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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advances in Calcium Signaling: Physiological Roles and Implications for Disease

edited by

Adán Dagnino-Acosta

and

Luis Castro-Sánchez

submission deadline 31 Aug 2026 | Viewed by 325 | Submission Open

Keywords: calcium signaling; intracellular calcium; calcium homeostasis; calcium channels; muscle physiology; signal transduction; calcium-related diseases; mitochondrial calcium; genetic control of calcium signaling

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms in Cardiovascular and Metabolic Diseases: Effective and Potential Treatments

edited by

Alex Cleber Improta-Caria

submission deadline 31 Aug 2026 | Viewed by 316 | Submission Open

Keywords: molecular mechanisms; cardiovascular diseases; metabolic diseases; microRNAs; circRNAs; long non-coding RNAs; epigenetics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Neuropharmacology: From Molecular Design to Preclinical Models

edited by

Jana Tchekalarova

and Miroslav A. Rangelov

submission deadline 31 Aug 2026 | Viewed by 315 | Submission Open

Keywords: neuropharmacology; drug discovery; molecular modeling; preclinical models

(This special issue belongs to the Section Molecular Neurobiology)

Research on Host–Oral Bacteria Interactions in Periodontal Pathogenesis

edited by

Ana María Fernández Presas

submission deadline 31 Aug 2026 | Viewed by 313 | Submission Open

Keywords: periodontitis; Porphyromonas gingivalis; biofilms; cytokines; dysbiosis; quorum sensing; gingipains; alveolar bone therapeutics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

DNA Damage and Repair Mechanisms in Cancer Development

edited by

Mengfan Tang

submission deadline 31 Aug 2026 | Viewed by 300 | Submission Open

Keywords: DNA damage response and repair; DNA replication; genome instability; drug resistance; targeted therapy; cellular senescence; innate immunity; nucleic acid homeostasis

(This special issue belongs to the Section Molecular Oncology)

Molecular Advances in Schwannomas: So-Called Benign Nervous System Tumors

edited by Sheila Mansouri

submission deadline 31 Aug 2026 | Viewed by 297 | Submission Open

Keywords: schwannoma; omics technology; liquid biopsy; tumour imaging; artificial intelligence; cell biology; tumour microenvironment; model organisms; organoids

(This special issue belongs to the Section Molecular Oncology)

Contemporary Advancement in Personalized Medicine in Urological Cancers

edited by

Elenko Popov

submission deadline 31 Aug 2026 | Viewed by 294 | Submission Open

Keywords: urological cancers; prostate cancer; bladder cancer; renal/kidney cancer; personalized medicine

(This special issue belongs to the Section Molecular Oncology)

Mycobacterial Infections: Redox Modulation, Cytokine Reprogramming, and Host-Directed Therapy

edited by

Vishwanath Venketaraman

submission deadline 31 Aug 2026 | Viewed by 284 | Submission Open

Keywords: TB; NTM; redox imbalance; cytokine reprogramming; host-directed thera

(This special issue belongs to the Section Molecular Microbiology)

Molecular Research in Bamboo, Tree, Grass, and Other Forest Products—2nd Edition

edited by

Huayu Sun

submission deadline 31 Aug 2026 | Viewed by 275 | Submission Open

Keywords: bamboo; tree; grass; molecular biology; gene function

(This special issue belongs to the Section Molecular Plant Sciences)

Tissue Regeneration Mechanisms and Applications in Degenerative and Inflammatory Diseases

edited by

Daiva Bironaite

submission deadline 31 Aug 2026 | Viewed by 272 | Submission Open

Keywords: regenerative medicine; stem cells; inflammation; degenerative disease models; extracellular matrix remodeling and intracellular signaling; tissue engineering; biomaterials and bioactive scaffolds; organoids; translational and cell-based therapies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Bacteriophages in the One Health Perspective: From Infection Therapy to Precision Medicine Through Diagnostics

edited by

Alicja Wegrzyn

submission deadline 31 Aug 2026 | Viewed by 270 | Submission Open

Keywords: bacteriophages; one health concept; bacteriophage therapy

(This special issue belongs to the Section Molecular Microbiology)

Innovative Advances in Cancer Therapy Through Nano-Based Systems

edited by

Lenuţa-Maria Şuta

and

Claudia Geanina Watz

submission deadline 31 Aug 2026 | Viewed by 259 | Submission Open

Keywords: nano-enabled delivery systems; innovative nanomaterials; smart nanocarriers; cancer nanotherapy; anti-tumorigenic activity

(This special issue belongs to the Section Molecular Nanoscience)

Current Advances and Challenges in Nanomedicine Delivery Systems

edited by

Shiyan Dong

submission deadline 31 Aug 2026 | Viewed by 257 | Submission Open

Keywords: nanomedicine; drug delivery; gene delivery; mRNA delivery; lipid nanoparticles (LNPs); liposomes; extracellular vesicles; biomimetic nanocarriers; targeted delivery; translational nanomedicine

(This special issue belongs to the Section Molecular Nanoscience)

Nanocarrier-Based Drug Delivery Systems: Design, Synthesis and Therapeutic Applications

edited by

Stefania Crispi

and

Carla Serri

submission deadline 31 Aug 2026 | Viewed by 250 | Submission Open

Keywords: nanoparticles; nanomedicine; nanotoxicology; cytotoxicity; oxidative stress; cancer; neurodegenerative disorders; inflammation

(This special issue belongs to the Section Molecular Nanoscience)

Multi-Omics Perspectives on Psychiatric Disorders: From Molecular Mechanisms to Clinical Translation

edited by Veronica Sfredel and Madalina Iuliana Mușat

submission deadline 31 Aug 2026 | Viewed by 247 | Submission Open

Keywords: molecular psychiatry; psychiatric multi-omics; neurobiological pathways; psychiatric biomarkers; gene–environment interactions; translational psychiatry; computational psychiatry

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Studies of Endothelial Dysfunction

edited by Alexandru Emil Caraba

submission deadline 31 Aug 2026 | Viewed by 246 | Submission Open

Keywords: atherosclerosis; cardiovascular diseases; chronic kidney disease; endothelial dysfunction; inflammation; inflammatory rheumatic diseases; metabolic syndrome; nailfold capillaroscopy; nitric oxide

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Exhaustive Chase: Investigation of Striated Muscle Regulation in Health and Disease

edited by P. Bryant Chase,

Maicon Landim-Vieira

and Michael Butcher

submission deadline 31 Aug 2026 | Viewed by 243 | Submission Open

Keywords: striated muscle contractility; thin filament regulation; calcium activation; cardiomyopathy; muscle energetics; muscle fiber mechanics; single fiber mechanics; muscle plasticity; muscle functional adaptation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Determinants of Response and Resistance in Cancer Immunotherapy

edited by

Pamela Salman

submission deadline 31 Aug 2026 | Viewed by 243 | Submission Open

Keywords: immune checkpoint inhibitors; adoptive cell therapies; cancer vaccines; tumor microenvironment remodeling; neoantigen dynamics; biomarker discovery; translational approaches to overcome therapeutic resistance

(This special issue belongs to the Section Molecular Oncology)

Research in Nutritional Physiology and Gut Microbiome

edited by

Haiqiang Yao

submission deadline 31 Aug 2026 | 1 articles | Viewed by 242 | Submission Open

Keywords: nutritional physiology; gut microbiome; microbial metabolites; nutrient sensing; metabolic homeostasis; gut–brain axis; prebiotics; probiotics; molecular nutrition

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Transition Metal Complexes: Recent Advances and Future Perspectives

edited by

Leszek Pazderski

submission deadline 31 Aug 2026 | Viewed by 241 | Submission Open

Keywords: transition metal complexes; crystal and molecular structure; spectroscopic properties; magnetic properties; biological activity; pharmacological application; catalysis

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

DNA Damage, Immune Signaling and Beyond

edited by

Sharbel Weidner Maluf

submission deadline 31 Aug 2026 | Viewed by 240 | Submission Open

Keywords: DNA damage response; immune signaling; genomic instability; cellular senescence; chronic inflammation; cancer and aging

(This special issue belongs to the Section Molecular Immunology)

Recent Advances in Pathophysiology and Immunology Related to Lung Cancer

edited by

Vito D’Agnano

and Luigi Della Gravara

submission deadline 31 Aug 2026 | Viewed by 233 | Submission Open

Keywords: lung cancer; NSCLC; SCLC; tumor immunology; immune checkpoints inhibitors; targeted therapy; epithelial–immune crosstalk; precision oncology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Histamine Receptors: Biology, Pharmacology, and Therapeutic Potential

edited by

Joachim Neumann

submission deadline 31 Aug 2026 | Viewed by 225 | Submission Open

Keywords: histamine; histamine receptor agonist; histamine receptor antagonist; signal transduction; polymorphisms

(This special issue belongs to the Section Molecular Biology)

Molecular Research on Insect-Symbiont Interactions

edited by Chen Luo

submission deadline 31 Aug 2026 | Viewed by 225 | Submission Open

Keywords: insect; endosymbiont; phenotypic effects; molecular mechanisms; immunity; resistance

(This special issue belongs to the Section Molecular Plant Sciences)

Design, Synthesis and Evaluation of Anticancer Agents

edited by

Gourav Kumar

submission deadline 31 Aug 2026 | Viewed by 223 | Submission Open

Keywords: anticancer drug design; structure–activity relationship (SAR); molecular targets in cancer; synthetic antitumor agents; in vitro and ex vivo cancer models; molecular pharmacology

(This special issue belongs to the Section Molecular Pharmacology)

Photoreceptors and the Optic Nerve

edited by Ruth Estela Rosenstein and Damian Dorfman

submission deadline 31 Aug 2026 | Viewed by 222 | Submission Open

Keywords: photoreceptors; optic nerve; neurodegeneration; neuroprotection; experimental models; retina

(This special issue belongs to the Section Molecular Neurobiology)

Advances in Allergen Prediction, Characterization, and Immunoinformatics

edited by

Katarina Smiljanić

submission deadline 31 Aug 2026 | Viewed by 209 | Submission Open

Keywords: allergen prediction; allergen characterization; proteomics; immunoinformatics; environmental allergens; food allergens; IgE epitopes; molecular docking; machine learning; mass spectrometry

(This special issue belongs to the Section Molecular Immunology)

Molecular Advances in Endocannabinoid Research

edited by Elisabetta Murru

submission deadline 31 Aug 2026 | Viewed by 201 | Submission Open

Keywords: endocannabinoid system; N-acylethanolamine (NAE); CB1 and CB2 receptors; lipid mediators; nutrition; dietary fatty acids; energy metabolism; metabolic homeostasis; neuroinflammation

(This special issue belongs to the Section Biochemistry)

Mechanistics Insights in Antidepressants: Charting New Pathways for Future Research

edited by Lucía Martínez-Mota

submission deadline 31 Aug 2026 | Viewed by 201 | Submission Open

Keywords: antidepressants; neuroplasticity; neurogenesis; neuronal excitability; treatment-resistant depression; major depression disorder

(This special issue belongs to the Section Molecular Pharmacology)

Glaucoma: From Molecular Mechanisms to Innovative Therapeutics

edited by Da-Wen Lu

submission deadline 31 Aug 2026 | Viewed by 199 | Submission Open

Keywords: neuroprotection; reinal ganglion cell; therapeutic strategies; Rho kinase inhibitor; molecular research

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Deciphering the Cellular Antiviral and Anti-Inflammatory Signalling Orchestrated by Plant-Derived Bioactives

edited by

Maria Teresa Sciortino

submission deadline 31 Aug 2026 | Viewed by 196 | Submission Open

Keywords: immunological aspects of herpesvirus infections; role of PCD in pathogenesis of viral infections; functional studies of UL49 and UL41 structural proteins during HSV replication; involvement of ERK1 pathway in the modu-lation of CCR5 receptor; studies of cyclodextrin carriers as drug or nucleic acid delivery systems for cancer therapy; imaging for antiviral treatment

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Human Papillomavirus and Cellular Pathway: Hits and Targets

edited by Elisa S. Gallo

submission deadline 31 Aug 2026 | Viewed by 193 | Submission Open

Keywords: human papillomavirus (HPV); squamous cell carcinoma (SCC); oncogenic HPV; HPV-induced SCC; skin cancer

(This special issue belongs to the Section Molecular Microbiology)

Molecular Mechanisms Underlying the Pathogenesis of Genetic Diseases

edited by

Debora Baroni

submission deadline 10 Sep 2026 | 7 articles | Viewed by 11353 | Submission Open

Keywords: genetic diseases; genotype–phenotype correlations; multi-omics approaches; current and investigational therapeutical approaches; personalized medicine

(This special issue belongs to the Section Molecular Genetics and Genomics)

Cellular and Molecular Progression of Cardiovascular Diseases: 2nd Edition

edited by

Andrea Borghini

Antonio Rizza

and

Alessandro Tonacci

submission deadline 10 Sep 2026 | 5 articles | Viewed by 4186 | Submission Open

Keywords: cardiovascular diseases; multi-omics data; biomarkers; molecular level

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Exercise in Health and Diseases: From the Molecular Perspectives

edited by

Nathalia Bernardes

and Danielle Dias

submission deadline 10 Sep 2026 | 4 articles | Viewed by 3441 | Submission Open

Keywords: exercise physiology; molecular mechanisms of exercise; exercise-induced cellular signaling; metabolic signaling pathways; redox biology and exercise

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Properties and Applications of Nanoparticles and Nanomaterials: 4th Edition

edited by Xiaogang Li

submission deadline 10 Sep 2026 | 1 articles | Viewed by 1030 | Submission Open

Keywords: nanostructures; nanoparticles; microstructure characterization; material design; evaluation of mechanical properties; applications of nanomaterials

(This special issue belongs to the Section Molecular Nanoscience)

Molecular and Cellular Advances in Coagulation and Bleeding

edited by

Muriel Meiring

submission deadline 10 Sep 2026 | 1 articles | Viewed by 950 | Submission Open

Keywords: thrombosis; haemostasis; inflammation-coagulation cross ralk; proteomics; molecular biomarkers

(This special issue belongs to the Section Molecular Biology)

Nanomaterials for Targeted Therapy and Drug Delivery

edited by Ceren Kimna

submission deadline 10 Sep 2026 | Viewed by 322 | Submission Open

Keywords: nanocarriers ; targeted therapies ; translational nanomedicine ; nano-bio interactions

(This special issue belongs to the Section Molecular Nanoscience)

Pain: From Bench to Bedside

edited by

Christopher Robinson

and Robert J. Yong

submission deadline 20 Sep 2026 | 1 articles | Viewed by 55755 | Submission Open

Keywords: CGRP pathway; chronic pain; drug discovery; ion channels; machine learning; molecular targets; neuroimmune signaling; non-opioid analgesics; translational pain research; Afrikaans; Albanian; Amharic; Arabic; Armenian; Azerbaijani; Bengali; Bulgarian; Catalan; Croatian; Czech; Danish; Dutch; English; Estonian; Finnish; French; German; Greek; Gujarati; Haitian Creole; Hebrew; Hindi; Hungarian; Icelandic; Indonesian; Italian; Japanese; Kannada; Kazakh; Khmer; Korean; Kurdish (Kurmanji); Lao; Latvian; Lithuanian; Malagasy; Malay; Malayalam; Maltese; Maori; Marathi; Myanmar (Burmese); Nepali; Norwegian; Pashto; Persian; Polish; Portuguese; Punjabi; Romanian; Russian; Samoan; Simplified Chinese; Slovak; Slovenian; Spanish; Swedish; Tamil; Telugu; Thai; Traditional Chinese; Turkish; Ukrainian; Urdu; Vietnamese; Welsh

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Autoimmune Diseases: From Pathogenesis to Treatment and Prognostic Markers

edited by Alessandra Bettiol

submission deadline 20 Sep 2026 | 13 articles | Viewed by 43344 | Submission Open

Keywords: autoimmune diseases; inflammation; immunity; pathogenesis; immunosuppressants; biologics; biomarkers

(This special issue belongs to the Section Molecular Immunology)

Drug Delivery to the Central Nervous System: From Design, Synthesis, and Evaluation

edited by

Masaru Tanaka

submission deadline 20 Sep 2026 | 6 articles | Viewed by 39553 | Submission Open

Keywords: central nervous system; central nervous system diseases; drug delivery systems; blood–brain barrier; blood–cerebrospinal fluid barrier; drug design; nanomedicine; neuropharmacology; neuroprotective agents; biomarkers

(This special issue belongs to the Section Molecular Neurobiology)

Plant Metabolomics: Uncovering the Hidden World of Plant Secondary Metabolites

edited by

Jen-Tsung Chen

submission deadline 20 Sep 2026 | 13 articles | Viewed by 32825 | Submission Open

Keywords: metabolomics; secondary metabolites; plant biochemistry; mass spectrometry; NMR spectroscopy; plant signaling pathways; natural products; chemical ecology; metabolic profiling; phytochemicals; medicinal plants; herbal medicines

(This special issue belongs to the Section Molecular Plant Sciences)

New Insights in Antibody Therapy

edited by

Loredana Frasca

submission deadline 20 Sep 2026 | 4 articles | Viewed by 20099 | Submission Open

Keywords: biological therapy; antibody therapy; non-communicable diseases; infectious diseases; chronic disease

(This special issue belongs to the Section Molecular Immunology)

Type 2 Diabetes: Molecular Pathophysiology and Treatment

edited by

Edit Szabó

submission deadline 20 Sep 2026 | 7 articles | Viewed by 18863 | Submission Open

Keywords: type 2 diabetes mellitus and comorbidity; bioinformatics; molecular pathways; genetic background; biomarkers; novel therapies

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Renin-Angiotensin System in Health and Diseases

edited by

Keiko Hosohata

submission deadline 20 Sep 2026 | 3 articles | Viewed by 17072 | Submission Open

Keywords: coronavirus disease 2019 (COVID-19); SARS-CoV-2; RAAS; spike protein; angiotensin; ACE2; clinical study; basic experiments

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Understanding Aging in Health and Disease

edited by

Laura Cianfruglia

submission deadline 20 Sep 2026 | 5 articles | Viewed by 16476 | Submission Open

Keywords: immunosenescence; age-related disease; ageing; oxidative stress; inflammaging

(This special issue belongs to the Section Molecular Biology)

Advances in Burn Wound Healing and Skin Regeneration: Innovations and Insights

edited by

H. Ibrahim Korkmaz

submission deadline 20 Sep 2026 | 2 articles | Viewed by 15832 | Submission Open

Keywords: burn wound healing; skin regeneration; novel biomaterials; wound dressings; regenerative therapies

(This special issue belongs to the Section Biochemistry)

Neurological Diseases: From Pathogenesis to Molecular Diagnosis and Treatment

edited by

Barbara Miziak

and

Stanisław Jerzy Czuczwar

submission deadline 20 Sep 2026 | 13 articles | Viewed by 15617 | Submission Open

Keywords: Alzheimer's disease; Parkinson's disease; Huntington's disease; epilepsy; stroke; neurological diseases; treatment of neurological diseases

(This special issue belongs to the Section Molecular Neurobiology)

25th Anniversary of IJMS: Advances in Physical Chemistry and Chemical Physics

edited by

Mihai V. Putz

Hyotcherl Ihee

and

Carlos Miguel Costa

submission deadline 20 Sep 2026 | 15 articles | Viewed by 15021 | Submission Open

Keywords: molecular dynamics; quantum chemistry; spectroscopic techniques; supramolecular interactions; computational modeling; AI in chemistry

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Molecular Research of Dystonia and Parkinson’s Disease

edited by

Ryoma Morigaki

submission deadline 20 Sep 2026 | 4 articles | Viewed by 14549 | Submission Open

Keywords: dystonia; Parkinson’s disease; molecular mechanism; molecular pathology; cell biology; genetic predisposition to disease; physiopathology; neural plasticity; animal models; biomedical translational science

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Displaying special issue 301-350 on page 7 of 64.

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