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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Protein Structure, Function and Design

edited by Tatiana de Arruda Campos Brasil de Souza

submission deadline 28 Feb 2027 | 1 articles | Viewed by 672 | Submission Open

Keywords: protein structure; protein function; protein design; protein engineering; structural biology; computational prediction; molecular dynamics; protein-protein interactions; therapeutic proteins; structure-function relationship

(This special issue belongs to the Section Biochemistry)

Molecular and Translational Research on Late-Life Cognitive and Neuropsychiatric Disorders

edited by

Ioannis Liampas

submission deadline 28 Feb 2027 | 1 articles | Viewed by 653 | Submission Open

Keywords: dementia; Alzheimer’s disease; mild cognitive impairment; mild behavioral impairment; movement disorders; Parkinson’s disease; biomarkers; neurogenetics; molecular research

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Mechanisms in Action of Hormones

edited by

Chirine Toufaily

submission deadline 28 Feb 2027 | Viewed by 632 | Submission Open

Keywords: G-protein coupled receptors; bias signaling; neuromodulators; nuclear receptors; small molecules; hormonal crosstalk; endocrine stressors; cell-cell communication; gene expression; spatial transcriptomics

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Viral Infection: Molecular Mechanisms and Vaccine Approaches

edited by

Ismaïl Moukadiri

submission deadline 28 Feb 2027 | 1 articles | Viewed by 626 | Submission Open

Keywords: viral infection; molecular virology; molecular mechanisms; antigen engineering; next-generation vaccine design

(This special issue belongs to the Section Molecular Immunology)

Novel Aspects in Diet-Induced Obesity and Diabetes

edited by

Salil Varshney

and Abhishek Gupta

submission deadline 28 Feb 2027 | Viewed by 602 | Submission Open

Keywords: obesity; adipocyte biology; insulin resistance; inflammation; adipokines

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Advances in Understanding Respiratory Virus–Host Interactions

edited by Kun Li

submission deadline 28 Feb 2027 | Viewed by 586 | Submission Open

Keywords: respiratory viruses; virus–host interactions; molecular mechanisms; viral replication; host–immune response; molecular pathogenesis; molecular signaling; antiviral strategies

(This special issue belongs to the Section Molecular Microbiology)

Latest Advances in Pituitary Endocrinology

edited by

Antonio M. Picó

and Cristina Lamas

submission deadline 28 Feb 2027 | Viewed by 569 | Submission Open

Keywords: pituitary tumors; hypopituitarism; growth and puberty disorders; acromegaly; Cushing’s disease and silent corticotroph tumors; silent pituitary tumors; hypophysitis; molecular endocrinology and transcription factors; hormone resistance; precision endocrinology

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Advances in Neurodevelopmental Toxicity

edited by

Anna Maria Lavezzi

submission deadline 28 Feb 2027 | 1 articles | Viewed by 554 | Submission Open

Keywords: developmental neurotoxicity (DNT); prenatal and perinatal exposure; multi-omics integration; brain organoids; endocrine disrupting chemicals (EDCs); epigenetic landscape; systems biology; translational biomarkers; synaptogenesis and neurogenesis; environmental risk assessment

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Research on Reproductive Physiology and Endocrinology—2nd Edition

edited by

Kamil Gill

submission deadline 28 Feb 2027 | 1 articles | Viewed by 552 | Submission Open

Keywords: reproductive; endocrinology; reproductive hormones; embryology; molecular research; IVF; obesity

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Novel Strategies in the Development of New Therapies, Drug Substances and Drug Carriers, 4rd Edition

edited by

Andrzej Kutner

Geoffrey Brown

and Enikö Kallay

submission deadline 28 Feb 2027 | 1 articles | Viewed by 552 | Submission Open

Keywords: drug design and discovery antimicrobial drugs; antiviral drugs; antibiotics; cancer prevention and treatment molecular modeling; molecular mechanisms; crystallography preclinical studies; pharmacokinetics; pharmacodynamics; pharmacognosy drug-protein interactions nuclear receptors; receptor agonists and antagonists; stem cells; activity profiling; vaccines; markers; and diagnostics drug carriers; dosage form; anti-crystal engineering; nanoparticles; dissolution testing

(This special issue belongs to the Section Molecular Pharmacology)

Advanced Diagnostic and Therapeutic Strategies for Male Infertility

edited by

Anastasios Potiris

, Sofoklis Stavros and Eirini Drakaki

submission deadline 28 Feb 2027 | Viewed by 522 | Submission Open

Keywords: male infertility; andrology; precision medicine; assisted reproduction; reproductive genetics; epigenetics; multi-omics; artificial intelligence; biomarkers; sperm biology

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Screening and Identification of Crop Abiotic Stress Tolerance Functional Genes: 2nd Edition

edited by

Liezhao Liu

submission deadline 28 Feb 2027 | 1 articles | Viewed by 520 | Submission Open

Keywords: plant; abiotic stress; gene; identification; function

(This special issue belongs to the Section Molecular Plant Sciences)

Recent Advances in Lipopolysaccharides

edited by

Satish Raina

and

Gracjana Klein

submission deadline 28 Feb 2027 | Viewed by 515 | Submission Open

Keywords: LPS structural diversity; lipid A; amino arabinose and phosphoethanolamine; TLR4; antibiotic resistance; Lpt transport system; phospholipids and fatty acids; cell envelope stress; lipid A acyltransferases

(This special issue belongs to the Section Molecular Biology)

New Molecular Insights into Antimicrobial Peptides

edited by

Gloria Bua

submission deadline 28 Feb 2027 | Viewed by 471 | Submission Open

Keywords: antimicrobial peptides; mode of action; molecular mechanism of biological activity; molecular targets; molecular modeling; structure–activity relationship

(This special issue belongs to the Section Molecular Microbiology)

Protection of Natural Products in Liver Injury

edited by

Jeon-Ok Moon

submission deadline 28 Feb 2027 | Viewed by 470 | Submission Open

Keywords: liver injury; natural product; antioxidant activity; modulation of inflammatory pathway; mitigation of fibrosis; pharmacology

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Pathophysiology of Preeclampsia and Gestational Diabetes: Shared Molecular Mechanisms in Pregnancy-Related Disorders

edited by Tamara Nikolic Turnic

submission deadline 28 Feb 2027 | Viewed by 470 | Submission Open

Keywords: preeclampsia; molecular mechanism; mechanism of preventive/curative strategies; placenta dysfunction

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Photosynthetic Mechanisms, Environmental Adaptation, and Genetic Engineering of Plants and Algae

edited by Maksymilian Zienkiewicz

submission deadline 28 Feb 2027 | Viewed by 469 | Submission Open

Keywords: algae; photosynthesis; photoprotection; photostasis; light-harvesting complexes; cyclic electron transport; stress tolerance; environmental adaptation; genetic engineering; CRISPR

(This special issue belongs to the Section Molecular Plant Sciences)

Recent Advances in Natural Products for Antiviral Drug Discovery

edited by

Thao Quyen Cao

submission deadline 28 Feb 2027 | Viewed by 464 | Submission Open

Keywords: bioactive natural compound; secondary metabolites; antiviral activity; molecular mechanisms; metabolomic-guided discovery; natural antivirals; food-derived bioactivity; AI-assisted prediction of antiviral natural products; microbe-derived antiviral metabolites; marine-derived antiviral metabolites

(This special issue belongs to the Section Molecular Pharmacology)

Recent Advances in Molecular Mechanisms of Human Papillomavirus Family (HPV) Induced Oncogenesis, 2nd Edition

edited by

Subhasis B. Biswas

submission deadline 28 Feb 2027 | Viewed by 447 | Submission Open

Keywords: human papillomavirus (HPV); oncogenesis; mechanism; diagnosis; classification; etiology; pathophysiology; biochemistry; genetics; molecular biology; epidemiology; cervical cancer; oropharyngeal cancer; oncology

(This special issue belongs to the Section Molecular Oncology)

Targeting Ion Channels for Novel Therapeutics

edited by María A. Gandini

submission deadline 28 Feb 2027 | Viewed by 442 | Submission Open

Keywords: ion channel; channelopathies; membrane trafficking; post-translation regulation; electrophysiology; signal transduction

(This special issue belongs to the Section Molecular Biology)

Antioxidants in Healthspan Regulation: From Molecular Mechanisms to Cellular Signaling

edited by

Grzegorz Bartosz

and

Izabela Sadowska-Bartosz

submission deadline 28 Feb 2027 | Viewed by 433 | Submission Open

Keywords: antioxidant; reactive oxygen species; lifespan; healthspan; molecular mechanisms; cellular effects; supplementation

(This special issue belongs to the Section Biochemistry)

JAK/STAT Pathway in Stem Cell Biology

edited by Willis Li

submission deadline 28 Feb 2027 | Viewed by 429 | Submission Open

Keywords: JAK/STAT signaling; stem cell self-renewal; cellular differentiation; pluripotency; hematopoietic stem cells; signal transduction; cytokine receptors; transcriptional regulation; stem cell niche; regenerative medicine

(This special issue belongs to the Section Molecular Biology)

New Insights into Natural Products with Antimicrobial Activities

edited by Jose Javier Sanz Gomez

submission deadline 28 Feb 2027 | Viewed by 428 | Submission Open

Keywords: bioactive compounds; biotechnological substances; essential oils; plant extracts; mechanism of action; interactions; biofilms; active packaging; technological processes; safety

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Decoding Nuclear Receptor Networks: Dynamics, Microenvironment, and Therapeutic Intervention

edited by

Andreas Von Knethen

submission deadline 28 Feb 2027 | Viewed by 426 | Submission Open

Keywords: non-genomic mechanisms; interactome; agonists/antagonists; sequestration; pro- vs. anti-inflammatory; transcriptome; metabolome

(This special issue belongs to the Section Molecular Immunology)

Cellulose and Its Applications, 2nd Edition

edited by

Suresh Valiyaveettil

and Ce Sun

submission deadline 28 Feb 2027 | Viewed by 425 | Submission Open

Keywords: cellulose; biomedical applications; nanocomposites; biodegradable polymers; water purification; nanocellulose

(This special issue belongs to the Section Macromolecules)

Latest Advances in Novel Luminescent Materials

edited by K. Naveen Kumar

submission deadline 28 Feb 2027 | 1 articles | Viewed by 419 | Submission Open

Keywords: luminescent materials; rare-earth ions; nanophosphors; quantum dots; glass-ceramics; photoluminescence; upconversion luminescence; optical materials; photonic applications; light-emitting devices

(This special issue belongs to the Section Materials Science)

Advances in Host Immunity and Gut Microbiota

edited by

Md F. Kulyar

submission deadline 28 Feb 2027 | Viewed by 415 | Submission Open

Keywords: gut microbiota; host immunity; inflammasome; gut–bone axis; osteoarthritis; extracellular vesicles; dysbiosis; innate immunity; microbial metabolites; regenerative medicine

(This special issue belongs to the Section Molecular Microbiology)

From Discovery to Clinic: Overcoming Barriers in Antimicrobial Peptide Development

edited by José M. Pérez De la Lastra

submission deadline 28 Feb 2027 | Viewed by 408 | Submission Open

Keywords: antimicrobial peptides (AMPs); translational challenges; in vivo efficacy; drug delivery and formulation; computational approaches; pharmacokinetics; toxicity prediction; antibiotic resistance; animal models; nanotechnology

(This special issue belongs to the Section Molecular Microbiology)

Applications and Advances of Organic Synthesis in the Design of Antiparasitic, Antiviral, and Anticancer Drugs

edited by

Sergio Hernán Szajnman

and Juan B. Rodriguez

submission deadline 28 Feb 2027 | Viewed by 405 | Submission Open

Keywords: antiparasitic agents; antiviral agents; chagas disease; toxoplasmosis; medicinal chemistry

(This special issue belongs to the Section Molecular Pharmacology)

Molecular-Level Insights into Retinal Vascular Disorders

edited by

Nikhlesh Singh

submission deadline 28 Feb 2027 | Viewed by 403 | Submission Open

Keywords: retina; retinal neovascularization; diabetic retinopathy; retinopathy of prematurity; VEGF; blood–retinal barrier

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Multifunctional Application of Biopolymers and Biomaterials-3rd Edition

edited by

Valentina Siracusa

submission deadline 28 Feb 2027 | Viewed by 400 | Submission Open

Keywords: biopolymers; nanomaterials; biomaterials; functional materials; bioactive natural compounds; essential oil emulsion; natural colorant; plant extract; bioactive compounds; nanocomposite; functional composite; composite film and coatings

(This special issue belongs to the Section Materials Science)

Recent Advances in the Characterization and Activity Studies of Bioactive Peptides and Functional Proteins

edited by

Luis Vallejo-Castillo

submission deadline 28 Feb 2027 | Viewed by 399 | Submission Open

Keywords: bioactive peptides; bioactive proteins; preclinical assays; physicochemical characterization of biotherapeutics; biological characterization of biotherapeutics; developability assays; biodistribution; pharmacokinetics

(This special issue belongs to the Section Molecular Biology)

Molecular Insights into Mechanobiology of Regeneration

edited by

Christopher Robinson

and Timothy R. Deer

submission deadline 28 Feb 2027 | Viewed by 399 | Submission Open

Keywords: mechanotransduction; regeneration; stem cells; extracellular matrix; tissue repair

(This special issue belongs to the Section Molecular Biophysics)

Role of DNA Methylation Signatures in Genetic Disorders

edited by

Jair Tenorio-Castano

submission deadline 28 Feb 2027 | Viewed by 399 | Submission Open

Keywords: DNA methylation; genetic disorders; episignature; genomic medicine; differentially methylated regions

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Research on Steroid Hormones and Sex Hormones

edited by

Eloísa Da Silveira Loss

submission deadline 28 Feb 2027 | Viewed by 391 | Submission Open

Keywords: membrane androgen receptors; G protein-coupled estrogen receptor; membrane progesterone receptors; membrane glucocorticoid receptor; genomic steroid receptors; rapid immune effects; non-genomic signaling pathway

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Study of the Molecular Mechanisms Underlying the Involvement of Viruses in the Progression of Autoimmune Diseases

edited by

Marco Miceli

submission deadline 28 Feb 2027 | Viewed by 390 | Submission Open

Keywords: multiple sclerosis; central nervous system; autoimmune; genetic and environmental factors; herpesviruses; CMV; immunopathology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Phenotype-Targeted Nanomedicine: Navigating Multiscale Biological Barriers in the 2026 Clinical Era

edited by

Athina Angelopoulou

submission deadline 28 Feb 2027 | Viewed by 384 | Submission Open

Keywords: nanomedicine; nanotherapeutic; nanobiomaterials; TME

(This special issue belongs to the Section Molecular Nanoscience)

Molecular, Cellular Mechanisms and Pathophysiology of Glioblastoma

edited by Agnieszka Rusak

submission deadline 28 Feb 2027 | Viewed by 377 | Submission Open

Keywords: glioblastoma; targeted terapy; molecular patchway; drug carriers; biomaterials

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Design of Therapeutic Small-Molecular Blockers Against Channel Proteins

edited by Kingshuk Basu

submission deadline 28 Feb 2027 | Viewed by 371 | Submission Open

Keywords: channel proteins; channel blockers; membrane protein; drug design; drug screening; electrophysiology

(This special issue belongs to the Section Molecular Pharmacology)

Natural Antioxidants: Molecular Mechanisms, Formulations and Therapeutic Perspectives

edited by

Lavinia Anamaria Purza

submission deadline 28 Feb 2027 | Viewed by 370 | Submission Open

Keywords: natural antioxidants; oxidative stress; redox signaling; polyphenols; reactive oxygen species; bioactive compounds; nutraceuticals; phytochemicals

(This special issue belongs to the Section Bioactives and Nutraceuticals)

The Role of Tubulin in Human Diseases

edited by Souvik Banerjee

submission deadline 28 Feb 2027 | Viewed by 369 | Submission Open

Keywords: tubulin; microtubules; medicinal chemistry; chemotherapy; drug discovery and design; drug target; cancer; chemoresistance; microtubule-targeting agents

(This special issue belongs to the Section Molecular Biology)

Nutrition for Muscle Health and Metabolism

edited by

Hira Shakoor

submission deadline 28 Feb 2027 | Viewed by 365 | Submission Open

Keywords: nutrition; skeletal muscle; muscle metabolism; mitochondrial function; insulin sensitivity; myokines; metabolic health; metabolic disease

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Molecular Research on the Antioxidant, Anti-Inflammatory, and Antibacterial Activities of Natural Products

edited by

Carmen Lizette Del Toro Sánchez

and

Ariadna Thalia Bernal-Mercado

submission deadline 28 Feb 2027 | Viewed by 360 | Submission Open

Keywords: natural bioactive compounds; antioxidant mechanisms; anti-inflammatory pathways; antibacterial activity; agro-industrial byproducts; molecular docking; structure–activity relationship (SAR); omics technologies; drug delivery systems; nanobiotechnology; bioavailability

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Mechanisms Underlying the Pathogenesis and Treatment of Gastrointestinal Disorders

edited by

Andrzej Pławski

submission deadline 28 Feb 2027 | Viewed by 347 | Submission Open

Keywords: gastrointestinal disorders; molecular mechanisms; diagnosis; treatment; precision medicine; biomarkers; gastrointestinal cancer

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms of Dementia and Application of Biomarkers

edited by

Teresa Juárez-Cedillo

submission deadline 28 Feb 2027 | Viewed by 346 | Submission Open

Keywords: Alzheimer's; diagnosis; biological marker; protein; therapeutic target

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Spinal Cord Injury: A Comprehensive Approach to Pathophysiology, Treatment, and Recovery

edited by Raúl Silva Garcia and Elisa García-Vences

submission deadline 28 Feb 2027 | Viewed by 346 | Submission Open

Keywords: spinal cord injury; neuroprotection; inflammation; therapy; pathophysiology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Plant Secondary Metabolites and Their Regulatory Mechanisms

edited by

Daniela Trono

submission deadline 28 Feb 2027 | Viewed by 343 | Submission Open

Keywords: secondary metabolites; plant growth and development; response to biotic and abiotic stresses; biosynthesis and degradation; gene and enzyme regulation; metabolic engineering; omics approaches

(This special issue belongs to the Section Molecular Plant Sciences)

Phenolic Compounds as Adjunct Therapy in Cardiometabolic Disorders

edited by

Dalia Marija Kopustinskiene

submission deadline 28 Feb 2027 | Viewed by 343 | Submission Open

Keywords: phenolic compounds; cardiovascular diseases; metabolism; diabetes; obesity; hypertension; mitochondria; oxidative stress; gut microbiota; inflammation

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Advances in Calcium Signaling: Physiological Roles and Implications for Disease

edited by

Adán Dagnino-Acosta

and

Luis Castro-Sánchez

submission deadline 28 Feb 2027 | Viewed by 338 | Submission Open

Keywords: calcium signaling; intracellular calcium; calcium homeostasis; calcium channels; muscle physiology; signal transduction; calcium-related diseases; mitochondrial calcium; genetic control of calcium signaling

(This special issue belongs to the Section Molecular Biology)

Advances in Molecular Research of Supramolecular Polymers

edited by

Attila Bende

submission deadline 28 Feb 2027 | Viewed by 337 | Submission Open

Keywords: supramolecular polymers; supramolecular aggregates; molecular self-assemblies; photochemistry and photophysics of molecular materials

(This special issue belongs to the Section Materials Science)

Displaying special issue 2451-2500 on page 50 of 63.

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