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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Genetic Diversity, Founder Effects, and Migration in Neurodegeneration: Molecular and Population Perspectives

edited by

Dasiel Oscar Borroto-Escuela

submission deadline 30 Sep 2026 | Viewed by 339 | Submission Open

Keywords: neurodegeneration; population genetics; founder effects; genetic diversity; migration and disease risk; spinocerebellar ataxia; Alzheimer’s disease; Parkinson’s disease; genetic epidemiology; underrepresented populations

(This special issue belongs to the Section Molecular Neurobiology)

Advances in Therapeutic Antibody Engineering

edited by

Chatchai Tayapiwatana

submission deadline 30 Sep 2026 | Viewed by 336 | Submission Open

Keywords: therapeutic antibodies; bispecific antibodies; antibody-drug conjugates (ADCs); nanobodies; AI-driven drug design; Fc engineering; immunotherapy

(This special issue belongs to the Section Molecular Immunology)

Molecular Advances in Pituitary Neuroendocrine Tumors: From Growth Control to Plasticity and Evolutionary Pathogenesis

edited by Ana Lucía De Paul and Liliana del Valle Sosa

submission deadline 30 Sep 2026 | Viewed by 335 | Submission Open

Keywords: tumor heterogeneity; tumor biomarkers; transcriptomics; molecular neuroscience; clinical treatment; pathogenesis; pituitary neuroendocrine tumors; neuroendocrine tumors; nonfunctional; PIT1; pituitary adenoma

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Bioactive Lipids in Health and Disease: From Bench to Translational Insights

edited by

Claudio Bernal

submission deadline 30 Sep 2026 | 1 articles | Viewed by 334 | Submission Open

Keywords: functional lipids; lipids properties; fatty acids; lipid signaling; lipidomics; precision nutrition; cardiometabolic disease; inflammation; translational research

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Determinants of Cardiovascular Diseases

edited by

Susan Darroudi

submission deadline 30 Sep 2026 | Viewed by 332 | Submission Open

Keywords: atherosclerosis; hypertension; diabetes; dyslipidemia; endothelial dysfunction; vascular remodeling; inflammation and oxidative stress; mitochondrial dysfunction; molecular diagnostics; heart function

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Role of Bifunctional Antibodies in Human Cancer

edited by

Alessandro Canella

submission deadline 30 Sep 2026 | Viewed by 330 | Submission Open

Keywords: bispecific antibodies; tumor immune microenvironment (TIME); cancer immunotherapy; tumor associated antigens; biomarker discovery; T cell engagers (BiTEs, TriTEs, TriKEs); dual affinity retargeting antibodies (DARTs); Fc engineering and FcγR modulation; tumor associated antigen (TAA) avidity optimization; immune reprogramming; bispecific antibody pharmacokinetics and biodistribution; antibody–drug conjugate (ADC) hybrid formats; bifunctional antibodies

(This special issue belongs to the Section Molecular Oncology)

Current Trends in Nanophotonics and Molecular-Scale Light Control

edited by Mitradeep Sarkar

submission deadline 30 Sep 2026 | Viewed by 318 | Submission Open

Keywords: nanophotonics; light–matter interaction; metamaterials and 2D materials; photonic crystals; molecular sensing and imaging; quantum and nonlinear optics

(This special issue belongs to the Section Molecular Nanoscience)

Procoagulant Platelets in Vascular Disease and Beyond

edited by

Paresh P. Kulkarni

submission deadline 30 Sep 2026 | Viewed by 316 | Submission Open

Keywords: procoagulant platelets; thrombosis; hemostasis; coagulation; bleeding; vascular disease; cancer; cardiometabolic syndrome; inflammation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Studies of Cartilage Deformation

edited by

Kazuo Yudoh

submission deadline 30 Sep 2026 | Viewed by 316 | Submission Open

Keywords: osteoarthritis; chondrocyte; mitochondria function; mechanical stress; oxidative stress; cartilage metabolism

(This special issue belongs to the Section Molecular Biology)

Future Perspective and Challenge of Nanomaterials

edited by

Antreas Afantitis

submission deadline 30 Sep 2026 | Viewed by 295 | Submission Open

Keywords: nanomaterial; nanoinformatics; materials informatics; functional material; molecular dynamics

(This special issue belongs to the Section Molecular Nanoscience)

Targeted Therapies and Chemoresistance in Gastrointestinal Cancers

edited by Zheng Chen

submission deadline 30 Sep 2026 | Viewed by 291 | Submission Open

Keywords: gastrointestinal cancer; targeted therapy; chemoresistance; drug resistance; precision medicine; molecular biomarkers; signal transduction; tumor microenvironment; immunotherapy; novel therapeutics

(This special issue belongs to the Section Molecular Oncology)

Regulatory T Cells and Immune Tolerance: From Nobel Discoveries to Clinical Breakthroughs

edited by Raquel López-Mejías

submission deadline 30 Sep 2026 | Viewed by 288 | Submission Open

Keywords: regulatory T cells (Tregs); immune tolerance; FOXP3 gene; therapies; immunotherapy

(This special issue belongs to the Section Molecular Immunology)

Molecular Immunity to Parasitic Infections

edited by Jamie A. Whitelaw and Stuart Woods

submission deadline 30 Sep 2026 | Viewed by 287 | Submission Open

Keywords: parasitology; immunology; vaccines; cell therapy; gene editing; parasitic diseases; immune responses; inflammation; molecular mechanisms; immune evasion; host cell invasion and manipulation

(This special issue belongs to the Section Molecular Immunology)

Pathophysiology of Preeclampsia and Gestational Diabetes: Shared Molecular Mechanisms in Pregnancy-Related Disorders

edited by Tamara Nikolic Turnic

submission deadline 30 Sep 2026 | Viewed by 281 | Submission Open

Keywords: preeclampsia; molecular mechanism; mechanism of preventive/curative strategies; placenta dysfunction

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

TRIM Family Proteins and Beyond: Molecular Mechanisms in Tissue Homeostasis and Disease

edited by

Chuanxi Cai

submission deadline 30 Sep 2026 | Viewed by 281 | Submission Open

Keywords: TRIM family proteins; E3 ubiquitin ligases; protein homeostasis; autophagy and selective autophagy; innate immunity and antiviral defense; signal transduction; post-translational modifications; phase separation; tissue homeostasis; cancer biology; heart failure; neurodegeneration; inflammation and immunity; molecular mechanisms of disease; biomarkers and therapeutic targets

(This special issue belongs to the Section Molecular Biology)

MicroRNAs in Cancer: Molecular Mechanisms and Regulatory Networks

edited by

Yarely M. Salinas-Vera

submission deadline 30 Sep 2026 | Viewed by 278 | Submission Open

Keywords: microRNAs; cancer; non-coding RNAs; gene regulation; tumor microenvironment; transcriptomics; cancer signaling

(This special issue belongs to the Section Molecular Biology)

Protein Structure, Dynamics and Interactions

edited by

Gyula Batta

and

Orsolya Tőke

submission deadline 30 Sep 2026 | Viewed by 275 | Submission Open

Keywords: protein; structure; folding; dynamics; interactions; NMR; X-ray crystallography; cryo-electron microscopy; AlphaFold; in silico

(This special issue belongs to the Section Macromolecules)

Inherited Endocrine Tumors: Genetics, Genomics, and Molecular Pathogenesis

edited by Vito Guarnieri,

Alberto Falchetti

and Antonio Stefano Salcuni

submission deadline 30 Sep 2026 | Viewed by 273 | Submission Open

Keywords: parathyroid; adrenal; pancreas; thyroid; pituitary

(This special issue belongs to the Section Molecular Genetics and Genomics)

Deep Learning for Bioinformatics and Biomedicine

edited by

Burak Tasci

submission deadline 30 Sep 2026 | Viewed by 272 | Submission Open

Keywords: bioinformatics; deep learning; genomics (DNA); histopathology; multi-omics; molecular biomarkers; drug discovery; computational pathology; systems biology; precision medicine

(This special issue belongs to the Section Molecular Informatics)

Biological Effects and Toxicity of Nanomaterials

edited by Lucyna Kapka-Skrzypczak

submission deadline 30 Sep 2026 | Viewed by 271 | Submission Open

Keywords: nanotoxicology; nanomaterials; biological effects; cytotoxicity; oxidative stress; inflammation; genotoxicity; immunotoxicity; risk assessment; nanosafety; nanomedicine; environmental health; in vitro models; in vivo studies

(This special issue belongs to the Section Molecular Nanoscience)

Molecular Genetics in Metabolic Syndrome and Diabetes

edited by

Marijn Speeckaert

submission deadline 30 Sep 2026 | Viewed by 269 | Submission Open

Keywords: metabolic syndrome; diabetes mellitus; genetic variants; epigenetics; insulin resistance; obesity; dyslipidemia; inflammation; oxidative stress; mitochondrial dysfunction; non-coding RNAs; transcriptomics; proteomics

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Advances in Cell Signaling Pathways and Signal Transduction, 2nd Edition

edited by

Susumu Ohya

and Katsuhiko Muraki

submission deadline 30 Sep 2026 | Viewed by 265 | Submission Open

Keywords: signaling pathway; signal transduction; cell biology; signal transduction; cell communication; cell signaling

(This special issue belongs to the Section Biochemistry)

Effects of Radiation on Biomolecules and Cells: Mechanisms, Responses, and Biological Implications

edited by

Sachin Gulati

submission deadline 30 Sep 2026 | Viewed by 261 | Submission Open

Keywords: radiation biology; biomolecular damage; cellular responses; DNA damage and repair; oxidative stress; radioprotection; radiotherapy; dosimetry; molecular mechanisms; radiation-induced toxicity

(This special issue belongs to the Section Molecular Biology)

Molecular Targeting in Neuroinflammation: Uncovering Mechanisms, Pharmacological Targets and Neuropharmaceutical Developments

edited by

Nataša Mitrović

submission deadline 30 Sep 2026 | Viewed by 260 | Submission Open

Keywords: neuroinflammation; neurodegenerative disorders; neuro-immune crosstalk; glial cells; neuroprotective/anti-inflammatory agents; therapeutic strategies; pharmacological treatments

(This special issue belongs to the Section Molecular Neurobiology)

Multiscale Toxicology: From Cell Models to Whole Organisms

edited by

Elvira Brunelli

and

Rachele Macirella

submission deadline 30 Sep 2026 | Viewed by 249 | Submission Open

Keywords: toxicology; ecotoxicology; environmental risk assessment; multiscale toxicology; emerging contaminants; sentinel species; omics; mixture toxicity

(This special issue belongs to the Section Molecular Toxicology)

Advanced In Vitro Models: Integrating the 3Rs in Translational Science

edited by Glaucia Maria Machado-Santelli

submission deadline 30 Sep 2026 | Viewed by 249 | Submission Open

Keywords: 3Rs principles; advanced in vitro models; molecular mechanisms; cell signaling; organoids; organ-on-chip; translational research; molecular profiling; tissue engineering; redox biology; microphysiological systems; translational research; alternative methods to animal testing; nanotechnology in biomedicine; tissue engineering; drug discovery platforms

(This special issue belongs to the Section Molecular Biology)

Research on Drug Delivery in Health and Disease

edited by

Alejandro Ruiz-Picazo

submission deadline 30 Sep 2026 | Viewed by 248 | Submission Open

Keywords: precision medicine; nanomedicine; targeted delivery; biomarkers; personalized therapy; adaptive systems; AI-driven drug delivery

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Research into the Applications of Metabolites from Marine Organisms

edited by Carlos García

submission deadline 30 Sep 2026 | Viewed by 246 | Submission Open

Keywords: quantitative analysis; secondary metabolites; bioactive; disease; molecular insight; natural compounds

(This special issue belongs to the Section Biochemistry)

State-of-the-Art Molecular Plant Sciences in Thailand

edited by

Mayura Veerana

submission deadline 30 Sep 2026 | Viewed by 244 | Submission Open

Keywords: molecular plant sciences; plant biotechnology; functional genomics; molecular breeding; plant stress responses; omics technologies; plant–microbe interactions; sustainable agriculture; crop improvement

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Studies of Antibacterial Materials

edited by

Anna Baranowska-Korczyc

and

Adriana Nowak

submission deadline 30 Sep 2026 | Viewed by 240 | Submission Open

Keywords: antibacterial materials; molecular mechanisms; antimicrobial resistance; antimicrobial nanomaterials; antimicrobial polymers; microbial adhesion; microbial biofilms; biofilm inhibition; reactive oxygen species (ROS); antimicrobial coatings; bacterial membrane disruption; controlled ion release; biocompatibility and cytotoxicity assessment

(This special issue belongs to the Section Materials Science)

Immunological Mechanisms Against Human Fungal Pathogens

edited by

Kritsada Pruksaphon

submission deadline 30 Sep 2026 | Viewed by 239 | Submission Open

Keywords: fungal drug resistance; thermally dimorphic fungus; host–pathogen interaction; structural biology of host–pathogen interfaces; immune evasion or immune escape; monoclonal antibodies or therapeutic antibodies; structural antibodies; X-ray crystallography and cryo-electron microscopy (Cryo-EM); molecular docking or molecular dynamics simulations; extracellular vesicles; damage response framework

(This special issue belongs to the Section Molecular Immunology)

Molecular Mechanisms Underlying Genetic Variants of Parkinson’s Disease

edited by Michael Schlossmacher and

Ari Zimran

submission deadline 30 Sep 2026 | Viewed by 237 | Submission Open

Keywords: DNA; PD prevention; genetic variants of Parkinson's disease

(This special issue belongs to the Section Molecular Neurobiology)

Genomics Research on Plant Stress Resistance

edited by

Muhammad Waseem

submission deadline 30 Sep 2026 | Viewed by 236 | Submission Open

Keywords: stress-responsive genes; muti-omics; stress memory / priming; tolerance mechanisms

(This special issue belongs to the Section Molecular Genetics and Genomics)

Interactions Between Rhizosphere Microbiota and Plants

edited by

Anna Gałązka

submission deadline 30 Sep 2026 | Viewed by 235 | Submission Open

Keywords: microbiome and mycobiome of soil and plant rhizosphere; endorhizosphere; next-generation sequencing; soil and plant biodiversity

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Insights into Animal Nutrition: Oxidative Stress, Polyphenols and Functional Feed Materials

edited by

Sotiria Makri

and

Dimitrios Kouretas

submission deadline 30 Sep 2026 | Viewed by 232 | Submission Open

Keywords: animal nutrition; oxidative stress; reactive oxygen species; polyphenols; feed materials; molecular nutrition; antioxidant defense; animal physiology; nutritional toxicology

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Enhancing Plant Traits Through In Vitro Culture

edited by Jacek Gawroński

submission deadline 30 Sep 2026 | Viewed by 230 | Submission Open

Keywords: plant tissue culture; somatic embryogenesis; organogenesis; micropropagation; callus culture; in vitro regeneration; in vitro mutagenesis; haploid and doubled haploid production; molecular markers; genetic analysis; genomics; transcriptomics; epigenetic regulation; proteomic profiling; molecular mechanisms; gene expression analysis

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Mechanisms of Endocrine-Disrupting Chemicals in Reproductive Toxicity

edited by

Dragana Samardžija Nenadov

submission deadline 30 Sep 2026 | Viewed by 228 | Submission Open

Keywords: endocrine-disrupting chemicals (EDCs); reproductive toxicity; steroidogenesis; molecular mechanisms; intracellular signaling; hormone receptors; reproductive health

(This special issue belongs to the Section Molecular Toxicology)

Non-Coding RNAs as Key Players in Cancer Biology and Clinical Translation

edited by

Ana Cristina Gonçalves

Raquel Alves

and

Ana Bela Sarmento Ribeiro

submission deadline 30 Sep 2026 | Viewed by 227 | Submission Open

Keywords: non-coding RNAs; microRNAs; long non-coding RNAs; circular RNAs; RNA-based therapeutics; RNA delivery; systems; liquid biopsy; predictive biomarkers; drug resistance; clinical translation

(This special issue belongs to the Section Molecular Oncology)

Trends in Allergy and Autoimmunity: Pathogenesis, Biomarkers, and Treatment (Second Edition)

edited by

Ilaria Mormile

submission deadline 30 Sep 2026 | Viewed by 227 | Submission Open

Keywords: allergy; autoimmunity; autoimmune diseases; asthma; allergic rhinitis; urticaria; inflammation in allergic and autoimmune diseases; molecular pathway involved in allergic and autoimmune diseases; biomarkers of allergic and autoimmune diseases; target therapy

(This special issue belongs to the Section Molecular Immunology)

From Soil to Gut: Molecular Mechanisms of Microbial Remediation for Planetary and Human Health

edited by

Yi Yang

, Hao Zhou and

Xin Jin

submission deadline 30 Sep 2026 | Viewed by 225 | Submission Open

Keywords: microbiome restoration; biotherapeutic agents; in vivo/vitro detoxification; dysbiosis rescue; synthetic consortia; host-microbe interactions; bioremediation; ecohealth

(This special issue belongs to the Section Molecular Microbiology)

DNA Damage, DNA Repair, and Cancer, 3rd Edition

edited by

Kazuhiko Kuwahara

submission deadline 30 Sep 2026 | Viewed by 225 | Submission Open

Keywords: DNA-damage response; DNA repair molecules; genome instability; cellular senescence; animal models; DNA damage; DNA repair and cancer

(This special issue belongs to the Section Molecular Oncology)

Photosynthetic Mechanisms, Environmental Adaptation, and Genetic Engineering of Plants and Algae

edited by Maksymilian Zienkiewicz

submission deadline 30 Sep 2026 | Viewed by 225 | Submission Open

Keywords: algae; photosynthesis; photoprotection; photostasis; light-harvesting complexes; cyclic electron transport; stress tolerance; environmental adaptation; genetic engineering; CRISPR

(This special issue belongs to the Section Molecular Plant Sciences)

Cellular and Molecular Mechanisms of Plaque Development and Progression

edited by

Ida Daniela Perrotta

submission deadline 30 Sep 2026 | Viewed by 224 | Submission Open

Keywords: atherosclerosis; atherosclerotic plaque; endothelial dysfunction; vascular inflammation; macrophage polarization; smooth muscle cell phenotypic switching; lipid metabolism; oxidative stress; extracellular vesicles; epigenetic regulation; immune–vascular interactions; plaque instability

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Xenobiotic Toxicity: From Transcriptional Regulation to Reproductive and Behavioural Impacts

edited by Sylwia Swigonska

submission deadline 30 Sep 2026 | Viewed by 224 | Submission Open

Keywords: xenobiotic interactions; molecular mechanisms of toxicity; reproductive toxicology; early biomarkers; emerging contaminants; neurobehavioral toxicity; microbiota–xenobiotic interactions; biomolecular responses; environmental health; molecular toxicology

(This special issue belongs to the Section Molecular Toxicology)

Plant–Microbe Interactions: The Battle for Plant Infection and Prevention

edited by

Rezaee Danesh Younes

submission deadline 30 Sep 2026 | Viewed by 220 | Submission Open

Keywords: plant–microbe interactions; plant immunity; pathogen virulence; microbiome; biological control; trichoderma; arbuscular mycorrhizal fungi; omics technologies; RNA-based disease control; genome editing; sustainable agriculture; plant protection; microbial ecology; systems biology

(This special issue belongs to the Section Molecular Plant Sciences)

Genetics and Molecular Therapies in Common Age-Related and Inherited Retinal Diseases

edited by

Xiaoming Gong

submission deadline 30 Sep 2026 | Viewed by 220 | Submission Open

Keywords: inherited retinal diseases; molecular diagnosis; age-related retinal degeneration; genotype–phenotype correlations; gene and cell therapies; early biomarkers of retinal disease; AI‑driven analytics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Ion and Molecular Transport in Nanopores/Channels

edited by Haiqi Gao

submission deadline 30 Sep 2026 | Viewed by 220 | Submission Open

Keywords: gas separation; desalination; ion separation; COF; nanoporous graphene; first-principle calculation; molecular dynamics simulation; machine learning

(This special issue belongs to the Section Materials Science)

Advances in Genetics of Human Reproduction—2nd Edition

edited by

Jasenka Wagner

and

Borut Peterlin

submission deadline 30 Sep 2026 | Viewed by 220 | Submission Open

Keywords: genetic; human reproduction; infertility; medically assisted reproduction; pregnancy complications; recurrent miscarriage

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Basis of Rare Diseases and Functional Variant Interpretation

edited by

Adrijan Sarajlija

submission deadline 30 Sep 2026 | Viewed by 218 | Submission Open

Keywords: rare diseases; functional variant interpretation; variants of uncertain significance; molecular pathogenesis; functional assays; genotype–phenotype correlation; multiomics; clinical genetics

(This special issue belongs to the Section Molecular Genetics and Genomics)

Cardiac Protein Metabolism in Health and Diseases

edited by

Anindhya Sundar Das

submission deadline 30 Sep 2026 | Viewed by 218 | Submission Open

Keywords: cardiac proteostasis; translational regulation; protein synthesis; ubiquitin–proteasome system; autophagy; cardiac remodeling; cardiomyopathy; RNA biology; protein quality control

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Displaying special issue 1101-1150 on page 23 of 63.

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