Novel MSC Perspectives: From Cell Regulation to Tissue Regeneration 2.0

Dear Colleagues,

This Special Issue is a continuation of our previous Special Issue "Novel MSC Perspectives: From Cell Regulation to Tissue Regeneration" (https://www.mdpi.com/journal/ijms/special_issues/novel_msc).

The development in understanding mesenchymal stem cell (MSC) biology, gene regulation, and intercellular interactions is promising for the evolution of therapeutic approaches in tissue regeneration, both in humans and in animals. Thanks to their exclusive capacity to self-renew and commitment towards defined cell lineages, MSCs offer novel perspectives and tools for clinical application in a safe and effective manner. Recent knowledge in the crosstalk between MSCs and the microenvironment has highlighted that key soluble modulators, specific signaling pathways, and/or the employment of biomaterials are able to foster a wide array of MSC properties, including migration, behavior, and also gene expression and cell fate. This provides new insights for the genetic manipulation, reprogramming, and/or gene editing of MSCs addressing also physical, biological, and biochemical properties of MSCs in order to boost their regenerative capabilities and tissue repair. Finally, studies concerning the use of MSCs from different sources for tissue regeneration in preclinical and clinical applications will allow translating the knowledge on MSC functions “from the bench to the bedside”. Accordingly, we invite investigators to contribute with novel findings in the field of MSCs and therefore help to bridge the gap between biology of regeneration and regenerative medicine and to encourage a novel progression towards MSC-based translational research.

Gruppo Italiano Staminali Mesenchimali (GISM)

Prof. Dr. Heba Abdelrazik
Dr. Giovanni Barbanti-Bròdano
Prof. Dr. Elena De Falco
Prof. Dr. Emanuele Giordano
Prof. Dr. Alessandra Pelagalli
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.