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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Apoptosis and Autophagy in Cancer Research

edited by

Ioana Berindan-Neagoe

and

Radu Pirlog

submission deadline 20 Dec 2025 | 1 articles | Viewed by 674 | Submission Open

Keywords: apoptosis; autophagy; cancer biology; coding and noncoding genomes; cell homeostasis; therapeutic strategies; cell death and survival

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Signaling in GPCR Research

edited by

Zvi Naor

submission deadline 20 Dec 2025 | Viewed by 672 | Submission Open

Keywords: GPCR; G protein; signaling; drug design; cell surface receptors

(This special issue belongs to the Section Biochemistry)

Tumor Angiogenesis and Metastasis: From Molecular Signalling to Therapeutic Approaches

edited by

Federica Finetti

and

Lorenza Trabalzini

submission deadline 20 Dec 2025 | 1 articles | Viewed by 661 | Submission Open

Keywords: tumour angiogenesis; tumour invasion; tumour metastasis; molecular mechanisms; metabolic patterns; signalling pathways

(This special issue belongs to the Section Molecular Oncology)

Biomolecular Condensates and Their Role in Cellular Organization and Disease

edited by Anna Bratek-Skicki

submission deadline 20 Dec 2025 | Viewed by 609 | Submission Open

Keywords: biocondensates; membrane-less organelles; liquid-liquid phase separation; protein aggregation; neurogenerative diseases

(This special issue belongs to the Section Molecular Biology)

Red Blood Cells in Health and Disease

edited by Annamaria Russo and Ester Tellone

submission deadline 20 Dec 2025 | Viewed by 605 | Submission Open

Keywords: oxidative stress; metabolism; hemoglobin; erythrocytes

(This special issue belongs to the Section Biochemistry)

Molecular Research Advances in Metabolic Syndrome

edited by

Phileno Pinge-Filho

submission deadline 20 Dec 2025 | 1 articles | Viewed by 602 | Submission Open

Keywords: metabolic syndrome; sepsis; molecular mechanisms; inflammation; insulin resistance; cardiovascular parameters; immune– metabolic crosstalk; experimental models; biomarkers; therapeutic targets

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Exploring Natural Products for Antimicrobial Innovation: New Paths and Promising Leads

edited by

Shagufta Perveen

submission deadline 20 Dec 2025 | Viewed by 579 | Submission Open

Keywords: antimicrobial agents; drug resistance; plant-derived compounds; bioactive molecules; phytochemicals; marine natural products; fungal metabolites; novel drug discovery; microbial pathogens; natural product isolation; drug development; biotechnology in antimicrobial research

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Developmental Origins of Kidney Disease: Renal Programming

edited by Hyung-Eun Yim

submission deadline 20 Dec 2025 | 1 articles | Viewed by 548 | Submission Open

Keywords: air pollution; chronic kidney disease; congenital anomalies of the kidneys and urinary tract; high-risk pregnancy; nephrogenesis; renal programming; renin angiotensin system

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Histological and Molecular Perspectives on Immune Mechanisms of the Nasal and Bronchial Mucosa Diseases

edited by

Emanuela Chiarella

submission deadline 20 Dec 2025 | Viewed by 498 | Submission Open

Keywords: nasal and bronchial mucosa; nasal polyposis; bronchial inflammation; immunotherapy; mucosal immunity; inflammatory biomarkers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Design, Synthesis and Biological Activity of Heterocyclic Compounds

edited by

Monika Kadela-Tomanek

submission deadline 20 Dec 2025 | Viewed by 497 | Submission Open

Keywords: synthesis of new bioactive compounds; biological activity of heterocyclic compounds; structural analysis; pharmacokinetic analysis of potential drugs; molecular docking study of new heterocyclic compounds

(This special issue belongs to the Section Biochemistry)

Collagen-Based Biomaterials in Tissue Engineering and Regenerative Medicine

edited by Martin Braun,

Selestina Gorgieva

and

Eva Filova

submission deadline 20 Dec 2025 | Viewed by 487 | Submission Open

Keywords: collagen; tissue engineering; advanced biomaterials; biodegradable composites; scaffolds; protein structure; biochemical analysis; material characterization; medical application; gelatine

(This special issue belongs to the Section Macromolecules)

Role of EGFR in Colorectal Cancer

edited by

Verónica Moreno-Viedma

submission deadline 20 Dec 2025 | Viewed by 473 | Submission Open

Keywords: EGFR; RAS; biomarkers/prognosis; resistance mechanisms; tumor microenvironment; EGFR signaling pathways; EGFR inhibitors; onco-immunology

(This special issue belongs to the Section Biochemistry)

Physiopathology and Therapeutics of HIV Infection

edited by

Inês Bártolo

submission deadline 20 Dec 2025 | Viewed by 471 | Submission Open

Keywords: HIV; physiopathology; ART; HAART; NRTIs; NNRTIs; PIs; INSTIs; fusion inhibitors; CCR5 antagonists; post-attachment inhibitors; capsid inhibitors

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Mechanotransduction and Tissue Regeneration in Skeletal Muscle

edited by

Mahtab Nourbakhsh

submission deadline 20 Dec 2025 | Viewed by 465 | Submission Open

Keywords: skeletal muscle tissue regeneration; mechanotransduction; skeletal muscle spindles; tissue-resident macrophages

(This special issue belongs to the Section Molecular Biology)

Adipose Tissue and Adipose Tissue-Derived Stem Cells in Multidisciplinary Research

edited by Oliver Felthaus

submission deadline 20 Dec 2025 | Viewed by 439 | Submission Open

Keywords: adipose tissue; adipose-derived stem cells; regenerative medicine; tissue engineering

(This special issue belongs to the Section Molecular Biology)

Molecular and Immunological Biomarkers in Cervical Cancer

edited by Janaina Cristiana de Oliveira Crispim and

Ricardo Ney Oliveira Cobucci

submission deadline 20 Dec 2025 | Viewed by 429 | Submission Open

Keywords: cervical cancer; molecular biomarkers; immunological biomarkers; human papillomavirus (HPV); tumor microenvironment; immune responses; immunotherapy; diagnostic biomarkers; prognostic biomarkers; therapeutic targets

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Roles and Mechanisms of Non-Coding RNAs in Breast Cancer

edited by

Oliver Treeck

submission deadline 20 Dec 2025 | Viewed by 423 | Submission Open

Keywords: breast cancer; NcRNA; MmiRNA; LncRNA; CircRNA; PiRNA; exosome-packed ncRNA; role and mechanisms of ncRNA in breast cancer tissue or cell lines; modulation of ncRNA levels by knock-out or knock-down approaches; effects on breast cancer cell proliferation; invasion; or apoptosis; identification of BC-relevant ncRNA– mRNA networks; targeting ncRNAs with potential clinical implications

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Bacteria-Mediated Cancer Therapy: New Molecular Insights

edited by

Che-Hsin Lee

submission deadline 20 Dec 2025 | Viewed by 421 | Submission Open

Keywords: bacteria-mediated cancer therapy; tumor microenvironment (TME); tumour immunotherapy; anticancer bacteria

(This special issue belongs to the Section Molecular Oncology)

Molecular Advances in Chronic Pain: Mechanisms and Therapeutic Innovations

edited by

Roberto Tedeschi

submission deadline 20 Dec 2025 | Viewed by 420 | Submission Open

Keywords: chronic pain; pain mechanisms; pain management; therapeutic innovation; translational research

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Circumventing Resistance to Channel-Targeting Insecticides: A Challenge for Global Health and Food Security

edited by

Bruno Lapied

and David Barry Sattelle

submission deadline 20 Dec 2025 | Viewed by 419 | Submission Open

Keywords: pest insects and resistance; resistance in insect vectors of human and livestock diseases; mechanisms of resistance; circumventing resistance; ion channels and resistance; integrated approaches to resistance management; alternating insecticide classes; minimizing risk to beneficial insects; novel control strategies

(This special issue belongs to the Section Molecular Biology)

Pediatric Autoimmune Diseases: Molecular Basis, Diagnostic and Therapy

edited by

Marija Jelusic

submission deadline 20 Dec 2025 | Viewed by 417 | Submission Open

Keywords: autoimmunity; immune regulation; biomarker analysis; molecular pathways; precision medicine; genetics

(This special issue belongs to the Section Molecular Immunology)

Effects of Xenobiotic Exposure on Human Health: A Molecular Perspective

edited by

Maria Lisa Garavaglia

submission deadline 20 Dec 2025 | Viewed by 417 | Submission Open

Keywords: xenobiotic exposure; human health; toxic effects; environmental chemicals; molecular research

(This special issue belongs to the Section Molecular Toxicology)

Protein Modification: New Insights

edited by

Yeou-Guang Tsay

submission deadline 20 Dec 2025 | Viewed by 414 | Submission Open

Keywords: post-translational modifications (PTMs); side chain modifications; backbone modifications; analytical protein chemistry; mass spectrometry

(This special issue belongs to the Section Biochemistry)

The Molecular Life of Sperm: New Horizons in Male Infertility

edited by

Mónica Vazquez-Levin

and

Robert John Aitken

submission deadline 20 Dec 2025 | 1 articles | Viewed by 408 | Submission Open

Keywords: human sperm; fertilization; infertility; biomarkers; genetics

(This special issue belongs to the Section Molecular Biology)

Quantum Chemistry, Vibrational Spectroscopy and Biophysics on Biomolecules

edited by

Mauricio Alcolea Palafox

submission deadline 20 Dec 2025 | Viewed by 407 | Submission Open

Keywords: molecular simulations; computer calculations; structure predictions; molecular structure; DNA structure; nucleobases pairs; inter-molecular interactions; spectroscopic predictions; scaling; Raman simulations; macromolecular crystallography; molecular modeling; electronic properties

(This special issue belongs to the Section Molecular Biophysics)

Anticancer Antibiotics: Progresses, Opportunities and Challenges

edited by Jose Kaneti

submission deadline 20 Dec 2025 | Viewed by 382 | Submission Open

Keywords: tetracycline antibiotics; antitumor activity; molecular mechanism; G-quadruplex complexes; computational modeling; pharmacological evaluation

(This special issue belongs to the Section Molecular Pharmacology)

The Roles of AI in Disease Diagnosis and Treatment

edited by

Miguel Souto-Bayarri

submission deadline 20 Dec 2025 | Viewed by 380 | Submission Open

Keywords: artificial intelligence; radiomics; machine learning; deep learning; diagnosis; treatment; cancer

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Thrombo-Inflammatory Signaling and Complications in Autoimmune Disorders

edited by

Alexandros Tsoupras

submission deadline 20 Dec 2025 | Viewed by 378 | Submission Open

Keywords: inflammation; thrombosis; platelets; coagulation; autoimmune disorders; rheumatoid arthritis; systematic erythematosus lupus; antiphospholipid syndrome; thrombo-inflammation; antithrombotic; antiplatelet

(This special issue belongs to the Section Molecular Immunology)

Growth Factor Signaling in Cancer Progression

edited by

Hyeong-Reh Choi Kim

and Abdo J. Najy

submission deadline 20 Dec 2025 | Viewed by 376 | Submission Open

Keywords: growth factor signaling; proteolysis; cancer progression; tumor dormancy; metastasis; tumor microenvironment; therapeutic strategies

(This special issue belongs to the Section Molecular Biology)

Molecular Pharmacology of Cation-Permeable Ion Channels

edited by

Jian Shi

submission deadline 20 Dec 2025 | Viewed by 354 | Submission Open

Keywords: cation-permeable ion channel structure; cation-permeable ion channel functions; cation-permeable ion channel pharmacology; cation-permeable ion channel and diseases; innovative techniques for cation-permeable ion channel research

(This special issue belongs to the Section Molecular Pharmacology)

Antiviral Mechanisms of Natural/Synthetic Compounds

edited by Cybele Carina García

submission deadline 20 Dec 2025 | Viewed by 350 | Submission Open

Keywords: antiviral mechanisms; natural compound; synthetic compound; druggable viral/host target; emerging virus; host– virus interaction; innate antiviral response; cell-intrinsic restriction factor

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Coenzyme Q Redox State and Cellular Homeostasis: Implications for Clinical Practice

edited by

Iain P. Hargreaves

submission deadline 20 Dec 2025 | Viewed by 342 | Submission Open

Keywords: coenzyme Q; cellular homeostasis; cellular energy production; antioxidant defense

(This special issue belongs to the Section Molecular Biology)

Stem Cell or Exosome-Based Therapy for Kidney and Urinary Tract Diseases: Mechanisms, Applications, and Future Perspectives

edited by

Yuanyuan Zhang

submission deadline 20 Dec 2025 | Viewed by 334 | Submission Open

Keywords: stem cell therapy; exosome therapy; kidney disease; regenerative medicine; cell differentiation; tissue engineering; drug discovery; in vitro 3D models; anti-inflammation; antioxidant stress; antifibrosis; extracellular vesicles; precision medicine; bioengineering; artificial intelligence; bioinformatics

(This special issue belongs to the Section Molecular Biology)

Mechanistic and Data-Driven Modelling Approaches for Regulatory Networks and Diseases

edited by

Tianhai Tian

submission deadline 20 Dec 2025 | Viewed by 332 | Submission Open

Keywords: mathematical modelling; data-driven approach; mechanistic and data dual-driven approach; hybrid modelling; machine learning; modelling of regulatory network; inference of molecular regulation; cancer; infection disease; disease intervention

(This special issue belongs to the Section Molecular Informatics)

Chronic Kidney Disease: Novel Advances in Pathophysiology and Therapeutics

edited by

Shihping Hsu

submission deadline 20 Dec 2025 | Viewed by 331 | Submission Open

Keywords: anti-fibrosis; anti-inflammation; biomarker; chronic kidney disease; complement; glucagon-like peptide-1 receptor agonist; immuno modulaton; sodium– glucose cotransporter-2 inhibitor

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Abscisic Acid, a New Old Friend to Regulate Abiotic Stress Tolerance in Plants

edited by Marta Marina Pérez-Alonso and

Miguel González-Guzmán

submission deadline 20 Dec 2025 | Viewed by 327 | Submission Open

Keywords: abscisic acid (ABA); ABA perception; ABA signaling network; abiotic stress; hormonal crosstalk; crop species; stress tolerance; plant productivity; agriculture

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Insights into Chronic Liver Disease and Liver Failure

edited by Paolo Gallo

submission deadline 20 Dec 2025 | Viewed by 322 | Submission Open

Keywords: cirrhosis; portal hypertension; liver failure; advanced chronic liver disease; sarcopenia and malnutrition; ascites; medical treatment

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

DNA Methylation in Cancer: Progress and Challenges

edited by

Michael Eccles

submission deadline 20 Dec 2025 | Viewed by 320 | Submission Open

Keywords: DNA methylation; cancer; hypomethylation; hypermethylation; epigenetics; tumor onset; tumor progression; technologies

(This special issue belongs to the Section Molecular Genetics and Genomics)

Physiology and Pathophysiology of Neurodegeneration: New Insights and Advances from Molecular to Cellular Level

edited by

Alessandro Romano

and

Amilcare Barca

submission deadline 20 Dec 2025 | Viewed by 316 | Submission Open

Keywords: central and peripheral nervous systems; neuron homeostasis; neurodegeneration; neurodegenerative disease; neurophysiology; -omic technologies; induced pluripotent stem cell (iPSC); three-dimensional cell culture; organ-on-a-chip (OoC)

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Immunology of Infectious Diseases

edited by

Salvatore Giovanni De Simone

submission deadline 20 Dec 2025 | Viewed by 296 | Submission Open

Keywords: molecular immunology; infectious diseases; innate immunity; adaptive immunity; immunomodulation-based therapies

(This special issue belongs to the Section Molecular Immunology)

Advanced Cell Based Biomaterials for Musculoskeletal Tissue Engineering

edited by

Isabel Calejo

submission deadline 20 Dec 2025 | Viewed by 279 | Submission Open

Keywords: cell-based materials; bioprinting; microfluidics; hydrogels; vascularization; innervation; hierarchical; fiber technologies; microtissues

(This special issue belongs to the Section Materials Science)

Epigenetic and RNA-Based Regulation in Cancer: Mechanism, Therapeutic Targets, and Translational Perspectives

edited by

Moon Nyeo Park

submission deadline 20 Dec 2025 | Viewed by 279 | Submission Open

Keywords: molecular underpinnings of DNA; histone; RNA-based epigenetic regulation; small molecules and epigenetic inhibitors; epigenetic signatures; oncology

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Applications of Nanoparticles in Cancer Therapy

edited by Carlos Caro and Iñigo Martínez-Zubiaurre

submission deadline 20 Dec 2025 | Viewed by 265 | Submission Open

Keywords: nanomedicine; molecular biology of cancer; advanced therapies; tumor microenvironment; cellular crosstalk

(This special issue belongs to the Section Materials Science)

Emerging Trends in Adductomics: From Adduct Detection to Environmental Implications

edited by

Mu-Rong Chao

Marcus S. Cooke

and

Chiung Wen Hu

submission deadline 20 Dec 2025 | Viewed by 260 | Submission Open

Keywords: adductomics; covalent adducts; crosslinks; biomarkers; electrophilic species; exposome; environmental toxicants; high-resolution tandem mass spectrometry; post-data analysis

(This special issue belongs to the Section Molecular Toxicology)

Immunology and Immunotherapy for Head and Neck Cancer

edited by

Aurora Mirabile

submission deadline 20 Dec 2025 | Viewed by 240 | Submission Open

Keywords: immunotherapy; head and neck cancer; toxicity management; immune system; nutrition; immune therapy and organ failure; mechanisms of immunotherapy resistance

(This special issue belongs to the Section Molecular Immunology)

Advances in Targeted Cancer Therapy and Side-Effect Management

edited by Wei-Min Chang

submission deadline 20 Dec 2025 | Viewed by 239 | Submission Open

Keywords: targeted cancer therapy; novel therapy approaches; personalized treatment; small molecule inhibitors; combination strategies; multi-omics integration; proton therapy; reduced cancer treatment side effects; therapeutic resistance; biomarkers

(This special issue belongs to the Section Molecular Oncology)

Acute Leukemia: From Basic Research to Clinical Application, Second Edition

edited by

Luca Lo Nigro

submission deadline 20 Dec 2025 | Viewed by 235 | Submission Open

Keywords: acute lymphoblastic leukemia (ALL); acute myeloid leukemia (AML); genomic findings; post-genomic findings; targeted therapies; immunotherapies; novel markers

(This special issue belongs to the Section Molecular Oncology)

Bioactives in Processed Foods: Profiling and Bioavailability Assessment

edited by Cong Wang

submission deadline 20 Dec 2025 | Viewed by 224 | Submission Open

Keywords: food processing; food bioactives; composition; bioavailability; functionality; novel food processing techniques; structure/constituents– bioactivity relationship

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Myosin: Structure, Function and Evolution

edited by Barbara Baryłko and

Joseph P. Albanesi

submission deadline 20 Dec 2025 | Viewed by 220 | Submission Open

Keywords: myosins; actin; molecular motors; organelle trafficking; endocytosis; secretion; membrane tension; RNA transport; force generation; ATPase activity

(This special issue belongs to the Section Macromolecules)

The Role of Ion Channels in Health and Disease

edited by

Joohyun Nam

submission deadline 20 Dec 2025 | Viewed by 216 | Submission Open

Keywords: ion channel; molecular mechanisms; channelopathies; drug discovery; electrophysiology

(This special issue belongs to the Section Molecular Biology)

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