Inflammatory Bowel Disease: Pathogenesis and Treatment Advances
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 30 September 2026 | Viewed by 30
Special Issue Editor
Interests: inflammation; inflammatory bowel disease; ulcerative colitis; Crohn’s disease; multi-omics; drug targets; drug discovery; molecular signals of inflammation
Special Issue Information
Dear Colleagues,
Inflammatory bowel disease (IBD), encompassing ulcerative colitis, Crohn’s disease and microscopic colitis, represents a complex and multifactorial group of chronic inflammatory disorders of the gastrointestinal tract. Over the past decade, advances in molecular biology, multi-omics technologies, and systems medicine have significantly enhanced our understanding of the intricate pathways driving intestinal inflammation. These include immune dysregulation, the intestinal barrier, environmental triggers and host–microbiome interactions, all of which contribute to disease heterogeneity and variable therapeutic responses.
Despite these advances, significant gaps remain in translating molecular insights into clinically actionable strategies. There is an urgent need to identify robust biomarkers, novel drug targets, and precision-based therapeutic approaches that can improve patient outcomes and reduce disease burden globally. This gap in understanding also makes this an exciting area to watch in the coming years. Moreover, with the increasing use of Artificial Intelligence, novel approaches are made possible.
This Special Issue aims to bring together cutting-edge research that elucidates the molecular underpinnings of inflammation in IBD and related gastrointestinal disorders. The scope of this issue aligns closely with the International Journal of Molecular Sciences, particularly its focus on molecular mechanisms of disease, translational research, and innovative therapeutic strategies.
We invite submissions that explore fundamental and translational aspects of inflammation, including but not limited to molecular signaling pathways, immune modulation, microbiome dynamics, and drug discovery. By fostering interdisciplinary collaboration, this Special Issue seeks to advance the field toward precision medicine in IBD.
We welcome researchers to submit original research articles and comprehensive reviews in areas that include, but are not limited to, the following:
- Molecular signaling pathways in intestinal inflammation;
- Host–microbiome interactions and dysbiosis in IBD;
- Multi-omics approaches (genomics, transcriptomics, proteomics, metabolomics) in disease characterization;
- Biomarker discovery for diagnosis, prognosis, and therapeutic response;
- Novel drug targets and mechanisms of action in IBD therapy;
- Advances in biologics, small molecules, and precision therapeutics;
- Immune regulation and epithelial barrier function;
- Role of environmental and dietary factors in modulating inflammation;
- Artificial intelligence and computational biology in understanding disease mechanisms;
- Translational studies bridging bench to bedside in gastrointestinal inflammation.
We particularly encourage submissions that integrate molecular insights with clinical applicability, thereby contributing to the evolving paradigm of personalized medicine.
We look forward to receiving your valuable contributions and to assembling a high-impact collection of articles that will advance scientific understanding and clinical practice in this important field.
Dr. Uday N. Shivaji
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- inflammation
- inflammatory bowel disease
- ulcerative colitis
- Crohn’s disease
- multi-omics
- drug targets
- drug discovery
- molecular signals
- intestinal barrier
- IHC
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