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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Effects of Radiation on Biomolecules and Cells: Mechanisms, Responses, and Biological Implications
edited by
submission deadline 30 Sep 2026 | Viewed by 309 | Submission Open
Keywords: radiation biology; biomolecular damage; cellular responses; DNA damage and repair; oxidative stress; radioprotection; radiotherapy; dosimetry; molecular mechanisms; radiation-induced toxicity
(This special issue belongs to the Section Molecular Biology)
Targeted Therapies and Chemoresistance in Gastrointestinal Cancers
edited by Zheng Chen
submission deadline 30 Sep 2026 | Viewed by 308 | Submission Open
Keywords: gastrointestinal cancer; targeted therapy; chemoresistance; drug resistance; precision medicine; molecular biomarkers; signal transduction; tumor microenvironment; immunotherapy; novel therapeutics
(This special issue belongs to the Section Molecular Oncology)
Deep Learning for Bioinformatics and Biomedicine
edited by
submission deadline 30 Sep 2026 | Viewed by 300 | Submission Open
Keywords: bioinformatics; deep learning; genomics (DNA); histopathology; multi-omics; molecular biomarkers; drug discovery; computational pathology; systems biology; precision medicine
(This special issue belongs to the Section Molecular Informatics)
Molecular Immunity to Parasitic Infections
edited by Jamie A. Whitelaw and Stuart Woods
submission deadline 30 Sep 2026 | Viewed by 300 | Submission Open
Keywords: parasitology; immunology; vaccines; cell therapy; gene editing; parasitic diseases; immune responses; inflammation; molecular mechanisms; immune evasion; host cell invasion and manipulation
(This special issue belongs to the Section Molecular Immunology)
Advances in Cell Signaling Pathways and Signal Transduction, 2nd Edition
edited by and Katsuhiko Muraki
submission deadline 30 Sep 2026 | Viewed by 295 | Submission Open
Keywords: signaling pathway; signal transduction; cell biology; signal transduction; cell communication; cell signaling
(This special issue belongs to the Section Biochemistry)
Molecular Genetics in Metabolic Syndrome and Diabetes
edited by
submission deadline 30 Sep 2026 | Viewed by 295 | Submission Open
Keywords: metabolic syndrome; diabetes mellitus; genetic variants; epigenetics; insulin resistance; obesity; dyslipidemia; inflammation; oxidative stress; mitochondrial dysfunction; non-coding RNAs; transcriptomics; proteomics
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
State-of-the-Art Molecular Plant Sciences in Thailand
edited by
submission deadline 30 Sep 2026 | Viewed by 293 | Submission Open
Keywords: molecular plant sciences; plant biotechnology; functional genomics; molecular breeding; plant stress responses; omics technologies; plant–microbe interactions; sustainable agriculture; crop improvement
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Targeting in Neuroinflammation: Uncovering Mechanisms, Pharmacological Targets and Neuropharmaceutical Developments
edited by
submission deadline 30 Sep 2026 | Viewed by 279 | Submission Open
Keywords: neuroinflammation; neurodegenerative disorders; neuro-immune crosstalk; glial cells; neuroprotective/anti-inflammatory agents; therapeutic strategies; pharmacological treatments
(This special issue belongs to the Section Molecular Neurobiology)
Multiscale Toxicology: From Cell Models to Whole Organisms submission deadline 30 Sep 2026 | Viewed by 274 | Submission Open
Keywords: toxicology; ecotoxicology; environmental risk assessment; multiscale toxicology; emerging contaminants; sentinel species; omics; mixture toxicity
(This special issue belongs to the Section Molecular Toxicology)
Enhancing Plant Traits Through In Vitro Culture
edited by Jacek Gawroński
submission deadline 30 Sep 2026 | Viewed by 273 | Submission Open
Keywords: plant tissue culture; somatic embryogenesis; organogenesis; micropropagation; callus culture; in vitro regeneration; in vitro mutagenesis; haploid and doubled haploid production; molecular markers; genetic analysis; genomics; transcriptomics; epigenetic regulation; proteomic profiling; molecular mechanisms; gene expression analysis
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Mechanisms Underlying Genetic Variants of Parkinson’s Disease
edited by Michael Schlossmacher and
submission deadline 30 Sep 2026 | Viewed by 271 | Submission Open
Keywords: DNA; PD prevention; genetic variants of Parkinson's disease
(This special issue belongs to the Section Molecular Neurobiology)
Research on Drug Delivery in Health and Disease submission deadline 30 Sep 2026 | Viewed by 268 | Submission Open
Keywords: precision medicine; nanomedicine; targeted delivery; biomarkers; personalized therapy; adaptive systems; AI-driven drug delivery
(This special issue belongs to the Section Molecular Pharmacology)
Molecular Insights into Animal Nutrition: Oxidative Stress, Polyphenols and Functional Feed Materials submission deadline 30 Sep 2026 | Viewed by 266 | Submission Open
Keywords: animal nutrition; oxidative stress; reactive oxygen species; polyphenols; feed materials; molecular nutrition; antioxidant defense; animal physiology; nutritional toxicology
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Genomics Research on Plant Stress Resistance
edited by
submission deadline 30 Sep 2026 | Viewed by 266 | Submission Open
Keywords: stress-responsive genes; muti-omics; stress memory / priming; tolerance mechanisms
(This special issue belongs to the Section Molecular Genetics and Genomics)
Next-Generation Sequencing in Cancer: Genomics, Diagnostics and Therapeutics
edited by Adam Szpechciński and Magdalena Pelc
submission deadline 30 Sep 2026 | 1 articles | Viewed by 266 | Submission Open
Keywords: next-generation sequencing (massively parallel sequencing); whole-genome sequencing (WGS); whole-exome sequencing (WES); RNA sequencing (RNA-seq); single-cell sequencing (SCS); germline and somatic mutations; gene rearrangements (fusions); epigenetics; molecular diagnostics; bioinformatics
(This special issue belongs to the Section Molecular Genetics and Genomics)
Interactions Between Rhizosphere Microbiota and Plants
edited by
submission deadline 30 Sep 2026 | Viewed by 266 | Submission Open
Keywords: microbiome and mycobiome of soil and plant rhizosphere; endorhizosphere; next-generation sequencing; soil and plant biodiversity
(This special issue belongs to the Section Molecular Plant Sciences)
From Soil to Gut: Molecular Mechanisms of Microbial Remediation for Planetary and Human Health
edited by , Hao Zhou and
submission deadline 30 Sep 2026 | Viewed by 264 | Submission Open
Keywords: microbiome restoration; biotherapeutic agents; in vivo/vitro detoxification; dysbiosis rescue; synthetic consortia; host-microbe interactions; bioremediation; ecohealth
(This special issue belongs to the Section Molecular Microbiology)
Molecular Research into the Applications of Metabolites from Marine Organisms
edited by Carlos García
submission deadline 30 Sep 2026 | Viewed by 264 | Submission Open
Keywords: quantitative analysis; secondary metabolites; bioactive; disease; molecular insight; natural compounds
(This special issue belongs to the Section Biochemistry)
Immunological Mechanisms Against Human Fungal Pathogens submission deadline 30 Sep 2026 | Viewed by 262 | Submission Open
Keywords: fungal drug resistance; thermally dimorphic fungus; host–pathogen interaction; structural biology of host–pathogen interfaces; immune evasion or immune escape; monoclonal antibodies or therapeutic antibodies; structural antibodies; X-ray crystallography and cryo-electron microscopy (Cryo-EM); molecular docking or molecular dynamics simulations; extracellular vesicles; damage response framework
(This special issue belongs to the Section Molecular Immunology)
Molecular Studies of Antibacterial Materials submission deadline 30 Sep 2026 | Viewed by 262 | Submission Open
Keywords: antibacterial materials; molecular mechanisms; antimicrobial resistance; antimicrobial nanomaterials; antimicrobial polymers; microbial adhesion; microbial biofilms; biofilm inhibition; reactive oxygen species (ROS); antimicrobial coatings; bacterial membrane disruption; controlled ion release; biocompatibility and cytotoxicity assessment
(This special issue belongs to the Section Materials Science)
Advances in Xenobiotic Toxicity: From Transcriptional Regulation to Reproductive and Behavioural Impacts
edited by Sylwia Swigonska
submission deadline 30 Sep 2026 | Viewed by 261 | Submission Open
Keywords: xenobiotic interactions; molecular mechanisms of toxicity; reproductive toxicology; early biomarkers; emerging contaminants; neurobehavioral toxicity; microbiota–xenobiotic interactions; biomolecular responses; environmental health; molecular toxicology
(This special issue belongs to the Section Molecular Toxicology)
Trends in Allergy and Autoimmunity: Pathogenesis, Biomarkers, and Treatment (Second Edition)
edited by
submission deadline 30 Sep 2026 | Viewed by 261 | Submission Open
Keywords: allergy; autoimmunity; autoimmune diseases; asthma; allergic rhinitis; urticaria; inflammation in allergic and autoimmune diseases; molecular pathway involved in allergic and autoimmune diseases; biomarkers of allergic and autoimmune diseases; target therapy
(This special issue belongs to the Section Molecular Immunology)
Molecular Basis of Rare Diseases and Functional Variant Interpretation
edited by
submission deadline 30 Sep 2026 | Viewed by 260 | Submission Open
Keywords: rare diseases; functional variant interpretation; variants of uncertain significance; molecular pathogenesis; functional assays; genotype–phenotype correlation; multiomics; clinical genetics
(This special issue belongs to the Section Molecular Genetics and Genomics)
DNA Damage, DNA Repair, and Cancer, 3rd Edition
edited by
submission deadline 30 Sep 2026 | Viewed by 256 | Submission Open
Keywords: DNA-damage response; DNA repair molecules; genome instability; cellular senescence; animal models; DNA damage; DNA repair and cancer
(This special issue belongs to the Section Molecular Oncology)
Molecular Mechanisms of Endocrine-Disrupting Chemicals in Reproductive Toxicity submission deadline 30 Sep 2026 | Viewed by 256 | Submission Open
Keywords: endocrine-disrupting chemicals (EDCs); reproductive toxicity; steroidogenesis; molecular mechanisms; intracellular signaling; hormone receptors; reproductive health
(This special issue belongs to the Section Molecular Toxicology)
Molecular Mechanisms and Treatments in Respiratory Diseases
edited by
submission deadline 30 Sep 2026 | Viewed by 253 | Submission Open
Keywords: respiratory diseases; molecular mechanisms; airway inflammation; airway hyperresponsiveness; epithelial barrier function; cytokines and signaling pathways; tissue remodeling and fibrosis; ion channels and transporters; targeted therapy; translational research
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Cellular and Molecular Mechanisms of Plaque Development and Progression submission deadline 30 Sep 2026 | Viewed by 252 | Submission Open
Keywords: atherosclerosis; atherosclerotic plaque; endothelial dysfunction; vascular inflammation; macrophage polarization; smooth muscle cell phenotypic switching; lipid metabolism; oxidative stress; extracellular vesicles; epigenetic regulation; immune–vascular interactions; plaque instability
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Non-Coding RNAs as Key Players in Cancer Biology and Clinical Translation submission deadline 30 Sep 2026 | Viewed by 252 | Submission Open
Keywords: non-coding RNAs; microRNAs; long non-coding RNAs; circular RNAs; RNA-based therapeutics; RNA delivery; systems; liquid biopsy; predictive biomarkers; drug resistance; clinical translation
(This special issue belongs to the Section Molecular Oncology)
Advances in Genetics of Human Reproduction—2nd Edition submission deadline 30 Sep 2026 | Viewed by 250 | Submission Open
Keywords: genetic; human reproduction; infertility; medically assisted reproduction; pregnancy complications; recurrent miscarriage
(This special issue belongs to the Section Molecular Genetics and Genomics)
Plant–Microbe Interactions: The Battle for Plant Infection and Prevention submission deadline 30 Sep 2026 | Viewed by 248 | Submission Open
Keywords: plant–microbe interactions; plant immunity; pathogen virulence; microbiome; biological control; trichoderma; arbuscular mycorrhizal fungi; omics technologies; RNA-based disease control; genome editing; sustainable agriculture; plant protection; microbial ecology; systems biology
(This special issue belongs to the Section Molecular Plant Sciences)
Therapeutic Potential of Bioactives in Wound Healing
edited by
submission deadline 30 Sep 2026 | Viewed by 246 | Submission Open
Keywords: wound healing; bioactive compounds; tissue regeneration; natural products; molecular mechanisms; inflammation; oxidative stress; angiogenesis; cell signaling; drug delivery systems
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Ion and Molecular Transport in Nanopores/Channels
edited by Haiqi Gao
submission deadline 30 Sep 2026 | Viewed by 240 | Submission Open
Keywords: gas separation; desalination; ion separation; COF; nanoporous graphene; first-principle calculation; molecular dynamics simulation; machine learning
(This special issue belongs to the Section Materials Science)
AI-Driven Molecular Discovery and Design for Energy Materials and Applications
edited by Ruijie Zhu
submission deadline 30 Sep 2026 | Viewed by 235 | Submission Open
Keywords: artificial intelligence; machine learning; energy materials; batteries; fuel cells; solar cells; energy storage; computational chemistry; materials design
(This special issue belongs to the Section Molecular Informatics)
Genetics and Molecular Therapies in Common Age-Related and Inherited Retinal Diseases
edited by
submission deadline 30 Sep 2026 | Viewed by 234 | Submission Open
Keywords: inherited retinal diseases; molecular diagnosis; age-related retinal degeneration; genotype–phenotype correlations; gene and cell therapies; early biomarkers of retinal disease; AI‑driven analytics
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Advances in Human Leukocyte Antigen (HLA)
edited by Inaki Alvarez
submission deadline 30 Sep 2026 | Viewed by 234 | Submission Open
Keywords: HLA; immunopeptidome; antigen presentation; antigen processing; mass spectrometry
(This special issue belongs to the Section Molecular Immunology)
Cardiac Protein Metabolism in Health and Diseases submission deadline 30 Sep 2026 | Viewed by 231 | Submission Open
Keywords: cardiac proteostasis; translational regulation; protein synthesis; ubiquitin–proteasome system; autophagy; cardiac remodeling; cardiomyopathy; RNA biology; protein quality control
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Activation and Suppression of Plant Immunity submission deadline 30 Sep 2026 | Viewed by 230 | Submission Open
Keywords: plant immunity; plant–pathogen interactions; effector biology; resistance mechanisms; signaling pathways; crop protection; sustainable agriculture
(This special issue belongs to the Section Molecular Plant Sciences)
Fungi: From Molecular Biology to Biotechnology Applications submission deadline 30 Sep 2026 | Viewed by 229 | Submission Open
Keywords: fungi; fungal secondary metabolome; fungal bioactive compounds; edible and medicinal fungi; nutraceuticals; functional foods; fungal biotechnology; metabolomics; fungal natural products; fungal metabolism
(This special issue belongs to the Section Molecular Microbiology)
Neuroimmune Interactions: From Physiology to Pathology
edited by
submission deadline 30 Sep 2026 | Viewed by 227 | Submission Open
Keywords: neuroimmune interactions; metabolic and mitochondria reprogramming; sensory neurons; neurodegeneration; neuropathic and nociplastic pain; neuroinflammation cancer neuroimmunology glial cells
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Insights and Innovative Materials in Prosthodontics and Oral Implantology
edited by Ángel-Orión Salgado-Peralvo
submission deadline 30 Sep 2026 | Viewed by 225 | Submission Open
Keywords: dental implants; dental prosthesis, implant-supported; osseointegration; dental implantation; bone regeneration
(This special issue belongs to the Section Materials Science)
Metabolic Reprogramming in Cancer: Non-Coding RNAs as Regulators and Biomarkers submission deadline 30 Sep 2026 | Viewed by 224 | Submission Open
Keywords: metabolic enzymes; circulating biomarkers; non-coding RNAs; circulating free DNA; liquid biopsy; metabolic reprogramming; artificial intelligence; biomarker discovery; precision medicine
(This special issue belongs to the Section Molecular Biology)
Molecular Mechanisms of Plant Stress Responses: Adaptation and Resilience submission deadline 30 Sep 2026 | Viewed by 224 | Submission Open
Keywords: abiotic stress; phytohormones; molecular breeding; gene expression; osmotic and oxidative stress
(This special issue belongs to the Section Molecular Plant Sciences)
Gut Microbiome in Health and Disease: New Targets for Diagnosis, Prognosis, and Therapy submission deadline 30 Sep 2026 | Viewed by 219 | Submission Open
Keywords: microbiome; microbiomics; dysbiosis; probiotic; microbiome-based intervention; biomarker; nutrition; chronic disease; infection; inflammation
(This special issue belongs to the Section Molecular Microbiology)
Neurochemical and Biochemical Mechanisms of Depressive Disorders
edited by Ana B. Ramos-Hryb and Mauricio Peña Cunha
submission deadline 30 Sep 2026 | Viewed by 218 | Submission Open
Keywords: neurochemical signaling; molecular psychiatry; biochemical biomarkers; synaptic plasticity; neuroinflammation; oxidative stress; glutamatergic system; proteomics and metabolomics; signal transduction; neuroendocrine
(This special issue belongs to the Section Molecular Neurobiology)
Emerging Pharmacological Targets and Therapeutic Strategies in Diabetes and Obesity
edited by Roma Patel
submission deadline 30 Sep 2026 | Viewed by 218 | Submission Open
Keywords: diabetes; obesity; molecular pharmacology; therapeutic targets; insulin resistance; β-cell dysfunction; metabolic signaling pathways; adipose tissue biology; drug–target interactions
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Molecular Insights Into the Toxicology of Heavy Metals
edited by
submission deadline 30 Sep 2026 | Viewed by 218 | Submission Open
Keywords: heavy metal toxicology; environmental exposure; gut microbiome; mitochondrial dysfunction
(This special issue belongs to the Section Molecular Toxicology)
Nuclear Receptor-Mediated Signal Transduction submission deadline 30 Sep 2026 | Viewed by 218 | Submission Open
Keywords: transcriptional regulation; non-genomic signalling; environmental signalling; endocrine disruption; nuclear receptor crosstalk; coregulators; modulators; evolution
(This special issue belongs to the Section Biochemistry)
Arterial Hypertension: Renal Mechanisms, Metabolic Drivers, and Organ-Protective Strategies
edited by Andrea Pio-Abreu
submission deadline 30 Sep 2026 | Viewed by 217 | Submission Open
Keywords: hypertension; arterial hypertension; renal sodium handling; renin–angiotensin–aldosterone system (RAAS); cardio–kidney–metabolic disorder; renal mechanism; SGLT2 inhibition
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Challenges and Innovation in Neurodegenerative Diseases, 3rd Edition
edited by
submission deadline 30 Sep 2026 | Viewed by 216 | Submission Open
Keywords: neurodegenerative diseases; pathogenesis; biomarkers; disease model; natural product; new drug discovery; therapy; machine learning; stem cell therapy
(This special issue belongs to the Section Molecular Neurobiology)
Genetic and Genomic Regulation for Plant Nematode Resistance submission deadline 30 Sep 2026 | Viewed by 214 | Submission Open
Keywords: functional genomics; transcriptomics; genetic regulation; phytopathology; molecular plant–microbe interactions; nematodes; genetic resistance; gene pyramiding/stacking; gene discovery; resistance mechanisms
(This special issue belongs to the Section Molecular Plant Sciences)
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