Special Issue "Mechanisms of Insulin Resistance at the Crossroad of Obesity with Associated Metabolic Abnormalities"
Deadline for manuscript submissions: closed (30 April 2019)
Worldwide, the obesity epidemic has resulted in a surge of metabolic abnormalities and diseases stemming from the condition of insulin resistance that accompanies the obesity status. Insulin resistance represents an impaired biological response to insulin stimulation of target tissues, primarily liver, muscle, and adipose tissue. It is recognized as the root for hypertension, dyslipidemia, non alcholic fatty liver disease, policistic ovary syndome, atherosclerosis, and adverse cardiac remodeling/heart failure. Insulin resistance is also risk factor for cancer development. The list of target organs has recently been enlongated, recognizing its role in the pathogenesis of type 2 diabetes associated dementia and Alzheimer's disease (AD), a condition known as Type 3 diabetes (T3D). Furthermore, the impact of environment (e.g., exposure to bacteria or pollutants) on the onset of metabolic abnormalities is becoming evident.
Insulin resistance was first recognized as risk factor for several diseases in late 1990s by a group of investigators from different research backgrounds who joined the European Group for the study of Insulin Resistance (EGIR). Nowdays, in view of this renewed interest in the pathogenetic role of insulin resistance, the EGIR group has been recognized as a study group belonging to the European Association for the Study of Diabetes (EASD).
We invite investigators to contribute either original research articles or review articles focusing on the variety of molecular mechanisms that either contribute to the worsening of insulin resistance in obese patients, or that, triggered by insulin resistance, cause the onset and progression of comorbidities associated with obesity.
Prof. Dr. Melania Manco
Prof. Dr. Amalia Gastaldelli
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- dysregulated fatty acid and/or branched chain amino acids
- metabolic inflexibility
- tissue lipid accumulation, lipotoxicity and lipid mediated cell signaling
- insulin resistance reversal
- cancer development
- low-grade inflammation and/or altered expression, synthesis and degradation and bioavailability of IGF binding proteins
- environmental chemicals
- mechanisms of T3D
- microbiota and antimicrobials modulation
- endocrine disruptors
- altered immune system homeostasis