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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Design, Synthesis and Evaluations of Anticancer Activity of Multi-Target Inhibitors

edited by

Malgorzata Jelen

and

Małgorzata Dołowy

submission deadline 31 Dec 2026 | 1 articles | Viewed by 951 | Submission Open

Keywords: synthesis of anticancer compounds; multi-target inhibitors; kinase inhibitors; apoptosis modulation; cancer signaling pathways; structure–activity relationships; molecular docking; hybrid molecules

(This special issue belongs to the Section Molecular Pharmacology)

Telomere Dynamics in Aging and Disease: Biology, Regulation, and Pathogenesis

edited by Jidong Shan

submission deadline 31 Dec 2026 | 1 articles | Viewed by 950 | Submission Open

Keywords: telomeres; telomere length; telomerase; aging; diseases; disorders; cancer

(This special issue belongs to the Section Molecular Biology)

Addressing Autoimmunity in the 21st Century

edited by

Yun Liang

submission deadline 31 Dec 2026 | 1 articles | Viewed by 852 | Submission Open

Keywords: autoimmunity; autoimmune diseases; immune-mediated disorders; molecular mechanisms; molecular biomarkers; therapeutic strategies; immunomodulation; immune tolerance

(This special issue belongs to the Section Molecular Immunology)

Exploring Molecular Mechanisms Involved in Head and Neck Cancer

edited by Jae Won Chang

submission deadline 31 Dec 2026 | 1 articles | Viewed by 827 | Submission Open

Keywords: head and neck squamous cell carcinoma (HNSCC); molecular targeted therapy; tumor microenvironment (TME); therapeutic resistance; cancer stem cells (CSCs); immunotherapy; ferroptosis and cuproptosis; non-coding RNAs; microbiome and exosomes; precision oncology

(This special issue belongs to the Section Molecular Oncology)

Blood–Brain Barrier Dysfunction in Neurodegenerative Disorders

edited by

Amal Kaddoumi

submission deadline 31 Dec 2026 | Viewed by 824 | Submission Open

Keywords: blood–brain barrier; neurodegenerative diseases; Alzheimer’s disease; amyotrophic lateral sclerosis; Parkinson's disease; BBB as a therapeutic target; neuroinflammation; molecular mechanisms; cerebral blood flow

(This special issue belongs to the Section Molecular Neurobiology)

Cutting Edge Advances in Wound Healing

edited by Fui Ping Lim

submission deadline 31 Dec 2026 | 1 articles | Viewed by 819 | Submission Open

Keywords: wound repair; molecular pathways; regenerative biology; tissue remodelling; inflammation modulation

(This special issue belongs to the Section Molecular Biology)

Latest Research on Drug-Diagnostic Co-Development in Oncology

edited by

Laxmi Swetha Karanam

submission deadline 31 Dec 2026 | Viewed by 816 | Submission Open

Keywords: companion diagnostics; tumor; drug–diagnostic co-development; molecular profiling; biomarker; theranostics

(This special issue belongs to the Section Molecular Oncology)

Machine Learning and Advanced Feature Engineering: Deciphering the Complexity of Plant Functional Genomics

edited by

Enhui Shen

and

Qinjie Chu

submission deadline 31 Dec 2026 | 1 articles | Viewed by 744 | Submission Open

Keywords: machine learning; deep learning; feature engineering; plant functional genomics; genomic elements; plant evolution; gene regulatory networks; multi-omics integration; sequence encoding; explainable AI (XAI)

(This special issue belongs to the Section Molecular Plant Sciences)

Advanced Biomaterials for Neural Regeneration and Axogenesis: From Cellular Support to Functional Recovery

edited by Noela Rodríguez-Losada

submission deadline 31 Dec 2026 | Viewed by 743 | Submission Open

Keywords: neural regeneration; axogenesis; neurorepair; neuroprotection; biocompatible materials; extracellular matrix mimetics; graphene-based scaffolds; conductive polymers; hybrid hydrogels; carbon nanomaterials; neuroengineering

(This special issue belongs to the Section Molecular Neurobiology)

Environmental Microorganisms and Pathogen Infections

edited by

Jadwiga Wyszkowska

and

Magdalena Zaborowska

submission deadline 31 Dec 2026 | 1 articles | Viewed by 743 | Submission Open

Keywords: environmental microbiome; pathogens; resistance genes; molecular adaptation; microbial interactions; anthropogenic pollution; functional gene expression; ecosystem health

(This special issue belongs to the Section Molecular Microbiology)

Molecular Research on Orthopedic Materials

edited by Seung Hun Lee

submission deadline 31 Dec 2026 | 1 articles | Viewed by 735 | Submission Open

Keywords: orthopedic biomaterials; bone regeneration; musculoskeletal system; muscle tissue engineering; 3D bioprinting; functional scaffolds; hydrogels; cell–material interaction; regenerative medicine; myogenic differentiation

(This special issue belongs to the Section Materials Science)

Metallopharmaceuticals: Current Trends and Future Perspectives in Cancer Immunoediting

edited by

Marialuisa Piccolo

and

Claudia Riccardi

submission deadline 31 Dec 2026 | Viewed by 710 | Submission Open

Keywords: metal-based drugs; anticancer activity; mechanisms of action; tumor microenvironment; immune cell regulation; cancer immunity; metal–protein interactions; metal–nucleic acid interactions

(This special issue belongs to the Section Molecular Pharmacology)

Research Progress of Orthopedic Materials

edited by Robert Karpiński

submission deadline 31 Dec 2026 | Viewed by 704 | Submission Open

Keywords: biocompatibility; biomaterials; orthopedic implants; hydroxyapatite; biodegradable polymers; tissue engineering; bioactive surfaces; bone cements; bone regeneration; antibacterial coatings

(This special issue belongs to the Section Materials Science)

Molecular Advances in Obstetrical and Gynaecological Disorders: 2nd Edition

edited by

Panagiotis Christopoulos

submission deadline 31 Dec 2026 | 1 articles | Viewed by 700 | Submission Open

Keywords: gynaecological disorders; obstetrical disorders; gynaecological diseases; genetic markers; molecular therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Integrative Perspectives on Plant Signaling Pathways: From Growth Regulation to Stress Resilience and Adaptive Responses

edited by

Raheel Munir

submission deadline 31 Dec 2026 | Viewed by 700 | Submission Open

Keywords: plant signaling; hormonal regulation; plant growth and development; plant-peptide signal transduction; abiotic/biotic stress resilience; omics; molecular mechanisms; crop improvement

(This special issue belongs to the Section Molecular Plant Sciences)

Ion Channels in Human Health and Diseases

edited by

Ye Chun Ruan

and Jinghui Guo

submission deadline 31 Dec 2026 | 1 articles | Viewed by 689 | Submission Open

Keywords: ion channels; channelopathies; electrophysiology; organ systems; human diseases; membrane excitability; pharmacology and drug discovery; translational medicine

(This special issue belongs to the Section Molecular Biology)

Application of Polysaccharides and Their Derivatives in Drug Delivery

edited by

Pakorn Kraisit

submission deadline 31 Dec 2026 | 1 articles | Viewed by 683 | Submission Open

Keywords: polysaccharides; drug delivery; biomaterials; nanoparticles; controlled release; targeted delivery; hydrogels; biopolymers; drug carriers; biomedical applications

(This special issue belongs to the Section Macromolecules)

Synthesis and Activity of Natural Products and Analogues

edited by

Jin-pyo An

submission deadline 31 Dec 2026 | 1 articles | Viewed by 679 | Submission Open

Keywords: natural products; functional food; synthesis; high-resolution mass spectrometry; bioactive compound

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Research Progress of Nanocarriers

edited by

Diana Rita Barata Costa

submission deadline 31 Dec 2026 | 1 articles | Viewed by 669 | Submission Open

Keywords: controlled release; drug delivery systems; multimodal nanoplatforms; nanoparticles; precision medicine; stimuli-responsive nanocarriers; theranostics; therapeutic delivery; translational na-nomedicine

(This special issue belongs to the Section Molecular Nanoscience)

Plant Breeding and Genetics: New Findings and Perspectives, 2nd Edition

edited by

Andrés J. Cortés

submission deadline 31 Dec 2026 | 2 articles | Viewed by 657 | Submission Open

Keywords: quantitative genetics; classical plant breeding; marker assisted selection; genomic selection; speed breeding; gene editing and biotechnology

(This special issue belongs to the Section Molecular Plant Sciences)

Azoles and Fused Heterocycles in Antimicrobial Drug Discovery: Synthesis, Mechanisms, and Applications

edited by

Esra Tatar

submission deadline 31 Dec 2026 | 1 articles | Viewed by 641 | Submission Open

Keywords: drug design and discovery; bioactive molecules; azoles and fused heterocycles; antimicrobials

(This special issue belongs to the Section Molecular Pharmacology)

Recent Advances in Photodynamic Therapy for Antibacterial and Anticancer Applications

edited by

Sandile Phinda Songca

submission deadline 31 Dec 2026 | Viewed by 613 | Submission Open

Keywords: photodynamic therapy (PDT); sonodynamic therapy (SDT); radiodynamic therapy (RDT); chemodynamic therapy (CDT); photosensitizers; sonosensitizers; radiosensitizers; antimicrobial PDT; antimicrobial SDT; antimicrobial RDT; anticancer therapy; drug resistance; bacterial biofilms; reactive oxygen species; nanocarriers; nanoscale metal–organic frameworks; immunogenic cell death; targeted drug delivery; combination therapeutics

(This special issue belongs to the Section Molecular Biology)

Individualised Therapies for Rare Disorders

edited by Paul Gissen

submission deadline 31 Dec 2026 | 1 articles | Viewed by 604 | Submission Open

Keywords: individualised therapies; personalised medicine; rare diseases; omics; gene therapy; molecular pathways; mechanistic discovery

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Metal Toxicity and Particle Toxicity

edited by Alicja Piotrowska-Niczyporuk

submission deadline 31 Dec 2026 | 1 articles | Viewed by 589 | Submission Open

Keywords: metals; particles; toxicity; microplastic; environment pollution; animals; plants; algae

(This special issue belongs to the Section Molecular Toxicology)

Enzyme Inhibitory Assessment and Molecular Docking Studies of Natural and Synthetic Heterocyclic Compounds

edited by

Milen G. Bogdanov

submission deadline 31 Dec 2026 | Viewed by 588 | Submission Open

Keywords: heterocycles; enzyme inhibition; docking studies; drug discovery

(This special issue belongs to the Section Molecular Pharmacology)

Activity and Efficacy Evaluation of Natural Products

edited by Fazrena Nadia Md Akhir

submission deadline 31 Dec 2026 | 1 articles | Viewed by 569 | Submission Open

Keywords: natural products; bioactivity; pharmacological efficacy; medicinal plants; marine bioresources; anticancer; anti-inflammatory; synergistic effects; AI-guided discovery; metabolomics

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Next-Generation Natural Products in Drug Discovery: From Ethnopharmacology to Precision Medicine

edited by Idris Adewale Ahmed

submission deadline 31 Dec 2026 | Viewed by 565 | Submission Open

Keywords: phytochemicals; pharmacodynamics; pharmacokinetics; formulation strategies; commercialization; nanotechnology; delivery systems

(This special issue belongs to the Section Molecular Pharmacology)

Amino Acid Nutrition and Human Health

edited by

Terrence Piva

submission deadline 31 Dec 2026 | Viewed by 538 | Submission Open

Keywords: amino acids; dietary intake; metabolic disease; starvation; obesity; supplementation; parental nutrition; gene expression; tumour metabolism

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Effects of Nutrients and Functional Foods on Immune and Inflammatory Responses

edited by

Yaxi Zhou

and Wenjie Yan

submission deadline 31 Dec 2026 | 1 articles | Viewed by 537 | Submission Open

Keywords: nutrients and bioactive compounds; functional foods; immune response; chronic inflammation; inflammatory pathways; cytokines and chemokines; gut–immune axis; oxidative stress; immunomodulation; in vitro and in vivo models

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular and Physiological Effects of Exercise in Cachexia

edited by

Marilia Seelaender

and

Fábio Santos Lira

submission deadline 31 Dec 2026 | Viewed by 536 | Submission Open

Keywords: cachexia; skeletal muscle mass; skeletal muscle strength; exercise; muscle metabolism

(This special issue belongs to the Section Molecular Biology)

Nanomaterials in Tissue Engineering and Regenerative Medicine: Recent Advances and Future Prospects

edited by

Kapil D. Patel

submission deadline 31 Dec 2026 | Viewed by 533 | Submission Open

Keywords: nanoparticles; nanofibers; nanotubes; nanocomposites; hydrogels; ceramics; bioactive glass nanoparticles; tissue engineering; regenerative medicine

(This special issue belongs to the Section Molecular Nanoscience)

Decoding Animal Reproduction: From Molecular Mechanisms to Breeding Innovations

edited by

Mingtian Deng

submission deadline 31 Dec 2026 | 1 articles | Viewed by 530 | Submission Open

Keywords: embryo; epigenetics; multi-omics; breeding

(This special issue belongs to the Section Molecular Biology)

Sustainable Polymers: From Molecular Fundamentals to Real-World Applications

edited by

Zahid Iqbal Khan

submission deadline 31 Dec 2026 | Viewed by 527 | Submission Open

Keywords: sustainable polymers; recycled plastics; bio-based polymers; polymer blends; nanocomposites; membrane technology; water purification; CO2 capture

(This special issue belongs to the Section Materials Science)

Cellular Mechanisms of Pulmonary Arterial Hypertension

edited by

David P Marciano

and Saurabh Aggarwal

submission deadline 31 Dec 2026 | Viewed by 510 | Submission Open

Keywords: pulmonary arterial hypertension (PAH); pulmonary vascular remodeling; endothelial cells; endothelial dysfunction; smooth muscle cells; hyperplasia; pericytes; fibroblasts; monocytes; macrophage; neutrophil; mechanotransduction; oxidative stress; cytokines; extracellular vesicles; extracellular matrix; epigenetics; metabolism; biomarkers; therapeutics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Genomic and Molecular Insights into Emerging and Reemerging Pathogens

edited by

Fabio Scarpa

submission deadline 31 Dec 2026 | Viewed by 505 | Submission Open

Keywords: pathogens genomic analysis; evolution transmission dynamics; pathogenic mechanisms; viruses; bacteria; fungi; parasites; next-generation sequencing; metagenomics; bioinformatics; genetic variations; adaptive mutations; host–pathogen interactions; emerging pathogens; molecular epidemiology; host immune responses; pathogen genetics

(This special issue belongs to the Section Molecular Immunology)

Interfacial Chemistry, Conformational Dynamics, and Molecular Assemblies of Amphiphilic Molecules

edited by

Mihalj Poša

submission deadline 31 Dec 2026 | 1 articles | Viewed by 504 | Submission Open

Keywords: amphiphiles; surfactants; surface equations of state (SEOS); binary mixture of amphiphiles; conformations of amphiphiles; micellar aggregates; solubilization; thermodynamics of micelle formation; Jesús Gracia-Fadrique's surface pressure; enthalpy–entropy compensation

(This special issue belongs to the Section Biochemistry)

Mechanisms and Applications of Heterosis in Plants

edited by

Wenxin Liu

submission deadline 31 Dec 2026 | Viewed by 498 | Submission Open

Keywords: heterosis; mechanism; prediction; application; breeding; plant

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Engineering of Biomaterials for Advanced Additive Manufacturing

edited by

Johari Yap Abdullah

submission deadline 31 Dec 2026 | 1 articles | Viewed by 494 | Submission Open

Keywords: molecular engineering; biomaterials; polymer chemistry; additive manufacturing; 3D printing; supramolecular interactions; surface chemistry; biocompatibility; degradation mechanisms; functional polymers; bioactive materials; computational modeling; tissue engineering; regenerative medicine

(This special issue belongs to the Section Materials Science)

Research Progress on Cancer Biomarkers and Molecular Targets

edited by

José Vargas

submission deadline 31 Dec 2026 | 1 articles | Viewed by 487 | Submission Open

Keywords: cancer biomarkers; molecular targets; cellular senescence; autophagy; epigenetics; prognosis; tumor microenvironment; therapy resistance; precision medicine

(This special issue belongs to the Section Molecular Oncology)

Emerging Biomarkers of Inflammation and Cancer: From Molecular Pathways to Clinical Stratification

edited by

Ciriaco Carru

and

Donatella Coradduzza

submission deadline 31 Dec 2026 | Viewed by 480 | Submission Open

Keywords: chronic inflammation; cancer biomarkers; inflammatory indices; non-coding RNAs; clinical translation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Machine Learning–Based Perspectives in Plant Biology

edited by Silas Pessini Rodrigues

submission deadline 31 Dec 2026 | Viewed by 479 | Submission Open

Keywords: machine learning; artificial intelligence; plant molecular biology; multi-omics integration; feature selection; gene prioritization; plant stress responses; high-throughput phenotyping; crop improvement; biotechnology

(This special issue belongs to the Section Molecular Informatics)

Molecular Mechanisms of Neuroendocrine Regulations in Health and Pathology

edited by

Michael Ugrumov

and

Serguei Fetissov

submission deadline 31 Dec 2026 | 1 articles | Viewed by 475 | Submission Open

Keywords: neuroendocrine system; brain; hypothalamus; adenohypophysis; endocrine glands; (neuro)hormones; ontogenesis; neuroendocrine disorders

(This special issue belongs to the Section Molecular Neurobiology)

Ovarian Insufficiency: From Molecular Pathology to Novel Therapeutic Approach

edited by Aleksandar Ljubić

submission deadline 31 Dec 2026 | Viewed by 458 | Submission Open

Keywords: ovarian insufficiency; premature ovarian insufficiency; molecular pathology; regenerative medicine; stem cell therapy; platelet-rich plasma; epigenetics; intraovarian treatment; ovarian stem cells; mitochondrial dysfunction

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

3D Printing and Biomaterials for Hearing and Balance Restoration

edited by

Chenkai Dai

submission deadline 31 Dec 2026 | Viewed by 452 | Submission Open

Keywords: hearing; balancing; 3D printing; biomaterial

(This special issue belongs to the Section Materials Science)

Novel Therapeutic Strategies for Hepatocellular Carcinoma

edited by

Soon Kyu Lee

submission deadline 31 Dec 2026 | Viewed by 439 | Submission Open

Keywords: hepatocellular carcinoma; immune checkpoint inhibitors; tyrosine kinase inhibitors; radiotherapy; embolization; surgery; transplantation

(This special issue belongs to the Section Molecular Oncology)

Advances in Plant–Pathogen Interactions (4th Edition)

edited by

Fucheng Lin

submission deadline 31 Dec 2026 | Viewed by 433 | Submission Open

Keywords: host; effection; pathogenicity; pathogen; plant immunity; interactions

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Study of Foodborne Pathogens

edited by

Valeria Russini

and

Maria Laura De Marchis

submission deadline 31 Dec 2026 | Viewed by 432 | Submission Open

Keywords: foodborne pathogens; microbiology; molecular analysis; foodborne outbreak investigation; epidemiology; listeria monocytogenes; salmonella; campylobacter; virulence genes; antimicrobial gene; WGS; NGS

(This special issue belongs to the Section Molecular Microbiology)

Cutting-Edge Research and Advancements in Neurodegenerative Diseases

edited by Meera Soundararajan

submission deadline 31 Dec 2026 | Viewed by 430 | Submission Open

Keywords: neurodegenerative disorders; neurons; Alzheimer’s disease; Parkinsons disease; Amyotrophic Lateral Sclerosis (ALS); prion diseases; Huntington disease

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Dynamics of the Oral Microbiome in Periodontal Health and Disease

edited by