recent Advances and Future Directions

edited by Shabnam Malik

submission deadline 30 Nov 2026 | Viewed by 380 | Submission Open

Keywords: apoptosis; programmed cell death; health and disease; cellular homeostasis; cancer; neurodegenerative disorders

(This special issue belongs to the Section Molecular Biology)

Plant–Microbe Interactions in Alleviation of Abiotic Stress in Plants

edited by

Marzena Sujkowska-Rybkowska

submission deadline 30 Nov 2026 | Viewed by 372 | Submission Open

Keywords: abiotic stresses; plant–microbe interactions; symbiotic microbes; stress adaptation; stress-responsive genes; physio-logical responses

(This special issue belongs to the Section Molecular Plant Sciences)

Antiviral Drug Target Discovery and Design

edited by

Dongwei Kang

and Huajun Zhao

submission deadline 30 Nov 2026 | Viewed by 370 | Submission Open

Keywords: antiviral; drug discovery; drug resistance; immune and pharmacological mechanisms; immunotherapy; immunopathology; vaccines and adjuvants

(This special issue belongs to the Section Molecular Pharmacology)

Therapeutic Strategies for Surgical Tissue Damage, Repair and Regeneration

edited by

Alex K. Wong

submission deadline 30 Nov 2026 | Viewed by 365 | Submission Open

Keywords: surgical injury; tissue regeneration; vasculogenesis; wound healing in compromised settings; molecular therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Modern Synthetic Pathways for Anticancer Drug Discovery

edited by

Łukasz Struk

submission deadline 30 Nov 2026 | 1 articles | Viewed by 365 | Submission Open

Keywords: new anticancer agents; bioactive molecules; drug design; drug synthesis; cancer therapy; medicinal chemistry

(This special issue belongs to the Section Molecular Oncology)

New Insight into Pathogen Stress Effects on Plant Structure and Metabolism

edited by

Edmund Kozieł

and

Katarzyna Otulak-Kozieł

submission deadline 30 Nov 2026 | Viewed by 365 | Submission Open

Keywords: plant–pathogen interaction; innate immunity; ultrastructure; plant defense systems; plant physiology; signal transduction; resistance genes

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Insight into Polymer Dynamics

edited by

Sirui Ge

submission deadline 30 Nov 2026 | Viewed by 363 | Submission Open

Keywords: polymer dynamics; glass transition; segmental relaxation; bulk relaxation; structure–property relationship; functional polymers; spectroscopy; instrumental characterization; simulations and modeling; polymer diffusion

(This special issue belongs to the Section Materials Science)

Roles and Mechanisms of Non-Coding RNAs in Human Health and Disease: 2nd Edition

edited by

Marco Ragusa

and

Cristina Barbagallo

submission deadline 30 Nov 2026 | Viewed by 361 | Submission Open

Keywords: non-coding RNAs; microRNAs; long non-coding RNAs; circular RNAs; biomarkers; polymorphisms; cancer; degenerative diseases; therapy

(This special issue belongs to the Section Molecular Genetics and Genomics)

Research of Aldo-Keto Reductases in Human Disease

edited by

Ping Zhu

and

Hao Luo

submission deadline 30 Nov 2026 | 1 articles | Viewed by 347 | Submission Open

Keywords: aldo-keto reductase (AKR); protein engineering; AKR1B10; cancer biomarker; chemoresistance

(This special issue belongs to the Section Biochemistry)

Advances in the Reprogramming of Mitochondrial Signalling and Metabolism in Cancers

edited by

Maria Rosa Ciriolo

and

Fabio Ciccarone

submission deadline 30 Nov 2026 | Viewed by 345 | Submission Open

Keywords: mitochondrial dynamic; mitochondrial biogenesis; mitochondrial transfer; mitochondrial targeting; mitophagy; oxidative metabolism; mtDNA; ROS; oncometabolism

(This special issue belongs to the Section Molecular Oncology)

RNA Structure, Folding and Cellular Function: Mechanisms and Biological Significance

edited by

Ilias Skeparnias

submission deadline 30 Nov 2026 | Viewed by 343 | Submission Open

Keywords: RNA structure; RNA folding; RNA–protein interactions; R-loops; RNA:DNA hybrids; non-coding RNA; RNA biogenesis; gene regulation; ribozymes; RNA therapeutics

(This special issue belongs to the Section Molecular Biology)

Oxidative Stress, Biomarkers and Dysregulated Lipid Metabolism in Cardiovascular Diseases

edited by

Amilia Aminuddin

and Adila Abdul A. Hamid

submission deadline 30 Nov 2026 | 1 articles | Viewed by 343 | Submission Open

Keywords: cardiovascular diseases; oxidative stress; lipid metabolism; atherosclerosis; endothelial dysfunction; inflammation; biomarkers; reactive oxygen species (ROS); dyslipidemia; vascular function

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Natural Product Research: From Isolation to Functional Validation

edited by

Radosław Kowalski

submission deadline 30 Nov 2026 | Viewed by 341 | Submission Open

Keywords: natural products; secondary metabolites; bioactive compounds; extraction and isolation; green extraction; structural elucidation; metabolomics profiling (LC–HRMS/MS); dereplication; functional validation; molecular mechanisms; molecular docking; molecular modeling; ligand–protein interactions; structure–activity relationship (SAR); in vitro and in vivo studies; bioavailability and safety; antimicrobial activity; antioxidant activity; anticancer activity

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Advances in Brucella Research

edited by

Angel Oñate

submission deadline 30 Nov 2026 | Viewed by 341 | Submission Open

Keywords: Brucella abortus; molecular pathogenesis; host–pathogen interaction; virulence factors; oxidative stress response; intracellular survival; immune evasion; exosomes; vaccine development

(This special issue belongs to the Section Molecular Microbiology)

Stem Cell Research in Urological, Hepatological, and Ophthalmological Disorders

edited by Yuanyuan Zhang

submission deadline 30 Nov 2026 | Viewed by 337 | Submission Open

Keywords: stem cells; induced pluripotent stem cells (iPSCs); exosomes; tissue regeneration; urinary incontinence; kidney dysfunction; ocular disorders; molecular mechanisms

(This special issue belongs to the Section Molecular Biology)

The Role of Ferroptosis in Cancer Biology and Therapy

edited by Alessandra Di Paola and Elvira Pota

submission deadline 30 Nov 2026 | Viewed by 328 | Submission Open

Keywords: ferroptosis; cancer biology; tumor microenvironment; therapeutic targeting; anticancer immunity; targeted therapy

(This special issue belongs to the Section Molecular Oncology)

Hydrogels and Nanogels: Revolutionizing Drug Delivery and Disease Detection

edited by Enrico Gallo

submission deadline 30 Nov 2026 | Viewed by 322 | Submission Open

Keywords: hydrogel and nanogel networks; supramolecular systems; hydrogel synthesis and analysis; nanogel preparation and characterization; nanostructured fibers; multiphase gels; biomedicine applications; supramolecular probes for imaging; hydrogels and nanogels as drug release systems; coatings and surface treatments; polymeric systems; peptide-based supramolecular systems

(This special issue belongs to the Section Materials Science)

Innovative Nano- and Microcarrier Systems for Targeted Delivery

edited by

Matteo Perra

submission deadline 30 Nov 2026 | Viewed by 318 | Submission Open

Keywords: drug delivery systems; nanocarriers; microcarriers; targeted delivery; controlled release; bioactive compounds; nanomedicine

(This special issue belongs to the Section Molecular Nanoscience)

Gene Therapy for Ocular Diseases: Mechanisms, Advances and Therapeutic Applications

edited by Jiang-Hui Wang

submission deadline 30 Nov 2026 | Viewed by 318 | Submission Open

Keywords: AAV; capsid engineering; gene therapy; retinal diseases

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Pharmacognosy and Phytochemical Profiling in Natural Product Research

edited by Kamran Ashraf

submission deadline 30 Nov 2026 | Viewed by 317 | Submission Open

Keywords: molecular pharmacognosy; phytochemical profiling; natural products; bioactive compounds; metabolomics; chemometrics; LC–MS/MS; GC–MS; molecular mechanisms; drug discovery

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Advances in the Diagnosis and Treatment of Cardiovascular Disease and Diabetes Mellitus

edited by Ovidiu Nicolae Pop and

Cosmin Mihai Vesa

submission deadline 30 Nov 2026 | Viewed by 314 | Submission Open

Keywords: cardiovascular disease; diabetes mellitus; molecular medicine; precision medicine; cardiometabolic disease; biomarkers; inflammation; oxidative stress; epigenetics; non-coding rna; sglt2 inhibitors; glp-1 receptor agonists; gene therapy; regenerative medicine; translational therapeutics; personalized medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Interactions Between Bacteria and Viruses: Mechanisms and Pathogenic Insights

edited by Vasilis Petrakis

submission deadline 30 Nov 2026 | Viewed by 313 | Submission Open

Keywords: viral infections; HIV/AIDS; SARS-CoV-2; antibiotics; antimicrobial resistance; antiviral agents

(This special issue belongs to the Section Molecular Microbiology)

Molecular Mechanisms, Epigenetics and Therapeutics in Liver Cirrhosis

edited by Ana Soledad Sandoval-Rodríguez

submission deadline 30 Nov 2026 | Viewed by 313 | Submission Open

Keywords: liver cirrhosis; molecular pathogenesis; fibrosis and inflammation; epigenetics; hepatocellular carcinoma (HCC); viral hepatitis; molecular mechanism; hepatic nutrition; therapeutic targets; translational hepatology; MASLD; ALD

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Endometrial Cancer: From Molecular Mechanisms to Treatment

edited by Ursula Catena

submission deadline 30 Nov 2026 | Viewed by 310 | Submission Open

Keywords: endometrial cancer; molecular mechanisms; biomarkers; targeted therapy; immunotherapy; genomics; precision medicine

(This special issue belongs to the Section Molecular Oncology)

Molecular Research on Foodborne Pathogens and Biofilms

edited by

Arturo Ramirez-Peralta

submission deadline 30 Nov 2026 | Viewed by 304 | Submission Open

Keywords: foodborne pathogens; biofilms; food

(This special issue belongs to the Section Molecular Microbiology)

Deep Learning Biomarkers for Cancer Therapy

edited by

Hüseyin Fırat

submission deadline 30 Nov 2026 | Viewed by 301 | Submission Open

Keywords: deep learning; cancer biomarkers; precision oncology; histopathology; medical imaging; explainable AI; cancer detection; cancer segmentation; digital pathology; clinical decision support

(This special issue belongs to the Section Molecular Oncology)

Bioactive Phenolic Compounds in Human Health and Disease: Second Edition

edited by

Andrei Lobiuc

submission deadline 30 Nov 2026 | Viewed by 301 | Submission Open

Keywords: novel sources; synthesis; biological activity; molecular interactions; pharmacodynamics; pharmacokinetics; assay development; microbiota; sources and intake

(This special issue belongs to the Section Bioactives and Nutraceuticals)

The Design, Synthesis, and Application of Functional Porous Materials

edited by Qinhe Pan,

Shenzhen Chang

and

Shi-Cheng Wang

submission deadline 30 Nov 2026 | Viewed by 299 | Submission Open

Keywords: porous materials; functional guest species; functionalization; luminescence; electrochemistry; stimulus response; adsorption; sensing; photoelectric; catalysis

(This special issue belongs to the Section Materials Science)

Current Research in DNA Methylation

edited by Mikhail M. Baryshev

submission deadline 30 Nov 2026 | Viewed by 298 | Submission Open

Keywords: DNA methylation; cancer-specific DNA methylation; epigenetics; lncRNA; CpG, CHG, CHH, CCWGG methylation types; chromatin remodeling

(This special issue belongs to the Section Biochemistry)

Advances in Pharmacogenomics and Drug Repositioning

edited by

Vasudevan Ramachandran

and

Suresh Kumar

submission deadline 30 Nov 2026 | Viewed by 297 | Submission Open

Keywords: risk prediction; gene–drug interactions; genetic polymorphisms; repurposed drugs; integrative analytics; variant mapping; predictive modeling; molecular docking; cheminformatics; genotype-guided therapy; real-world evidence

(This special issue belongs to the Section Molecular Pharmacology)

Pathogenesis of Pathogenic Fungi: The Era of AI and New Technologies

edited by

Paul Wai Kei Tsang

submission deadline 30 Nov 2026 | Viewed by 284 | Submission Open

Keywords: artificial intelligence; molecular diagnosis and detection; therapeutic targeting; resistance and prediction; host relationships; immunity

(This special issue belongs to the Section Molecular Microbiology)

Research on Molecular Mechanisms of Food Quality Regulation

edited by Jun Yan

submission deadline 30 Nov 2026 | Viewed by 283 | Submission Open

Keywords: food quality regulation; molecular mechanism; omics technology; food macromolecules; postharvest preservation; gene transcription regulation

(This special issue belongs to the Section Molecular Biology)

Molecular Biomarkers and Precision Medicine in Cancer

edited by Ana Ĺivia Silva Galbiatti-Dias

submission deadline 30 Nov 2026 | Viewed by 281 | Submission Open

Keywords: biomarkers; RNA; cancer; exosomes

(This special issue belongs to the Section Molecular Oncology)

Plant Natural Products: New Advances in the Discovery, Regulation, and Engineering

edited by

Thiago Barbosa Cahú

and

Bruno Veras

submission deadline 30 Nov 2026 | Viewed by 275 | Submission Open

Keywords: polyphenols; glycoconjugates; plant protein; polysaccharides; crop production; processing wastes; circular economy; techno-economical evaluation

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Next-Generation Sequencing Assays in Precision Oncology

edited by Kakoli Das,

Jens Samol

and Chuah Khoon Leong

submission deadline 30 Nov 2026 | Viewed by 273 | Submission Open

Keywords: precision oncology; NGS; genomics; transcriptomics; proteomics; molecular pathology; multi-omics integration

(This special issue belongs to the Section Molecular Oncology)

Multi-Omic Data Integration in Oncology

edited by Hung-Yu Lin and

Hsing-Ju Wu

submission deadline 30 Nov 2026 | Viewed by 273 | Submission Open

Keywords: bioinformatics; multi-omics at bulk level; single-cell omics; spatial multi-omics; metabolomics; proteomics; pharmacogenomics; tumor microenvironment; tumor molecular profiling; therapy resistance

(This special issue belongs to the Section Molecular Informatics)

Latest Research on Mixed Biofilms: Bacterial and Antimicrobial Agents

edited by

Anis Rageh Mohammad Al-Maleki

submission deadline 30 Nov 2026 | Viewed by 272 | Submission Open

Keywords: antimicrobial resistance (AMR); biofilms; mixed-species biofilms; microbial interactions; anti-biofilm strategies; microbial virulence; host–pathogen interactions; microbiome; omics approaches (proteomics, genomics, metabolomics); infectious diseases

(This special issue belongs to the Section Molecular Microbiology)

Toxicology of Cyanobacterial Toxins

edited by

Carlos García

submission deadline 30 Nov 2026 | Viewed by 263 | Submission Open

Keywords: toxicology; cyanotoxins; cyanobacteria; harmful effects; health risk

(This special issue belongs to the Section Molecular Toxicology)

Trace Elements in Nutrition and Health Research

edited by

Kyria Jayanne Clímaco Cruz

submission deadline 30 Nov 2026 | Viewed by 262 | Submission Open

Keywords: trace elements; essential elements; toxic trace elements; micronutrient homeostasis; bioavailability; nutrient interactions; deficiency and overload; human health; disease prevention

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Smart and Sustainable Hydrogels for Environmental Applications

edited by Rolando Chamy

submission deadline 30 Nov 2026 | Viewed by 260 | Submission Open

Keywords: hydrogel; biomaterials; sustainable materials; regenerative medicine

(This special issue belongs to the Section Materials Science)

Molecular Crosstalk Between Allergens, Microbes, and the Mucosal Immune System

edited by Stefanie Gilles

submission deadline 30 Nov 2026 | Viewed by 257 | Submission Open

Keywords: allergens and innate immunity; mucosal immune signaling; epithelial barrier and inflammation; pathogen-allergen crosstalk; bioaerosol exposure; allergen recognition mechanisms; environmental immunology

(This special issue belongs to the Section Molecular Immunology)

Translational Pharmacogenomics and Precision Medicine: From Discovery to Application

edited by

Sukru Tuzmen

submission deadline 30 Nov 2026 | Viewed by 254 | Submission Open

Keywords: pharmacogenomics; personalized medicine; drug discovery; cancer genetics; wellness; nutrigenomics; mindfulness; genome; health; dentistry; education; microbiome

(This special issue belongs to the Section Molecular Genetics and Genomics)

Encephalitis: Mechanisms, Models, and Treatment Strategies

edited by

Hasan Tarik Atmaca

and

Gungor Cagdas Dincel

submission deadline 30 Nov 2026 | Viewed by 251 | Submission Open

Keywords: encephalitis; neuroinflammation; host–pathogen interactions; central nervous system; experimental models; comparative medicine; veterinary medicine; human medicine; molecular mechanisms; treatment strategies

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Insights in Cardiovascular Disease

edited by

Sudhir Pandey

submission deadline 30 Nov 2026 | Viewed by 248 | Submission Open

Keywords: heart failure; gut microbiome dysbiosis-cardiotoxicity; diabetic cardiomyopathy; cardiovascular aging; chemotherapy associated cardiotoxicity; autophagy; mitochondrial dysfunction; rhythmic disorders; risk factors; ion channels; energy metabolism; cardiac hypertension; echocardiography; remodelling; transplantation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Displaying special issue 1651-1700 on page 34 of 64.

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