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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Latest Advances in Aquatic Genetic Improvement

edited by Jun Qiang,

Yifan Tao

and Wenjing Tao

submission deadline 30 Jan 2026 | 1 articles | Viewed by 755 | Submission Open

Keywords: aquaculture genetic breeding; genomic selection; gene editing; disease-resistant breeding; multi-omics analysis; stress resistance enhancement; smart aquaculture; artificial intelligence

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Research and Insights into Anti-Cancer Vaccines

edited by

Alfredo Martínez

submission deadline 30 Jan 2026 | 1 articles | Viewed by 638 | Submission Open

Keywords: anti-cancer vaccines; tumor antigens; molecular mechanisms; immunotherapy; molecular oncology

(This special issue belongs to the Section Molecular Oncology)

Mechanistic and Small Molecule Discoveries for Therapeutic Advances in Hypertrophic and Dilated Cardiomyopathies

edited by Osha Roopnarine

submission deadline 30 Jan 2026 | Viewed by 601 | Submission Open

Keywords: hypertrophic cardiomyopathy; dilated cardiomyopathies; cardiomyopathies

(This special issue belongs to the Section Molecular Pharmacology)

Chemoinformatics and Bioinformatics Tools in Structure-Activity Modelling in Molecular Sciences: 3rd Edition

edited by

Bono Lučić

submission deadline 30 Jan 2026 | Viewed by 600 | Submission Open

Keywords: chemoinformatics tools and models; bioinformatics tools and models; structure– activity modeling; structure– property modeling; QSAR; QSPR; drug/structure identification in bioprospecting research; molecular docking; molecular interactions; protein– protein interactions; development of algorithms; databases and web servers; data mining in chemoinformatics and bioinformatics; structure representation and optimization; molecular descriptors; modeling of health and environmentally relevant endpoints (activities; properties); toxicity modeling and prediction; carcinogenicity modeling and prediction; computational methods in molecular sciences; model validation approaches; multivariate modeling; predictive modeling; descriptive modeling; continuous data modeling; classification data modeling; machine learning in molecular sciences; deep learning in molecular sciences; structure visualization tools

(This special issue belongs to the Section Molecular Informatics)

Experimental Models and Applications in Muscle Regeneration

edited by

Daiva Bironaite

submission deadline 30 Jan 2026 | Viewed by 561 | Submission Open

Keywords: stem cells; internal and external stimuli; scaffolds; signaling systems; muscle regeneration mechanisms

(This special issue belongs to the Section Molecular Biology)

Protease and Carbonic Anhydrase Inhibitors: 3rd Edition

edited by

Alessio Nocentini

submission deadline 30 Jan 2026 | Viewed by 560 | Submission Open

Keywords: carbonic anhydrase; protease; inhibitor; antiviral drug; antitumor drug; drug design; serine protease; metalloprotease; aspartic protease

(This special issue belongs to the Section Biochemistry)

Autoimmune and Inflammatory Diseases: Latest Advances and Prospects

edited by

Paola Galozzi

submission deadline 30 Jan 2026 | Viewed by 490 | Submission Open

Keywords: autoimmunity; autoimmune disease; inflammation; inflammatory disease; cellular pathways; molecular mechanisms; pathogenesis; therapy

(This special issue belongs to the Section Molecular Immunology)

Insights into Neurological and Psychiatric Diseases from Invertebrate Models

edited by

Efthimios M. C. Skoulakis

submission deadline 30 Jan 2026 | Viewed by 485 | Submission Open

Keywords: disease model development; disease model validation; GWAS validation; ameliorative approaches; pharmacogenetics; pharmacoproteomics; disease mechanisms; suppressor/enhancer genetic screens; synthetic lethality screens; biomarker screens and validation

(This special issue belongs to the Section Molecular Neurobiology)

Inflammation and Metabolic Response in Mitochondrial Diseases

edited by

Guido Primiano

submission deadline 30 Jan 2026 | Viewed by 425 | Submission Open

Keywords: mitochondrial diseases; mitochondria; mtDNA; metabolic remodeling; inflammation; immunity; cell death; neurodegenration

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Artificial Intelligence in Human Disease: Current and Future Perspectives in Digital Medicine

edited by

Dumache Raluca-Oana

submission deadline 30 Jan 2026 | Viewed by 400 | Submission Open

Keywords: molecular genetics; artificial intelligence; pharmacogenomics; internet of things; molecular pathology; genomic medicine

(This special issue belongs to the Section Molecular Informatics)

New Insights in Nanomaterials and Electroactive Molecules—in Memory of Prof. Royce W. Murray

edited by

Zeev Porat

submission deadline 30 Jan 2026 | Viewed by 378 | Submission Open

Keywords: nanomaterials; organic electrochemistry; macromolecules and polymers; analytical chemistry

(This special issue belongs to the Section Molecular Nanoscience)

Advances in Post-Mortem Toxicology

edited by

Rafał Skowronek

submission deadline 30 Jan 2026 | 1 articles | Viewed by 378 | Submission Open

Keywords: post-mortem toxicology; fatal poisoning; new psychoactive substances; opioids; analytical methods; interpretation of test results

(This special issue belongs to the Section Molecular Toxicology)

Tumor Specific Immunotherapeutic Targets

edited by

Roberto Perris

submission deadline 30 Jan 2026 | Viewed by 375 | Submission Open

Keywords: immunotherapy; immunotherapeutics; tumour-specific antigens; immunotherapeutic targets; multi-omics approaches

(This special issue belongs to the Section Molecular Immunology)

Artificial Intelligence Advancing Computer-Aided Drug Discovery

edited by

Raju Dash

submission deadline 30 Jan 2026 | 1 articles | Viewed by 363 | Submission Open

Keywords: machine learning; deep learning; computer-aided drug design; target identification; AI-assisted molecular diagnosis; AI-driven pharmacokinetic profiling; virtual screening; network pharmacology; drug repurposing; molecular dynamics simulation; computational chemistry; AI in nanotechnology

(This special issue belongs to the Section Molecular Informatics)

Plant Cell/Organ Structure and Function Research

edited by

Bartosz Płachno

submission deadline 30 Jan 2026 | Viewed by 347 | Submission Open

Keywords: leaf development; root development; plant cell ultrastructure; plant morphogenesis; plant organs and bacteria; fungi and animal interactions

(This special issue belongs to the Section Molecular Plant Sciences)

Nutritional Modulators of Healthy Longevity: Mechanisms and Interventions

edited by

Shaokang Wang

submission deadline 30 Jan 2026 | Viewed by 320 | Submission Open

Keywords: aging; healthspan; nutrient signaling; oxidative stress; inflammation; autophagy; sarcopenia; bioactive compounds; molecular nutrition; protein metabolism

(This special issue belongs to the Section Molecular Biology)

Developing Methods and Molecular Basis in Plant Biotechnology: 2nd Edition

edited by

Wojciech Makowski

submission deadline 30 Jan 2026 | Viewed by 280 | Submission Open

Keywords: plant biotechnology; plant genetics; plant proteomics; plant metabolomics; stress

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular and Genetic Insights into Neuropsychiatric Disorders: From Mechanisms to Management

edited by

James Alan Bourgeois

submission deadline 30 Jan 2026 | 1 articles | Viewed by 277 | Submission Open

Keywords: psychiatry; neurology; psychotic disorders; depressive disorders; neurocognitive disorders; neuropsychiatry; genetics; psychopharmacology; neuromodulation; genome-wide association studies (GWAS); transcriptomics; epigenetics; gene-environment interactions

(This special issue belongs to the Section Molecular Neurobiology)

Photosensitizers for Photodynamic Therapy: From Molecular Design to Application

edited by

Carlos Monteiro

M. Amparo F. Faustino

and

Leandro M. O. Lourenço

submission deadline 30 Jan 2026 | Viewed by 241 | Submission Open

Keywords: photodynamic therapy (PDT); photosensitizers (PS); reactive oxygen species (ROS); molecular design; nanocarriers; porphyrins and analogs; targeted drug delivery; translational medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Peripheral Neuropathy: Exploring Pathogenic Pathways and Therapeutic Approaches

edited by Yuehling Hsieh

submission deadline 30 Jan 2026 | Viewed by 222 | Submission Open

Keywords: peripheral neuropathy; biochemical mechanisms; biomarkers; nerve regeneration; therapeutic approaches; pain management; denervated muscle atrophy; translational medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Insight into Oral Health: Disease and Medicine

edited by Norio Sogawa

submission deadline 30 Jan 2026 | Viewed by 176 | Submission Open

Keywords: oral health; disease; molecular medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Synthesis and Molecular Applications of Nanomaterials

edited by

Fernando J. Pereira

A. Javier Aller

and

Roberto Lopez

submission deadline 30 Jan 2026 | Viewed by 167 | Submission Open

Keywords: nanomaterials; synthesis; molecular applications

(This special issue belongs to the Section Molecular Nanoscience)

Interaction of Gut Microbiota and Food Bioactive Compounds

edited by

Yiming Feng

and

Xiaohong Sun

submission deadline 30 Jan 2026 | Viewed by 166 | Submission Open

Keywords: gut microbiome; molecular mechanisms; metabolomics; transcriptomics; bioactive compounds; microbial enzymes; host– microbe signaling; personalized nutrition; systems biology; functional genomics

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Research on Immune Mechanisms in Kidney Disease

edited by Niels Olsen Saraiva Câmara

submission deadline 30 Jan 2026 | Viewed by 159 | Submission Open

Keywords: kidney disease; molecular sensors; kidney metabolism; immunity; AKI to CKD transition

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Advances in Endometriosis Pathophysiology and Pharmacological Treatment (2nd Edition)

edited by

René Wenzl

submission deadline 30 Jan 2026 | Viewed by 158 | Submission Open

Keywords: endometriosis; pathophysiology; pharmacological treatment; estrogen

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Plant–Rhizobium Interaction

edited by Rujin Chen

submission deadline 30 Jan 2026 | Viewed by 157 | Submission Open

Keywords: legume; rhizobia; symbiotic nitrogen fixation

(This special issue belongs to the Section Molecular Plant Sciences)

Cellular and Molecular Pathogenesis of Gynecologic Diseases: Focus on Uterine and Ovarian Dysfunction

edited by

Seung-Yup Ku

submission deadline 30 Jan 2026 | Viewed by 143 | Submission Open

Keywords: molecular pathogenesis; uterine diseases; ovarian dysfunction; cellular mechanisms; translational research

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advanced Therapy for Human Haemoglobinopathy

edited by Alex Felice and

Joseph Borg

submission deadline 30 Jan 2026 | Viewed by 141 | Submission Open

Keywords: haemoglobin (Hb); hemoglobinopathy (Hbpy); globin; thalassaemia; sickle cell; stem cell; gene therapy/editing; therapeutics; HbF inducing agents

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Research and Application of Platelet-Rich Plasma

edited by

Jorge U. Carmona

submission deadline 30 Jan 2026 | Viewed by 140 | Submission Open

Keywords: platelet-rich plasma; fibrin scaffold; regenerative medicine; molecular biology; translational medicine

(This special issue belongs to the Section Molecular Biology)

Molecular Advances of Osteomuscolar Conditions

edited by

Nicola Veronese

submission deadline 30 Jan 2026 | Viewed by 138 | Submission Open

Keywords: osteomuscular conditions; musculoskeletal disorders; bone; cartilage; and muscle degeneration

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Rewriting Medicine: Stem Cells and Regeneration

edited by

Tadahisa Sugiura

submission deadline 30 Jan 2026 | Viewed by 137 | Submission Open

Keywords: regenerative medicine; stem cell biology; stem cell therapy; induced pluripotent stem cell; tissue engineering

(This special issue belongs to the Section Molecular Biology)

Recent Research on Gut Microbiota in Health and Disease

edited by Li Cui

submission deadline 30 Jan 2026 | Viewed by 135 | Submission Open

Keywords: microbiota-host crosstalk; HMA models; microbial metabolites; gut– brain axis; translational microbiome

(This special issue belongs to the Section Molecular Microbiology)

25th Anniversary of IJMS: Updates and Advances in Molecular Toxicology

edited by

Marco E. M. Peluso

submission deadline 30 Jan 2026 | Viewed by 132 | Submission Open

Keywords: molecular toxicology; biomarkers; mechanisms of toxicity; xenobiotics; cancer diagnosis

(This special issue belongs to the Section Molecular Toxicology)

Recent Advances in Brain Cancers: Second Edition

edited by

Monika Gudowska-Sawczuk

and

Karolina Orywal

submission deadline 30 Jan 2026 | Viewed by 130 | Submission Open

Keywords: brain tumors; malignant brain tumor; advanced cancer biology

(This special issue belongs to the Section Molecular Oncology)

Targeting Hallmarks of Acute Myelocytic Leukemia (AML): Differentiation Induction in Non-Acute Promyelocytic Leukemia (Non-APL) AML

edited by

Albrecht Reichle

submission deadline 30 Jan 2026 | Viewed by 121 | Submission Open

Keywords: differentiation induction in non-APL AML; phenotypic unlocking of AML hallmarks; targeting non-oncogene addictions in AML; small molecules with differentiation-inducing capacity; epigenetic modelling in AML (azacitidine; decitabine); receptor-triggered transcription factors in AML; combined targeting of receptor-triggered transcription factors in AML; metronomic application of AML therapy; reduction in treatment toxicity by phenotypic unlocking of AML hallmarks; combination therapies for phenotypic unlocking of AML hallmarks; acquired genetic/molecular-genetic aberrations and adaptation of differentiation promoting therapy in AML

(This special issue belongs to the Section Molecular Oncology)

DNA Damage, Genome Stability and the Human Disease

edited by

Fiammetta Verni

submission deadline 30 Jan 2026 | Viewed by 117 | Submission Open

Keywords: DNA damage; human diseases; DNA repair; genomic instability; therapeutic strategies

(This special issue belongs to the Section Molecular Genetics and Genomics)

Tumor Viruses: Infection, Carcinogenesis, and Treatment

edited by

Sherif T.S. Hassan

submission deadline 30 Jan 2026 | Viewed by 115 | Submission Open

Keywords: tumor viruses; viral oncogenesis; EBV; HPV; KSHV; HBV; HCV; HTLV-1; and MCPyV; virus-associated cancers; merging oncoviruses; viral latency; immune evasion; antiviral therapy; immunotherapy; cancer vaccines; gene-editing technologies

(This special issue belongs to the Section Molecular Microbiology)

Cardiovascular Diseases: From Molecular Diagnosis to Treatment

edited by

Li Wang

submission deadline 30 Jan 2026 | Viewed by 107 | Submission Open

Keywords: cardiovascular diseases; molecular diagnosis; multi-omics approaches; liquid biopsies; molecular imaging; gene and cell therapies; nanomedicine; pharmacogenomics; targeted molecular therapies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Neural Signaling: The Perspective of Molecular Genetics

edited by

Chunlai Wu

submission deadline 30 Jan 2026 | Viewed by 83 | Submission Open

Keywords: molecular neurogenetics; neural signaling; gene editing; neural circuits; neural plasticity; neurodegenerative disorders; single-cell technologies

(This special issue belongs to the Section Molecular Genetics and Genomics)

Sarcomeric Proteins in Health and Disease: Progress and Prospects

edited by

Thomas C. Irving

submission deadline 30 Jan 2026 | Viewed by 83 | Submission Open

Keywords: sarcomeric proteins; muscle contraction; sarcomere

(This special issue belongs to the Section Molecular Biophysics)

New Advances in Environmental Carcinogenesis

edited by Grażyna Gromadzka

submission deadline 30 Jan 2026 | Viewed by 82 | Submission Open

Keywords: environmental carcinogenesis; molecular mechanisms; gene– environment interaction; endocrine disruptors; oxidative stress; epigenetics; cancer biomarkers; environmental pollutants; molecular epidemiology; cancer prevention; cancer treatment

(This special issue belongs to the Section Molecular Toxicology)

The Regulation of Metabolism by Sugars During Plant Responses to Environmental Factors and Their Function During Development

edited by

Iwona Morkunas

submission deadline 30 Jan 2026 | Viewed by 72 | Submission Open

Keywords: plant metabolism; sugar signalling; enzymes of sucrose metabolism; environmental factors; plant defense responses; developmental regulation; phytohormones; secondary metabolites

(This special issue belongs to the Section Molecular Plant Sciences)

Functional Roles of Epithelial and Endothelial Cells

edited by

Lucie Germain

and

Stéphanie Proulx

submission deadline 31 Jan 2026 | 9 articles | Viewed by 18520 | Submission Open

Keywords: epithelial cells; wound healing; endothelial cells; skin; cornea; functionality; barrier

(This special issue belongs to the Section Biochemistry)

Common Mechanisms in Gestational Diabetes, Preeclampsia, and Coronavirus Disease 2019

edited by

Sandor G. Vari

submission deadline 31 Jan 2026 | 6 articles | Viewed by 7998 | Submission Open

Keywords: gestational diabetes; preeclampsia; inflammation; immunoglobulins; glycolisation; platelet aggregation; microvascular thrombosis; coronavirus disease 2019

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Pituitary Tumors: An Update in the Pathogenetic Mechanisms, the Diagnostic Methods and the Therapeutic Approaches

edited by

Dimitrios Kanakis

submission deadline 31 Jan 2026 | 3 articles | Viewed by 7631 | Submission Open

Keywords: pituitary neuroendocrine tumors (PitNETs); pituitary transcription factors; PIT1; TPIT; SF1; GATA3; ERα ; pituicytoma; hypothalamic neurocytoma; hypothalamic gangliocytoma

(This special issue belongs to the Section Molecular Oncology)

Studies on Lactic Acid Bacteria and Their Products in Health and Diseases: 3rd Edition

edited by

Ilavenil Soundharrajan

submission deadline 31 Jan 2026 | 5 articles | Viewed by 4299 | Submission Open

Keywords: lactic acid bacteria; probiotics health benefits; gut microbiota modulation; functional foods with biological applications; immunomodulatory mechanisms; antimicrobial peptide production and its mechanisms; host-microbe interactions; functional dairy and meat products; inflammatory bowel diseases; metabolic health improvement; bioactive microbial metabolites; food safety and management; metabolic diseases and disorders; antibiotic-associated complications

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Cytokines and Other Biomarkers of Health Status

edited by Anna Cywińska and

Ewelina Maculewicz

submission deadline 31 Jan 2026 | 5 articles | Viewed by 4201 | Submission Open

Keywords: cytokine concentration; cytokine gene expression; cytokine receptors; biomarkers; pathogenesis; adaptation; homeostasis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Research into Chronic Heart Failure

edited by

Velia Cassano

submission deadline 31 Jan 2026 | 2 articles | Viewed by 3960 | Submission Open

Keywords: heart failure; oxidative stress; cardiac remodeling; cardiomyopathy; proteomic; molecular science

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Circulating Biomarkers for the Diagnosis of Neurobiological Diseases—3rd Edition

edited by

Yasemin M. Akay

submission deadline 31 Jan 2026 | 1 articles | Viewed by 3891 | Submission Open

Keywords: circulating miRNAs; differently expressed genes; long COVID-19; neurobiological diseases; mesenchymal stem cells; circulating pasma exosomes; neuropathogenesis; proteomic analysis

(This special issue belongs to the Section Molecular Neurobiology)

Fish Nutrition, Biochemical Pathways, and Physiological Adaptations

edited by Paula Simó-Mirabet and Fernando Naya-Català

submission deadline 31 Jan 2026 | 2 articles | Viewed by 3441 | Submission Open

Keywords: fish; nutrition; metabolism; physiology; growth performance; fish stress; transcriptomics; metataxonomics; metagenomics; epigenomics; aquaculture

(This special issue belongs to the Section Molecular Biology)

Displaying special issue 851-900 on page 18 of 67.

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