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Special Issue "Novel MSC Perspectives: From Cell Regulation to Tissue Regeneration"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 15 April 2019

Special Issue Editors

Guest Editor
Prof. Dr. Heba Abdelrazik

Department of Clinical Pathology, Immunology and Cell Therapy Unit, Cairo University, Cairo, Egypt; Department of Medical Genetics, University of Oslo, Norway
Website | E-Mail
Interests: MSCs for immune-modulation and regenerative medicine; reprogramming, gene editing and target gene therapy; neural lineage differentiation; intercellular communication and drug interactions
Guest Editor
Dr. Giovanni Barbanti-Bròdano

Chirurgia Vertebrale Oncologica & Degenerativa (CVOD), Istituti Ortopedici Rizzoli, Via Pupilli 1, 40136 Bologna, Italy
Website 1 | Website 2 | E-Mail
Interests: MSCs interaction with biomaterials; MSCs for treatment of benign spine tumors; clinical use of MSCs from different sources
Guest Editor
Prof. Dr. Elena De Falco

University of Rome Sapienza, Faculty of Pharmacy and Medicine, Department of Medico-Surgical Sciences and Biotechnologies, C.so della Repubblica 79, 04100 Latina, Italy
Website | E-Mail
Interests: cardiac-transdifferentiation of MSCs; MSC-based cell therapies in cardiovascular diseases and regenerative medicine; cell plasticity of MSCs; platelet lysate and MSCs
Guest Editor
Prof. Dr. Emanuele Giordano

Laboratory of Cellular and Molecular Engineering "Silvio Cavalcanti" - Department of Electrical, Electronic and Information Engineering "Guglielmo Marconi" (DEI), University of Bologna, Via Venezia 52, 47521 Cesena (FC), Italy; Health Sciences and Technologies - Interdepartmental Center for Industrial Research (HST-ICIR), University of Bologna, Via Tolara di Sopra 41/E, 40064 Ozzano dell’Emilia (BO), Italy; Advanced Research Center on Electronic Systems (ARCES), University of Bologna, Via Vincenzo Toffano 2/2, 40125 Bologna, Italy
Website | E-Mail
Interests: tissue engineering for regenerative medicine; epigenetic regulation of gene expression; protocols in synthetic biology
Guest Editor
Prof. Dr. Alessandra Pelagalli

Department of Advanced Biomedical Sciences, University of Naples "Federico II", Naples, Italy; Institute of Biostructure and Bioimaging, National Research Council, Naples, Italy
Website | E-Mail
Interests: MSCs from domestic animal species; MSCs physiology and behavior for translational regenerative medicine; migration and proliferation of MSCs and role of Aquaporin (AQPs); MSCs, conditioned medium and microenvironment in physiological condition

Special Issue Information

Dear Colleagues,

The development in understanding mesenchymal stem cell (MSC) biology, gene regulation and intercellular interactions is holding promise for the evolution of therapeutic approaches in tissue regeneration, both in humans and in animals. For their exclusive capacity to self renew and commitment towards defined cell lineages, MSCs offer novel perspectives and tools for clinical application in a safe and effective manner. Recent knowledge in the crosstalk between MSCs and the microenvironment has highlighted that key soluble modulators, specific signaling pathways and/or the employment of biomaterials are able to foster a wide array of MSC properties including migration, behavior and also gene expression and cell fate. This provides new insights for the genetic manipulation, reprogramming and/or gene editing of MSCs addressing also physical, biological and biochemical properties of MSCs in order to boost their regenerative capabilities and tissue repair. Finally, studies concerning the use of MSCs from different sources for tissue regeneration in pre-clinical and clinical applications will allow to translate the knowledge on MSC functions “from the bench to the bedside”. Accordingly, we invite investigators to contribute with novel findings in the field of MSCs and therefore helping to bridge the gap between biology of regeneration and regenerative medicine and to encourage a novel progression towards the MSC-based translational research.

Gruppo Italiano Staminali Mesenchimali (GISM)

Prof. Dr. Heba Abdelrazik
Dr. Giovanni Barbanti-Bròdano
Prof. Dr. Elena De Falco
Prof. Dr. Emanuele Giordano
Prof. Dr. Alessandra Pelagalli
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Mesenchymal stem cells (MSCs)
  • Regenerative medicine
  • Tissue engineering
  • Tissue repair
  • Bioactive materials
  • Cell differentiation
  • Cell behaviour and cell fate
  • Translational medicine
  • Animal sources
  • Gene editing
  • Reprogramming

Published Papers (1 paper)

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Open AccessArticle In Vitro Induction of Tendon-Specific Markers in Tendon Cells, Adipose- and Bone Marrow-Derived Stem Cells is Dependent on TGFβ3, BMP-12 and Ascorbic Acid Stimulation
Int. J. Mol. Sci. 2019, 20(1), 149; https://doi.org/10.3390/ijms20010149
Received: 20 December 2018 / Accepted: 27 December 2018 / Published: 3 January 2019
PDF Full-text (22920 KB) | HTML Full-text | XML Full-text | Supplementary Files
Mesenchymal Stem Cells (MSCs) and tissue-specific progenitors have been proposed as useful tools for regenerative medicine approaches in bone, cartilage and tendon-related pathologies. The differentiation of cells towards the desired, target tissue-specific lineage has demonstrated advantages in the application of cell therapies and [...] Read more.
Mesenchymal Stem Cells (MSCs) and tissue-specific progenitors have been proposed as useful tools for regenerative medicine approaches in bone, cartilage and tendon-related pathologies. The differentiation of cells towards the desired, target tissue-specific lineage has demonstrated advantages in the application of cell therapies and tissue engineering. Unlike osteogenic and chondrogenic differentiation, there is no consensus on the best tenogenic induction protocol. Many growth factors have been proposed for this purpose, including BMP-12, b-FGF, TGF-β3, CTGF, IGF-1 and ascorbic acid (AA). In this study, different combinations of these growth factors have been tested in the context of a two-step differentiation protocol, in order to define their contribution to the induction and maintenance of tendon marker expression in adipose tissue and bone marrow derived MSCs and tendon cells (TCs), respectively. Our results demonstrate that TGF-β3 is the main inducer of scleraxis, an early expressed tendon marker, while at the same time inhibiting tendon markers normally expressed later, such as decorin. In contrast, we find that decorin is induced by BMP-12, b-FGF and AA. Our results provide new insights into the effect of different factors on the tenogenic induction of MSCs and TCs, highlighting the importance of differential timing in TGF-β3 stimulation. Full article
(This article belongs to the Special Issue Novel MSC Perspectives: From Cell Regulation to Tissue Regeneration)

Figure 1

Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Title: Role of mesenchymal stem cells (MSCs) in vasculogenesis of endothelial colony forming cells (ECFCs) in the hyperglycemia
Author: Kyu-Tae Kang
Short summary: Our results demonstrate that MSCs enhance ECFCs vasculogenesis even in hyperglycemic condition, which suggests that combined delivery of ECFCs and MSCs can apply to the regeneration of functional vascular network in diabetic ischemic region.
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
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