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Molecular and Genetic Determinants of Glioma Cell Invasion

Department of Pathology, Tokyo Women’s Medical University, Tokyo 162-8666, Japan
Ludwig Institute for Cancer Research, University of California San Diego, La Jolla, CA 92093, USA
Author to whom correspondence should be addressed.
These authors contributed equally to the work.
Int. J. Mol. Sci. 2017, 18(12), 2609;
Received: 6 November 2017 / Revised: 27 November 2017 / Accepted: 2 December 2017 / Published: 4 December 2017
(This article belongs to the Special Issue Glioma Cell Invasion)
A diffusely invasive nature is a major obstacle in treating a malignant brain tumor, “diffuse glioma”, which prevents neurooncologists from surgically removing the tumor cells even in combination with chemotherapy and radiation. Recently updated classification of diffuse gliomas based on distinct genetic and epigenetic features has culminated in a multilayered diagnostic approach to combine histologic phenotypes and molecular genotypes in an integrated diagnosis. However, it is still a work in progress to decipher how the genetic aberrations contribute to the aggressive nature of gliomas including their highly invasive capacity. Here we depict a set of recent discoveries involving molecular genetic determinants of the infiltrating nature of glioma cells, especially focusing on genetic mutations in receptor tyrosine kinase pathways and metabolic reprogramming downstream of common cancer mutations. The specific biology of glioma cell invasion provides an opportunity to explore the genotype-phenotype correlation in cancer and develop novel glioma-specific therapeutic strategies for this devastating disease. View Full-Text
Keywords: glioma cell invasion; microenvironment; isocitrate dehydrogenase (IDH); mammalian target of rapamycin complex 2 (mTORC2); metabolic reprogramming glioma cell invasion; microenvironment; isocitrate dehydrogenase (IDH); mammalian target of rapamycin complex 2 (mTORC2); metabolic reprogramming
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Masui, K.; Kato, Y.; Sawada, T.; Mischel, P.S.; Shibata, N. Molecular and Genetic Determinants of Glioma Cell Invasion. Int. J. Mol. Sci. 2017, 18, 2609.

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