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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Flow Cytometry: Applications and Challenges

edited by

Alessandra Falda

submission deadline 20 Jan 2026 | 7 articles | Viewed by 16946 | Submission Open

Keywords: flow cytometry; non-conventional flow cytometry; hematology; morphology; molecular tests; cell biology; immunology; target therapy; microbiology; antigens; functional mechanisms; new technologies

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms Involved in Sperm Development, Maturation, and Fertilization (3rd Edition)

edited by

Jan Tesarik

submission deadline 20 Jan 2026 | 5 articles | Viewed by 16713 | Submission Open

Keywords: sperm physiology; seminal plasma; extracellular vesicles; reproduction; spermatogenesis; capacitation; fertility

(This special issue belongs to the Section Molecular Biology)

Advances in Research on Neurotransmitters

edited by

Mario Manto

Hiroshi Mitoma

and Jing-Ning Zhu

submission deadline 20 Jan 2026 | 6 articles | Viewed by 16568 | Submission Open

Keywords: neurotransmitter; GABA; glutamate; monoamines; dopamine; serotonin; norepinephrine; neuropeptides; nitric oxide; neurosteroids; stress; neurotrophins; epigenetics; gut– brain axis

(This special issue belongs to the Section Molecular Neurobiology)

Recent Advances of Novel Pharmaceutical Designs for Anti-Cancer Therapies, 3rd Edition

edited by

Bernhard Biersack

submission deadline 20 Jan 2026 | 8 articles | Viewed by 16551 | Submission Open

Keywords: cancer; anticancer drugs; drug design; targeted therapy; immunotherapy; molecular target; molecular mechanism; drug resistance

(This special issue belongs to the Section Molecular Pharmacology)

Genomic Research of Rare Diseases

edited by Shira Rockowitz and Piotr Sliz

submission deadline 20 Jan 2026 | 7 articles | Viewed by 16086 | Submission Open

Keywords: rare disease ontology; variants of uncertain significance; candidate genes; whole genome sequencing; long read whole genome sequencing; machine learning; multi-omics

(This special issue belongs to the Section Molecular Genetics and Genomics)

Transporters in Health and Disease

edited by

Giuliano Ciarimboli

submission deadline 20 Jan 2026 | 7 articles | Viewed by 15734 | Submission Open

Keywords: transporters; disease; regulation; drugs; toxicity; signaling

(This special issue belongs to the Section Molecular Biology)

Growth Hormone Deficiency: Molecular Pathologies and Therapeutic Strategies

edited by

Renata Stawerska

submission deadline 20 Jan 2026 | 8 articles | Viewed by 15642 | Submission Open

Keywords: growth hormone (GH); growth hormone deficiency (GHD); growth hormone therapy; long-acting growth hormone (LAGH); insulin-like growth factor-1 (IGF-1); growth hormone secretagogues; signaling pathways of the GH-IGF-1 axis; transition phase

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Diagnosis and Monitoring of Kidney Disease: From Biology to Biomarkers

edited by

Susana Coimbra

Flávio Reis

and

Alice Santos-Silva

submission deadline 20 Jan 2026 | 6 articles | Viewed by 15487 | Submission Open

Keywords: chronic kidney disease (CKD); end-stage renal disease; CKD biomarkers; CKD progression; metabolomics; molecular pathways; biomolecules; CKD anemia; cardiovascular disease risk; CKD-related disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Bioactive Compounds in the Prevention of Chronic Diseases

edited by

Diego A. Moreno

Antonio J. Ruiz-Alcaraz

and

Paola Maycotte

submission deadline 20 Jan 2026 | 6 articles | Viewed by 15241 | Submission Open

Keywords: bioactives; chronic disease; inflammation; oxidative stress; obesity; diabetes; cancer

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Recent Advances in Pathophysiology and Immunology Related to SARS-CoV-2 Infection

edited by

Vito D’Agnano

submission deadline 20 Jan 2026 | 9 articles | Viewed by 15214 | Submission Open

Keywords: SARS-CoV-2; COVID-19; immunology; pathophysiology; immunopathology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Novel Insight into Epigenomic Studies of Human Disease

edited by

Mitsuko Masutani

and Takashi Ito

submission deadline 20 Jan 2026 | 7 articles | Viewed by 14787 | Submission Open

Keywords: epigenetic regulation; DNA methylation; protein methylation; protein acetylation; histone modification; noncoding RNAs (ncRNAs); post-translational modifications (PTMs); chromatin; human disease

(This special issue belongs to the Section Molecular Genetics and Genomics)

Focus on Hippocampus Biology: From Neurophysiology to Dysfunctions (2nd Edition)

edited by

Manuela Dicarlo

submission deadline 20 Jan 2026 | 4 articles | Viewed by 14129 | Submission Open

Keywords: hippocampus; dentate gyrus; cornu ammonis (CA); spatial memory; episodic memory; learning; spatial navigation; synaptic plasticity; neuroplasticity; neurogenesis; ischemia; neuroinflammation; chronic stress; aging; neurodegenerative diseases; Alzheimer’ s disease; epilepsy; depression; anxiety

(This special issue belongs to the Section Molecular Neurobiology)

Cytotoxicity, Antioxidant and Anticancer Activity of Natural Products, 2nd Edition

edited by

Balik Dzhambazov

submission deadline 20 Jan 2026 | 7 articles | Viewed by 14040 | Submission Open

Keywords: natural products; anticancer activity; apoptosis; immunomodulation; free radicals; proliferation; phytomolecules; nanoparticles; drug delivery

(This special issue belongs to the Section Bioactives and Nutraceuticals)

New Insights into the Treatment of Metabolic Syndrome and Diabetes

edited by

Igor Kovalchuk

submission deadline 20 Jan 2026 | 5 articles | Viewed by 13614 | Submission Open

Keywords: metabolic dysfunction; metabolic disorder; diabetes

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Editorial Board Members’ Collection Series: Cardiovascular Diseases

edited by

Melania Gaggini

and

Cristina Vassalle

submission deadline 20 Jan 2026 | 5 articles | Viewed by 12997 | Submission Open

Keywords: cardiovascular disease; metabolism; cardiometabolic risk; coronary artery disease; CVD

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

The Structures and Biologic Activity of Marine Natural Products

edited by

Alexanra S. Silchenko

and

Vladimir Kalinin

submission deadline 20 Jan 2026 | 4 articles | Viewed by 12871 | Submission Open

Keywords: marine natural products; secondary metabolites; structure elucidation; biologic activity; structure-activity relationships; taxonomic distribution; biosynthesis; functions

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Insights into Zoology

edited by

Valeria Maselli

submission deadline 20 Jan 2026 | 9 articles | Viewed by 12870 | Submission Open

Keywords: zoology; genomics; transcriptomics; phylogeny; molecular evolution; mtDNA; eDNA; RNA; molecular zoolog

(This special issue belongs to the Section Molecular Biology)

Research Advances in the Bioinformatics of Genome Editing and Gene Function Analysis

edited by

Hidemasa Bono

submission deadline 20 Jan 2026 | 4 articles | Viewed by 12504 | Submission Open

Keywords: genome editing; functional genomics; genome analysis; transcriptome analysis; metagenome analysis; meta-analysis; bioinformatics; large language model (LLM); public databases

(This special issue belongs to the Section Molecular Informatics)

Molecular Progression of Genetics in Breeding of Farm Animals

edited by

Karel Novák

submission deadline 20 Jan 2026 | 6 articles | Viewed by 11852 | Submission Open

Keywords: farm animal; livestock; genome sequencing

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Aspects of Bacterial Infection

edited by

María Soledad Ramírez

submission deadline 20 Jan 2026 | 5 articles | Viewed by 11342 | Submission Open

Keywords: bacterial pathogenesis; antimicrobial resistance; molecular mechanism of host-pathogen interaction; biofilm; infectious diseases

(This special issue belongs to the Section Molecular Microbiology)

Molecular Advances in Neurologic and Neurodegenerative Disorders

edited by

Ioana-Miruna Balmus

and

Ioannis Mavroudis

submission deadline 20 Jan 2026 | 4 articles | Viewed by 11295 | Submission Open

Keywords: traumatic brain injury; chronic traumatic encephalopathy; Alzheimer’ s disease; motor neuron disease; amyotrophic lateral sclerosis; neurosignalling; neurodegeneration; brain– gut axis impairment; oxidative stress; chronic inflammation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Renin-Angiotensin System in Health and Diseases

edited by

Keiko Hosohata

submission deadline 20 Jan 2026 | 3 articles | Viewed by 11188 | Submission Open

Keywords: coronavirus disease 2019 (COVID-19); SARS-CoV-2; RAAS; spike protein; angiotensin; ACE2; clinical study; basic experiments

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Molecular Forensic Pathology and Toxicology: An Update

edited by

Angelo Montana

submission deadline 20 Jan 2026 | 5 articles | Viewed by 11116 | Submission Open

Keywords: biomarkers; immunohistochemistry; histopathology; forensic pathology; forensic toxicology; forensic biomarkers; toxicological biomarkers; neuropathology; mRNA; post-mortem interval; cerebral damage; in vitro; in vivo; and in silico models; hypoxic– ischemic brain injury; pregnancy biomarkers; vitality

(This special issue belongs to the Section Molecular Biology)

Inflammation in Chronic Disease: Molecular Mechanisms and Signaling Pathways

edited by

Nadia Lampiasi

submission deadline 20 Jan 2026 | 4 articles | Viewed by 10840 | Submission Open

Keywords: inflammation; neuroinflammation; immune response; inflammation-associated disease; inflammation mediators (proteins; enzymes; ecc); cytokines; macrophages; mast cells; monocytes; dendritic cells; oxidative stress; signaling pathways

(This special issue belongs to the Section Molecular Immunology)

Molecular Mechanism Underlying Plant Drought and Salinity Stress Tolerance

edited by

Marzena Kurowska

and

Boris Lazarević

submission deadline 20 Jan 2026 | 4 articles | Viewed by 10828 | Submission Open

Keywords: drought; salinity; oxidative stress; antioxidant mechanism; photosynthesis; aquaporins; gene expression analysis

(This special issue belongs to the Section Molecular Plant Sciences)

New Advances in the Treatment and Diagnosis of Neuromuscular Diseases

edited by Silvia Consalvi

submission deadline 20 Jan 2026 | 2 articles | Viewed by 10682 | Submission Open

Keywords: neuromuscular diseases; gene therapies; stem cell therapy; treatment and diagnosis

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Studies of Natural Compounds and Plant Extracts—3rd Edition

edited by

Hsinjung Ho

submission deadline 20 Jan 2026 | 5 articles | Viewed by 10286 | Submission Open

Keywords: bioactive substances; plant chemistry; polysaccharides; flavonoids; alkaloids; saponins; terpenes; phenolic acids; volatile oils; antioxidant/anti-inflammatory/anti-cancer; blood pressure lowering; blood sugar lowering; antibacterial; antiviral; antiallergic

(This special issue belongs to the Section Biochemistry)

Developmental Biology: Computational and Experimental Approaches, 2nd Edition

edited by

Mikhail P. Ponomarenko

submission deadline 20 Jan 2026 | 5 articles | Viewed by 10276 | Submission Open

Keywords: animal; plant; fungus; biological organization hierarchy; evolutionary limitations

(This special issue belongs to the Section Molecular Biology)

Natural Compounds in Human Health and Disease

edited by

Kazuhiko Nakadate

submission deadline 20 Jan 2026 | 4 articles | Viewed by 10237 | Submission Open

Keywords: nutrition; human health; obesity; polyphenol; tea; pathology; animal model

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Recent Trends in Experimental Models for Cancer Research

edited by

Patrícia M. A. Silva

and

Cristina Pinto Ribeiro Xavier

submission deadline 20 Jan 2026 | 4 articles | Viewed by 10178 | Submission Open

Keywords: experimental models; cancer research; cell culture; animal models; organoids; computational models

(This special issue belongs to the Section Molecular Oncology)

Molecular Perspective of Precision Medicine Revolutionizing Kidney Disease

edited by

Miguel Hueso

and

Alfredo Vellido

submission deadline 20 Jan 2026 | 1 articles | Viewed by 10133 | Submission Open

Keywords: personalized medicine; kidney diseases; genomics; biomarkers; therapeutics; proteomics; metabolomics; machine learning

(This special issue belongs to the Section Molecular Informatics)

Respiratory Virus Infection

edited by Nikolaos Siafakas

submission deadline 20 Jan 2026 | 6 articles | Viewed by 9596 | Submission Open

Keywords: respiratory virus; diagnosis; surveillance; epidemiology; therapy; vaccination; influenza virus; coronavirus; respiratory syncytial virus; rhinovirus/enterovirus

(This special issue belongs to the Section Molecular Microbiology)

Multiple Sclerosis: From Molecular Pathology to Novel Therapeutic Approaches

edited by

László Vécsei

and

Masaru Tanaka

submission deadline 20 Jan 2026 | 6 articles | Viewed by 9558 | Submission Open

Keywords: progression-independent relapses (PIRAs); smouldering-associated worsening (SAW); lack of new relapses and of new magnetic resonance imaging activity (NEIDA); slowly expanding lesions (SEL); no evidence of smouldering disease activity (NESDA); neurofilament (NfL); glial fibrillary acidic protein (GFAP); patient-reported outcome (PRO); paramagnetic rim lesions (PRLs); relapse-associated worsening (RAW)

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Biomarkers in Cancers: Advances and Challenges, 2nd Edition

edited by

Paramjit S. Tappia

and

Bram Ramjiawan

submission deadline 20 Jan 2026 | 6 articles | Viewed by 8911 | Submission Open

Keywords: cancer; cancer staging; diagnostic tools; novel biomarkers; proteomics; molecular markers; metabolic profiling; prognostic value

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Protein and Protein Interactions

edited by Wu Xu

submission deadline 20 Jan 2026 | 4 articles | Viewed by 8632 | Submission Open

Keywords: protein and protein interactions; ligand and protein interactions; computational method; geometry-based; energy-based; conformational changes; binding site prediction; structural biology; computational biology and bioinformatics

(This special issue belongs to the Section Molecular Biology)

Biochemical and Molecular Aspects of Bioremediation of Soils with Organic Pollutants by Microorganisms

edited by

Mariusz Cycoń

submission deadline 20 Jan 2026 | 5 articles | Viewed by 8601 | Submission Open

Keywords: bioremediation; soil pollution; organic pollutants; microorganisms; microbial communities; gene expression; enzyme degradation; molecular tools; indigenous soil microorganisms; contaminated soils

(This special issue belongs to the Section Molecular Microbiology)

Molecular Research in Bone and Soft Tissue Tumors

edited by

Shinji Miwa

submission deadline 20 Jan 2026 | 4 articles | Viewed by 8400 | Submission Open

Keywords: sarcoma; therapeutic target; metastasis; anticancer agent; immunotherapy

(This special issue belongs to the Section Molecular Oncology)

Abiotic Stresses in Plants: From Molecules to Environment—2nd Edition

edited by

Martin Bartas

submission deadline 20 Jan 2026 | 6 articles | Viewed by 8188 | Submission Open

Keywords: stress signaling; abiotic stress; oxidative stress; genotoxic stress

(This special issue belongs to the Section Molecular Plant Sciences)

Herpes Simplex Virus: Immunity, Pathogenicity, Immune Escape Mechanisms, and Antiviral Strategies

edited by

Maria Teresa Sciortino

submission deadline 20 Jan 2026 | 2 articles | Viewed by 8174 | Submission Open

Keywords: herpes simplex virus (HSV); latency; immune evasion; tegument proteins; epigenetic mechanisms; viral pathogenesis; antiviral strategies; molecular mechanisms; therapeutic interventions

(This special issue belongs to the Section Molecular Immunology)

Recent Advances in Electrochemical-Related Materials

edited by Celia García-Hernandez

submission deadline 20 Jan 2026 | 6 articles | Viewed by 8023 | Submission Open

Keywords: novel electrochemical devices; advanced micro- and nanomaterials for electrochemical applications; batteries; fuel and photoelectrochemical cells; electrochemical sensors and biosensors; new advances in supercapacitors; electrochemical electrolyzers; advanced electrochemical materials for environmental applications

(This special issue belongs to the Section Materials Science)

Diabetes and Its Complications: From Molecular Mechanisms to Novel Therapeutic Approaches—2nd Edition

edited by

Andrea Paola Rojas Gil

submission deadline 20 Jan 2026 | 1 articles | Viewed by 7744 | Submission Open

Keywords: diabetes; diabetes complications; environmental factors; endocrine disruptors; nutrition; sleep; therapy; molecular mechanisms

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Insights into the Immunopathology of Infectious Diseases

edited by Marta Camici

submission deadline 20 Jan 2026 | 4 articles | Viewed by 7741 | Submission Open

Keywords: infection immunology; immune dysregulation in infectious diseases; interactions between infective agents and immune responses; modeling of the immune system; new pathways of pathogenesis

(This special issue belongs to the Section Molecular Immunology)

Molecular Mechanisms and Therapies for Melanoma

edited by Anna Piotrowska

submission deadline 20 Jan 2026 | 3 articles | Viewed by 7736 | Submission Open

Keywords: melanoma; targeted therapy; BRAF/MEK inhibitors; immunotherapy; anti-PD-1 and anti-CTLA-4 immunotherapy; melanoma microenvironment; cancer-associated fibroblasts (CAFs)/melanoma-associated fibroblasts (MAFs); MAPK (mitogen-activated protein kinase) signaling pathway

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Latest Research on Plant Genomics and Genome Editing, 2nd Edition

edited by

Fabrizio Carbone

submission deadline 20 Jan 2026 | 5 articles | Viewed by 7724 | Submission Open

Keywords: next-generation sequencing; structural and functional genomics; SNPs; miRNA; LncRNA; CRISPR/Cas9; TALEN; genome editing

(This special issue belongs to the Section Molecular Plant Sciences)

Mesenchymal Stem Cell-Based Therapy: Cell Therapy vs. EV Therapy

edited by Masahito Nakazaki

submission deadline 20 Jan 2026 | 1 articles | Viewed by 7666 | Submission Open

Keywords: mesenchymal stromal/stem cells; small extracellular vesicles; large extracellular vesicles; clinical trials; spinal cord injury; cerebrovascular disease

(This special issue belongs to the Section Biochemistry)

Investigating Host-Parasite Interactions for the Discovery of Novel Therapies and Vaccine Targets

edited by

Natalie Nieuwenhuizen

submission deadline 20 Jan 2026 | 5 articles | Viewed by 7556 | Submission Open

Keywords: parasites; host-pathogen interactions; helminths; worms; protozoans; leishmania; malaria; schistosomiasis; trypanosomiasis; ascariasis; anisakiasis; vectors; mosquitoes; ticks; neglected tropical diseases

(This special issue belongs to the Section Molecular Immunology)

Advanced Electrode and Electrolyte Materials: Molecular Scale Design, Synthesis, Mechanisms and Applications

edited by

Christian Julien

submission deadline 20 Jan 2026 | 3 articles | Viewed by 7440 | Submission Open

Keywords: cathode; anode; electrolyte; synthesis; electrochemistry; rechargeable batteries; lithium-ion batteries; all-solid-state lithium metal batteries

(This special issue belongs to the Section Materials Science)

Biomaterials for Drug Delivery and Advanced Therapies

edited by

Annalisa Bianchera

submission deadline 20 Jan 2026 | 3 articles | Viewed by 7359 | Submission Open

Keywords: polymers; biomaterials; drug delivery; scaffold; ATMPs; tissue regeneration

(This special issue belongs to the Section Materials Science)

Virus Infection and Infectious Diseases: Unraveling Mechanisms, Innovations and Therapeutic Strategies—Second Edition

edited by Jung-Hyun Lee

submission deadline 20 Jan 2026 | 5 articles | Viewed by 7330 | Submission Open

Keywords: mechanism of virus infection; host immune responses; innovations in diagnostics and surveillance; therapeutic strategies; epidemiology and global health; data science for infectious disease; zoonotic transmission; virus evolution

(This special issue belongs to the Section Molecular Immunology)

Molecular Mechanism and Pathogenesis of Cardiac Disease

edited by Yu-Hsun Kao

submission deadline 20 Jan 2026 | 3 articles | Viewed by 7275 | Submission Open

Keywords: cardiac diseases; cardiac metabolidm; epigenetics; ER stress; mitochondrial dysfunction; molecular mechanisms; therapeutic targets

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Displaying special issue 551-600 on page 12 of 67.

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