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Special Issue "Osteoarthritis and Cartilage Regeneration: Focus on Pathophysiology and Molecular Mechanisms"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (31 January 2019).
Department of Orthopedic Surgery, Exp. Orthopedics, ZMB/Biopark 1, University of Regensburg, 93053 Regensburg, Germany
Interests: osteoarthritis; chondrocytes; MSC; bone cells; cartilage regeneration; bone biology and regeneration; chondrogenic and osteogenic differentiation; sensory nervous system
Experimental Surgery and Regenerative Medicine, Clinic for General, Trauma and Reconstructive Surgery, Ludwig-Maximilians-University, Munich, Germany
Interests: skeletal development; cartilage; chondrocyte differentiation; osteochondrodysplasias; osteoarthritis; cartilage regeneration; extracellular matrix proteins; integrins
Osteoarthritis (OA) is an age-related and/or trauma-induced multi-factorial, slowly-progressing, and, primarily, non-inflammatory degenerative disorder of the synovial joints culminating in the irreversible destruction of the articular cartilage. Although OA is the most common musculoskeletal condition that causes significant health and social problems worldwide, its exact etiology is still unclear. Age-related wear, overuse, limb mal-alignment and genetic disorders, as well as metabolic problems (obesity, immune responses, diabetes), play important roles in the onset of OA. OA is not exclusively a disorder of articular cartilage; it can be considered as an organ failure of the whole joint with additional abnormalities, especially in bone, ligaments, synovium and the joint capsule.
Joint cartilage and other joint tissues such as tendons/ligaments have a poor intrinsic capacity to heal. Therefore, restoration of a diseased articular surface and of tendons/ligaments at an early stage is a significant challenge for clinicians and researchers. Current orthopaedic therapeutic strategies include bone marrow stimulation, osteochondral transfer and several cell-based techniques. Current pharmacological strategies either seek to relieve pain and increase mobility (symptom modifying drugs) or aim to affect the disease (DMOAD, disease modifying osteoarthritis drugs). To date, none of the current DMOAD-based approaches will stop disease progression, nor regenerate damaged cartilage. Thus, there is an ultimate need for the development of new, non-invasive or minimal-invasive treatments that could slow down and/or stop OA progression and substitute joint replacement for end-stage OA-patients.
This Special Issue calls for original research papers, mini and full reviews, and perspectives that address the progress and current knowledge on the pathophysiological mechanisms of osteoarthritis. This includes therapeutic pharmacological and cell-based strategies, as well as protective surgical interventions, such as reconstruction of chondral and osteochondral lesions and ruptured ligaments and tendons.Prof. Dr. Susanne Grässel
PD Dr. Attila Aszodi
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Pathophysiology of osteoarthritis (OA)
- Regenerative strategies to restore joints tissues
- Inflammation and immune response in OA
- Biomechanical and biochemical mechanisms in OA pathophysiology
- Structure to function relationship of the extracellular matrix
- Molecular and neuronal pathways in OA
- Biomarkers for OA progression
- Advanced imaging techniques for cartilage and bone