Adipose Stem Cells 3.0

Dear Colleagues,

This Special Issue is a continuation of our 2019 Special Issue, “Adipose Stem Cells 2019”.

Adipose tissue is a complex organ and, in this last years, it has received considerable attention due to its high stem cell content of adipose stem cells (ASC).

By definition, a stem cell is characterized by its ability to undergo self-renewal and differentiation, and form terminally differentiated cells. Ideally, a stem cell for regenerative medicinal applications should meet the following set of criteria: (i) found in abundant quantities (millions to billions of cells), (ii) able to be collected and harvested by a minimally invasive procedure, (iii) can be differentiated along multiple cell lineage pathways in a reproducible manner, and (iv) can be safely and effectively transplanted to either an autologous or allogeneic host. Adipose tissue serves as an abundant, accessible, and rich source of adult stem cells with multipotent properties suitable for tissue engineering and regenerative medical applications.

The plasticity of ASC most often refers to the inherent ability of stem cells to cross lineage barriers and adopt the phenotypic, biochemical, and functional properties of cells unique to other tissues.

Interest has increased in adipose-derived stem cells (ASCs) for tissue engineering, regenerative medicine, biomaterial development, and application. As such, the aim of the present Special Issue is the:

1) Characterization of the physiology of ASCs,

2) Characterization of the secretoma activity of ASCs,

3) Definition of transcriptional and non-transcriptional events related to their commitment, and

4) Application of ASCs as tools to test novel biomaterials for regenerative medicine.

Prof. Dr. Hirofumi Noguchi
Guest Editor

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