Vitamin D in Health and Disease (3rd Edition)

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Immunology and Immunotherapy".

Deadline for manuscript submissions: 30 June 2024 | Viewed by 609

Special Issue Editor


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Guest Editor
Head of Allergology and Clinical Immunology Unit, Department of Internal Medicine, University of Genoa and San Bartolomeo Hospital, Sarzana, Italy
Interests: immunodeficiency; autoimmunity; neuro-endocrino-immunology; pharmacogenomics; soluble molecules; immune-mediated diseases; allergies; vaccines
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Dear Colleagues,

Vitamin D (VD) is a lipo-soluble hormone well known for its effects on calcium homeostasis and bone metabolism. Recently, there has been growing interest in the extra-skeletal effects of VD. In particular, recent studies have highlighted how VD plays a fundamental role in immunomodulation processes in the context of both innate and adaptive immunity, with consequent anti-inflammatory and anti-oxidant effects on different immune-mediated pathologies, such as systemic sclerosis, psoriasis, atopic dermatitis, and rheumatoid arthritis, as well as in various pro-inflammatory processes affecting the airways. Recent evidence has shown that VD is also closely related to other components such as the microbiome, with which it appears to be interconnected in the pathophysiology of many allergic diseases. In addition to the known immunomodulatory effects of VD, several studies have reported that it is also endowed with important anti-proliferative, anti-angiogenic, and pro-differentiative effects in cancer thanks to its effects on the modulation of the expression of tumor miRNAs through its action at the VD receptor (VDR) level. In view of this, it is clear that VD supplementation represents a safe and valid therapeutic strategy capable of improving the clinical outcome of many diseases.

Prof. Dr. Giuseppe Murdaca
Guest Editor

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Keywords

  • vitamin D and the immune system
  • vitamin D and cytokines
  • vitamin D and microbiome
  • vitamin D and respiratory diseases
  • vitamin D and autoimmune diseases
  • vitamin D and allergies

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Published Papers (1 paper)

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17 pages, 1215 KiB  
Review
Gender Differences in the Interplay between Vitamin D and Microbiota in Allergic and Autoimmune Diseases
by Giuseppe Murdaca, Luca Tagliafico, Elena Page, Francesca Paladin and Sebastiano Gangemi
Biomedicines 2024, 12(5), 1023; https://doi.org/10.3390/biomedicines12051023 - 7 May 2024
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Abstract
The synergic role of vitamin D and the intestinal microbiota in the regulation of the immune system has been thoroughly described in the literature. Vitamin D deficiency and intestinal dysbiosis have shown a pathogenetic role in the development of numerous immune-mediated and allergic [...] Read more.
The synergic role of vitamin D and the intestinal microbiota in the regulation of the immune system has been thoroughly described in the literature. Vitamin D deficiency and intestinal dysbiosis have shown a pathogenetic role in the development of numerous immune-mediated and allergic diseases. The physiological processes underlying aging and sex have proven to be capable of having a negative influence both on vitamin D values and the biodiversity of the microbiome. This leads to a global increase in levels of systemic inflammatory markers, with potential implications for all immune-mediated diseases and allergic conditions. Our review aims to collect and analyze the relationship between vitamin D and the intestinal microbiome with the immune system and the diseases associated with it, emphasizing the effect mediated by sexual hormones and aging. Full article
(This article belongs to the Special Issue Vitamin D in Health and Disease (3rd Edition))
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