Special Issue "Glioma Cell Invasion"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (30 September 2017) | Viewed by 55700
Interests: brain cancer (paediatric and adult); tumour cell invasion; blood brain barrier; subventricular zone; neuropathology
Tumour cell invasion is a key hallmark in primary malignant brain cancer in both adults and children and remains one of the most critical factors involved in therapeutic resistance and recurrence. Lacking somewhat in the literature is how components of the tumour microenvironment (which change during tumour growth and in response to therapy) work together to support tumour growth, resistance, adaptation and recurrence. The aim of this Special Issue is to bring together specific areas and provide a broad overview on the topic of “Microenvironmental Influences on Glioma Cell Invasion” in the context of cell to cell bidirectional and unidirectional communication, molecular/signalling drivers, immunologic perspectives, metabolic influences, physical/mechanical perspectives, flow dynamics (vascular and CSF), radiation and therapeutic effects, mathematical models, and future perspectives on translational considerations. In addition, the types or modes of tumour dissemination will also be a topic. This Special Issue will provide an overview on the spatial and temporal dynamic impact on glioma cell invasion.
Prof. Geoffrey J. Pilkington
Prof. Helen L. Fillmore
Manuscript Submission Information
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- Glioma invasion
- CSF flow dynamics
- Metabolism and cell migration
- CNS interstitial space
- Cellular organelle changes during invasion
- Immune system
- Modelling cell migration/invasion
- Subventricular Zone
- White matter tracts
- Cell cycle