Special Issue "Therapeutic Molecular Targets in Tumor Microenvironment"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 30 September 2020.
Interests: cancer biology; cell proliferation; cancer biomarkers; tumor microenvironment; immunohistochemistry; histology
The complexity and dynamic nature of the tumor microenvironment (TME) still remains a challenge for the pre- and clinical studies of tumors. TME components such as cancer-associated fibroblasts (CAFs), tumor-associated macrophages (TAMs) or tumor-infiltrating lymphocytes (TILs) are promising therapeutic targets associated with tumor regression and patient prognosis. They are mostly involved in cancer promotion and progression controlling various processes, i.e., cancer cell proliferation, angiogenesis, metastasis formation or epithelial to mesenchymal transition (EMT) phenomenon. TME promotes tumorigenesis by secreting cytokines and initiating extracellular matrix (ECM) remodeling. ECM proteins such as fibronectin, tenascin-C, and periostin can also play an important role in the regulation of cancer cell biology, metastatic potential, and patient outcome. Recent cancer immunotherapies are focused equally on tumor cells and on key components of the TME. In this Special Issue, we will discuss the biology and composition of TME, its prognostic and predictive value, as well as potential therapeutic strategies for cellular and molecular TME targets.
Prof. Piotr Dzięgiel
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
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- Extracellular matrix
- Immune response
- Cancer-associated fibroblasts
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Title: Why lung cancer cells – fibroblasts heterotypic spheroids can be an inadequate model for the drug efficacy testing
Title: Heparan sulfate proteoglycan signalings in tumor microenvironment
Title: Modeling Immune Checkpoint Inhibitor Efficacy in Syngeneic Mouse Tumors in an Ex Vivo Immuno-Oncology Dynamic Environment