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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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The Applicability of Graphene-Based Materials in the Pharmaceutical, Biological and Biomedical Sectors

edited by

Lidia Magerusan

and Pogacean Florina

submission deadline 20 Oct 2025 | 6 articles | Viewed by 11713 | Submission Open

Keywords: graphene; graphene-based composites; graphene-based sensors; biomedical applications; tissue engineering; drug delivery

(This special issue belongs to the Section Molecular Nanoscience)

Research and Application of Platelet-Rich Plasma (PRP)

edited by

Tomoyuki Kawase

submission deadline 20 Oct 2025 | 4 articles | Viewed by 11189 | Submission Open

Keywords: platelet-rich plasma; platelet-rich fibrin; platelets; exosome; mitochondria; growth factors; tissue regeneration

(This special issue belongs to the Section Molecular Biology)

Cellular and Molecular Mechanisms of Autoimmune Disorders

edited by

Ritva Tikkanen

submission deadline 20 Oct 2025 | 3 articles | Viewed by 10727 | Submission Open

Keywords: autoimmune diseases; self-tolerance; immune cells; autoantibodies; autoantigens; pathomechanisms

(This special issue belongs to the Section Molecular Immunology)

Molecular Mechanisms and Therapeutic Targets in Skin Diseases

edited by Hanna Mys̈liwiec

submission deadline 20 Oct 2025 | 6 articles | Viewed by 10701 | Submission Open

Keywords: inflammatory skin diseases; systemic inflammation; infectious skin diseases; comorbidity; pathogenesis; cytokines

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Genetic Mutations in Health and Disease

edited by

Eva Bagyinszky

submission deadline 20 Oct 2025 | 8 articles | Viewed by 10606 | Submission Open

Keywords: genetic diseases; mutations; genetic screening; structure prediction; haploinsufficeincy; germline mutations; somatic mutations; gene enviroment interaction; gene-gene interations

(This special issue belongs to the Section Molecular Genetics and Genomics)

Mesenchymal Stem Cells and Cancer

edited by Krisztián Németh and Balazs Mayer

submission deadline 20 Oct 2025 | 4 articles | Viewed by 10091 | Submission Open

Keywords: cancer; microenvironment; tumor stroma; cancer-associated fibroblast; mesenchymal stem cell; cancer immunology; angiogenesis; metastasis; targeted cancer therapy; checkpoint inhibitor; CAR-T cells; immunotherapy; signal transduction; small molecules

(This special issue belongs to the Section Molecular Oncology)

Targeting RNA Molecules

edited by

Constantinos Stathopoulos

submission deadline 20 Oct 2025 | 3 articles | Viewed by 10046 | Submission Open

Keywords: riboswitch; noncoding RNA; antibiotics; resistance; bacteria; antimicrobial resistance

(This special issue belongs to the Section Molecular Biology)

Editorial Board Members’ Collection Series: Human Traits and Genomics

edited by

Giovanni Malerba

Lidia Larizza

and

Salvatore Saccone

submission deadline 20 Oct 2025 | 5 articles | Viewed by 9841 | Submission Open

Keywords: genetic data analysis; genomic profiling; trait inheritance; DNA and RNA sequencing approaches; deep learning methods

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Mechanisms of Cancer Invasion and Metastasis

edited by

Zbigniew Baster

submission deadline 20 Oct 2025 | 5 articles | Viewed by 9812 | Submission Open

Keywords: cancer; cancer invasion; metastasis; tumor microenvironment; molecular basis of cancer; immunotherapy; cell motility; cancer genetics; cancer development

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Genetics- and Genomics-Based Crop Improvement and Breeding: 3rd Edition

edited by Jian Ma

submission deadline 20 Oct 2025 | 6 articles | Viewed by 9794 | Submission Open

Keywords: crop; germplasm; genetics; genomics; breeding

(This special issue belongs to the Section Molecular Plant Sciences)

Recent Advances in RNA Drug Development

edited by Hidenori Tani

submission deadline 20 Oct 2025 | 3 articles | Viewed by 9681 | Submission Open

Keywords: RNA therapeutics; drug development; antisense oligonucleotides; siRNA; miRNA; aptamers; CRISPR-Cas9; delivery systems; clinical applications; emerging technologies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Current Research on Cancer Biology and Therapeutics: Third Edition

edited by

Rafael Coveñas Rodríguez

submission deadline 20 Oct 2025 | 8 articles | Viewed by 9550 | Submission Open

Keywords: antiangiogenic; anticancer therapy; antimetastatic; apoptosis; antiproliferative; cancer; peptides; signaling molecules; transcription factors; tumor

(This special issue belongs to the Section Molecular Oncology)

Innovative Antimicrobial Therapies: Overcoming Virulence of Microorganisms and Drug Resistance

edited by

Anna Majewska

submission deadline 20 Oct 2025 | 4 articles | Viewed by 9383 | Submission Open

Keywords: antibiotics; antimicrobial resistance; antivirals; commensal; pathogenesis; virulence

(This special issue belongs to the Section Molecular Microbiology)

Spinocerebellar Ataxias: Uncovering Their Molecular Mechanisms, Biomarker Development, and Therapies

edited by Anna Sulek

submission deadline 20 Oct 2025 | 5 articles | Viewed by 9243 | Submission Open

Keywords: spinocerebellar ataxia; biomarker; neurodegeneration; preclinical models; transcriptomics; proteomics; microRNA; iPSC; dynamic mutations

(This special issue belongs to the Section Molecular Neurobiology)

Gut Microbiota in Disease and Health 3.0

edited by

Javier Modrego

and

Dulcenombre Gómez Garre

submission deadline 20 Oct 2025 | 3 articles | Viewed by 9185 | Submission Open

Keywords: microbiota; microbiome; gut metabolites; short-chain fatty acids; secondary bile acids; microRNA; microvesicles; cell signaling; prebiotics/probiotics; nutrition; fecal transplantation; bacteriophages; gene editing

(This special issue belongs to the Section Molecular Microbiology)

MicroRNA and Non-Coding RNA: From Basic Research to Potential Clinical Application

edited by

Erika Cione

submission deadline 20 Oct 2025 | 7 articles | Viewed by 9129 | Submission Open

Keywords: miRNA; ncRNA; biomarkers; therapeutics; microarray; NGS

(This special issue belongs to the Section Molecular Genetics and Genomics)

Extracellular Vesicles: From Molecular Mechanisms to Therapeutic Applications

edited by Jung-Hyun Lee

submission deadline 20 Oct 2025 | 7 articles | Viewed by 8862 | Submission Open

Keywords: extracellular vesicles; intercellular communications; biomarkers; drug delivery systems

(This special issue belongs to the Section Biochemistry)

Advances in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), 2nd Edition

edited by

Vincent C. Lombardi

submission deadline 20 Oct 2025 | 2 articles | Viewed by 8389 | Submission Open

Keywords: ME/CFS; PASC; long COVID-19; inflammation; innate immunity; adaptive immunity; mast cell activation; post-infection syndrome; metabolism; autoantibodies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Role of Extracellular Matrix Proteins in Pathogenesis: 2nd Edition

edited by

Davide Raineri

submission deadline 20 Oct 2025 | 10 articles | Viewed by 8248 | Submission Open

Keywords: extracellular matrix proteins; autoimmune disease; cancer; cardiovascular diseases; inflammation; chronic diseases; human diseases

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Exosomes—3rd Edition

edited by

Abdelnaby Khalyfa

submission deadline 20 Oct 2025 | 5 articles | Viewed by 8224 | Submission Open

Keywords: extracellular vesicles (EVs); exosomes; cancer; sleep cardiovascular diseases; lung disease and upper airways; obesity; sleep and end-organ morbidity

(This special issue belongs to the Section Molecular Biology)

Metabolic Dysfunction-Associated Steatotic Liver Disease: From Basic Science to Therapy

edited by

Łukasz Bułdak

submission deadline 20 Oct 2025 | 4 articles | Viewed by 8146 | Submission Open

Keywords: MASLD; liver steatosis; steatohepatitis; liver cirrhosis; hepatocellular carcinoma; in vivo; in vitro; therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular and Cellular Research in Pregnancy-Related Complications, 2nd Edition

edited by

Regina Komsa-Penkova

submission deadline 20 Oct 2025 | 4 articles | Viewed by 7843 | Submission Open

Keywords: pregnancy loss/miscarriage; pregnancy complications; pre-eclampsia; maternal– placental– fetal interactions; trophoblast; immune cells; immune tolerance; red blood cells; oxidative stress; blood and fetal proteins; DNA; RNA; stem cells

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Advances in Epigenetics and Epigenomics

edited by Vicki Maltby

submission deadline 20 Oct 2025 | 4 articles | Viewed by 7750 | Submission Open

Keywords: epigenetics; epigenomics; multi-omics; epitranscriptomics; single cell

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Research and Treatment of Prostate Cancer

edited by

Manuela Zavatti

and

Sandra Marmiroli

submission deadline 20 Oct 2025 | 3 articles | Viewed by 7647 | Submission Open

Keywords: prostate cancer; PI3K/AKT pathway; resistance mechanism; androgen receptor; MAPK

(This special issue belongs to the Section Molecular Oncology)

New Molecular Insights into Antimicrobial Photo-Treatments

edited by Pietro Delcanale

submission deadline 20 Oct 2025 | 3 articles | Viewed by 7552 | Submission Open

Keywords: photodynamic inactivation; photo-thermal therapy; photosensitization; antimicrobials; reactive oxygen species; photo-treatments; antibiotic resistance; singlet oxygen; antivirals

(This special issue belongs to the Section Molecular Microbiology)

Mitochondrial and Energy Metabolic Function in Heart and Skeletal Muscle

edited by Yoshitake Cho

submission deadline 20 Oct 2025 | 1 articles | Viewed by 7527 | Submission Open

Keywords: heart; skeletal muscle; metabolism; glucose; mitochondria; metabolic disorder

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Editorial Board Members’ Collection Series: “Selenium and Sulfur Chemistry”

edited by

Claudio Santi

and

Narimantas K. Cenas

submission deadline 20 Oct 2025 | 3 articles | Viewed by 7074 | Submission Open

Keywords: selenium; sulfur; redox; catalysis; selenoproteins; green chemistry; materials; stereoselective synthesis

(This special issue belongs to the Section Biochemistry)

Brain Plasticity in Health and Disease

edited by

Pawan Faris

submission deadline 20 Oct 2025 | 3 articles | Viewed by 6833 | Submission Open

Keywords: brain plasticity; brain structure and function; cerebral cortex; cerebellum; neurological disorders; neuropsychiatric disorders; neurophysiology; computational modeling; brain imaging; Neuroplasticity

(This special issue belongs to the Section Molecular Neurobiology)

Ion Channels as a Potential Target in Pharmaceutical Designs 2.0

edited by

Sheng-Nan Wu

submission deadline 20 Oct 2025 | 7 articles | Viewed by 6725 | Submission Open

Keywords: ion currents; current kinetics; gating properties; voltage-dependent hysteresis; frequency-dependent regulation; small-molecule modulator

(This special issue belongs to the Section Molecular Biology)

Novel Extracellular Vesicle-Based Therapy for Central Nervous System Diseases

edited by Andrea Cabrera-Pastor

submission deadline 20 Oct 2025 | 2 articles | Viewed by 6718 | Submission Open

Keywords: extracellular vesicles (EVs); exosomes; therapy; CNS disorders; neuroinflammation; signal transduction; mechanism; interorgan crosstalk; biomarker; EVs from MSCs; drug delivery

(This special issue belongs to the Section Molecular Neurobiology)

Depression: From Molecular Basis to Therapy—2nd Edition

edited by

Terezia Kiskova

submission deadline 20 Oct 2025 | 5 articles | Viewed by 6637 | Submission Open

Keywords: depression; neurobiology; molecular basis; neurotransmitters; genetic factors; psychopharmacology; psychotherapy; genetic markers

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Genetics in Ovarian Cancer

edited by

Bruna Scaggiante

submission deadline 20 Oct 2025 | 5 articles | Viewed by 6593 | Submission Open

Keywords: chemotherapy resistance; differential gene expression; genomic structural variation; ovarian cancer mutations; ovarian cancer metastasis; ovarian cancer treatment; novel molecular targets

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Research and Treatment in Multiple Sclerosis

edited by Nada Starčević Čizmarević and

Borut Peterlin

submission deadline 20 Oct 2025 | 4 articles | Viewed by 6575 | Submission Open

Keywords: multiple sclerosis; neuroinflammation; neurodegeneration; genetics; molecular research; biomarkers; neuroimaging; therapy

(This special issue belongs to the Section Molecular Biology)

Advanced Research in Plant–Fungus Interactions: Second Edition

edited by

Jiangyun Gao

submission deadline 20 Oct 2025 | 3 articles | Viewed by 6459 | Submission Open

Keywords: plant– fungus interactions; symbiotic association; endophytes; plant conservation; mycorrhizal symbioses

(This special issue belongs to the Section Molecular Plant Sciences)

Cell Signaling and Molecular Pathology of Retinal Diseases: 2nd Edition

edited by

Hiroshi Tomita

submission deadline 20 Oct 2025 | 4 articles | Viewed by 6403 | Submission Open

Keywords: retinal degeneration; regenerative medicine; gene therapy; electroretinogram; visually evoked potential; RNA-seq; apoptosis; animal model

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Heart Failure: From Molecular Basis to Therapeutic Strategies

edited by

Michele Ciccarelli

submission deadline 20 Oct 2025 | 4 articles | Viewed by 6197 | Submission Open

Keywords: heart failure; cardiac metabolism; mitochondria; inflammatory pathway; neurohormonal system; therapeutical strategies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Biomarkers in Cancer Immunology

edited by

Wioletta Olejarz

submission deadline 20 Oct 2025 | 2 articles | Viewed by 6055 | Submission Open

Keywords: immunotherapy; adoptive cell transfer; CAR-T cells; immune checkpoint inhibitors; tumor microenvironment; extracellular vesicles; biomarkers; miRNA; DNA

(This special issue belongs to the Section Molecular Immunology)

The Role of Mesenchymal Stem Cells in Organ Repair and Tissue Regeneration

edited by

Sara Cruciani

submission deadline 20 Oct 2025 | 4 articles | Viewed by 6047 | Submission Open

Keywords: stem cells; differentiation; cell therapy; tissue regeneration; cell mechanisms; regenerative medicine; immunomodulation

(This special issue belongs to the Section Molecular Biology)

Design, Synthesis, and Bioapplications of Multifunctional Materials

edited by

Raluca Nicoleta Darie-Nita

and

Anamaria Irimia

submission deadline 20 Oct 2025 | 3 articles | Viewed by 5974 | Submission Open

Keywords: bioactivity; biodegradability; polymers; composite materials; (nano)structured materials; packaging; biological and biomedical materials

(This special issue belongs to the Section Materials Science)

New Insights into Liver Biology and Disease Pathogenesis: Shedding Light on Novel Diagnostic and Therapeutic Approaches

edited by

Thiago Almeida Pereira

submission deadline 20 Oct 2025 | 3 articles | Viewed by 5949 | Submission Open

Keywords: liver molecular biology; novel biomarkers; liver regeneration; liver repair; liver carcinogenesis; brain– gut– liver axis; novel therapeutic targets; molecular diagnostic tools; host– pathogen interactions; novel in vitro and in vivo models of liver diseases

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Chronic Kidney Disease: The State of the Art and Future Perspectives

edited by Alberto Rosati

submission deadline 20 Oct 2025 | 4 articles | Viewed by 5892 | Submission Open

Keywords: glomerulonephritis; chronic kidney disease; prevention; screening; cardiovascular mortality; patient outcomes; CKD progression

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Research on Cancer and Molecular Imaging

edited by Mi-Ae Park

submission deadline 20 Oct 2025 | 3 articles | Viewed by 5606 | Submission Open

Keywords: molecular imaging; radiology; cancer detection; precision medicine; cancer mechanisms

(This special issue belongs to the Section Molecular Biology)

The Role of Heat Shock Proteins: From Molecular Mechanisms to Therapeutics: 2nd Edition

edited by

Gregory Blatch

submission deadline 20 Oct 2025 | 2 articles | Viewed by 5462 | Submission Open

Keywords: heat shock proteins; molecular chaperones; co-chaperones; protein folding; chronic diseases; infectious diseases

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Advances in Skin Diseases: 3rd Edition

edited by

Naoko Kanda

submission deadline 20 Oct 2025 | 3 articles | Viewed by 5428 | Submission Open

Keywords: infection; inflammation; molecular; neoplasm; pathogenesis; skin diseases

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Cell Motility and Its Underlying Cellular and Molecular Mechanisms

edited by

Maria Giulia Lionetto

submission deadline 20 Oct 2025 | 2 articles | Viewed by 5306 | Submission Open

Keywords: cell motility; cell migration; cytoskeleton; adhesion; signaling; imaging; microscopy; molecular biology

(This special issue belongs to the Section Biochemistry)

Macrophage Polarization: Learning to Manage It (4th Edition)

edited by

Nadia Lampiasi

submission deadline 20 Oct 2025 | 2 articles | Viewed by 5269 | Submission Open

Keywords: macrophages; macrophage plasticity; macrophage polarization; innate immunity; IFN-γ ; TNF-α ; immunomodulators; diseases; homeostasis; inflammation; cancer

(This special issue belongs to the Section Molecular Immunology)

Roles of Mast Cells in Immune-Induced Diseases

edited by Paul L.A. Van Daele and Willem A. Dik

submission deadline 20 Oct 2025 | 1 articles | Viewed by 5204 | Submission Open

Keywords: mast cell; fibrosis; inflammation; autoinflammation; autoimmunity; transplantation; gastrointestinal; pulmonary; cytokines; MRGPRX2; rejection

(This special issue belongs to the Section Molecular Immunology)

Oxidation in Human Health and Disease

edited by

Isabel Fort

submission deadline 20 Oct 2025 | 3 articles | Viewed by 5177 | Submission Open

Keywords: oxidative stress; oxidative balance; biochemical markers; reactive oxygen species TRANSLATE with x English Arabic Hebrew Polish Bulgarian Hindi Portuguese Catalan Hmong Daw Romanian Chinese Simplified Hungarian Russian Chinese Traditional Indonesian Slovak Czech Italian Slovenian Danish Japanese Spanish Dutch Klingon Swedish English Korean Thai Estonian Latvian Turkish Finnish Lithuanian Ukrainian French Malay Urdu German Maltese Vietnamese Greek Norwegian Welsh Haitian Creole Persian // TRANSLATE with COPY THE URL BELOW Back EMBED THE SNIPPET BELOW IN YOUR SITE Enable collaborative features and customize widget: Bing Webmaster Portal Back // This page is in English Translate to Simplified Chinese Afrikaans Albanian Amharic Arabic Armenian Azerbaijani Bengali Bulgarian Catalan Croatian Czech Danish Dutch English Estonian Finnish French German Greek Gujarati Haitian Creole Hebrew Hindi Hungarian Icelandic Indonesian Italian Japanese Kannada Kazakh Khmer Korean Kurdish (Kurmanji) Lao Latvian Lithuanian Malagasy Malay Malayalam Maltese Maori Marathi Myanmar (Burmese) Nepali Norwegian Pashto Persian Polish Portuguese Punjabi Romanian Russian Samoan Simplified Chinese Slovak Slovenian Spanish Swedish Tamil Telugu Thai Traditional Chinese Turkish Ukrainian Urdu Vietnamese Welsh Always translate English to Simplified Chinese Never translate English Never translate admin.mdpi.com

(This special issue belongs to the Section Molecular Immunology)

Interplay Between the Human Microbiome and Diseases

edited by

Tihamer Molnar

and

Zoltán Péterfi

submission deadline 20 Oct 2025 | 4 articles | Viewed by 4942 | Submission Open

Keywords: microbiome; metagenome; gastrointestinal tract; skin; seminal fluid; lung; saliva; oral mucosa; conjunctiva; dysbiosis; fecal microbiota transplantation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Extracellular Vesicles: The Biology and Therapeutic Applications, 2nd Edition

edited by

Tamás Visnovitz

submission deadline 20 Oct 2025 | 2 articles | Viewed by 4872 | Submission Open

Keywords: extracellular vesicles (EVs); exosomes; release; uptake; bio-distribution; methods; biomarkers; therapeutic applications

(This special issue belongs to the Section Molecular Biology)

Displaying special issue 1101-1150 on page 23 of 68.

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