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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Obesity and Cancer: Molecular, Cellular and Systemic Mechanisms Underlying Tumor Initiation, Progression and Prognosis

edited by

María Herranz-López

and

María Losada Echeberría

submission deadline 31 Mar 2027 | Viewed by 310 | Submission Open

Keywords: obesity; cancer metabolism; tumor microenvironment; adipose tissue; adipokines; inflammation; insulin resistance; metabolic reprogramming

(This special issue belongs to the Section Molecular Oncology)

Molecular and Cellular Mechanisms Underlying Chronic Pain

edited by Patrícia Rodrigues

submission deadline 31 Mar 2027 | Viewed by 309 | Submission Open

Keywords: chronic pain; neuroinflammation; oxidative stress; ion channels; GPCR channels; nociception; peripheral sensitization; central sensitization; pain biomarkers; molecular signaling

(This special issue belongs to the Section Molecular Neurobiology)

Oxidative Stress and the Kidney: From Physiological Homeostasis to Pathophysiology and Nutraceutical Interventions

edited by

Daniele La Russa

and

Daniela Pellegrino

submission deadline 31 Mar 2027 | Viewed by 307 | Submission Open

Keywords: oxidative stress; nutraceuticals; CVD risk; CKD; antioxidant

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Effects and Applications of Nanoparticles in Plant Physiology

edited by

Fan Zhang

submission deadline 31 Mar 2027 | Viewed by 303 | Submission Open

Keywords: nano-enabled agriculture; nanotoxicology; molecular mechanisms; nanosafety; micro/nanoparticle stresses; combined risk

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Targeting in Neuroinflammation: Uncovering Mechanisms, Pharmacological Targets and Neuropharmaceutical Developments

edited by

Nataša Mitrović

submission deadline 31 Mar 2027 | Viewed by 300 | Submission Open

Keywords: neuroinflammation; neurodegenerative disorders; neuro-immune crosstalk; glial cells; neuroprotective/anti-inflammatory agents; therapeutic strategies; pharmacological treatments

(This special issue belongs to the Section Molecular Neurobiology)

Research in Cannabinoid Therapeutics: Novel Insights and Products

edited by

Daniela Sedan

and Dario Andrinolo

submission deadline 31 Mar 2027 | Viewed by 300 | Submission Open

Keywords: cannabinoids; acidic cannabinoids; entourage effect; full spectrum; endocannabinoid system; endocannabinoidome; endocannabinoids; endocannabinoid-like compounds; cannabis derivatives; endocannabinoidome receptors

(This special issue belongs to the Section Molecular Neurobiology)

Impact of Maternal Diet and Nutrition on Infant Neurodevelopment

edited by

Ana Sofia Vallés

submission deadline 31 Mar 2027 | Viewed by 294 | Submission Open

Keywords: nutrition; neurodevelopment; molecular mechanisms; epigenetics; neuroinflammation; metabolic programming; brain development; developmental origins of health and disease; pregnancy; maternal diet

(This special issue belongs to the Section Bioactives and Nutraceuticals)

State-of-the-Art Molecular Neurobiology in Malaysia

edited by

Mohamad Fairuz Yahaya

submission deadline 31 Mar 2027 | Viewed by 294 | Submission Open

Keywords: molecular neurobiology; traumatic brain injury; stroke; synaptic plasticity; biomarkers; neurotherapeutics; neurodegeneration; neuroinflammation; traumatic brain injury; stroke; synaptic plasticity; biomarkers; neurotherapeutics

(This special issue belongs to the Section Molecular Neurobiology)

Immunological Mechanisms Against Human Fungal Pathogens

edited by

Kritsada Pruksaphon

submission deadline 31 Mar 2027 | Viewed by 284 | Submission Open

Keywords: fungal drug resistance; thermally dimorphic fungus; host–pathogen interaction; structural biology of host–pathogen interfaces; immune evasion or immune escape; monoclonal antibodies or therapeutic antibodies; structural antibodies; X-ray crystallography and cryo-electron microscopy (Cryo-EM); molecular docking or molecular dynamics simulations; extracellular vesicles; damage response framework

(This special issue belongs to the Section Molecular Immunology)

Genomics Research on Plant Stress Resistance

edited by

Muhammad Waseem

submission deadline 31 Mar 2027 | Viewed by 284 | Submission Open

Keywords: stress-responsive genes; muti-omics; stress memory / priming; tolerance mechanisms

(This special issue belongs to the Section Molecular Genetics and Genomics)

Advances in Starch-Based Composite Systems

edited by

Angel H. Cabrera-Ramirez

submission deadline 31 Mar 2027 | Viewed by 281 | Submission Open

Keywords: starch-based composites; biopolymer materials; hydrogels and aerogels; controlled release systems; biodegradable packaging; nanocomposites; structure–property relationships; functional biomaterials; pharmaceutical excipients; sustainable materials

(This special issue belongs to the Section Macromolecules)

Advances in Structural, Dynamic, and Functional Biophysics of Membrane Proteins

edited by

F. Luis González Flecha

submission deadline 31 Mar 2027 | Viewed by 280 | Submission Open

Keywords: cryo-EM; x-ray crystallography and scattering; NMR spectroscopy; neutron scattering and reflectometry; single-molecule biophysics; molecular dynamics simulations; membrane protein dynamics; free energy analysis; mechanistic models of transport and signaling; membrane mimetics (nanodiscs, SMALPs, etc)

(This special issue belongs to the Section Molecular Biophysics)

From Natural Products to Synthetic Small-Molecule Antioxidants: Mechanistic and Kinetic Foundations for Drug Discovery

edited by Cvijeta Jakobušić Brala

submission deadline 31 Mar 2027 | Viewed by 275 | Submission Open

Keywords: oxidative stress; antioxidant mechanisms; reaction kinetics; natural products; small-molecule antioxidants; drug discovery

(This special issue belongs to the Section Molecular Pharmacology)

KCTD Proteins in Cellular Processes Regulation: Advances and Challenges

edited by

Giovanni Pecoraro

submission deadline 31 Mar 2027 | Viewed by 273 | Submission Open

Keywords: KCTD proteins; cancer biology; cell signaling pathway; ubiquitination; genetic disorder; protein–protein interaction; developmental biology; protein stability; gene expression; new therapeutic target

(This special issue belongs to the Section Molecular Biology)

Molecular and Cellular Mechanisms in the Pathophysiology of Gliomas

edited by

Sylvester Omoruyi

submission deadline 31 Mar 2027 | Viewed by 271 | Submission Open

Keywords: genetic and epigenetic alterations; cellular signalling pathways; tumour microenvironment; glioma stem cells; molecular targets and biomarkers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Nanocarrier-Based Drug Delivery Systems: Design, Synthesis and Therapeutic Applications

edited by

Stefania Crispi

and

Carla Serri

submission deadline 31 Mar 2027 | Viewed by 265 | Submission Open

Keywords: nanoparticles; nanomedicine; nanotoxicology; cytotoxicity; oxidative stress; cancer; neurodegenerative disorders; inflammation

(This special issue belongs to the Section Molecular Nanoscience)

Molecular Research on Viral Genetics

edited by

Gabriela Goujgoulova

submission deadline 31 Mar 2027 | Viewed by 261 | Submission Open

Keywords: viral genetics; molecular virology; viral genomics; viral evolution; virus–host interactions; viral replication; genetic diversity; emerging viruses; next-generation sequencing; antiviral resistance

(This special issue belongs to the Section Molecular Microbiology)

The Exhaustive Chase: Investigation of Striated Muscle Regulation in Health and Disease

edited by P. Bryant Chase,

Maicon Landim-Vieira

and Michael Butcher

submission deadline 31 Mar 2027 | Viewed by 248 | Submission Open

Keywords: striated muscle contractility; thin filament regulation; calcium activation; cardiomyopathy; muscle energetics; muscle fiber mechanics; single fiber mechanics; muscle plasticity; muscle functional adaptation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms of Plant Stress Responses: Adaptation and Resilience

edited by

Abdelali Boussakouran

submission deadline 31 Mar 2027 | Viewed by 247 | Submission Open

Keywords: abiotic stress; phytohormones; molecular breeding; gene expression; osmotic and oxidative stress

(This special issue belongs to the Section Molecular Plant Sciences)

The Effect of Vitamin D on COVID-19 Infection and Progression: An Update

edited by Fábio Falcao

submission deadline 31 Mar 2027 | Viewed by 238 | Submission Open

Keywords: vitamin D; COVID-19; SARS-CoV-2; long COVID; immune regulation; inflammation; nutritional inequality; global health; supplementation; precision medicine

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Latest Molecular Research on Solid Electrolytes

edited by

Wanping Chen

submission deadline 31 Mar 2027 | Viewed by 224 | Submission Open

Keywords: solid-state electrolytes; polymer electrolytes; ion transport mechanisms; electrolyte–electrode interfaces; molecular structure–property relationships; interfacial chemistry

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Molecular Interfaces in Animal Nutrition: From Gut Microbiomes and Transcriptomics to Sustainable Feed Strategies

edited by

Ali Mujtaba Shah

and Rui Hu

submission deadline 31 Mar 2027 | Viewed by 216 | Submission Open

Keywords: Nutrigenomics; Meta-genomics; Transcriptomics; Cattle production; Meat quality; Protein and lipid metabolism; Plant extracts; Agriculture waste in animal feed; Solid state fermentation; Mycotoxin; Waterfowl, chicken and ruminant nutrition; Yak health and nutrition; Heat stress

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Mechanistics Insights in Antidepressants: Charting New Pathways for Future Research

edited by Lucía Martínez-Mota

submission deadline 31 Mar 2027 | Viewed by 210 | Submission Open

Keywords: antidepressants; neuroplasticity; neurogenesis; neuronal excitability; treatment-resistant depression; major depression disorder

(This special issue belongs to the Section Molecular Pharmacology)

Human Papillomavirus and Cellular Pathway: Hits and Targets

edited by Elisa S. Gallo

submission deadline 31 Mar 2027 | Viewed by 202 | Submission Open

Keywords: human papillomavirus (HPV); squamous cell carcinoma (SCC); oncogenic HPV; HPV-induced SCC; skin cancer

(This special issue belongs to the Section Molecular Microbiology)

The Molecular Landscape of Gastroesophageal Cancer: Pathways to Novel Therapies

edited by

Ravindran Caspa Gokulan

submission deadline 31 Mar 2027 | Viewed by 202 | Submission Open

Keywords: targeted therapy; tumor microenvironment; chemoprevention; signaling pathways; oxidative stress and tumorigenesis

(This special issue belongs to the Section Molecular Oncology)

Molecular Biological Response Mechanisms of Agricultural Nanomaterials

edited by

Bingxu Cheng

submission deadline 31 Mar 2027 | Viewed by 193 | Submission Open

Keywords: agricultural nanomaterials; molecular biological response mechanisms; engineered nanomaterials; nano-agriculture; biosafety

(This special issue belongs to the Section Molecular Nanoscience)

Molecular Insights into Nanoparticles–Glioma Interactions for Diagnosis and Therapy

edited by Alelí Salazar

submission deadline 31 Mar 2027 | Viewed by 184 | Submission Open

Keywords: glioma; nano-therapy; nanoparticle–glioma interactions

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Bio-Based Corrosion Inhibitors: Approaches and Mechanisms

edited by Laila Afia

submission deadline 31 Mar 2027 | Viewed by 167 | Submission Open

Keywords: green corrosion inhibitors; phytochemical adsorption; scanning electron microscopy (SEM); X-ray photoelectron spectroscopy (XPS); electrochemical impedance spectroscopy (EIS); density functional theory (DFT); molecular dynamics (MD)

(This special issue belongs to the Section Materials Science)

Natural Bioactive Compounds in Cardiometabolic Diseases and Aging: Molecular Mechanisms and Advances in Delivery Strategies

edited by

Siew-Keah Lee

submission deadline 31 Mar 2027 | Viewed by 151 | Submission Open

Keywords: natural bioactive compounds; cardiometabolic diseases; aging and senescence; molecular mechanisms; oxidative stress; inflammation; mitochondrial dysfunction; signaling pathway; delivery strategies; bioavailability; nanomedicine; nanoformulation

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Nuclear Mechanotransduction and Envelope Dynamics in Cancer Progression

edited by Jaekyung Shim

submission deadline 31 Mar 2027 | Viewed by 150 | Submission Open

Keywords: nuclear envelope; nuclear mechanotransduction; nuclear mechanics; lamin A/C; LINC complex; nuclear pore complex; chromatin organization; genome regulation; nuclear stiffness; cell migration; cancer progression; metastasis; mechanobiology; epigenetic regulation; nuclear en-velope dynamics

(This special issue belongs to the Section Molecular Biology)

New Horizons in the Discovery of Antiviral and Antibacterial Agents

edited by

Livia G. A. V. Sa

submission deadline 31 Mar 2027 | Viewed by 141 | Submission Open

Keywords: antiviral agents; antibacterial agents; antimicrobial resistance; drug discovery; natural products; medicinal chemistry; nanotechnology; drug repurposing; molecular docking; anti-infective therapies

(This special issue belongs to the Section Molecular Pharmacology)

New Materials for Solar Batteries

edited by

Yuqian Yang

submission deadline 31 Mar 2027 | Viewed by 130 | Submission Open

Keywords: perovskite solar cells; interface engineering; self-assembled monolayers (SAMs); flexible photovoltaics; perovskite modules; charge transport; device stability; thin-film photovoltaics; optoelectronic materials; encapsulation; mechanical reliability

(This special issue belongs to the Section Materials Science)

Neuroprotective Potential of Natural Products: From Molecular Insights to Therapeutic Application

edited by

Yuh-Fung Chen

submission deadline 31 Mar 2027 | Viewed by 121 | Submission Open

Keywords: natural products; neuroprotection; molecular mechanisms; neuroinflammation; therapeutic applications

(This special issue belongs to the Section Molecular Neurobiology)

Glycosphingolipids and Gangliosides: New Perspectives in Immune Regulation, Neuronal Function, Inflammation, and Disease

edited by Jin-ichi Inokuchi and Kei-ichiro Inamori

submission deadline 31 Mar 2027 | Viewed by 103 | Submission Open

Keywords: glycosphingolipids; GSLs; gangliosides; cellular function; genetic deficiencies

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Research and Biomarkers in Systemic Sclerosis

edited by

Jakub Trefler

submission deadline 31 Mar 2027 | Viewed by 97 | Submission Open

Keywords: systemic sclerosis; biomarkers; autoimmunity; autoantibodies; fibrosis; cytokines; complement system proteins; interstitial lung diseases; pulmonary arterial hypertension; precision medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Bioactive Natural Products and Plant-Derived Molecules in Inflammation and Degenerative Diseases: Molecular Mechanisms and Therapeutic Potential

edited by

Valentina Vassallo

submission deadline 31 Mar 2027 | Viewed by 84 | Submission Open

Keywords: natural products; plant extracts; phytochemicals; bioactive compounds; inflammation; degenerative diseases; oxidative stress; molecular mechanisms; signal transduction; immunomodulation; tissue remodeling; translational medicine; therapeutic potential

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Insights into the Function and Evolution of Carnivorous Plants

edited by Takashi Ohyama and

Naoki Arai

submission deadline 31 Mar 2027 | Viewed by 82 | Submission Open

Keywords: carnivorous plants; plant molecular evolution; plant genomics; prey trapping mechanisms; gene expression and regulation; functional proteomics

(This special issue belongs to the Section Molecular Genetics and Genomics)

Targeting KRAS in Thoracic Malignancies

edited by

Magda Spella

and

Antonia Marazioti

submission deadline 31 Mar 2027 | Viewed by 82 | Submission Open

Keywords: KRAS-mutant thoracic malignancies; KRAS inhibitors; precision oncology; resistance; immunotherapies; tumor microenvironment; tumor epigenetics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Translational Approaches in Neurodegeneration and Rare Neurological Disorders: Insights from Animal Models

edited by

Francesco Liguori

and

Susanna Amadio

submission deadline 31 Mar 2027 | Viewed by 81 | Submission Open

Keywords: neurodegenerative diseases; neurodevelopmental disorders; mouse models; zebrafish; Drosophila; C. elegans; neuroinflammation; neuromuscular crosstalk; non-cell-autonomous mechanisms; drug repurposing

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Insights into Preclinical and Clinical Pharmacology

edited by

Maria Bogdan

and

Ianis Kevyn Stefan Boboc

submission deadline 31 Mar 2027 | Viewed by 78 | Submission Open

Keywords: preclinical pharmacology; clinical pharmacology; pharmacokinetics; molecular mechanisms; pharmacodynamics; pharmacogenomics; molecular toxicology; drug safety; targeted therapies; therapeutic efficacy; translational medicine; precision medicine; cellular signaling; drug discovery; in vitro/in vivo models; biomarkers

(This special issue belongs to the Section Molecular Pharmacology)

Biology and Chemistry of Medicinal Plants: From Resources to Applications

edited by

Mohamed Bouhrim

submission deadline 31 Mar 2027 | Viewed by 69 | Submission Open

Keywords: medicinal plants; phytochemistry; bioactive compounds; ethnopharmacology; molecular mechanisms; phytotherapy; diabetes mellitus; metabolic disorders; oxidative stress; drug discovery

(This special issue belongs to the Section Molecular Pharmacology)

New Advances in Brain Drug Delivery

edited by

Nazeer Hasan

submission deadline 31 Mar 2027 | Viewed by 69 | Submission Open

Keywords: blood–brain barrier; brain drug delivery; nanostructured lipid carriers; solid lipid nanoparticles; nose-to-brain delivery; receptor-mediated transcytosis; biomimetic nanoparticles; neurodegenerative diseases; Alzheimer’s disease; brain tumor; long-acting injectable; quality by design; CNS targeting; molecular imaging

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Insights into Placental Pathology: 2nd Edition

edited by Ana Correia-Branco and

Mary Wallingford

submission deadline 31 Mar 2027 | Viewed by 69 | Submission Open

Keywords: placenta; trophoblast; implantation; obstetrics; pre-eclampsia; placentation; maternal–fetal interface; pregnancy health; placenta diagnostics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms Underlying Floral Scent and Color in Plants

edited by Yiwei Zhou and Huimin Hu

submission deadline 31 Mar 2027 | Viewed by 66 | Submission Open

Keywords: floral scent; flower color; volatile organic compounds (VOCs); pigments; anthocyanins; carotenoids; multi-omics integration; biosynthetic pathways; metabolic engineering

(This special issue belongs to the Section Molecular Plant Sciences)

Advanced Body Fluid-Derived Stem Cells and Cell-Free Biomaterial Platforms for Tissue Regeneration

edited by Yuanyuan Zhang

submission deadline 31 Mar 2027 | Viewed by 60 | Submission Open

Keywords: body fluid-derived stem cells; urine-derived stem cells (USCs); extracellular vesicles and exosomes; paracrine signaling; biomaterial scaffolds and bioprinting; cell-free therapeutics; tissue regeneration

(This special issue belongs to the Section Molecular Biology)

Insights into Cardiotoxicity: From Mechanisms to Therapeutics

edited by María Hortigón-Vinagre and Godfrey L. Smith

submission deadline 31 Mar 2027 | Viewed by 58 | Submission Open

Keywords: cardiotoxicity; radioprotection; anticancer therapies; pollutants; hiPSC-CMs; in silico modelling; cell death; cardiac electrophysiology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Advances in Bioactive Properties of Algae

edited by

Kai Ling Yu

and Chia Shir Reen

submission deadline 31 Mar 2027 | Viewed by 55 | Submission Open

Keywords: macroalgae; microalgae; algal bioactive compounds; algae biorefinery and valorization; cultivation and metabolic engineering; next-generation algae biotechnology; biosynthesis; omics technologies; intelligent modelling of algae systems; bioprocessing and circular bioeconomy

(This special issue belongs to the Section Molecular Biology)

Novel Molecular Targets and Therapeutic Strategies for Overcoming EGFR-TKI Resistance in Malignant Tumors

edited by

Ning Liu

Jiye Liu

and Cong Jiang

submission deadline 31 Mar 2027 | Viewed by 55 | Submission Open

Keywords: EGFR-TKI resistance; malignant tumors; cellular signaling pathways; molecular targets; epigenetic regulation; histone deacetylase inhibitors; combination therapy strategies

(This special issue belongs to the Section Molecular Oncology)

Molecular Regulation of Angiogenesis and Vascular Remodeling: Mechanisms and Therapeutic Targets

edited by

Geetika Kaur

submission deadline 31 Mar 2027 | Viewed by 50 | Submission Open

Keywords: angiogenesis; endothelial cell; vascular development; molecular pathways; VEGF/VEGFR signaling; endothelial crosstalk; vascular network

(This special issue belongs to the Section Molecular Biology)

Molecular Insights into Neuromuscular Diseases

edited by

Maria Gavriilaki

submission deadline 31 Mar 2027 | Viewed by 47 | Submission Open

Keywords: neuromuscular disorders; biomarkers; systematic review; molecular mechanisms of pharmacological action; precision medicine; motor neuron disease; muscular diseases; neuromuscular junction diseases; peripheral nervous system diseases

(This special issue belongs to the Section Molecular Neurobiology)

Displaying special issue 2851-2900 on page 58 of 62.

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