Animal Models of Parkinson's Disease and Related Disorders
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (15 April 2020) | Viewed by 97949
Special Issue Editor
Interests: Drosophila genetics; neurodegeneration; Parkinson's disease; iPS cells; mitochondria; synaptic dynamics; unfolded protein stress
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear colleagues,
Parkinson's disease (PD), one of the most common movement disorders, is characterized by age-dependent dysfunction and degeneration of the midbrain dopaminergic neurons. Understanding of the pathogenic mechanisms of PD has progressed with neurotoxin-induced and α-synunclein propagation models. Moreover, recent advances in human molecular genetics have led to the identification of familial and PD risk genes. Analyses of model animals in which mutations of these PD genes are introduced promise to shed light on the pathogenic mechanisms underlying both idiopathic and familial PD.
We invite authors to submit manuscripts focused on the molecular mechanisms of neurodegeneration, therapeutic challenges using model animals, the development of new screening methods, and the generation of new PD and related models to this Special Issue. Both high-quality research articles and reviews of the most recent progress in the area are welcome. Moreover, papers dealing with new methods to detect the degeneration of dopaminergic neurons as well as other cells are of great interest. The key topics include, but are not limited to, the following:
- PD studies using vertebrate models;
- PD studies using non-vertebrate models;
- PD studies using other organisms;
- Drug screening using PD model organisms;
- Development of therapeutic strategies using PD model organisms;
- Development of experimental techniques.
Prof. Yuzuru Imai
Guest Editor
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Keywords
- α-synuclein propagation
- mitochondrial quality control
- mitochondrial respiratory function
- autophagy and mitophagy
- lysosomal functions
- vesicular transport
- synaptic vesicle endocytosis and recycling
- oxidative stress and ER stress
- lipid metabolism
- glymphatic system
- neuroinflammation
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