Special Issue "Role of Insulin Clearance in Insulin Action"
Deadline for manuscript submissions: 29 January 2021.
Special Issues and Collections in MDPI journals
Special Issue in International Journal of Molecular Sciences: Mechanisms of Insulin Resistance at the Crossroad of Obesity with Associated Metabolic Abnormalities
Special Issue in International Journal of Molecular Sciences: Mechanisms of Insulin Resistance at the Crossroad of Obesity with Associated Metabolic Abnormalities and Cognitive Dysfunction
Department of Physiology and Pharmacology, University of Toledo College of Medicine and Life Sciences, Toledo, OH 43614, USA
Department of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH 45701, USA
Metabolic diseases are reaching an epidemic worldwide. In addition to insulin resistance, altered insulin secretion and clearance contribute to the worsening of glucose tolerance. Once secreted from pancreatic beta cells, insulin is metabolized mostly by the liver (the first target organ), and subsequently by peripheral tissues, in particular skeletal muscle. Thus, peripheral insulin concentrations are the result of a balance between insulin secretion and clearance. The mechanisms underlying insulin secretion have been widely explored. In contrast, mechanisms underlying insulin clearance remain poorly understood.
This Special Issue focuses on presenting a comprehensive view on insulin metabolism and regulation with an overarching goal to highlight the current knowledge on the mechanisms as well as the physiologic impact of altered insulin clearance (and secretion) on metabolic processes.
We invite investigators to contribute either original research or review articles focusing on the variety of molecular mechanisms of altered insulin secretion and clearance in animal models and in subjects with different degrees of glucose intolerance. Articles should also discuss how these mechanisms cause or contribute to the progression to type 2 diabetes and associated metabolic disease, and how they are modulated by race and environmental factors.
Prof. Dr. Sonia Michael Najjar
Prof. Dr. Amalia Gastaldelli
Dr. Hilda E. Ghadieh
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Insulin secretion
- Insulin clearance
- Insulin endocytosis and degradation
- Insulin signaling and metabolism
- Mechanisms of altered insulin clearance
- Hepatic vs. peripheral insulin extraction
- Insulin uptake in endothelial cells and extrahepatic extraction
- Racial disparity in insulin clearance
- Environmental factors and insulin clearance
- Drugs targeting insulin clearance