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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Computer-Aided Drug Discovery: Insights From Computational Chemistry and Cheminformatics submission deadline 31 Jul 2026 | Submission Open
Keywords: computer-aided drug design (CADD); computational chemistry; cheminformatics; molecular dynamics simulations; molecular modeling; QSAR modeling; virtual screening; artificial intelligence in drug discovery
(This special issue belongs to the Section Molecular Informatics)
Fluorescent Nanoparticles: Composition, Properties, and Biomedical Applications
edited by Bonghwan Chon
submission deadline 1 Aug 2026 | Viewed by 85 | Submission Open
Keywords: fluorescent nanoparticles; bioimaging; targeted drug delivery; cancer nanotherapy; quantum dots; surface functionalization; biomedical nanotechnology; theragnostic; fluorescence imaging; deep tissue imaging
(This special issue belongs to the Section Molecular Nanoscience)
New Advances in Animal Reproduction
edited by Valdevane Rocha Araújo
submission deadline 10 Aug 2026 | Viewed by 47 | Submission Open
Keywords: folliculogenesis; oogenesis; oocyte maturation; follicle growth; preantral follicles; antral follicles; spermatogenesis; spermatozoa; bioengineering; scaffolds
(This special issue belongs to the Section Molecular Biology)
Molecular Pathogenesis and Treatments of Pediatric Leukemias
edited by
submission deadline 10 Aug 2026 | Viewed by 8 | Submission Open
Keywords: monoclonal antibodies; tyrosine kinase inhibitors; CAR-T; chemotherapy; drug induced toxicity
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Plant Development and Hormonal Signaling
edited by
submission deadline 20 Aug 2026 | 6 articles | Viewed by 13362 | Submission Open
Keywords: plant growth; reproductive growth; phytohormones; signal transduction; transcription factors; root development; shoot development; floral development; seed development; environmental interactions; regulatory networks; apical dominance
(This special issue belongs to the Section Molecular Plant Sciences)
Toxicity Mechanism of Emerging Pollutants: 2nd Edition submission deadline 20 Aug 2026 | 4 articles | Viewed by 4945 | Submission Open
Keywords: emerging pollutant; toxicology; cancer; EDC; pesticides; microplastic; human cell lines; environment; molecular mechanisms
(This special issue belongs to the Section Molecular Toxicology)
Extracellular Vesicles (EVs) in Cancer Progression and Metastasis: Molecular Insights and Clinical Outlook
edited by Alfredo Cappariello
submission deadline 20 Aug 2026 | 2 articles | Viewed by 4840 | Submission Open
Keywords: mammalian extracellular vesicles; plant-derived extracellular vesicles; bacterial-derived extracellular vesicles; cancer progression; cell migration and invasion; tumor microenvironment; epithelial-to-mesenchymal transition (EMT); drug delivery; diagnostics; precision medicine
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Functional Genomics in Translational Medicine
edited by , Oana Zanoaga and
submission deadline 20 Aug 2026 | 2 articles | Viewed by 4784 | Submission Open
Keywords: functional genomics; omics approaches; drug response/resistance; therapeutic targets; genomics and transcriptomic alteration; bioinformatic analysis; data integration; human disease; personalized medicine
(This special issue belongs to the Section Molecular Genetics and Genomics)
Advances in Seed Development and Germination submission deadline 20 Aug 2026 | 3 articles | Viewed by 4620 | Submission Open
Keywords: seed aging; seed development; seed dormancy; seed germination; seed metabolism; seed preservation; seed priming; seed responses to stress
(This special issue belongs to the Section Molecular Plant Sciences)
Ferroptosis and Cuproptosis: Mechanism and Crosstalk in Cancer, Neurodegeneration, and Metabolic Syndrome
edited by
submission deadline 20 Aug 2026 | 2 articles | Viewed by 1533 | Submission Open
Keywords: ferroptosis; cuproptosis; Alzheimer's disease; colorectal cancer; neurodegeneration; metabolic syndrome; regulated cell death; iron metabolism; copper metabolism; psychiatric disorders
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Antibiotics Science: Molecular Insights, Detection Strategies, Resistance Challenges and Interdisciplinary Applications
edited by
submission deadline 20 Aug 2026 | 2 articles | Viewed by 1122 | Submission Open
Keywords: antibiotics; antibiotic molecular design and synthesis; antibiotic action mechanism; antibiotics resistance; environmental contamination; therapeutic monitoring; antibiotic sensing and detection; food and environmental safety
(This special issue belongs to the Section Molecular Microbiology)
Advances in the Synthesis and Study of Novel Bioactive Molecules submission deadline 20 Aug 2026 | 1 articles | Viewed by 816 | Submission Open
Keywords: organic compounds; metal complexes; bioactive molecules
(This special issue belongs to the Section Biochemistry)
Decoding the Microbial Influence on Host Gene Expression submission deadline 20 Aug 2026 | 1 articles | Viewed by 409 | Submission Open
Keywords: microbiota; host; gene expression; in silico; bioinformatics; in vitro; in vivo
(This special issue belongs to the Section Molecular Microbiology)
Molecular Research on Embryo Developmental Potential: 2nd Edition
edited by
submission deadline 20 Aug 2026 | 1 articles | Viewed by 395 | Submission Open
Keywords: embryo developmental potential; oocyte quality; sperm quality; non-invasive techniques; molecular biomarkers
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Aspects of Diabetes and Its Complications
edited by
submission deadline 20 Aug 2026 | Viewed by 196 | Submission Open
Keywords: obesity; insulin resistance; type 2 diabetes; atherosclerosis; endothelial dysfunction; cardiovascular disease; peripheral artery disease; diabetic feet; diabetic micoangiopathy; diabetic neuropathy; regenerative medicine
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Lipopolysaccharide as a Drug Target
edited by
submission deadline 20 Aug 2026 | Viewed by 132 | Submission Open
Keywords: tissue barriers; neuroinflammation; macrophages; microglia; organoids; scaffolds; infections; cry-EM
(This special issue belongs to the Section Molecular Pharmacology)
Vitamin D in Reproductive Disorders: Determinants, Metabolism, and Downstream Biological Mechanisms submission deadline 20 Aug 2026 | Viewed by 84 | Submission Open
Keywords: vitamin D; perinatal corticosteroids; placental insufficiency; intrauterine growth restriction; cortisol metabolism
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Effects of Radiation in Health and Disease submission deadline 20 Aug 2026 | Viewed by 4 | Submission Open
Keywords: extremely low-frequency magnetic fields; proteins and gene interaction; ionizing and non-ionizing radiations
(This special issue belongs to the Section Molecular Biology)
Current Research on Lipidomics
edited by Agata Kot-Wasik
submission deadline 25 Aug 2026 | Viewed by 5 | Submission Open
Keywords: lipids  ; hyphenated chromatography– mass spectrometry  ; biological samples  ; sample preparation
(This special issue belongs to the Section Molecular Biology)
Neurotransmitter Dysregulation in Brain Disease: Focus on Epilepsy and Its Comorbidities submission deadline 30 Aug 2026 | Viewed by 76 | Submission Open
Keywords: neurotransmitter dysregulation; epilepsy; addiction; serotonin; GABA; molecular neuroscience; neuropharmacology; brain networks
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Mechanisms Fueling Glioblastoma Progression and Resistance: Emerging Therapeutic Opportunities
edited by
submission deadline 30 Aug 2026 | Viewed by 46 | Submission Open
Keywords: glioblastoma; cancer stem cells; radioresistance; chemoresistance; targeted therapies; tumor plasticity; tumor heterogeneity; invasion; immune escape
(This special issue belongs to the Section Molecular Neurobiology)
MiRNA Stromal Interaction in the Tumor Microenvironment
edited by
submission deadline 30 Aug 2026 | Viewed by 37 | Submission Open
Keywords: microRNAs; early tumor microenvironment (TME); stromal/ECM interaction; vascularization; ECM remodelling; signalling pathways
(This special issue belongs to the Section Molecular Oncology)
The Role of Neuropeptides and Their GPCRs in the Neuroendocrine System
edited by
submission deadline 31 Aug 2026 | Viewed by 535 | Submission Open
Keywords: neuropeptides; G-protein-coupled receptors (GPCRs); neuroendocrine system; signal transduction; hypothalamus
(This special issue belongs to the Section Molecular Neurobiology)
Advanced Research in Veterinary Drugs
edited by Jianyong Li
submission deadline 20 Sep 2026 | 1 articles | Viewed by 1617 | Submission Open
Keywords: veterinary drug; target; chemical structure; mechanism; medicinal chemistry; toxicity; pharmacodynamics; pharmacokinetics; residues
(This special issue belongs to the Section Molecular Pharmacology)
Exopolysaccharides of Microbial Origin: Production, Analysis and Modification
edited by Marzena Jedrzejczak-Krzepkowska and
submission deadline 20 Sep 2026 | Viewed by 57 | Submission Open
Keywords: exopolysaccharide; biopolymer; biofilm; microorganism; biosynthesis; genetic engineering; molecular design; modification; analysis
(This special issue belongs to the Section Molecular Microbiology)
Molecular Research on Tea Flavor and Chemistry
edited by
submission deadline 29 Sep 2026 | Viewed by 45 | Submission Open
Keywords: tea processing; tea chemistry; tea functional components; tea sensory evaluation; tea quality control
(This special issue belongs to the Section Biochemistry)
Molecular Mechanisms in Forensic Pathology
edited by
submission deadline 29 Sep 2026 | Viewed by 12 | Submission Open
Keywords: molecular investigation; molecular thanatocronology; molecular autopsy; lesion vitality; molecu-lar forensic toxicology; pharmacogenomics; molecular identification
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Genetic, Functional and Therapeutic Aspects of Procoagulant and Anticoagulant Factors (Third Edition)
edited by and
submission deadline 30 Sep 2026 | 1 articles | Viewed by 695 | Submission Open
Keywords: procoagulant factors; anticoagulant factors; hemostasis; inflammation; genetics; therapeutics; cell signaling
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Phytochemical Insights and Green Extraction Strategies for Bioactive Natural Compounds submission deadline 30 Sep 2026 | Viewed by 142 | Submission Open
Keywords: plant and algal bioactive metabolites; phytochemistry; green extraction techniques; natural sustainable solvents (NADES); structural elucidation of natural molecules; molecular characterization
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Mechanism, Pathogenesis, and Precision Therapeutics in Thyroid Cancer
edited by
submission deadline 30 Sep 2026 | Viewed by 21 | Submission Open
Keywords: thyroid cancer; molecular pathogenesis; driver mutations; tumor microenvironment; targeted therapy; resistance mechanisms; immunotherapy; precision oncology; liquid biopsy; prognostic biomarkers
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advance in Plant Abiotic Stress: 4th Edition
edited by and
submission deadline 30 Oct 2026 | 1 articles | Viewed by 421 | Submission Open
Keywords: abiotic stress; cold; drought; salt; heat; nutrient deficiency; secondary metabolism; stress resistance; plant
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Mechanisms and Emerging Therapies in Neurovascular Disease
edited by Leonidas D. Panos
submission deadline 20 Nov 2026 | 3 articles | Viewed by 11621 | Submission Open
Keywords: neurovascular diseases; blood– brain barrier; endothelial dysfunction; cellular signaling; gene therapy
(This special issue belongs to the Section Molecular Neurobiology)
Research Progress on Disease Models Based on Induced Pluripotent Stem Cells submission deadline 30 Dec 2026 | Viewed by 54 | Submission Open
Keywords: induced pluripotent stem cells; iPSC-derived cells; disease modeling; precision and regenerative medicine; genome editing; CRISP/Cas; organoid; cell sheet; personalized therapeutics; drug discovery
(This special issue belongs to the Section Molecular Biology)
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