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Insights into the Role of Membrane Lipids in the Structure, Function and Regulation of Integral Membrane Proteins

Department of Life Sciences, Imperial College London, Exhibition Road, London SW7 2AZ, UK
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Author to whom correspondence should be addressed.
Academic Editor: Masoud Jelokhani-Niaraki
Int. J. Mol. Sci. 2021, 22(16), 9026; https://doi.org/10.3390/ijms22169026
Received: 20 July 2021 / Revised: 15 August 2021 / Accepted: 17 August 2021 / Published: 21 August 2021
(This article belongs to the Special Issue Membrane Proteins: Structure, Function and Motion)
Membrane proteins exist within the highly hydrophobic membranes surrounding cells and organelles, playing key roles in cellular function. It is becoming increasingly clear that the membrane does not just act as an appropriate environment for these proteins, but that the lipids that make up these membranes are essential for membrane protein structure and function. Recent technological advances in cryogenic electron microscopy and in advanced mass spectrometry methods, as well as the development of alternative membrane mimetic systems, have allowed experimental study of membrane protein–lipid complexes. These have been complemented by computational approaches, exploiting the ability of Molecular Dynamics simulations to allow exploration of membrane protein conformational changes in membranes with a defined lipid content. These studies have revealed the importance of lipids in stabilising the oligomeric forms of membrane proteins, mediating protein–protein interactions, maintaining a specific conformational state of a membrane protein and activity. Here we review some of the key recent advances in the field of membrane protein–lipid studies, with major emphasis on respiratory complexes, transporters, channels and G-protein coupled receptors. View Full-Text
Keywords: integral membrane protein; membrane lipid; structure; function; oligomeric state; cryo-EM; advanced mass spectrometry; molecular dynamics; membrane mimetic systems integral membrane protein; membrane lipid; structure; function; oligomeric state; cryo-EM; advanced mass spectrometry; molecular dynamics; membrane mimetic systems
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MDPI and ACS Style

Renard, K.; Byrne, B. Insights into the Role of Membrane Lipids in the Structure, Function and Regulation of Integral Membrane Proteins. Int. J. Mol. Sci. 2021, 22, 9026. https://doi.org/10.3390/ijms22169026

AMA Style

Renard K, Byrne B. Insights into the Role of Membrane Lipids in the Structure, Function and Regulation of Integral Membrane Proteins. International Journal of Molecular Sciences. 2021; 22(16):9026. https://doi.org/10.3390/ijms22169026

Chicago/Turabian Style

Renard, Kenta, and Bernadette Byrne. 2021. "Insights into the Role of Membrane Lipids in the Structure, Function and Regulation of Integral Membrane Proteins" International Journal of Molecular Sciences 22, no. 16: 9026. https://doi.org/10.3390/ijms22169026

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