Novel Approaches to Hematologic Malignancies by Immunotherapy

Dear Colleagues,

The landscape of immunotherapy for the treatment hematogic malignancies (HMs) has become crowded in light of new modalities. Some HMs can escape T-cell-mediated cellular cytotoxicity by exloiting the inhibitory programmed cell-death protein 1 (PD-1)/ programmed cell-death protein 1 ligand 1 (PD-L1) immune checkpoint. Therapeutic antibodies that block the PD-1-PD-L1 axis or other types of checkpoint inhibitors induce durable clinical responses against a growing list of various HMs. Chimeric antigen receptor (CAR) T cells, bispecific T-cell engagers (BiTEs), and antibody-drug conjugates (ADCs) are also promising candidates. In this issue, we would like to show the novel immunotherapy in translational research and clinical development for the treatment of HMs.

Dr. Yosuke Minami
Guest Editor

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