Serotonin in Health and Disease

Dear Colleagues,

Serotonin is a neurotransmitter acting in the central nervous system and neurohormone controlling the function of peripheral organs. Despite the distinct organization of the serotonergic system in lower animals compared to vertebrates, its function which impacts virtually all biological processes is quite well conserved across the animal kingdom. Serotonin acts on a variety of serotonin receptors conferring some specificity of the serotonergic transmission in biological processes due to the distinct distribution and/or coupling efficiency of each serotonergic receptor. Beyond its widespread implication in physiology, the serotonergic system is involved in numerous diseases of the central nervous system (e.g., depression, anxiety, schizophrenia, obsessive-compulsive disorders, addiction, Parkinson’s disease) and peripheral organs (e.g., gastrointestinal disorders, cardiac arrhythmia, hypertension). Numerous drugs targeting the serotonergic system are currently used in the clinic for different purposes. The recent progress made on the function and dysfunction of the serotonergic system will certainly increase their number.

The purpose of this Special Issue is to review the current state of knowledge of serotonergic mechanisms in health and diseases which will consider both original research articles and reviews. Contributions from different fields of research are welcomed.

Prof. Philippe De Deurwaerdère
Prof. Giuseppe Di Giovanni
Guest Editors

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