Urolithiasis: From Molecular Pathology to Novel Therapeutic Approach
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (15 February 2024) | Viewed by 305
Special Issue Editor
Special Issue Information
Dear Colleagues,
Urinary stones are a common condition among the general population, with a current prevalence of 10–15% and a lifetime recurrence risk of 60–80%. According to most recent data, these numbers are increasing further with obvious and negative implications on people health and subsequent increasing costs for health care systems. Although usually considered a benign condition, a variety of severe events are associated with urinary stones, including severe pain, risk of death due to severe infectious complications, and renal function loss. Additionally, surgeries for urinary tract stones might represent a serious discomfort for individuals and a deterioration of their quality of life, particularly for those requiring multiple treatments during their lifetime. The main aspects of stone formation have been investigated, including the role of renal cell injury, retention of crystals, cell apoptosis, role of Randall’s plaques, stone inhibitors and promoters, and their genetics. Nevertheless, many uncertainties remain in stone formation, and its harm on renal parenchyma still to be fully investigated.
This issue aims to provide an updated overview of most recent developments and advancements in urolithiasis research, including the understanding of molecular bases, physicochemical and genetic aspects of stone formation, the role of risk factors, and the effect of surgical treatments and urinary tract obstruction in the renal parenchyma. Also, we aim to offer to researchers an opportunity to present studies on new pharmacological treatments, including original research and reviews.
Dr. Giorgio Mazzon
Guest Editor
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Keywords
- urinary stones
- hyperoxaluria
- renal obstruction
- crystal growth
- crystal–cell interaction
- kidney stone inhibitors and promoters
- infections stones
- gut microbiome
- renal obstruction
- intra-renal pressure
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