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Special Issue "Therapeutic Molecular Targets in Tumor Microenvironment"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 30 September 2020.

Special Issue Editor

Prof. Piotr Dzięgiel
Website
Guest Editor
Wroclaw Medical University, 50-367 Wrocław, Poland
Interests: cancer biology; cell proliferation; cancer biomarkers; tumor microenvironment; immunohistochemistry; histology

Special Issue Information

Dear Colleagues,

The complexity and dynamic nature of the tumor microenvironment (TME) still remains a challenge for the pre- and clinical studies of tumors. TME components such as cancer-associated fibroblasts (CAFs), tumor-associated macrophages (TAMs) or tumor-infiltrating lymphocytes (TILs) are promising therapeutic targets associated with tumor regression and patient prognosis. They are mostly involved in cancer promotion and progression controlling various processes, i.e., cancer cell proliferation, angiogenesis, metastasis formation or epithelial to mesenchymal transition (EMT) phenomenon. TME promotes tumorigenesis by secreting cytokines and initiating extracellular matrix (ECM) remodeling. ECM proteins such as fibronectin, tenascin-C, and periostin can also play an important role in the regulation of cancer cell biology, metastatic potential, and patient outcome. Recent cancer immunotherapies are focused equally on tumor cells and on key components of the TME. In this Special Issue, we will discuss the biology and composition of TME, its prognostic and predictive value, as well as potential therapeutic strategies for cellular and molecular TME targets.

Prof. Piotr Dzięgiel
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Cancer
  • Microenvironment
  • Extracellular matrix
  • Immune response
  • Fibronectin
  • Cancer-associated fibroblasts
  • Lymphocytes

Published Papers (2 papers)

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Review

Open AccessReview
Vitamins and Uterine Fibroids: Current Data on Pathophysiology and Possible Clinical Relevance
Int. J. Mol. Sci. 2020, 21(15), 5528; https://doi.org/10.3390/ijms21155528 - 01 Aug 2020
Abstract
Uterine fibroid (UF) is the most common benign tumor pathology of the female reproductive organs. UFs constitute the main reason for a hysterectomy and hospitalization due to gynecological conditions. UFs consist of uterine smooth muscle immersed in a large amount of extracellular matrix [...] Read more.
Uterine fibroid (UF) is the most common benign tumor pathology of the female reproductive organs. UFs constitute the main reason for a hysterectomy and hospitalization due to gynecological conditions. UFs consist of uterine smooth muscle immersed in a large amount of extracellular matrix (ECM). Genetic studies have demonstrated that UFs are monoclonal tumors originating from the myometrial stem cells that have underwent specific molecular changes to tumor initiating stem cells which proliferate and differentiate later under the influence of steroid hormones. There is growing interest in the role of micronutrients, for example, vitamins, in UFs. This article is a comprehensive review of publications regarding the available data concerning the role of vitamins in the biology and management of UFs. In summary, the results showed that some vitamins are important in the biology and pathophysiology of UFs. For example, vitamins A and D deserve particular attention following studies of their influence on the treatment of UF tumors. Vitamins B3, C, and E have not been as widely studied as the abovementioned vitamins. However, more research could reveal their potential role in UF biology. Full article
(This article belongs to the Special Issue Therapeutic Molecular Targets in Tumor Microenvironment)
Open AccessReview
The Role of miRNA and Related Pathways in Pathophysiology of Uterine Fibroids—From Bench to Bedside
Int. J. Mol. Sci. 2020, 21(8), 3016; https://doi.org/10.3390/ijms21083016 - 24 Apr 2020
Abstract
Uterine fibroids (UFs) are the most common benign tumors of the female genital tract. Their prevalence usually is estimated at 30–40%, but may reach up to 70–80% in predisposed groups of women. UFs may cause various clinical issues which might constitute the major [...] Read more.
Uterine fibroids (UFs) are the most common benign tumors of the female genital tract. Their prevalence usually is estimated at 30–40%, but may reach up to 70–80% in predisposed groups of women. UFs may cause various clinical issues which might constitute the major reason of the overall deterioration of the quality of life. The mechanisms leading to UFs formation and growth still remain poorly understood. The transformation of smooth muscle cells of the uterus into abnormal, immortal cells, capable of clonal division, is thought to be a starting point of all pathways leading to UF formation. Micro-ribonucleic acids (miRNAs) are non-coding single-stranded RNAs about 22 nucleotides in length, that regulate gene expression. One of recent advances in this field is the comprehension of the role of miRNAs in tumorigenesis. Alterations in the levels of miRNAs are related to the formation and growth of several tumors which show a distinct miRNA signature. The aim of this review is to summarize the current data about the role of miRNAs in the pathophysiology of UFs. We also discuss future directions in the miRNA research area with an emphasis on novel diagnostic opportunities or patient-tailored therapies. In our opinion data concerning the regulation of miRNA and its gene targets in the UFs are still insufficient in comparison with gynecological malignancies. The potential translational use of miRNA and derived technologies in the clinical care is at the early phase and needs far more evidence. However, it is one of the main areas of interest for the future as the use of miRNAs in the diagnostics and treatment of UFs is a new and exciting opportunity. Full article
(This article belongs to the Special Issue Therapeutic Molecular Targets in Tumor Microenvironment)
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Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Title: Why lung cancer cells – fibroblasts heterotypic spheroids can be an inadequate model for the drug efficacy testing

Title: Heparan sulfate proteoglycan signalings in tumor microenvironment

Title: Modeling Immune Checkpoint Inhibitor Efficacy in Syngeneic Mouse Tumors in an Ex Vivo Immuno-Oncology Dynamic Environment

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