Special Issue "Molecular and Cellular Mechanisms of Brain Disease: Hippocampus as a Nodal Point"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 31 December 2021.
2. Head of Basic Research Division, Scientific and Clinical Psychoneurological Center of Moscow Health Department, Moscow, Russia
Interests: adaptation; Alzheimer animal models; apoptosis; behaviour; biomarkers; cellular models; cerebral ischemia; dementia; depression; epilepsy; excitotoxicity; free radicals; glia; glucocorticoid signalin
The complicated structure of the hippocampus (different subfields, septotemporal gradient) and its connections with numerous essential parts of the brain provide its key position in realizing different forms of behavioral plasticity and response to environmental factors. Notably, the dentate gyrus of the hippocampus maintains the production of new neurons throughout life.
A critical brain structure for working and spatial memory as well as for emotional behaviors in animals and humans, the hippocampus is a very plastic brain structure. However, the price for its high plasticity is its selective vulnerability to the development of pathological processes induced by numerous stress factors, as well as ischemia, seizures, head trauma, aging, etc. and mediated by signal transduction associated with stress hormones and neuroinflammation. Altered neurogenesis and damage of hippocampal neurons are suggested to be involved in the onset of numerous brain illnesses, particularly mental disorders and neurodegenerative diseases. Over the past decade, it has become clear that hippocampal malfunction is a nodal point for comorbidity between neurological and psychiatric diseases, in particular cognitive disturbances, epilepsy, and affective disorders.
This Special Issue of the International Journal of Molecular Sciences focuses on the involvement of hippocampus in brain diseases and welcomes both original research articles and review papers that deal with the molecular and cellular mechanisms underlying various cerebral pathologies associated with hippocampal dysfunction.
Prof. Dr. Natalia V. Gulyaeva
Manuscript Submission Information
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- adult hippocampal neurogenesis
- mental diseases
- translational research
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Author: Burnyasheva A.O., Stefanova N.A., Kozlova T.A.,Peunov D.A., Kolosova N.G., Rudnitskaya E.A.
Artical: Changes in glial support of hippocampus during development of Alzheimer's disease-like pathology and its correction by mitochondria-targeted antioxidant SkQ1