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Article

Changes in Glial Support of the Hippocampus during the Development of an Alzheimer’s Disease-like Pathology and Their Correction by Mitochondria-Targeted Antioxidant SkQ1

1
Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (ICG SB RAS), 10 Lavrentyeva Ave., 630090 Novosibirsk, Russia
2
Faculty of Natural Sciences, Novosibirsk State University, 2 Pirogova St., 630090 Novosibirsk, Russia
*
Author to whom correspondence should be addressed.
Academic Editor: Natalia V. Gulyaeva
Int. J. Mol. Sci. 2022, 23(3), 1134; https://doi.org/10.3390/ijms23031134
Received: 29 November 2021 / Revised: 18 January 2022 / Accepted: 19 January 2022 / Published: 20 January 2022
Astrocytes and microglia are the first cells to react to neurodegeneration, e.g., in Alzheimer’s disease (AD); however, the data on changes in glial support during the most common (sporadic) type of the disease are sparse. Using senescence-accelerated OXYS rats, which simulate key characteristics of sporadic AD, and Wistar rats (parental normal strain, control), we investigated hippocampal neurogenesis and glial changes during AD-like pathology. Using immunohistochemistry, we showed that the early stage of the pathology is accompanied by a lower intensity of neurogenesis and decreased astrocyte density in the dentate gyrus. The progressive stage is concurrent with reactive astrogliosis and microglia activation, as confirmed by increased cell densities and by the acquisition of cell-specific gene expression profiles, according to transcriptome sequencing data. Besides, here, we continued to analyze the anti-AD effects of prolonged supplementation with mitochondria-targeted antioxidant SkQ1. The antioxidant did not affect neurogenesis, partly normalized the gene expression profile of astrocytes and microglia, and shifted the resting/activated microglia ratio toward a decrease in the activated-cell density. In summary, both astrocytes and microglia are more vulnerable to AD-associated neurodegeneration in the CA3 area than in other hippocampal areas; SkQ1 had an anti-inflammatory effect and is a promising modality for AD prevention and treatment. View Full-Text
Keywords: Alzheimer’s disease; astrocyte; microglia; mitochondria-targeted antioxidant; OXYS rats; SkQ1 Alzheimer’s disease; astrocyte; microglia; mitochondria-targeted antioxidant; OXYS rats; SkQ1
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MDPI and ACS Style

Rudnitskaya, E.A.; Burnyasheva, A.O.; Kozlova, T.A.; Peunov, D.A.; Kolosova, N.G.; Stefanova, N.A. Changes in Glial Support of the Hippocampus during the Development of an Alzheimer’s Disease-like Pathology and Their Correction by Mitochondria-Targeted Antioxidant SkQ1. Int. J. Mol. Sci. 2022, 23, 1134. https://doi.org/10.3390/ijms23031134

AMA Style

Rudnitskaya EA, Burnyasheva AO, Kozlova TA, Peunov DA, Kolosova NG, Stefanova NA. Changes in Glial Support of the Hippocampus during the Development of an Alzheimer’s Disease-like Pathology and Their Correction by Mitochondria-Targeted Antioxidant SkQ1. International Journal of Molecular Sciences. 2022; 23(3):1134. https://doi.org/10.3390/ijms23031134

Chicago/Turabian Style

Rudnitskaya, Ekaterina A., Alena O. Burnyasheva, Tatiana A. Kozlova, Daniil A. Peunov, Nataliya G. Kolosova, and Natalia A. Stefanova. 2022. "Changes in Glial Support of the Hippocampus during the Development of an Alzheimer’s Disease-like Pathology and Their Correction by Mitochondria-Targeted Antioxidant SkQ1" International Journal of Molecular Sciences 23, no. 3: 1134. https://doi.org/10.3390/ijms23031134

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