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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Endocrine Regulation in Health and Diseases

edited by Fady Hannah-Shmouni

submission deadline 30 Jun 2026 | 1 articles | Viewed by 2910 | Submission Open

Keywords: exposome and endocrine disruptors; endocrine-disrupting chemicals (EDCs); environmental toxicology and hormonal health; epigenetics and endocrine function; endocrine regulation and chronic disease; public health and exposure mitigation; endocrine disruptors in the home and community

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Functional Genomics and Molecular Mechanisms of Plant Stress Responses

edited by

Zupeng Wang

submission deadline 30 Jun 2026 | 1 articles | Viewed by 815 | Submission Open

Keywords: plant stress responses; abiotic stress; biotic stress; molecular mechanisms; functional genomics

(This special issue belongs to the Section Molecular Plant Sciences)

Oxidative Stress Unveiled: Mechanisms and Implications in Cardiac Pathologies

edited by Sukkum Ngullie Chang and Vernat Exil

submission deadline 30 Jun 2026 | Viewed by 643 | Submission Open

Keywords: reactive oxygen species (ROS); electron transport chain (ETC); mitochondrial permeability transition pore (mPTP); endothelial– cardiomyocyte– fibroblast crosstalk; metabolic adaptation; inflammation; cardiovascular disease (CVD)

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advanced Functional Materials for Catalysis and Storage

edited by

Kaixin Zhu

submission deadline 30 Jun 2026 | 1 articles | Viewed by 497 | Submission Open

Keywords: functional materials; energy catalysis; small molecule conversion; energy storage

(This special issue belongs to the Section Materials Science)

RNA Modifications in Response to Physical Activity: Implications for Rehabilitation and Disease Management

edited by Roberto Tedeschi and Francesca Gorini

submission deadline 30 Jun 2026 | Viewed by 371 | Submission Open

Keywords: RNA modifications; non-coding RNAs (ncRNAs); physical activity; gene expression; rehabilitation and disease management; epigenetic regulation; exercise-induced RNA expression; miRNA in inflammation control

(This special issue belongs to the Section Molecular Biology)

Gynaecological Diseases: From Emergence to Translational Medicine

edited by

Pawel Kordowitzki

submission deadline 30 Jun 2026 | 1 articles | Viewed by 342 | Submission Open

Keywords: gynaecological diseases; reproductive biology; endometriosis; ovarian dysfunction

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Genetic Regulation of Plant Growth and Protection (2nd Edition)

edited by

Yuxuan Hou

and

Zhiyong Li

submission deadline 30 Jun 2026 | Viewed by 220 | Submission Open

Keywords: molecular regulation; genetic resources; functional genomics; plant growth and development; abiotic and biotic stresses; plant– microbe interactions

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Insights and Therapeutic Advances in Atherosclerosis

edited by

Zhu Bo

submission deadline 30 Jun 2026 | 1 articles | Viewed by 203 | Submission Open

Keywords: atherosclerosis; molecular mechanisms; lipid metabolism; inflammation; endothelial dysfunction; RNA therapeutics; nanomedicine; cardiovascular disease; biomarkers; translational medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Molecular Genetics and Molecular Therapy for Gastric Cancers

edited by

Binnari Kim

submission deadline 30 Jun 2026 | Viewed by 188 | Submission Open

Keywords: gastric cancer; molecular genetics; targeted therapy; tumor microenvironment; immunotherapy; biomarkers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms and Pathophysiology of Peripheral Neuropathies and Neuromuscular Disorders

edited by

Eleonora Galosi

submission deadline 30 Jun 2026 | Viewed by 187 | Submission Open

Keywords: peripheral neuropathies; neuromuscular disorders; small fiber neuropathy; neuropathic pain; nerve regeneration; molecular pathways; next-generation sequencing

(This special issue belongs to the Section Molecular Neurobiology)

Biomaterials and Nanotechnology in Cancer Therapy and Regenerative Medicine

edited by Manoochehr Rasekh

submission deadline 30 Jun 2026 | Viewed by 178 | Submission Open

Keywords: biomaterials; nanoparticle drug delivery; cancer therapy; stimuli-responsive nanocarriers; targeted therapeutics; regenerative medicine; tissue engineering; theranostics

(This special issue belongs to the Section Materials Science)

Effect of Molecular Structure on the Distribution, Pharmacokinetics, and Metabolic Transformation of Bioactive Compounds

edited by

Mohammed Salah

submission deadline 30 Jun 2026 | Viewed by 169 | Submission Open

Keywords: molecular structure; pharmacokinetics; metabolic transformation; bioavailability; structure– activity relationship (SAR); drug metabolism; bioactive compounds; molecular modeling; ADMET; medicinal chemistry

(This special issue belongs to the Section Molecular Pharmacology)

Nanodrug Bioavailability and Biocompatibility in Cancer and CNS Disorders

edited by

Athina Angelopoulou

submission deadline 30 Jun 2026 | Viewed by 160 | Submission Open

Keywords: nanomedicine; bioavailability; biocompatibility; tumor microenvironment; Blood– Brain Barrier; targeted drug delivery; neurodegenerative diseases

(This special issue belongs to the Section Molecular Nanoscience)

Mitigating Metal Toxicity: Contaminated Environment, Animal Studies and Human Health

edited by

Agnieszka Scibior

Manuel Aureliano

and

Juan Llopis

submission deadline 30 Jun 2026 | Viewed by 157 | Submission Open

Keywords: heavy metal toxicity; heavy metal pollution; heavy metal bioaccumulation and interactions; health risk; mechanistic analysis; dysregulation of cellular homeostasis; natural plant bioactive compounds; human diseases; environmental pollution; in vitro/animal studies; innovative strategies; polyoxometalates (POMs); metal-organic frameworks (MOFs)

(This special issue belongs to the Section Molecular Toxicology)

From DNA Damage to Cell Death: Emerging Drug Targets and Therapeutic Opportunities

edited by

Mateusz Kciuk

and Beata Marciniak

submission deadline 30 Jun 2026 | 1 articles | Viewed by 147 | Submission Open

Keywords: apoptosis; cancer therapy; cell death pathways; chemoresistance; DNA damage response (DDR); DNA repair inhibitors; drug discovery; ferroptosis; genomic instability; therapeutic targets

(This special issue belongs to the Section Molecular Biology)

Bridging Basic and Clinical Science: Shared Molecular and Metabolic Mechanisms in Preeclampsia, Gestational Diabetes and Gestational Weight Gain

edited by

Reyna Sámano

, Hector Borboa-Olivares, Verónica Zaga-Clavellina and

Gabriela Chico-Barba

submission deadline 30 Jun 2026 | Viewed by 139 | Submission Open

Keywords: preeclampsia; gestational diabetes; gestational weight gain; metabolic mechanisms; molecular pathways; placental biology; maternal– fetal interface; biomarkers; insulin resistance; inflammation; translational research

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Unraveling Neurodevelopmental Disorders: A Molecular Perspective

edited by Marija-Magdalena Petrinovic

submission deadline 30 Jun 2026 | Viewed by 135 | Submission Open

Keywords: neurodevelopmental disorders; molecular neuroscience; genetics; epigenetics; functional MRI (fMRI); magnetic resonance spectroscopy (MRS); PET imaging; imaging biomarkers; translational neuroscience; precision medicine

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Mechanism and Therapeutics in Human Cancer

edited by

Rachel Bar-Shavit

submission deadline 30 Jun 2026 | Viewed by 128 | Submission Open

Keywords: oncogenes; Wnt/b-catenin; G-protein-coupled receptors (GPCR); translational means; cancer stem cells; ubiquitination and deubiquitinating in cancer

(This special issue belongs to the Section Molecular Oncology)

Advances in Alzheimer’s Disease

edited by

Giulia Bivona

submission deadline 30 Jun 2026 | Viewed by 120 | Submission Open

Keywords: Alzheimer’ s Disease; amyloid beta; molecular target

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Insights into the Stability and Degradation of Perovskite Solar Cells

edited by

Amal Bouich

submission deadline 30 Jun 2026 | Viewed by 112 | Submission Open

Keywords: perovskite; thin films; solar cells; PCE; stability; molecular structure evolution (perovskite); perovskite precursor molecular design

(This special issue belongs to the Section Materials Science)

Aptamers in Cancer Therapy: Mechanisms, Applications, and Translational Perspectives

edited by

Gabor I. Csonka

submission deadline 30 Jun 2026 | Viewed by 107 | Submission Open

Keywords: aptamers; targeted drug delivery; cancer immunotherapy; molecular imaging; biomarkers; precision oncology; SELEX; theranostics; translational oncology; mechanistic insights

(This special issue belongs to the Section Molecular Oncology)

Molecular Discoveries in Pharmacogenetics: From Bench to Bedside

edited by

Kumaraswamy Naidu Chitrala

submission deadline 30 Jun 2026 | Viewed by 106 | Submission Open

Keywords: pharmacogenetics; clincial practice; artficial intelligence; bioinformatics; personalized medicine; drug response; genetic variations

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Mechanisms of Human Liver Diseases: 3rd Edition

edited by

Elena Grossini

submission deadline 30 Jun 2026 | Viewed by 105 | Submission Open

Keywords: non-alcoholic fatty liver disease (NAFLD); non-alcoholic steatohepatitis (NASH); alcoholic steatohepatitis (ASH); Wilson’ s disease; hemochromatosis; viral hepatitis; autoimmune hepatitis; hepatocellular carcinoma; signaling pathways; molecular mechanisms; metabolic dysfunction-associated steatotic liver disease (MASLD); metabolic dysfunction-associated steatohepatitis (MASH)

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Latest Research Progress of Biomaterial Modification

edited by

Manuel José Lis

submission deadline 30 Jun 2026 | Viewed by 103 | Submission Open

Keywords: functionalization of carbohydrates; molecular aggregation; simulation of biopolymers; biopolymeric microcapsules; biopolymeric devices

(This special issue belongs to the Section Materials Science)

Thermogenic Adipocytes and Skeletal Muscle: Novel Molecular Targets for the Treatment of Diabetes and Obesity

edited by

Hiroshi Sakaue

submission deadline 30 Jun 2026 | Viewed by 99 | Submission Open

Keywords: metabolic diseases; obesity; type 2 diabetes; molecular signaling pathway

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Preparation and Applications of Colloidal Emulsions

edited by

Bakht Ramin Shah

submission deadline 30 Jun 2026 | Viewed by 92 | Submission Open

Keywords: emulsions; fabrication; characterization; applications; encapsulation; delivery systems

(This special issue belongs to the Section Molecular Biology)

Anesthetics and Neurovascular Health: Molecular Pathways

edited by Gabriele Melegari

submission deadline 30 Jun 2026 | Viewed by 91 | Submission Open

Keywords: neurovascular paths; blood– brain barrier (BBB) and anesthesia; neurovascular coupling; perioperative neuroprotection; neuroinflammation; endothelial dysfunction; cerebral autoregulation; cerebral blood flow; perioperative brain health

(This special issue belongs to the Section Molecular Neurobiology)

Recent Advances in Natural Products for Antiviral Drug Discovery

edited by

Thao Quyen Cao

submission deadline 30 Jun 2026 | Viewed by 84 | Submission Open

Keywords: bioactive natural compound; secondary metabolites; antiviral activity; molecular mechanisms; metabolomic-guided discovery; natural antivirals; food-derived bioactivity; AI-assisted prediction of antiviral natural products; microbe-derived antiviral metabolites; marine-derived antiviral metabolites

(This special issue belongs to the Section Molecular Pharmacology)

Identification of Molecular Biomarkers Through Digital Pathology

edited by

Rafael Parra-Medina

submission deadline 30 Jun 2026 | Viewed by 81 | Submission Open

Keywords: digital pathology; molecular biomarkers; computational pathology; artificial intelligence; deep learning; spatial biology; multi-omics integration; tumor microenvironment; precision medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Reproductive Endocrinology Research: 2nd Edition

edited by

Tsung-Hsien Lee

submission deadline 30 Jun 2026 | Viewed by 80 | Submission Open

Keywords: molecular endocrinology; reproductive genetics; hormonal signaling pathways; fertility and infertility; epigenetics in reproduction; environmental impact on reproduction

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

The Roles of Glucagon-Like Peptide-1 (GLP-1) Receptor Agonists in Health and Disease

edited by

Katarzyna Kaczyńska

submission deadline 30 Jun 2026 | Viewed by 78 | Submission Open

Keywords: GLP-1; GLP-1 receptor; GLP-1 signaling pathway; mechanism of action; GLP-1 agonists; human diseases; adverse effects

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Molecular and Biochemical Advances in Kidney Diseases and Genetics

edited by

Silvio R. De Luka

submission deadline 30 Jun 2026 | Viewed by 73 | Submission Open

Keywords: pathophysiology; molecular mechanisms; biomarkers; in silico data analysis; image analysis; animal models

(This special issue belongs to the Section Molecular Genetics and Genomics)

Pharmacological Effects of Bioactive Compounds Derived from Plants

edited by

Ibrahim Mssillou

submission deadline 30 Jun 2026 | Viewed by 72 | Submission Open

Keywords: bioactive compounds; wound healing; anti-cancer; anti-inflammatory; mechanism of action; antioxidants; neuroprotection; pharmacological properties

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Ovarian Insufficiency: From Molecular Pathology to Novel Therapeutic Approach

edited by Aleksandar Ljubić

submission deadline 30 Jun 2026 | Viewed by 72 | Submission Open

Keywords: ovarian insufficiency; premature ovarian insufficiency; molecular pathology; regenerative medicine; stem cell therapy; platelet-rich plasma; epigenetics; intraovarian treatment; ovarian stem cells; mitochondrial dysfunction

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Exploring the Crossroads of Autoimmunity, Inflammatory Diseases, and Cancer

edited by Xuming Mao

submission deadline 30 Jun 2026 | Viewed by 72 | Submission Open

Keywords: autoimmune disorders; tumor microenvironment; chronic inflammation; immune checkpoint inhibitors; machine learning; epidemiology

(This special issue belongs to the Section Molecular Immunology)

Leukemia in the Omics Era: From Mechanisms to Therapies

edited by Marco Rossi

submission deadline 30 Jun 2026 | Viewed by 70 | Submission Open

Keywords: FLT3 inhibitors; JAK inhibitors; BTK inhibitors; BCL 2 inhibitors; BTK degraders; menin inhibitors; IDH inibitors

(This special issue belongs to the Section Molecular Oncology)

Advances in Polymeric Nanomaterials in Medicine

edited by Prabhanjan Giram

submission deadline 30 Jun 2026 | Viewed by 68 | Submission Open

Keywords: nanomaterials; nanocomposites; biomolecules; nano pharmaceuticals; nanoparticles; applications of nanomaterials; nanoformulation design; characterization; nanodrug delivery system; targeted and controlled release therapies

(This special issue belongs to the Section Molecular Nanoscience)

Recent Trends in Metal–Organic and Covalent Organic Frameworks

edited by

Muhammad Asad

submission deadline 30 Jun 2026 | Viewed by 68 | Submission Open

Keywords: metal– organic frameworks; covalent organic frameworks; porous materials; electrocatalysis; sustainable energy systems; adsorption; supercapacitors

(This special issue belongs to the Section Materials Science)

Modern Approaches in Regenerative Therapy

edited by

Daria Chudakova

and

Vladimir P. Baklaushev

submission deadline 30 Jun 2026 | Viewed by 66 | Submission Open

Keywords: regenerative therapy; regeneration; neuroregeneration; cell reprogramming; cell therapy; regenerative bio-scaffolds; extracellular vesicles; mesenchymal stromal/stem cells (MSCs); cell differentiation; omics technologies

(This special issue belongs to the Section Molecular Biology)

Viral Infections and Host Antiviral Responses: Molecular Mechanisms and Molecular Regulation

edited by Hong Jia

submission deadline 30 Jun 2026 | Viewed by 66 | Submission Open

Keywords: antiviral immunity; viral entry; host– virus interaction; innate immunity; interferon signaling; viral immune evasion; non-coding RNAs; post-translational modifications; molecular therapeutics; viral pathogenesis

(This special issue belongs to the Section Molecular Microbiology)

From Drug Design to Mechanistic Understanding and Resistance

edited by

Yuan Ma

submission deadline 30 Jun 2026 | Viewed by 63 | Submission Open

Keywords: drug resistance; drug discovery; targeted protein degradation; systems pharmacology; structural biology

(This special issue belongs to the Section Molecular Pharmacology)

Molecular and Metabolic Mechanisms Regulating Reproduction and Development in Animals

edited by Borhan Shokrollahi and Kimberly M. Davenport

submission deadline 30 Jun 2026 | Viewed by 59 | Submission Open

Keywords: molecular nutrition; metabolic signaling; reproductive physiology; epigenetic programming; placental biology; transcriptomics and metabolomics; mitochondrial function; oxidative stress pathways; developmental programming; ruminant health

(This special issue belongs to the Section Molecular Biology)

Molecular Advances on Pathogen Interaction and Host Immune

edited by

Karolina Kot

submission deadline 30 Jun 2026 | Viewed by 57 | Submission Open

Keywords: host– pathogen interactions; innate and adaptive immunity; pattern recognition receptors (PRRs); immune signaling pathways; cytokines and interferons; immune evasion mechanisms; molecular pathogenesis; infectious diseases

(This special issue belongs to the Section Molecular Immunology)

Advanced Research on Antimicrobial Nanomaterials

edited by

Nenad Filipovic

submission deadline 30 Jun 2026 | Viewed by 57 | Submission Open

Keywords: antimicrobial nanomaterials; metal/metal-oxide nanoparticles; stimuli-responsive platforms; photothermal/photodynamic mechanisms; biofilm inhibition

(This special issue belongs to the Section Materials Science)

Advanced Biomaterials for Tissue Regeneration

edited by

Liviu Duta

and

Valentina Grumezescu

submission deadline 30 Jun 2026 | Viewed by 55 | Submission Open

Keywords: biomaterials; tissue regeneration; molecular mechanisms; cell-instructive scaffolds; injectable hydrogels; ECM-mimetic materials; bioactive ceramics; bioactive surface coatings; mechanotransduction/mechanobiology; immunomodulation; angiogenesis and vascularization; biofabrication (3D/4D printing)

(This special issue belongs to the Section Materials Science)

The Role of Natural Products in Drug Discovery: 2nd Edition

edited by

Luciana Scotti

and

Marcus Tullius Scotti

submission deadline 30 Jun 2026 | Viewed by 55 | Submission Open

Keywords: natural product; medicinal chemistry; drug design; drug discovery; pharmacy; chemistry

(This special issue belongs to the Section Molecular Pharmacology)

Advances in Retinal Diseases: 3rd Edition

edited by Minzhong Yu

submission deadline 30 Jun 2026 | Viewed by 53 | Submission Open

Keywords: retina; optic nerve; ocular disorder; retinal disease; genetic mutation; aging; drug side effects; novel mutations/biomarkers; signaling pathways; spectral domain optical coherence tomography; stem cells; gene therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Plant Secondary Metabolites and Their Regulatory Mechanisms

edited by

Daniela Trono

submission deadline 30 Jun 2026 | Viewed by 49 | Submission Open

Keywords: secondary metabolites; plant growth and development; response to biotic and abiotic stresses; biosynthesis and degradation; gene and enzyme regulation; metabolic engineering; omics approaches

(This special issue belongs to the Section Molecular Plant Sciences)

New Advances in Bioactive Compounds

edited by

Samuel Cota Teixeira

submission deadline 30 Jun 2026 | Viewed by 49 | Submission Open

Keywords: bioactive compound; natural products; polyphenols; carotenoids; alkaloids

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Studies on Obesity and Related Diseases

edited by

Juliana Soares Severo

Francisco L. Torres-Leal

and

Moisés Tolentino B. Da Silva

submission deadline 30 Jun 2026 | Viewed by 49 | Submission Open

Keywords: obesity; adipose tissue; immunometabolism; adipokines; metabolomics; gut microbiota; thermogenesis; NAFLD; inflammation; precision nutrition

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Displaying special issue 2851-2900 on page 58 of 64.

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