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Carcinoembryonic Cell Adhesion-Related Molecule 2 Regulates Insulin Secretion and Energy Balance

1
Department of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH 45701-2979, USA
2
Department of Zoology, Faculty of Science, Sohag University, Sohag 82524, Egypt
3
Diabetes Institute, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH 45701-2979, USA
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(13), 3231; https://doi.org/10.3390/ijms20133231
Received: 17 May 2019 / Revised: 12 June 2019 / Accepted: 25 June 2019 / Published: 1 July 2019
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Abstract

The Carcinoembryonic Antigen-Related Cell Adhesion Molecule (CEACAM) family of proteins plays a significant role in regulating peripheral insulin action by participating in the regulation of insulin metabolism and energy balance. In light of their differential expression, CEACAM1 regulates chiefly insulin extraction, whereas CEACAM2 appears to play a more important role in regulating insulin secretion and overall energy balance, including food intake, energy expenditure and spontaneous physical activity. We will focus this review on the role of CEACAM2 in regulating insulin metabolism and energy balance with an overarching goal to emphasize the importance of the coordinated regulatory effect of these related plasma membrane glycoproteins on insulin metabolism and action. View Full-Text
Keywords: hyperinsulinemia; insulin clearance; insulin resistance; hyperphagia; energy balance hyperinsulinemia; insulin clearance; insulin resistance; hyperphagia; energy balance
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Salaheldeen, E.; Jaume, A.; Michael Najjar, S. Carcinoembryonic Cell Adhesion-Related Molecule 2 Regulates Insulin Secretion and Energy Balance. Int. J. Mol. Sci. 2019, 20, 3231.

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