Special Issue "The Mode of Actions of the Current Point-of-Care Treatments for Osteoarthritis of the Knee"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (15 September 2021).
Osteoarthritis of the knee (OAK) is the most common cause of disability in the worldwide population and is an intractable degenerative disease of the joint that is slow progressing and globally prevalent. It has heterogeneous phenotypes, including cartilage breakdown, synovitis, osteophyte formation, and bone marrow lesions. Histological studies show that OAK patients have variable degrees of synovitis, with higher levels of pro-inflammatory cytokines and infiltration of immune cells, predominantly macrophages. A fundamental treatment for OAK does not exist, and its development is an imperative. Currently, a conservative approach using intra-articular injections, such as so-called stem cell therapy and platelet rich plasma, has become widely available. Mesenchymal stem cells express a variety of growth factors and cytokines that aid in the repair of degraded tissue, restoration of normal tissue metabolism and, most importantly, counteracting inflammation. However, the mode of actions of these point-of-care treatments remains unclear. This Special Issue calls for original research papers, full reviews, and perspectives that address the progress and current knowledge of the molecular mechanisms of these point-of-care treatments for OAK.
Dr. Masato Sato
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- molecular mechanisms
- platelet rich plasma
- adipose cells
- immune cells
- matrix degradation