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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Carbon-Based Nanomaterials: From Synthesis and Functionalization to Biomedical Applications

edited by

Marta Kutwin

submission deadline 30 Sep 2026 | 1 articles | Viewed by 894 | Submission Open

Keywords: carbon-based nanomaterials; graphene; graphene oxide; carbon nanotubes; fullerenes; carbon quantum dots; surface functionalization; nano– bio interface; drug and gene delivery; cancer nanotherapeutics

(This special issue belongs to the Section Materials Science)

Cellular Plasticity and Tissue Remodeling in Chronic Diseases and Cancer

edited by

Inamul Haque

submission deadline 30 Sep 2026 | Viewed by 859 | Submission Open

Keywords: epithelial plasticity; epithelial–mesenchymal transition (EMT); tissue remodeling; chronic diseases; cancer; fibrosis; inflammatory signaling; extracellular matrix (ECM); organoids; air–interface liquid culture advanced in vitro models

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Production and Biomedical Translation of Functional Biomolecules

edited by

Loredana Capobianco

and

Giorgia Natalia Iaconisi

submission deadline 30 Sep 2026 | 1 articles | Viewed by 851 | Submission Open

Keywords: functional biomolecules; recombinant production; molecular engineering; structural characterization

(This special issue belongs to the Section Molecular Biology)

MicroRNAs in Cancer: Molecular Mechanisms and Regulatory Networks

edited by

Yarely M. Salinas-Vera

submission deadline 30 Sep 2026 | 1 articles | Viewed by 846 | Submission Open

Keywords: microRNAs; cancer; non-coding RNAs; gene regulation; tumor microenvironment; transcriptomics; cancer signaling

(This special issue belongs to the Section Molecular Biology)

State-of-the-Art Bioactives and Nutraceuticals in Thailand

edited by Lalita Chotphruethipong

submission deadline 30 Sep 2026 | 1 articles | Viewed by 827 | Submission Open

Keywords: phytochemicals; advanced extraction technologies; therapeutic mechanisms; bioavailability enhancement; botanical valorization; functional food matrices

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Multifactorial Aspects of Hypertension: Advances and Challenges

edited by Marcelo Vatta and Ximena Caeiro

submission deadline 30 Sep 2026 | 1 articles | Viewed by 821 | Submission Open

Keywords: hypertension; pathogenesis; molecular mechanisms; genetic susceptibility; inflammation; immune response; biomarkers; precision medicine; pathogenesis; risk factors; therapeutic approaches

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Integrative Genomics of Trait Improvement and Plant Stress Responses: From Gene Discovery to Crop Resilience

edited by

Intikhab Alam

submission deadline 30 Sep 2026 | 1 articles | Viewed by 817 | Submission Open

Keywords: integrative genomics; plant stress responses; trait improvement; abiotic stress; biotic stress; multi-omics; genome editing; CRISPR/Cas; crop resilience; functional genomics

(This special issue belongs to the Section Molecular Plant Sciences)

Inflammatory Bowel Disease: Pathogenesis and Treatment Advances

edited by Uday N. Shivaji

submission deadline 30 Sep 2026 | 1 articles | Viewed by 808 | Submission Open

Keywords: inflammation; inflammatory bowel disease; ulcerative colitis; Crohn’s disease; multi-omics; drug targets; drug discovery; molecular signals; intestinal barrier; IHC

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Microbial Strategies to Combat Antimicrobial Resistance

edited by

Chonticha Romyasamit

submission deadline 30 Sep 2026 | 1 articles | Viewed by 805 | Submission Open

Keywords: probiotics; postbiotics; antimicrobial resistance; bacteriophages; microbial bioactives; functional foods; molecular microbiology; biomedical innovation

(This special issue belongs to the Section Molecular Microbiology)

Molecular and Histological Advance in Neural Regeneration

edited by Wiktor Pascal

submission deadline 30 Sep 2026 | 1 articles | Viewed by 804 | Submission Open

Keywords: neural regeneration; peripheral nerve injury; central nervous system; Schwann cells; axonal regeneration; stem cells; neurotrophic factors; biomaterials; histology; molecular mechanisms

(This special issue belongs to the Section Molecular Neurobiology)

Pharmacological Agents for Soft Tissue and Articular Injections: From Mechanisms to Clinical Applications

edited by

Carmelo Pirri

submission deadline 30 Sep 2026 | 1 articles | Viewed by 787 | Submission Open

Keywords: injectable pharmacological agents; musculoskeletal disorders; injection therapies; platelet-rich plasma (PRP); hyaluronic acid

(This special issue belongs to the Section Molecular Pharmacology)

Novel Insights into Vascular Biology

edited by

Cristina Ribas Fürstenau

submission deadline 30 Sep 2026 | 1 articles | Viewed by 786 | Submission Open

Keywords: interorgan vascular communication; vascular immunology; endothelial metabolism; mechanotransduction; vascular plasticity

(This special issue belongs to the Section Molecular Biology)

Deciphering the Molecular Mechanisms Underlying Plant Growth, Development, Stress Responses and Productivity

edited by

Acga Cheng

submission deadline 30 Sep 2026 | 1 articles | Viewed by 772 | Submission Open

Keywords: plant molecular biology; omics; stress tolerance; gene regulation; genome editing; plant–microbe interactions; crop productivity

(This special issue belongs to the Section Molecular Plant Sciences)

Emerging Trends in the Diagnosis and Treatment of Hematologic Disorders

edited by Fabio Stagno and

Stefania Stella

submission deadline 30 Sep 2026 | 1 articles | Viewed by 758 | Submission Open

Keywords: hematological disorders; leukemia; lymphoma; anemia; blood malignancies; targeted therapies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Role of Cytokines in Immunological Disorders and Their Therapies

edited by

Mohammad Massumi

submission deadline 30 Sep 2026 | Viewed by 758 | Submission Open

Keywords: cytokines; autoimmune diseases; autoinflammatory diseases; TNF-alpha; interleukin-17; IL-6; immune tolerance; biologic therapy; JAK inhibitors; inflammation

(This special issue belongs to the Section Molecular Immunology)

Nutritional Approaches to Cardiovascular Health

edited by Aleksandar Kibel

submission deadline 30 Sep 2026 | Viewed by 756 | Submission Open

Keywords: cardiovascular disease; dietary patterns; hypertension; dyslipidemia; inflammation; endothelial function; omega-3 fatty acids; dietary fiber; gut microbiome; precision nutrition

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Advanced In Vitro Models: Integrating the 3Rs in Translational Science

edited by Glaucia Maria Machado-Santelli

submission deadline 30 Sep 2026 | 1 articles | Viewed by 737 | Submission Open

Keywords: 3Rs principles; advanced in vitro models; molecular mechanisms; cell signaling; organoids; organ-on-chip; translational research; molecular profiling; tissue engineering; redox biology; microphysiological systems; translational research; alternative methods to animal testing; nanotechnology in biomedicine; tissue engineering; drug discovery platforms

(This special issue belongs to the Section Molecular Biology)

Pharmacological Mechanisms of Natural Products in the Treatment of Pulmonary Diseases

edited by

Longshuang Huang

and

Chen Bai

submission deadline 30 Sep 2026 | Viewed by 704 | Submission Open

Keywords: Natural Products; pulmonary diseases; herbal active components; pharmacological mechanisms; signaling pathways; clinical studies

(This special issue belongs to the Section Molecular Pharmacology)

Next-Generation Sequencing in Cancer: Genomics, Diagnostics and Therapeutics

edited by Adam Szpechciński and Magdalena Pelc

submission deadline 30 Sep 2026 | 2 articles | Viewed by 702 | Submission Open

Keywords: next-generation sequencing (massively parallel sequencing); whole-genome sequencing (WGS); whole-exome sequencing (WES); RNA sequencing (RNA-seq); single-cell sequencing (SCS); germline and somatic mutations; gene rearrangements (fusions); epigenetics; molecular diagnostics; bioinformatics

(This special issue belongs to the Section Molecular Genetics and Genomics)

Mechanistic Studies on Microbiota–Host Interactions

edited by Min-Jin Kwak

submission deadline 30 Sep 2026 | 1 articles | Viewed by 696 | Submission Open

Keywords: microbiome; host-microbe interactions; gut-organ axis; extracellular vesicles; multi-omics; metagenomics; metabolomics; transcriptomics; barrier function

(This special issue belongs to the Section Molecular Microbiology)

Molecular Mechanisms and Biology of Gynecological Cancers

edited by

Kuo-Hu Chen

submission deadline 30 Sep 2026 | 1 articles | Viewed by 661 | Submission Open

Keywords: gynecologic cancer; tumor marker; ovarian cancer; endometrial cancer; uterine cancer; cervical cancer; chemotherapy; radiotherapy; target therapy; immune therapy

(This special issue belongs to the Section Molecular Oncology)

Molecular and Biotechnological Approaches for Enhancing Stress Resistance in Plants

edited by

Muhammad Umair Yasin

, Maozhi Ren and

Xiumei Luo

submission deadline 30 Sep 2026 | 1 articles | Viewed by 652 | Submission Open

Keywords: plant stress resistance; molecular mechanisms; abiotic stress; biotic stress; plant biotechnology; omics technologies; gene regulation; stress signaling pathways; crop resilience; plant–microbe interactions

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Diagnosis of Bacterial Infections and Antimicrobial Resistance

edited by

Murat Aral

submission deadline 30 Sep 2026 | 1 articles | Viewed by 650 | Submission Open

Keywords: molecular diagnostics; bacterial infections; PCR; real-time PCR; digital PCR; next-generation sequencing; antimicrobial resistance; multiplex assays; metagenomics; point-of-care testing; assay validation; MIQE guidelines

(This special issue belongs to the Section Molecular Microbiology)

Advances in Neuroscience of Mental Disorders: Neuropsychological, Neurobiological and Neuromolecular Perspectives

edited by

Phakkharawat Sittiprapaporn

submission deadline 30 Sep 2026 | Viewed by 628 | Submission Open

Keywords: mental health; mental disorders; neurosciences; neurobiological markers

(This special issue belongs to the Section Molecular Neurobiology)

Novel Nanostructured Systems for the Formulation of Anticancer Compounds

edited by

Norbert Varga

submission deadline 30 Sep 2026 | 1 articles | Viewed by 624 | Submission Open

Keywords: encapsulation of anticancer drugs; polymer-based drug delivery systems; lipid-based drug delivery systems; protein-based drug delivery systems; determination of release kinetic parameters; dissolution studies; physicochemical characterization of drug carriers

(This special issue belongs to the Section Molecular Nanoscience)

Protein Structure, Dynamics and Interactions

edited by

Gyula Batta

and

Orsolya Tőke

submission deadline 30 Sep 2026 | 1 articles | Viewed by 615 | Submission Open

Keywords: protein; structure; folding; dynamics; interactions; NMR; X-ray crystallography; cryo-electron microscopy; AlphaFold; in silico

(This special issue belongs to the Section Macromolecules)

Molecular Mechanisms of Endocrine-Disrupting Chemicals in Reproductive Toxicity

edited by

Dragana Samardžija Nenadov

submission deadline 30 Sep 2026 | 1 articles | Viewed by 604 | Submission Open

Keywords: endocrine-disrupting chemicals (EDCs); reproductive toxicity; steroidogenesis; molecular mechanisms; intracellular signaling; hormone receptors; reproductive health

(This special issue belongs to the Section Molecular Toxicology)

Ion Channels in Physiology and Pathophysiology

edited by

Yonghui Zhao

and

Tarek Mohamed Abd El-Aziz

submission deadline 30 Sep 2026 | Viewed by 598 | Submission Open

Keywords: ion channels; physiology; pathophysiology; channelopathies; membrane proteins; cellular signaling; electrophysiology; structural biology; inflammation; therapeutic targets

(This special issue belongs to the Section Molecular Biology)

Emerging Challenges for Renal Health-Biomarkers and Vulnerability to Xenobiotics

edited by

Susana Coimbra

and

Alice Santos-Silva

submission deadline 30 Sep 2026 | 1 articles | Viewed by 584 | Submission Open

Keywords: xenobiotics; nephrotoxicity; mechanisms of renal damage; molecular pathways; acute kidney injury; chronic kidney disease; novel renal biomarkers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Research Progress in Food Packaging Materials

edited by

Anouar Mouhoub

submission deadline 30 Sep 2026 | 1 articles | Viewed by 583 | Submission Open

Keywords: molecular design; intermolecular interactions; structure–property relationships; bio-based polymers; controlled release systems; active packaging; sustainable materials

(This special issue belongs to the Section Materials Science)

Nutritional Modulation of Lipid Metabolism and Gut–Tissue Axis: Mechanisms and Translational Insights

edited by

Piotr Dobrowolski

submission deadline 30 Sep 2026 | Viewed by 583 | Submission Open

Keywords: lipid metabolism; fatty acids; gut barrier; microbiota; metabolic programming; inflammation; FABP; nutrigenomics; obesity; zebrafish

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Effects of Radiation on Biomolecules and Cells: Mechanisms, Responses, and Biological Implications

edited by

Sachin Gulati

submission deadline 30 Sep 2026 | 1 articles | Viewed by 582 | Submission Open

Keywords: radiation biology; biomolecular damage; cellular responses; DNA damage and repair; oxidative stress; radioprotection; radiotherapy; dosimetry; molecular mechanisms; radiation-induced toxicity

(This special issue belongs to the Section Molecular Biology)

CAR-T Cell Biology and Clinical Translation

edited by

Antonio Pérez Martínez

and

Daniel Ka Leung Cheuk

submission deadline 30 Sep 2026 | Viewed by 569 | Submission Open

Keywords: chimeric antigen receptor (CAR) T cells; gene engineering; genome editing; T‑cell exhaustion; tumor microenvironment; cytokine release syndrome (CRS); ICANS (immune effector cell–associated neurotoxicity syndrome); allogeneic CAR‑T cells; dual‑targeting CAR‑T cells; point‑of‑care manufacturing

(This special issue belongs to the Section Molecular Immunology)

Molecular Antimicrobial Resistance in Cancers

edited by Nicola Silvestris and Massimo Andreoni

submission deadline 30 Sep 2026 | Viewed by 551 | Submission Open

Keywords: antimicrobial resistance; host–pathogen interaction; immune dysfunction; immunosuppression; infection; biomarker; novel antimicrobials; cancer; frail patient

(This special issue belongs to the Section Molecular Oncology)

Bioactive Lipids in Health and Disease: From Bench to Translational Insights

edited by

Claudio Bernal

submission deadline 30 Sep 2026 | 1 articles | Viewed by 541 | Submission Open

Keywords: functional lipids; lipids properties; fatty acids; lipid signaling; lipidomics; precision nutrition; cardiometabolic disease; inflammation; translational research

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Cellular and Molecular Mechanisms of Biological Interactions with Carbon-Based Materials

edited by Ângela Almeida and

Francesca Coppola

submission deadline 30 Sep 2026 | 1 articles | Viewed by 536 | Submission Open

Keywords: carbon (nano)materials; (nano)toxicology; biomaterial interactions; biosensors; remediation; risk assessment

(This special issue belongs to the Section Molecular Nanoscience)

A Window to the Brain: From Retinal Cellular and Soluble Biomarkers Towards Neurodegeneration

edited by

Bijorn Omar Balzamino

Rosanna Squitti

and

Alessandra Micera

submission deadline 30 Sep 2026 | Viewed by 522 | Submission Open

Keywords: retinal signaling; oxidative stress; retinal neurodegeneration; biomarkers; therapeutic targets

(This special issue belongs to the Section Molecular Neurobiology)

Transformation and Associated Isotope Kinetics of Halogenated Organic Pollutants in the Environment and Living Organisms

edited by Chenchen Huang

submission deadline 30 Sep 2026 | 1 articles | Viewed by 519 | Submission Open

Keywords: halogenated organic pollutants; compound-specific isotope analysis; isotope fractionation; source apportionment; transformation discrimination; mechanism elucidation; biotic and abiotic transformation; transformation kinetics and pathways; environmental fate

(This special issue belongs to the Section Biochemistry)

Diverse Biomolecular Probes in the Development of Single-Molecule Biosensors

edited by

Kevin D. Belfield

and

Xiaohan Chen

submission deadline 30 Sep 2026 | Viewed by 519 | Submission Open

Keywords: biomolecular probes; single-molecule method; biosensors; diseases diagnosis; biomarkers; nanotechnology

(This special issue belongs to the Section Materials Science)

T Cell Receptor (TCR) Signaling at the Crossroads of Immunity, Tolerance, and Disease

edited by Amar Singh

submission deadline 30 Sep 2026 | Viewed by 518 | Submission Open

Keywords: T cell receptor (TCR) signaling; immune tolerance; effector T cell differentiation; regulatory T cells (Tregs, Tr1); T cell heterogeneity; metabolic reprogramming; T cell memory and exhaustion; TCR repertoire analysis; autoimmunity and inflammation; TCR-based immunotherapy; CAR-T cells

(This special issue belongs to the Section Molecular Immunology)

Molecular Advances of Gut–Brain Communications

edited by

Walter Pirovano

submission deadline 30 Sep 2026 | Viewed by 514 | Submission Open

Keywords: gut-brain axis; microbiome; molecular profiling; omics/multi-omics data; functional measurements; analytical methods; computational methods; neurological disorders; neuropsychiatric disorders

(This special issue belongs to the Section Molecular Biology)

Emerging Cardiovascular Drugs and Nutraceuticals: Mechanistic Insights, Translational Research and Clinical Impacts

edited by Pietro Mazzeo,

Vincenzo Vestuto

and Elena Mele

submission deadline 30 Sep 2026 | Viewed by 514 | Submission Open

Keywords: cardiovascular disease; drug mechanisms; nutraceuticals; precision medicine; multi-omics approaches

(This special issue belongs to the Section Molecular Pharmacology)

Recent Advances in Electrochemical-Related Materials: 2nd Edition

edited by Celia García-Hernandez

submission deadline 30 Sep 2026 | 1 articles | Viewed by 508 | Submission Open

Keywords: novel electrochemical devices; advanced micro- and nanomaterials for electrochemical applications; batteries; fuel and photoelectrochemical cells; electrochemical sensors and biosensors; new advances in supercapacitors; electrochemical electrolyzers; advanced electrochemical materials for environmental applications

(This special issue belongs to the Section Materials Science)

Valorization of Agri-Food Wastes: Extraction, Characterization and Functional Applications of Bioactive Compounds

edited by Pittaya Chaikham

submission deadline 30 Sep 2026 | Viewed by 507 | Submission Open

Keywords: agri-food waste valorization; bioactive compounds; functional foods; green extraction; food sustainability; plant-based ingredients; antioxidants; circular economy; probiotics; food processing

(This special issue belongs to the Section Biochemistry)

Cellular Pathways and Cytokine Networks in Tuberous Sclerosis: Mechanisms and Therapeutic Targets

edited by Uchenna John Unachukwu

submission deadline 30 Sep 2026 | Viewed by 501 | Submission Open

Keywords: mTOR signaling dysregulation; neurocristopathy; cytokine crosstalk; TSC1/TSC2 complex; epigenetic modifiers; metabolic reprogramming; molecular biomarkers; spatial transcriptomics

(This special issue belongs to the Section Molecular Biology)

Computational Intelligence and Algorithmic Advances in Genome Editing

edited by

Anderson Rodrigues dos Santos

submission deadline 30 Sep 2026 | 1 articles | Viewed by 491 | Submission Open

Keywords: CRISPR/cas systems; genome engineering; bioinformatics; gRNA design; off-target prediction; machine learning; structural modeling; molecular informatics; DNA repair pathways

(This special issue belongs to the Section Molecular Informatics)

Omega-6 and Omega-3 Fatty Acid Imbalance: Roles in Human Health and Pathogenesis of Diseases

edited by

Jing X. Kang

submission deadline 30 Sep 2026 | Viewed by 490 | Submission Open

Keywords: omega-6/omega-3 ratio; omega-6 fatty acids; omega-3 fatty acids; omega-6/omega-3 imbalance; lipid metabolism; inflammation; chronic diseases; cardiovascular disease; cancer; metabolic syndrome; neurodegenerative diseases; autoimmune diseases; nutritional interventions; polyunsaturated fatty acids (PUFAs); molecular mechanisms; disease pathogenesis; disease management; health promotion

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Patient-Derived iPSC Models in Chronic Disease Research

edited by

Valentina Parra

submission deadline 30 Sep 2026 | Viewed by 460 | Submission Open

Keywords: induced pluripotent stem cells; patient-derived iPSCs; chronic diseases; disease modeling; molecular mechanisms; stem cell differentiation; gene editing; organoids; personalized medicine; multi-omics

(This special issue belongs to the Section Molecular Biology)

Research on Immune Mechanisms in Kidney Disease

edited by Niels Olsen Saraiva Câmara

submission deadline 30 Sep 2026 | Viewed by 455 | Submission Open

Keywords: kidney disease; molecular sensors; kidney metabolism; immunity; AKI to CKD transition

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

DNA Damage, DNA Repair, and Cancer, 3rd Edition

edited by

Kazuhiko Kuwahara

submission deadline 30 Sep 2026 | 1 articles | Viewed by 446 | Submission Open

Keywords: DNA-damage response; DNA repair molecules; genome instability; cellular senescence; animal models; DNA damage; DNA repair and cancer

(This special issue belongs to the Section Molecular Oncology)

Displaying special issue 501-550 on page 11 of 62.

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