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Special Issue "Novel MSC Perspectives: From Cell Regulation to Tissue Regeneration 2.0"

Special Issue Editors

Prof. Dr. Heba Abdelrazik
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Guest Editor
Department of Clinical Pathology, Immunology and Cell Therapy Unit, Cairo University, Cairo, Egypt; Department of Medical Genetics, University of Oslo, Norway
Interests: MSCs for immune-modulation and regenerative medicine; reprogramming, gene editing and target gene therapy; neural lineage differentiation; intercellular communication and drug interactions
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Dr. Giovanni Barbanti-Bròdano
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Guest Editor
Chirurgia Vertebrale Oncologica & Degenerativa (CVOD), Istituti Ortopedici Rizzoli, Via Pupilli 1, 40136 Bologna, Italy
Interests: MSCs interaction with biomaterials; MSCs for treatment of benign spine tumors; clinical use of MSCs from different sources
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Prof. Dr. Elena De Falco
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Guest Editor
University of Rome Sapienza, Faculty of Pharmacy and Medicine, Department of Medico-Surgical Sciences and Biotechnologies, C.so della Repubblica 79, 04100 Latina, Italy
Interests: cardiac-transdifferentiation of MSCs; MSC-based cell therapies in cardiovascular diseases and regenerative medicine; cell plasticity of MSCs; platelet lysate and MSCs
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Prof. Dr. Emanuele Giordano
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Guest Editor
Laboratory of Cellular and Molecular Engineering "Silvio Cavalcanti" - Department of Electrical, Electronic and Information Engineering "Guglielmo Marconi" (DEI), University of Bologna, Via Venezia 52, 47521 Cesena (FC), Italy; Health Sciences and Technologies - Interdepartmental Center for Industrial Research (HST-ICIR), University of Bologna, Via Tolara di Sopra 41/E, 40064 Ozzano dell’Emilia (BO), Italy; Advanced Research Center on Electronic Systems (ARCES), University of Bologna, Via Vincenzo Toffano 2/2, 40125 Bologna, Italy
Interests: tissue engineering for regenerative medicine; epigenetic regulation of gene expression; protocols in synthetic biology
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Prof. Dr. Alessandra Pelagalli
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Guest Editor
Department of Advanced Biomedical Sciences, University of Naples ""Federico II"", Naples, Italy; Institute of Biostructure and Bioimaging, National Research Council, Naples, Italy
Interests: MSCs from domestic animal species; MSCs physiology and behavior for translational regenerative medicine; migration and proliferation of MSCs and role of Aquaporin (AQPs); MSCs, conditioned medium and microenvironment in physiological condition
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue is a continuation of our previous Special Issue "Novel MSC Perspectives: From Cell Regulation to Tissue Regeneration" (https://www.mdpi.com/journal/ijms/special_issues/novel_msc).

The development in understanding mesenchymal stem cell (MSC) biology, gene regulation, and intercellular interactions is promising for the evolution of therapeutic approaches in tissue regeneration, both in humans and in animals. Thanks to their exclusive capacity to self-renew and commitment towards defined cell lineages, MSCs offer novel perspectives and tools for clinical application in a safe and effective manner. Recent knowledge in the crosstalk between MSCs and the microenvironment has highlighted that key soluble modulators, specific signaling pathways, and/or the employment of biomaterials are able to foster a wide array of MSC properties, including migration, behavior, and also gene expression and cell fate. This provides new insights for the genetic manipulation, reprogramming, and/or gene editing of MSCs addressing also physical, biological, and biochemical properties of MSCs in order to boost their regenerative capabilities and tissue repair. Finally, studies concerning the use of MSCs from different sources for tissue regeneration in preclinical and clinical applications will allow translating the knowledge on MSC functions “from the bench to the bedside”. Accordingly, we invite investigators to contribute with novel findings in the field of MSCs and therefore help to bridge the gap between biology of regeneration and regenerative medicine and to encourage a novel progression towards MSC-based translational research.

Gruppo Italiano Staminali Mesenchimali (GISM)

Prof. Dr. Heba Abdelrazik
Dr. Giovanni Barbanti-Bròdano
Prof. Dr. Elena De Falco
Prof. Dr. Emanuele Giordano
Prof. Dr. Alessandra Pelagalli
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Mesenchymal stem cells (MSCs)
  • Regenerative medicine
  • Tissue engineering
  • Tissue repair
  • Bioactive materials
  • Cell differentiation
  • Cell behavior and cell fate
  • Translational medicine
  • Animal sources
  • Gene editing
  • Reprogramming

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Published Papers

This special issue is now open for submission.
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