Int. J. Mol. Sci. 2017, 18(6), 1295; https://doi.org/10.3390/ijms18061295
EGFR and EGFRvIII Promote Angiogenesis and Cell Invasion in Glioblastoma: Combination Therapies for an Effective Treatment
Stefanie Keller 1 and Mirko H. H. Schmidt 1,2,3,*
1
Molecular Signal Transduction Laboratories, Institute for Microscopic Anatomy and Neurobiology, Focus Program Translational Neuroscience (FTN), Rhine Mainz Neuroscience Network (rmn2), Johannes Gutenberg University, School of Medicine, 55131 Mainz, Germany
2
German Cancer Consortium (DKTK), partner site Frankfurt/Mainz, 55131 Mainz, Germany
3
German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany
*
Author to whom correspondence should be addressed.
Academic Editor: Geoffrey J. Pilkington
Received: 30 March 2017 / Revised: 9 June 2017 / Accepted: 14 June 2017 / Published: 18 June 2017
(This article belongs to the Special Issue Glioma Cell Invasion)
Abstract
Epidermal growth factor receptor (EGFR) and the mutant EGFRvIII are major focal points in current concepts of targeted cancer therapy for glioblastoma multiforme (GBM), the most malignant primary brain tumor. The receptors participate in the key processes of tumor cell invasion and tumor-related angiogenesis and their upregulation correlates with the poor prognosis of glioma patients. Glioma cell invasion and increased angiogenesis share mechanisms of the degradation of the extracellular matrix (ECM) through upregulation of ECM-degrading proteases as well as the activation of aberrant signaling pathways. This review describes the role of EGFR and EGFRvIII in those mechanisms which might offer new combined therapeutic approaches targeting EGFR or EGFRvIII together with drug treatments against proteases of the ECM or downstream signaling to increase the inhibitory effects of mono-therapies. View Full-TextKeywords:
glioblastoma multiforme; invasion; angiogenesis; EGFR; EGFRvIII
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Keller, S.; Schmidt, M.H.H. EGFR and EGFRvIII Promote Angiogenesis and Cell Invasion in Glioblastoma: Combination Therapies for an Effective Treatment. Int. J. Mol. Sci. 2017, 18, 1295.
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