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Int. J. Mol. Sci. 2019, 20(3), 768;

IL-10 Could Play a Role in the Interrelation between Diabetes Mellitus and Osteoarthritis

Institute of Anatomy, Paracelsus Medical University, Nuremberg and Salzburg, Prof. Ernst Nathan Str. 1, 90419 Nuremberg, Germany
Department of Biosciences, Paris Lodron University Salzburg, Hellbrunnerstr. 34, 5020 Salzburg, Austria
Department of Orthopedics and Trauma Surgery, Nuremberg General Hospital, Paracelsus Medical University, Nueremberg. Breslauer Strasse 201, 90471 Nuremberg, Germany
Author to whom correspondence should be addressed.
Single senior author.
Received: 27 December 2018 / Revised: 19 January 2019 / Accepted: 31 January 2019 / Published: 12 February 2019
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The association between osteoarthritis (OA), obesity and metabolic syndrome suggests an interrelation between OA and diabetes mellitus (DM). Little is known about the role of anti-inflammatory cytokine interleukin (IL)-10 in the interrelation between OA and DM. Hence, the effects of IL-10 under hyperglycemia (HG) and hyperinsulinemia (HI) in human articular chondrocytes (hAC) and chondrosarcoma cell line Okayama University Medical School (OUMS)-27 were examined. HAC and OUMS-27, cultured in normoglycemic (NG) and HG conditions were stimulated with insulin and/or IL-10. Cell survival, metabolic activity, proliferation and extracellular matrix (ECM) synthesis were immunocytochemically examined. No significant differences in vitality of hAC neither in pure NG (NGw/o) nor HG (HGw/o) conditions were found. Applying HI and/or IL-10 in both conditions reduced significantly the vitality of hAC but not of OUMS-27. HG impaired significantly hAC metabolism. When combined with HI + IL-10 or IL-10 alone it decreased also significantly hAC proliferation compared to NGw/o. In OUMS-27 it induced only a trend of impaired proliferation compared to NGw/o. hAC but not OUMS-27 reduced significantly their collagen type (col) I, SOX9 and proteoglycan (PG) synthesis in HG combined with HI +/− IL-10 compared to NGw/o. IL-10 could not moderate HI and HG effects. In contrast to hAC OUMS-27 showed limited sensitivity as DM model. View Full-Text
Keywords: osteoarthritis; diabetes mellitus; hyperglycemia; hyperinsulinemia; IL-10; human articular chondrocytes osteoarthritis; diabetes mellitus; hyperglycemia; hyperinsulinemia; IL-10; human articular chondrocytes

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Silawal, S.; Willauschus, M.; Schulze-Tanzil, G.; Gögele, C.; Geßlein, M.; Schwarz, S. IL-10 Could Play a Role in the Interrelation between Diabetes Mellitus and Osteoarthritis. Int. J. Mol. Sci. 2019, 20, 768.

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